Patents Assigned to Diagnostics, Inc.
  • DEGRADABLE CATIONIC SURFACTANTS AND USE THEREOF IN ENHANCING CHEMILUMINESCENCE
    Publication number: 20190234883
    Abstract: The present invention relates to methods of enhancing chemiluminescence from a chemiluminescent label comprising contacting a chemiluminescent label with an acid in the presence of a degradable cationic surfactant and hydrogen peroxide followed by the addition of a base. Related kits containing such degradable cationic surfactant are also provided. The degradable cationic surfactant can compress light emission time of the chemiluminescent label to an extent that is comparable to or shorter than conventional surfactants. The degradable cationic surfactant can also increase chemiluminescence of the chemiluminescent label, providing increased light emission output that is comparable to conventional surfactants.
    Type: Application
    Filed: September 7, 2018
    Publication date: August 1, 2019
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Anand Natrajan, David Wen
  • DEVICES AND METHODS FOR MOLECULAR DIAGNOSTIC TESTING
    Publication number: 20190232283
    Abstract: A hand-held molecular diagnostic test device includes a housing, an amplification (or PCR) module, and a detection module. The amplification module is configured to receive an input sample, and defines a reaction volume. The amplification module includes a heater such that the amplification module can perform a polymerase chain reaction (PCR) on the input sample. The detection module is configured to receive an output from the amplification module and a reagent formulated to produce a signal that indicates a presence of a target amplicon within the input sample. The amplification module and the detection module are integrated within the housing.
    Type: Application
    Filed: April 5, 2019
    Publication date: August 1, 2019
    Applicant: Click Diagnostics, Inc.
    Inventors: Boris ANDREYEV, Keith E. MORAVICK, Brian CIOPYK, Victor BRIONES, Gregory LONEY, Adam DE LA ZERDA, Jesus CHING, Steven CHU, David SWENSON, Helen HUANG, Colin KELLY
  • REAGENT CARD ALIGNMENT SYSTEM AND METHOD
    Publication number: 20190234885
    Abstract: A reagent analyzer and method is described. In the method, a reagent card having a reagent pad is passed through an optical signal path between an optical signal source and an optical signal detector. A transition between a first electrical signal and a second electrical signal is detected to determine a substantially exact position of a leading end or a trailing end of the reagent pad. The first electrical signal is indicative of the substrate interfering with the optical signal. The second electrical signal is indicative of the substrate and reagent pad of the reagent card interfering with the optical signal. The reagent pad is moved to a known second location upon determining the substantially exact position of at least one of the leading end and the trailing end of the reagent pad. At the second location a sample is dispensed onto the reagent pad by a sample dispenser.
    Type: Application
    Filed: April 10, 2019
    Publication date: August 1, 2019
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Lawrence Milesky, George N. Zantos
  • SYSTEM AND METHOD FOR CONDITION BASED MONITORING AND MAINTENANCE OF AN AUTOMATION TRACK
    Publication number: 20190237190
    Abstract: Systems and methods for use in an in vitro diagnostics setting incorporating existing or additional sensors in an automation system to assess the health and maintenance status of the automation system are disclosed. Such systems include any of a variety of sensors, such as Hall Effect sensors, temperature probes/thermocouples, ohm meters, volt meters, etc., which are in communication with a local or preferably remote monitoring station that can alert a user or maintenance personnel of needed service.
    Type: Application
    Filed: July 19, 2017
    Publication date: August 1, 2019
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Shannon FRONE, Baris YAGCI
  • Multimarker Risk Stratification
    Publication number: 20190237197
    Abstract: Measurement of circulating ST2 and natriuretic peptide (e.g., NT-proBNP) concentrations is useful for the prognostic evaluation of subjects, in particular for the prediction of adverse clinical outcomes, e.g., mortality, transplantation, and heart failure.
    Type: Application
    Filed: April 10, 2019
    Publication date: August 1, 2019
    Applicant: Critical Care Diagnostics, Inc.
    Inventors: James V. Snider, Robert W. Gerwien, Sven Jacobson
  • SINGLE POINT CHAIN OF CUSTODY WITHIN A DISTRIBUTED AUTOMATION PLATFORM
    Publication number: 20190228846
    Abstract: Embodiments are directed to a combination of an automation system that continuously tracks the identity and positions of all of its pucks with a single sample identification station and covers/interlocks in order to provide sample chain of custody without the need to re-identify the sample at points of interaction (aspiration, de-capping, etc.). This eliminates the need to have sample identification stations at each interaction point. This reduction of hardware allows the system to be cheaper, smaller, and more reliable. It also allows not only the automation system, but also existing pre-analytical/analytical equipment connected to the automation system, to run more efficiently.
