Patents Assigned to Diagnostics, Inc.
  • BIOSENSORS PRODUCED FROM ENZYMES WITH REDUCED SOLUBILITY AND METHODS OF PRODUCTION AND USE THEREOF
    Publication number: 20200064296
    Abstract: Multi-use biosensors are disclosed that include enzymes that have been modified to reduce the solubility thereof; the multi-use biosensors are used to detect analytes in fluidic biological samples, and the biosensors also maintain their enzyme activity after many uses. Multi-sensor arrays are disclosed that include multiple biosensors. Also disclosed are methods of producing and using these devices.
    Type: Application
    Filed: May 3, 2018
    Publication date: February 27, 2020
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventor: Michael S. WILSON
  • DEVICES AND METHODS FOR MINIMIZING HOOK EFFECT INTEFERENCE IN IMMUNOASSAYS
    Publication number: 20200064339
    Abstract: Methods of minimizing hook effect interference in an immunoassay are disclosed. Also disclosed are reagents, kits, and immunoassay devices that may be utilized in accordance with the method.
    Type: Application
    Filed: May 4, 2018
    Publication date: February 27, 2020
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Chris Zimmerle, Gary Rheinheimer
  • SAMPLE RACK HANDLER AND ROTATION ASSEMBLY FOR A SAMPLE ANALYSIS SYSTEM
    Publication number: 20200064363
    Abstract: An embodiment is a sample analysis system for analyzing a sample that includes at least one test device for analyzing the sample. The system also includes a rack handler operable to move a sample from a first location to a second location along a travel path. The rack handler has a rotation assembly including a) an engagement element for engagement with the sample rack, and b) a motor coupled to the engagement element and is operable to cause rotation of the engagement element. The rotation assembly rotates the sample rack from a first orientation into a second orientation along the travel path when the engagement element engages the sample rack.
    Type: Application
    Filed: May 8, 2018
    Publication date: February 27, 2020
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: William Perry, Michael Chen, Steven Geehan, Gyula Hojer, Norbert Laszka
  • SAMPLE RACK FOR SAMPLE ANALYSIS SYSTEM
    Publication number: 20200064362
    Abstract: An embodiment of the disclosure is a rack adapted to engage a rack handler. The rack includes a rack body. The rack body has a bottom, a top opposite the bottom, and a receptacle that extends from the top toward the bottom. The receptacle is sized to receive the sample collection unit. The rack body has a first interior surface that extends from the bottom toward the top, and a second interior surface that extends from the bottom toward the top. The second interior surface is opposite to the first interior surface so as to at least partially define a slot along the bottom. The rack body also includes an interference groove in the slot along at least one of the first interior surface and the second interior surface. The slot and the interference groove are sized to engage a portion of the rack handler.
    Type: Application
    Filed: May 8, 2018
    Publication date: February 27, 2020
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: William Perry, Michael Chen, Steven Geehan, Gyula Hojer, Norbert Laszka
  • INTERNAL ELECTROLYTE LAYER COMPRISING CARBON PASTE FOR POTENTIOMETRIC ION SELECTIVE ELECTRODE
    Publication number: 20200057017
    Abstract: Disclosed are internal electrolyte layers for ion selective electrodes, wherein the internal electrolyte layers contain carbon paste doped with a metal salt. Also disclosed are ion selective electrodes and sensor array assemblies containing the internal electrolyte layers. Also disclosed are methods of producing and using the internal electrolyte layers, ion selective electrodes, and sensor array assemblies.
    Type: Application
    Filed: May 8, 2018
    Publication date: February 20, 2020
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Wei Zhang, Robert Bergquist, Amir Dolaty, Todd Andrade, Amanda Whittaker
  • System and method for retrieving and analyzing particles
    Patent number: 10564090
    Abstract: A system and method for isolating and analyzing single cells, including: a substrate having a broad surface; a set of wells defined at the broad surface of the substrate, and a set of channels, defined by the wall, that fluidly couple each well to at least one adjacent well in the set of wells; and fluid delivery module defining an inlet and comprising a plate, removably coupled to the substrate, the plate defining a recessed region fluidly connected to the inlet and facing the broad surface of the substrate, the fluid delivery module comprising a cell capture mode.
    Type: Grant
    Filed: August 2, 2019
    Date of Patent: February 18, 2020
    Assignee: Celsee Diagnostics, Inc.
    Inventors: Kalyan Handique, Austin Payne, Vishal Sharma, Kyle Gleason, Priyadarshini Gogoi, Karthik Ganesan, Brian Boniface, Will Chow
  • Neoantigen treatment prioritization using multivariate analysis based on: HLA genotype, self-similarity, similarity to known antigens, antigen expression levels and mutant allele frequency
    Patent number: 10563266
    Abstract: Cancer immunology provides promising new avenues for cancer treatment but validation of potential neoantigens to target is costly and expensive. Analysis of MHC binding affinity, antigen processing, similarity to known antigens, predicted expression levels (as mRNA or proteins), self-similarity, and mutant allele frequency, provides screening method to identify and prioritize candidate neoantigens using sequencing data. Methods of the invention thereby save time and money by identifying the priority candidate neoantigens for further experimental validation.
