Patents Assigned to Diagnostics, Inc.
  • Publication number: 20190169699
    Abstract: The present invention relates to the methods and products for detection of colorectal cancer. Additionally, the present invention relates to methods and products for determining the probability, risk or incidence of colorectal cancer and of colorectal cancer metastasis. The products and methods of the present invention include detecting the level of expression of COL10A1 or MMP11, in combination, from samples, including tissue samples, from humans who currently have been diagnosed with cancer or who were previously diagnosed with cancer and those who are thought to have cancer and are undergoing diagnosis.
    Type: Application
    Filed: February 14, 2019
    Publication date: June 6, 2019
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Michael Stürzl, Roland S. Croner, Andreas Konrad
  • Publication number: 20190170759
    Abstract: Chemiluminescent detection systems, kits, and microfluidics devices containing same, as well as methods of production and use thereof, are disclosed. A capture antibody is attached to a surface of a microfluidics device for capturing a sandwich complex formed of target analyte bound by sensitizer and a composition comprising a single oxygen-activatable chemiluminescent compound.
    Type: Application
    Filed: February 6, 2019
    Publication date: June 6, 2019
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: David J. Ledden, Roland Janzen
  • Patent number: 10308981
    Abstract: The present invention provides assay systems and methods for detection of copy number variation at one or more loci and polymorphism detection at one or more loci in a mixed sample from an individual.
    Type: Grant
    Filed: August 8, 2011
    Date of Patent: June 4, 2019
    Assignee: Ariosa Diagnostics, Inc.
    Inventors: Andrew Sparks, Craig Struble, Eric Wang, Arnold Oliphant
  • Publication number: 20190160666
    Abstract: Methods of positioning a gripper to pick or place a specimen container from a sample rack. One method includes providing a robot including the gripper, the gripper moveable in a coordinate system by the robot and including gripper fingers, providing a sample rack including receptacles containing specimen containers, providing data, obtained by imaging, regarding the specimen containers in the sample rack, and dynamically orienting the gripper based upon the data. The data may include population and/or configuration data and the dynamic orientation may include gripper finger opening distance, gripper finger rotational position, and/or gripper offset distance. Gripper positioning apparatus for carrying out the method are disclosed, as are other aspects.
    Type: Application
    Filed: June 27, 2017
    Publication date: May 30, 2019
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Benjamin S. Pollack, Steven Pollack
  • Patent number: 10302572
    Abstract: A reagent card analyzer comprises an optical signal source configured to transmit an optical signal and an optical signal detector spaced a distance from the optical signal source to define an optical signal path into which the optical signal is transmitted, the optical signal detector configured to detect the optical signal and to output an electrical signal indicative of the optical signal. A reader is configured to read a reagent pad of a reagent card. A reagent card moving mechanism is configured to move the reagent card having the reagent pad including a leading and trailing end through the optical signal path. An optical detector interface is electrically coupled with the optical signal detector and configured to receive electrical signals and to output a pad detect signal indicative of at least one of the leading and the trailing end as the reagent card is moved through the optical signal path.
    Type: Grant
    Filed: December 14, 2012
    Date of Patent: May 28, 2019
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Lawrence Milesky, George N. Zantos
  • Patent number: 10301681
    Abstract: The present invention relates generally to the field of biomarker analysis, particularly determining gene expression signatures from urine samples. The disclosure provides compositions, kits and methods for diagnosing a prostate disorder such as prostate cancer in a male subject.
    Type: Grant
    Filed: August 6, 2014
    Date of Patent: May 28, 2019
    Assignee: Exosome Diagnostics, Inc.
    Inventors: Johan Karl Olov Skog, Mikkel Noerholm
  • Patent number: 10303844
    Abstract: Measurement of circulating ST2 and natriuretic peptide (e.g., NT-proBNP) concentrations is useful for the prognostic evaluation of subjects, in particular for the prediction of adverse clinical outcomes, e.g., mortality, transplantation, and heart failure.
    Type: Grant
    Filed: December 20, 2016
    Date of Patent: May 28, 2019
    Assignee: Critical Care Diagnostics, Inc.
    Inventors: James V. Snider, Robert W. Gerwien, Sven Jacobson
  • Publication number: 20190151851
    Abstract: Methods, devices, and kits, related to embodiments for uniformly coating at least one inner surface of a capillary with at least one anticoagulant compound.
    Type: Application
    Filed: November 14, 2018
    Publication date: May 23, 2019
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventor: Aaron Kauffmann
  • Publication number: 20190151844
    Abstract: A method includes conveying a detection solution containing a target amplicon into a detection module of a molecular diagnostic test device. The detection module includes a detection surface including a series of capture probes to which a first portion of the target amplicon is bound when the detection solution is conveyed. A first reagent formulated to produce a visible signal indicating a presence of the target amplicon is then conveyed into the detection module. The first reagent is bound to a second portion of the target amplicon when the first reagent is conveyed. A second reagent is conveyed into the detection module. The second reagent includes a precipitating substrate formulated to catalyze the production of the visible signal by producing an insoluble colored product when the second reagent is in contact with the first reagent. The method includes viewing the visible signal via a transparent portion of the detection module.