    Type: Application
    Filed: July 19, 2017
    Publication date: July 25, 2019
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Benjamin S. Pollack, Colin Mellars, Baris Yagci
  • MASKING CAMERA FLASH USING REFLECTANCE
    Publication number: 20190230272
    Abstract: One embodiment provides systems and methods for masking the effects of a flash on an operator including: a drawer system configured to receive a tray comprising one or more laboratory containers, wherein upon receiving the tray, the drawer system centers the tray underneath an image capture device; a flash device configured to activate, based on said centering, to illuminate the one or more laboratory containers; and an image capture device configured to capture an illuminated image of the one or more laboratory containers.
    Type: Application
    Filed: July 19, 2017
    Publication date: July 25, 2019
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventor: Benjamin S. Pollack
  • METHODS OF DETECTING GENE FUSIONS
    Publication number: 20190226013
    Abstract: Disclosed herein are methods of detecting presence of a gene fusion in a sample from a subject. In some embodiments, the methods of detecting presence of a fusion gene in a sample from a subject utilize a fusion probe that spans the point of fusion between two nucleic acids or genes. In other embodiments, the methods of detecting presence of a fusion gene in a sample from a subject utilize two or more probes that flank the point of fusion between two nucleic acids or genes. In additional embodiments, the methods can include determining the percentage of gene fusion in the sample relative to the first nucleic acid or the second nucleic acid.
    Type: Application
    Filed: April 8, 2019
    Publication date: July 25, 2019
    Applicant: HTG Molecular Diagnostics, Inc.
    Inventors: Bruce A. Seligmann, BJ Kerns, John Luecke, Matt Rounseville, Ihab Botros, Mark Schwartz
  • Methods and Systems for Detecting Bovine Spongiform Encephalopathy in Cattle
    Publication number: 20190226025
    Abstract: The present invention provides methods and systems for identify bovine spongiform encephalopathy in bovine, and related uses, agents, and kits. The invention includes and methods for detecting and diagnosing BSE.
    Type: Application
    Filed: August 27, 2018
    Publication date: July 25, 2019
    Applicant: CNA Diagnostics Inc.
    Inventors: Anne Balkema-Buschmann, Robert B. Church, Paul M. K. Gordon, Martin H. Groschup, Christoph W. Sensen, Maria Sensen, Deepthi T. Thomas Kannanayakal
  • Medical devices, systems, and methods for performing eye exams and eye tracking
    Patent number: 10357153
    Abstract: Apparatus and methods for eye tracking using an optical coherence tomography (OCT) device are disclosed. Such eye tracking may be performed by using information about the shape of the cornea and the corneal apex or using the iris/pupil border obtained using the OCT device.
    Type: Grant
    Filed: May 1, 2017
    Date of Patent: July 23, 2019
    Assignee: Envision Diagnostics, Inc.
    Inventors: Alexander C. Walsh, Paul G. Updike, Richard Castro
  • Diagnostic apparatus
    Patent number: 10359614
    Abstract: An automated microscope apparatus comprises an outer housing having an external wall; optionally but preferably an internal wall in the housing configured to form a first compartment and a separate second compartment in the outer housing; a microscope assembly in the housing (preferably in the first compartment); a microprocessor in the housing (preferably in the second compartment), and (optionally but preferably) a heat sink mounted on the housing external wall, preferably adjacent the second compartment, with the microprocessor thermally coupled to said heat sink and operatively associated with the microscope assembly. Systems and methods employing the same are also described, along with component parts thereof.
    Type: Grant
    Filed: July 2, 2013
    Date of Patent: July 23, 2019
    Assignee: Advanced Animal Diagnostics, Inc.
