Patents Assigned to Diagnostics, Inc.
  • Patent number: 10725034
    Abstract: A method of determining a macromolecular analyte in a sample suspected of containing the macromolecular analyte is disclosed. The sample and a conjugate reagent comprising a small molecule and a binding partner for the macromolecular analyte are combined in a medium. The conjugate reagent and a labeled binding partner for the small molecule are combined. The conjugate reagent or the medium is examined for an amount of labeled binding partner for the small molecule that is bound to the small molecule, which is related to the amount of the macromolecular analyte in the sample.
    Type: Grant
    Filed: March 1, 2019
    Date of Patent: July 28, 2020
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventor: James E. Duffy
  • Patent number: 10722890
    Abstract: Covers for microwells, the covers comprising open portions to allow a pipette access to one or more wells and impermeable portions which prevent the liquids from getting into wells shielded by the impermeable portion. The open portions and impermeable portions are preferably arranged and sized to align with alternating rows of wells in a particular microplate. Preferred covers are movably positioned on the microplate and comprise alignment adjusting members for adjusting the alignment of the cover with a microplate. Automated dispensing apparatus for use with microplates and microwell covers comprises a programmable controller, and suitable interfaces which allow the apparatus to be programmed, and which control a dispensing head such that pipettes are moved in the desired manner in order to take advantage of the protective features of the microwell covers. The apparatus also preferably comprises at least one transfer mechanism for moving a cover relative to a microplate at a dispensing station.
    Type: Grant
    Filed: July 8, 2019
    Date of Patent: July 28, 2020
    Assignee: Biochemical Diagnostics, Inc.
    Inventor: Allen I. Panetz
  • Patent number: 10725060
    Abstract: A method of tube slot localization is provided using a tray coordinate system and a camera coordinate system. The method includes receiving, a series of images from at least one camera of a tray comprising tube slots arranged in a matrix of rows and columns. Each tube slot is configured to receive a sample tube. The method also includes automatically detecting fiducial markers disposed on cross sectional areas between the tube slots on the tray and receiving an encoder value indicating when each row of the tray is substantially at the center of the camera's field of view. The method further includes determining calibration information to provide mapping of locations from the tray coordinate system to locations from the camera coordinate system and automatically aligning the tray based on the encoder value and calibration information.
    Type: Grant
    Filed: February 16, 2016
    Date of Patent: July 28, 2020
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Yao-Jen Chang, Patrick Wissmann, Wen Wu, Guillaume Dumont, Benjamin Pollack, Terrence Chen
  • Publication number: 20200232908
    Abstract: Embodiments provide a method of using image-based tube top circle detection based on multiple candidate selection to localize the tube top circle region in input images. According to embodiments provided herein, the multi-candidate selection enhances the robustness of tube circle detection by making use of multiple views of the same tube to improve the robustness of tube top circle detection. With multiple candidates extracted from images under different viewpoints of the same tube, the multi-candidate selection algorithm selects an optimal combination among the candidates and provides more precise measurement of tube characteristics. This information is invaluable in an IVD environment in which a sample handler is processing the tubes and moving the tubes to analyzers for testing and analysis.
    Type: Application
    Filed: June 25, 2018
    Publication date: July 23, 2020
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Yao-Jen Chang, Stefan Kluckner, Benjamin S. Pollack, Terrence Chen
  • Patent number: 10717787
    Abstract: Disclosed is an antibody which binds to a symmetrically dimethylated arginine analyte that can be used to detect a symmetrically dimethylated arginine analyte in a sample, such as in a homogeneous enzyme immunoassay method.
    Type: Grant
    Filed: December 20, 2019
    Date of Patent: July 21, 2020
    Assignee: ARK Diagnostics, Inc.
    Inventors: Johnny Valdez, Byung Sook Moon, Ki Chung, Yunfei Chen
  • Patent number: 10718019
    Abstract: The present invention provides processes for determining accurate risk probabilities for fetal aneuploidies. Specifically, the invention provides non-invasive evaluation of genomic variations through chromosome-selective sequencing and non-host fraction data analysis of maternal samples.
    Type: Grant
    Filed: September 14, 2015
    Date of Patent: July 21, 2020
    Assignee: Ariosa Diagnostics, Inc.
    Inventors: Arnold Oliphant, Andrew Sparks, Eric Wang, Craig Struble
  • Patent number: 10716516
    Abstract: A monitor recorder-implemented method for electrocardiography data compression and an electrocardiography monitor recorder with integral data compression are provided. A series of data items are obtained, each of the data items associated with a magnitude of an ECG signal sensed by a monitor recorder. A range is set for an initial one of the data items in the series. Each of the data items remaining in the series is processed, including: obtaining an estimation of probabilities of the data items appearing next to that data item in the series; dividing the further range into sub-ranges, each sub-range representing a fraction of the further range proportional to the probabilities of the next data items; selecting the sub-range corresponding to the data item next to that data item in the series; and representing the next data item by the selected sub-range in a non-volatile memory.