    Type: Application
    Filed: December 21, 2018
    Publication date: May 23, 2019
    Applicant: Click Diagnostics, Inc.
    Inventors: Boris ANDREYEV, Rajinder K. BHATIA, Victor BRIONES, Phoebe CAO, Jesus CHING, Brian CIOPYK, Adam DE LA ZERDA, Jonathan H. HONG, Helen HUANG, Colin KELLY, Adrienne C. LAM, Gregory LONEY, Danielle MCSHEERY, Keith E. MORAVICK, Valeria REVILLA, Shaunak ROY, David D. SWENSON
  • Patent number: 10294515
    Abstract: Disclosed herein are methods of detecting presence of a gene fusion in a sample from a subject. In some embodiments, the methods of detecting presence of a fusion gene in a sample from a subject utilize a fusion probe that spans the point of fusion between two nucleic acids or genes, and detecting the fusion probe after nuclease treatment. In other embodiments, the methods of detecting presence of a fusion gene in a sample from a subject utilize two or more probes that flank the point of fusion between two nucleic acids or genes, and detecting these probes after nuclease treatment. In additional embodiments, the methods can include determining the percentage of gene fusion in the sample relative to the first nucleic acid or the second nucleic acid.
    Type: Grant
    Filed: December 7, 2011
    Date of Patent: May 21, 2019
    Assignee: HTG Molecular Diagnostics, Inc.
    Inventors: Bruce Seligmann, BJ Kerns, John Luecke, Matt Rounseville, Ihab Botros, Mark Schwartz
  • Publication number: 20190144177
    Abstract: Embodiments are directed to a removable cap with a conduction seal closure for sealing an opening of a container. The cap has a side wall and a top wall with an open access hole there-through. A flat upper portion surrounds the open access hole, which is sealed by the conduction seal. The conduction seal comprises a first polymer sealing layer, an aluminum foil layer on top of the first layer to heat seal the first layer to the cap, and a second polymer layer arranged on top of the aluminum foil layer for protection. The aluminum foil provides a formable shaping strength such that upon seal piercing, a permanent memory spread of the first and third layers is achieved. Removal of the cap does not damage the seal. Access to the container contents is achieved without probe contact to the as-pierced seal.
    Type: Application
    Filed: June 22, 2017
    Publication date: May 16, 2019
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: James W. Kegelman, Joseph E. Brennan, William E. Hudson
  • Publication number: 20190147718
    Abstract: A remote control warning device enabling communication of warnings and/or communication of information with a remote operation device. The remote control warning device includes a housing, a proximity sensor coupled to the housing configured to sense a presence of a person located within a safety zone, one or more warning devices coupled to the housing and configured to display and/or sound a warning to the person, a user interface coupled to the housing and configured to display information and/or allow input by a local operator, and a communication interface operatively coupleable with a communication network to provide communication with the remote operator. Warnings may be provided to the local operator. Automated processing systems including the remote control warning device and methods of operation are provided, as are other aspects.
    Type: Application
    Filed: June 1, 2017
    Publication date: May 16, 2019
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventor: Silvio Gnecco
  • Publication number: 20190147457
    Abstract: A service request interface is provided in association with a laboratory instrument. The interface may be displayed on an interactive display unit, such as a touchscreen monitor associated with the laboratory instrument. When a user initiates a service request by interacting with the interface, relevant system software files containing instrument location, software version, configuration, customer contact, and event codes corresponding to instrument performance and/or status are encrypted and transmitted to a remote ticketing interface for creation of a service ticket and associated ID. Other instrument data files may be transmitted, in association with the service ticket ID, to a remote data services back end. Remote support personnel have access to the data associated with the service ticket ID in the remote ticketing interface and the remote data services back end. Communications between the remote service personnel and the service request or take place via a remote collaboration services back end.
    Type: Application
    Filed: January 13, 2017
    Publication date: May 16, 2019
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Steve Magowan, Catalin Tudose
  • Publication number: 20190145996
    Abstract: Embodiments are directed to transferring and opening reagent containers for use in a clinical analyzer in an in vitro diagnostics (WD) environment. Contents of a reagent container may be automatically recorded, and the container is positioned and opened, making available its contents to a transfer probe. A set of mechanical fingers open and close relative to one another, to release and grip the reagent container on opposite sides thereof for transferring the container. Once the container is positioned, the mechanical fingers raise and are positioned above a seal concealing the contents of the reagent container. The fingers are configured to close together and travel in a downward trajectory to piece the seal. The reagent container is originally presented as an un-opened package to prevent spillage and to control reagent life expectancy. According to an embodiment, a method of performing a cycle unload, transfer, and load, without operator intervention, is provided.