    Inventors: Stefano Bresolin, David A. Calderwood, Tobias M. Heineck, David Newcomb, Chris Paul, Jasper N. Pollard, Rodolfo R. Rodriguez, Demetris Young
  • Process for separation of prokaryotic DNA from eukaryotic DNA in a whole blood sample
    Patent number: 10358640
    Abstract: A process for separating prokaryotic DNA from eukaryotic DNA in a whole blood sample infected by pathogen is provided. The process includes extracting prokaryotic and eukaryotic DNA from the whole blood sample, contacting the prokaryotic DNA in the whole blood sample with a motif that specifically binds to the prokaryotic DNA, and generating a bound pair. The process also includes separating the bound pair. The whole blood sample is transfected with bacteriophages genetically modified to contain a defined DNA sequence having a selectable marker DNA. The DNA sequence integrates into the prokaryotic DNA, and the motif is an oligonucleotide specific to the defined DNA sequence in the engineered bacteriophages.
    Type: Grant
    Filed: August 18, 2015
    Date of Patent: July 23, 2019
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Subhadra Rukmini Jayaraman, Ramya Vutukuru
  • Module with collapsible fluid chamber and onboard fluid chamber compression element
    Patent number: 10357774
    Abstract: A module for processing fluids includes one or more collapsible fluid chambers supported on a substrate, a compression element supported on the substrate and configured to be movable with respect to the one or more chambers, and an actuating element coupled to the compression element and configured to effect movement of the compression element relative to the one or more fluid chambers to collapse each fluid chamber by compressing the fluid chamber between the compression element and the substrate as the compression element moves over the fluid chamber.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: July 23, 2019
    Assignee: GenMark Diagnostics, Inc.
    Inventor: David Walter Wright
  • Methods for detecting nucleic acid fragments
    Patent number: 10351899
    Abstract: Provided are methods for detecting and analyzing polynucleotides in a biological sample or sample derived therefrom for example, using a synthetic template polynucleotide. In some aspects, a target polynucleotide in the sample hybridizes to the template polynucleotide and is extended by a polymerase, generating an extended target polynucleotide. In some examples, the extended target polynucleotide is amplified, for example, by polymerase chain reaction, and sequences of the target polynucleotide determined, for example, by priming in the region of the extended target polynucleotide generated by extension and sequencing towards the region having identity to the target polynucleotide. In some aspects, the target polynucleotide is thereby detected in the sample and its sequence identified.
    Type: Grant
    Filed: September 25, 2014
    Date of Patent: July 16, 2019
    Assignee: Bio-ID Diagnostics Inc.
    Inventor: Thuraiayah Vinayagamoorthy
  • System including multiple instrument modules and arrangement thereof
    Patent number: D854704
    Type: Grant
    Filed: January 29, 2018
    Date of Patent: July 23, 2019
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Daniel LiCalzi, Youngsang Lee, Robert Faranda, Richard Watson, Justin Cumming
  • System including multiple instrument modules and arrangement thereof
    Patent number: D855198
    Type: Grant
    Filed: January 29, 2018
    Date of Patent: July 30, 2019
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Daniel LiCalzi, Youngsang Lee, Mark Lloyd, Gregory Bange, Richard Warwick, Robert Faranda, Richard Watson, Justin Cumming, Scott Salmon, Josh Hartl
  • System including multiple instrument modules and arrangement thereof
    Patent number: D855199
    Type: Grant
    Filed: January 29, 2018
    Date of Patent: July 30, 2019
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Daniel LiCalzi, Youngsang Lee, Mark Lloyd, Gregory Bange, Richard Warwick, Robert Faranda, Richard Watson, Justin Cumming
  • System including multiple instrument modules and arrangement thereof
    Patent number: D855200
    Type: Grant
    Filed: January 31, 2018
    Date of Patent: July 30, 2019
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Daniel LiCalzi, Youngsang Lee, Robert Faranda, Richard Watson, Justin Cumming, Scott Salmon, Josh Hartl
  • System including multiple instrument modules and arrangement thereof
    Patent number: D855201
    Type: Grant
    Filed: February 1, 2018
    Date of Patent: July 30, 2019
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Daniel LiCalzi, Youngsang Lee, Mark Lloyd, Gregory Bange, Richard Warwick, Robert Faranda, Richard Watson, Justin Cumming
  • System including multiple instrument modules and arrangement thereof
    Patent number: D855202
    Type: Grant
    Filed: February 1, 2018
    Date of Patent: July 30, 2019
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Daniel LiCalzi, Youngsang Lee, Robert Faranda, Richard Watson, Justin Cumming, Scott Salmon, Josh Hartl