    Type: Grant
    Filed: August 14, 2017
    Date of Patent: July 21, 2020
    Assignee: Bardy Diagnostics, Inc.
    Inventors: Jason Felix, Ezra M. Dreisbach
  • Patent number: 10718024
    Abstract: The present invention provides processes for determining accurate risk probabilities for fetal aneuploidies. Specifically, the invention provides non-invasive evaluation of genomic variations through chromosome-selective sequencing and non-host fraction data analysis of maternal samples.
    Type: Grant
    Filed: August 8, 2018
    Date of Patent: July 21, 2020
    Assignee: Ariosa Diagnostics, Inc.
    Inventors: Arnold Oliphant, Andrew Sparks, Eric Wang, Craig Struble
  • Publication number: 20200222857
    Abstract: The invention relates to a gas in/outlet-adapter system for a container/rack assembly for a diagnostic robot comprising: —a receptacle (15) comprising a gas-inlet wherein the receptacle (15) is attached to a container (12), —a nozzle (16) comprising a gas-outlet wherein the nozzle (16) is attached to a rack to supply the container (12) via the receptacle (15) with a gas at a defined pressure level, wherein the receptacle (12) —provides one opening (24) —which provides for a fluidic contact to the interior of the container (12) —and a second opening (25) —which provides for a gas leak-proof connection to the nozzle (16) on the rack when the receptacle (15) is placed over the nozzle (16), and wherein the nozzle (16) —provides one opening (26)—which provides for a fluidic contact to a tubing system of the rack—and a second opening (27)—which provides for a fluidic contact to the nozzle (16) when the receptacle (15) is placed to cover the nozzle (15).
    Type: Application
    Filed: February 18, 2017
    Publication date: July 16, 2020
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventor: Claus Tuma
  • Patent number: 10710962
    Abstract: Zwitterion-containing compounds for the modification of hydrophobic molecules to improve their solubility and/or to lower their non-specific binding as provided. The zwitterion-containing compounds may be suitable for modification of detectable labels such as biotin and fluorescein to improve their solubility. The zwitterion-containing compounds may also be useful for the preparation of conjugates of proteins, peptides and other macromolecules or for crosslinking molecules and/or macromolecules.
    Type: Grant
    Filed: May 28, 2016
    Date of Patent: July 14, 2020
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Anand Natrajan, David Sharpe, David Wen, Qingping Jiang
  • Publication number: 20200217839
    Abstract: Methods and reagents are disclosed for minimizing a false result in an assay measurement for determining a concentration of an analyte in a sample suspected of containing the analyte. The method comprises pretreating both an antibody and a sample to be subjected to a non-agglutination immunoassay. In the method the antibody and the sample are combined with a pretreatment agent selected from the group consisting of hydroxyphenyl-substituted C1-C5 carboxylic acids and metallic salts thereof and halogen-substituted C1-C5 carboxylic acids and metallic salts thereof in an amount effective to enhance the accuracy of the non-agglutination immunoassay.
    Type: Application
    Filed: March 19, 2020
    Publication date: July 9, 2020
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Tie Q. Wei, Christy Schaible
  • Patent number: 10705103
    Abstract: Systems and methods for use in an in vitro diagnostics setting may include an automation track, a plurality of carriers configured to carry a plurality of sample vessels along the automation track, and a characterization station including a plurality of optical devices. A processor, in communication with the characterization station, can be configured to analyze images to automatically characterize physical attributes related to each carrier and/or sample vessel. A method may include receiving a plurality of images from a plurality of optical devices of a characterization station, wherein the plurality of images comprise images from a plurality of perspectives of a sample vessel being transported by a carrier, automatically analyzing the plurality of images, using a processor, to determine certain characteristics of the sample vessel, and automatically associating the characteristics of the sample vessel with the carrier in a database.
    Type: Grant
    Filed: February 8, 2018
    Date of Patent: July 7, 2020
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Benjamin Pollack, Ryan German
  • Patent number: 10706260
    Abstract: A method for analyzing digital holographic microscopy (DHM) data for hematology applications includes receiving a DHM image acquired using a digital holographic microscopy system and identifying one or more erythrocytes in the DHM image. For each respective erythrocyte included in the one or more erythrocytes, a cell thickness value for the respective erythrocyte using a parametric model is estimated, and a cell volume value is calculated for the respective erythrocyte using the cell thickness value.