    Type: Application
    Filed: June 22, 2017
    Publication date: May 16, 2019
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Peter L. Gebrian, Joseph E. Brennan, Ronald G. Barlow, William E. Hudson, William H. Reigle, Jr.
  • Patent number: 10288628
    Abstract: Kits, microfluidics devices, and assays for use in methods of spectroscopically determining a ratio of glycated hemoglobin to total hemoglobin in a whole blood sample are disclosed.
    Type: Grant
    Filed: April 10, 2015
    Date of Patent: May 14, 2019
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventor: David J. Ledden
  • Patent number: 10288542
    Abstract: An imaging device for determining particle size distribution including a sample receptacle containing a sample and an imager capable of capturing a plurality of images of the sample in a region of observation. The imaging device further includes a radiation source provided linearly opposite to the imager and a base platform that supports the imager and the radiation source.
    Type: Grant
    Filed: February 2, 2016
    Date of Patent: May 14, 2019
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Anant Kumar Mishra, Naveen Kumar Ssm
  • Patent number: 10290090
    Abstract: Embodiments provide a method of using image-based tube top circle detection that includes extracting, from one of a series of images of a tube tray, a region of interest (ROI) patch having a target tube top circle and boundaries constrained by two dimensional (2D) projections of different types of tube top circle centers. The method also includes calculating an edge gradient magnitude map of the ROI patch and constructing a three dimensional (3D) map of a circle parameter space, each location in the 3D map corresponding to a circle parameter having a center location and a diameter. The method further includes accumulating weighted votes in the 3D map from edge points in the edge gradient magnitude map along edge point gradient directions, determining locations in the 3D map as circle candidates based on the accumulated votes and selecting a target tube top circle based on the greatest accumulated votes.
    Type: Grant
    Filed: February 16, 2016
    Date of Patent: May 14, 2019
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Yao-Jen Chang, Wen Wu, Guillaume Dumont, Benjamin Pollack, Terrence Chen
  • Patent number: 10279346
    Abstract: A hand-held molecular diagnostic test device includes a housing, an amplification (or PCR) module, and a detection module. The amplification module is configured to receive an input sample, and defines a reaction volume. The amplification module includes a heater such that the amplification module can perform a polymerase chain reaction (PCR) on the input sample. The detection module is configured to receive an output from the amplification module and a reagent formulated to produce a signal that indicates a presence of a target amplicon within the input sample. The amplification module and the detection module are integrated within the housing.
    Type: Grant
    Filed: September 28, 2018
    Date of Patent: May 7, 2019
    Assignee: Click Diagnostics, Inc.
    Inventors: Boris Andreyev, Keith E. Moravick, Brian Ciopyk, Victor Briones, Gregory Loney, Adam De La Zerda, Jesus Ching, Steven Chu, David Swenson, Helen Huang, Colin Kelly
  • Patent number: 10283399
    Abstract: The inventive concepts disclosed herein are generally directed to a sensor array device that has a prolonged shelf life but requires only a minimal amount of sample volume in order to test two or more analytes concurrently. In order to ensure the sensor array has a sufficient shelf life, anti-diffusion regions are positioned among the reaction wells in order to slow the processes of diffusion. The use of anti-diffusion regions, as described herein, can be used to optimize the number of sensors that can be fit into a sensor array designed for reduced sample liquid volumes (e.g., less than 100 ?L) as well as extending the test strip's shelf life.
    Type: Grant
    Filed: May 21, 2018
    Date of Patent: May 7, 2019
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventor: Donna S. Orvedahl
  • Patent number: 10278603
    Abstract: A system and method for secure physiological data acquisition and storage. An identifier of a physiological monitoring patch is obtained by a programming wand, the patch configured to store the identifier within a cryptographic circuit. A password for accessing physiological monitoring data collected using that patch is generated based on at least a portion of the identifier, the password is encrypted using a secret key, and the encrypted password is loaded into the cryptographic circuit. The key is loaded onto a monitor recorder that couples with the patch and obtains the physiological monitoring data using the patch, wherein the monitor recorder offloads the data together with the identifier and the decoded password. The identifier and the password are reported to a server that stores the offloaded physiological monitoring data using the identifier within a secure database and grants access to the data upon receipt of the decoded password.
    Type: Grant
    Filed: April 30, 2018
    Date of Patent: May 7, 2019
    Assignee: Bardy Diagnostics, Inc.
    Inventors: Jason Felix, Ezra M. Dreisbach, Jon Mikalson Bishay, Corey Bailey Williamson, Gust H. Bardy