    Type: Grant
    Filed: July 14, 2016
    Date of Patent: February 18, 2020
    Assignee: Personal Genome Diagnostics Inc.
    Inventors: Victor Velculescu, Theresa Zhang, James Robert White, Luis Diaz
  • Prefixation for increased rare cell recovery
    Patent number: 10564075
    Abstract: Traditionally, enriching or isolating rare circulating cells from a sample has proven difficult as rare circulating cells can be heterogeneous, which limits the use of techniques based on biological properties (e.g., cell surface markers), and can be flexible, which hinders techniques based on physical properties (e.g., diameter size). Methods disclosed herein are capable of enriching or isolating rare circulating cells are minimally impacted by heterogeneity or flexibility of rare circulating cells, and therefore, overcome disadvantages observed with prior techniques. For example, a method for enriching or isolating rare circulating cells from a sample of a subject including fixing one or more rare circulating cells in a sample to create a fixed sample, and isolating the one or more rare circulating cell from the fixed sample using a size exclusion technique is disclosed.
    Type: Grant
    Filed: February 23, 2016
    Date of Patent: February 18, 2020
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Xiaolei Qiu, Sunil Pandit
  • MICROFLUIDIC CHIP WITH SEALED ON-BOARD REAGENT
    Publication number: 20200038855
    Abstract: A microfluidic product pouch assembly may be used in a microfluidic chip. The microfluidic product pouch may include a pouch surrounding an inner chamber and having a rupturing portion and an inner membrane positioned within the inner chamber. The inner membrane may separate the inner chamber into a first cavity and a second cavity. A reagent may be positioned within the first cavity and/or the second cavity. The microfluidic product pouch assembly may also include a rupturing structure. The rupturing structure may be configured to selectively break the rupturing portion of the microfluidic product pouch.
    Type: Application
    Filed: October 10, 2019
    Publication date: February 6, 2020
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Dafeng Chen, James E. Rasmussen, Manish Deshpande
  • WASTE RAMP FOR REAGENT CARDS
    Publication number: 20200041482
    Abstract: An automated analyzer for reagent cards having a leading end, a trailing end and a length between the leading end and the trailing end comprises a travel surface assembly having a card travel surface and an edge. A test analyzing mechanism is adjacent to the travel surface, and a waste receptacle is adjacent to the edge below the travel surface. The waste receptacle has a side and a waste cavity. A ramp member positioned below the travel surface has an end and a sloped surface, and is movable between an extended position where the sloped surface extends into the waste cavity, and a retracted position where the end is spaced from the side a distance greater than the length of the reagent card. A moving mechanism operably coupled with the ramp member is configured to move the ramp member between the extended position and the retracted position.
    Type: Application
    Filed: October 7, 2019
    Publication date: February 6, 2020
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Kenneth Galano, Michael Parker, Aaron Sung-Lien Tang
  • SAMPLE CUP
    Publication number: 20200030789
    Abstract: A cup used to receive, hold, measure and pour liquids, such a specimens, such as for a medical assay, is described. The cup comprises an open receiving upper chamber, two or more open sample-directing channels, and an open, calibrated and marked measuring column. When sitting on a level surface, fluid flows freely from the upper chamber through the sample-directing channels into the measuring column. A foot is under each fluid-directing channel. The base of the measuring column functions as an additional, such as a third, foot. Cups nest, with the two feet of the upper cup sitting into two sample-directing columns of lower cup. The measuring column and upper chamber taper to permit nesting. If the cup is tipped, it rests on two of three of: the two feet and the base of the measuring column, and a point on a lower perimeter of the upper chamber, such that fluid will not spill.
    Type: Application
    Filed: May 20, 2017
    Publication date: January 30, 2020
    Applicant: Sandstone Diagnostics, Inc.
    Inventors: Ulrich Schaff, Jon Epperson, Laura Fredriksen, Kirk Harmon
  • PROTEOLYTIC DIGESTION OF CARDIAC TROPONIN I
    Publication number: 20200031889
    Abstract: A fluid sample container comprising a protease, when a sample fluid is placed in the fluid sample container the protease breaking a target analyte in the sample fluid into at least two peptides, the at least two peptides being smaller than the original target analyte.
    Type: Application
    Filed: October 11, 2019
    Publication date: January 30, 2020
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: David Ledden, Eric Cowden
  • Alignment system for cuvette segments on clinical chemistry instruments
    Patent number: 10545162
    Abstract: A method for aligning a reaction ring in an analyzer system using a gauge vertical reaction ring comprising at least one end slot includes inserting a light beam gauge into an aperture operable to hold the light beam gauge at a height corresponding to a photometer included in the analyzer system. The gauge vertical reaction ring is rotated on the reaction ring until the light beam gauge engages the end slot to confirm alignment of the reaction ring with the photometer.