    Type: Grant
    Filed: June 16, 2015
    Date of Patent: July 7, 2020
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Noha Youssry El-Zehiry, Bogdan Georgescu, Lance Anthony Ladic, Ali Kamen, Shanhui Sun
  • Publication number: 20200208099
    Abstract: Selective enrichment media and methods for selectively growing and detecting Salmonella spp. and/or Shiga toxin-producing E. coli. The media may comprise a carbon and nitrogen source, an inorganic salt, a fermentable sugar, one or more selective agents, and an efflux pump inhibitor. Various selective agents include sulfa drugs, surfactants, aminocoumarins, cycloheximide, supravital stains, ascorbic acid, bromobenzoic acid, myricetin, nitrofurantoin, rifamycins, polyketides, and oxazolidinones. Various efflux pump inhibitors include arylpiperazines, such as 1-(1-naphthylmethyl)piperazine, and quinoline derivatives, such as 4-chloroquinoline. Methods of selectively growing and detecting Salmonella and/or Shiga toxin-producing E. coli are provided.
    Type: Application
    Filed: March 10, 2020
    Publication date: July 2, 2020
    Applicant: Paradigm Diagnostics, Inc.
    Inventor: Alan D. Olstein
  • Patent number: 10695803
    Abstract: Methods and apparatus configured and adapted to provide less carryover in an automated clinical analyzer are disclosed. The methods include immersing a pipette into a neutralizing liquid vessel and aspirating a neutralizing liquid (e.g., a hypochlorite solution) into an interior of a pipette. The aspirated portion of the neutralizing liquid used to cleanse the pipette interior is then dispensed back into the neutralizing liquid vessel, rather than disposing of the used neutralizing liquid to a waste station. Apparatus and systems configured to carry out the methods are provided, as are other aspects.
    Type: Grant
    Filed: February 9, 2016
    Date of Patent: June 30, 2020
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Carl Gebauer, Moses Peter
  • Publication number: 20200200730
    Abstract: A method and a device for determining the concentration of an analyte in whole blood is disclosed. In one embodiment, the method includes generating a plasma layer in the whole blood sample. Furthermore, the method includes exposing the plasma layer to light. The method also includes capturing light reflected from the plasma layer. Additionally, the method includes analyzing the reflected light to determine the concentration of the analyte.
    Type: Application
    Filed: June 7, 2018
    Publication date: June 25, 2020
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Satish Kumar Dubey, Ashish Kumar Lal, Vishal Manjanath Prabhu, David Ledden
  • Publication number: 20200197923
    Abstract: Devices, kits, and methods related to embodiments of an improved liquid test sample injection device for use in diagnostic assays and for the collection of liquid waste produced from such diagnostic assays.
    Type: Application
    Filed: September 13, 2018
    Publication date: June 25, 2020
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventor: Aman Ullah
  • Publication number: 20200200698
    Abstract: In vitro diagnostic sensors are disclosed that include membranes formed of a polymer matrix that has been modified to contain surface adhesion functional group(s) that enables attachment of the membrane to a substrate of the sensor. Also disclosed are membranes of these sensors as well as multi-sensor arrays that include multiple sensors. In addition, methods of producing and using these membranes, sensors, and arrays are disclosed.
    Type: Application
    Filed: September 13, 2018
    Publication date: June 25, 2020
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventor: John Benco
  • Patent number: 10690608
    Abstract: A sensor assembly has a substrate with a first surface and a second surface opposite the first surface, at least one analyte sensor positioned on at least one of the first surface and the second surface of the substrate, and at least one electrical contact positioned on the substrate in electrical communication with a corresponding one of the at least one analyte sensor. The substrate is configured to define a tube having an interior surface, and an exterior surface. At least a portion of the first surface of the substrate defines the interior surface of the tube, and the at least one analyte sensor is disposed on at least one of the interior surface and the exterior surface of the tube.
    Type: Grant
    Filed: May 14, 2018
    Date of Patent: June 23, 2020
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Jennifer A. Samproni, Jeffrey R. Jasperse
  • Patent number: 10690597
    Abstract: The timing of the reaction of moisture-sensitive reagents for detecting the presence of analytes, e.g. leukocytes in urine samples, is used to detect when the reagents have been compromised by excess humidity. The ratio of light reflectance at wavelengths characteristic of the products of reaction between the reagents and the analyte and an infra-red reference dye is measured at two preset times after a urine sample has been applied to a test strip and used to determine whether the reagents have been compromised by excessive humidity. The presence of unusually dark samples is determined from the reflected light at 470 and 625 nm in order to confirm that the test strips are humidity-compromised.
    Type: Grant
    Filed: February 26, 2018
    Date of Patent: June 23, 2020
    Assignee: Siemens Healthcare diagnostics Inc.
    Inventors: Chris T. Zimmerle, Michael J. Pugia