    Type: Grant
    Filed: July 19, 2017
    Date of Patent: January 28, 2020
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Donald Phillips, Tan Bui
  • Method of preparing clinical samples for nucleic acid amplification
    Patent number: 10544446
    Abstract: The present disclosure is a method of preparing a clinical sample comprising host cells, microbes, proteins and a polyanionic polymer nucleic acid amplification inhibitor.
    Type: Grant
    Filed: February 28, 2019
    Date of Patent: January 28, 2020
    Assignee: Day Zero Diagnostics, Inc.
    Inventor: Chiahao Tsui
  • ELECTROCHEMICAL MOISTURE MEASUREMENT
    Publication number: 20200025708
    Abstract: Disclosed are methods of measuring moisture. Specifically, methods of measuring moisture on dry or nearly dry surfaces using an electrochemical sensor are disclosed. The method comprises applying a coating comprising an electrolyte to an electrode wherein water in the air can permeate the coating, applying a voltage to the electrode, detecting a current and, determining if the current indicates the presence of moisture. As a voltage is applied, oxygen in the water is reduced and produces a measurable signal. The method includes measuring the amount of or decrease of dissolved oxygen (in the form of water) at the surface of the electrode over time. Reduction of oxygen acts as a surrogate for water/moisture and, as such, the dryness of the surface of the electrode is calculated based on a predetermined relationship between current and dissolved oxygen (in the form of water).
    Type: Application
    Filed: July 23, 2018
    Publication date: January 23, 2020
    Applicant: GenMark Diagnostics, Inc.
    Inventor: Christopher E. UHEGBU
  • System and method for isolating and analyzing cells
    Patent number: 10533229
    Abstract: A system and method for isolating cells, comprising: a substrate having a broad surface; an array comprising a set of wells defined at the broad surface of the substrate, each well including: a base surface, an open surface directly opposing the base surface, defined at the broad surface of the substrate, and configured to receive one of a single cell and a single cluster of cells from a direction perpendicular to the broad surface of the substrate, and a set of channels that fluidly couple each well to at least one adjacent well; wherein the set of wells includes an interior subset and an exterior subset fluidly coupled to and surrounding the interior subset by way of the set of channels; and a fluid delivery module surrounding the array and fluidly coupled to each well in the set of wells.
    Type: Grant
    Filed: November 22, 2017
    Date of Patent: January 14, 2020
    Assignee: Celsee Diagnostics, Inc.
    Inventors: Kalyan Handique, Priyadarshini Gogoi, Yi Zhou, Saedeh Sepehri, Christopher Siemer
  • Cell capture system and method of use
    Patent number: 10533936
    Abstract: A cell capture system including an array, an inlet manifold, and an outlet manifold. The array includes a plurality of parallel pores, each pore including a chamber and a pore channel, an inlet channel fluidly connected to the chambers of the pores; an outlet channel fluidly connected to the pore channels of the pores. The inlet manifold is fluidly connected to the inlet channel, and the outlet channel is fluidly connected to the outlet channel. A cell removal tool is also disclosed, wherein the cell removal tool is configured to remove a captured cell from a pore chamber.
    Type: Grant
    Filed: October 11, 2019
    Date of Patent: January 14, 2020
    Assignee: Celsee Diagnostics, Inc.
    Inventor: Kalyan Handique
  • Detection of target nucleic acids using hybridization
    Patent number: 10533223
    Abstract: The present invention provides detection systems and methods for detection of loci and genomic regions in a sample, including mixed samples, using hybridization to an array.
    Type: Grant
    Filed: December 20, 2016
    Date of Patent: January 14, 2020
    Assignee: Ariosa Diagnostics, Inc.
    Inventors: Arnold Oliphant, Jacob Zahn, Kara Juneau, Patrick Bogard, Stephanie Huang
  • SYSTEM AND METHOD FOR THERMAL CONTROL OF INCUBATION SYSTEM IN DIAGNOSTIC ANALYZER
    Publication number: 20200011857
    Abstract: An incubation system for use in an in vitro diagnostic analyzer utilizes a fixed base and a rotatable ring that holds reaction cuvettes. Thermal regulation is provided by directly mounting a heating element to the rotatable ring and controlling the temperature using a temperature controller and thermal sensor for detecting the temperature of the ring, either of which may be mounted to the ring.
    Type: Application
    Filed: February 20, 2018
    Publication date: January 9, 2020
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Ayman Ismail, Eric Gerolstein
  • Collection and storage case for dry blood samples
    Patent number: D875271
    Type: Grant
    Filed: August 3, 2018
    Date of Patent: February 11, 2020
    Assignees: VDI Laboratory, LLC., Kepler Diagnostics, Inc.
    Inventors: Randy Ringold, Tyson Ringold