Abstract: A new class of polychelants, their chelates with metal ions and their physiologically acceptable salts, useful, either as they are or in association or formulation with other components, for diagnostic imaging as general or specific contrast agents for specific tissues, organs or body compartments.

Abstract: Compounds of the formula when chelated with metals exhibit improved serum relaxivity and are used in magnetic resonance imaging, particularly for imaging the blood pool.

Abstract: A process based on ion exchange with separated beds is disclosed for the deionization of substances that are not stable in the presence of strongly acidic cation exchangers, wherein the solution to be deionized is contacted with a first bed consisting of a basic anion exchanger in the form of hydrogen carbonate and subsequently with a second bed, connected in series, consisting of a weakly acidic cation exchanger in hydrogen form.

Abstract: 1,4,7,10-tetraazacyclododecane-1,4-diacetic acid of formula (I): as well as its chelated complex salts with bi-valent metal ions having atomic numbers from 20 to 31, 39, 42, 43, 44, 49, or from 57 to 83, as well as their salts with anions of physiologically acceptable organic acid selected from acetate, succinate, citrate, fumarate, maleate, oxalate, or with anions of inorganic acids selected from halo acids ions. The compounds are intermediates for preparing 1,4,7,10-tetraaza-cyclododecane chelating agents.

Abstract: Compounds of formula (I): are used as their paramagnetic chelates as contrast agents in magnetic resonance imaging. These compounds have high affinity to plasma proteins and exhibit extremely high values of relaxivity in serum and are thus useful as blood pool contrast agents.

Abstract: Compounds of formula (I) in which R is in which R is hydrogen, a straight or branched or cyclic C1-C6 alkyl group, unsubstituted or substituted by 1 to 10 oxygen atoms, or a C1-C20 alkyl group, optionally interrupted by a phenylene, in turn substituted by a straight or branched C1-C6 alkyl group, unsubstituted or substituted by 1 to 3 C1-C7 alkyl groups; the phenylene group being unsubstituted or substituted by alkoxy, carboxy, sulfamoyl, hydroxyalkyl, amino groups; as well as its complexes with a bi- or trivalent metal ion having an atomic number from 20 to 31, 39, 42, 43, 44, 49, or from 57 to 83, as well as its salts with anions of physiologically acceptable organic acids chelated complexes of these compounds are used as contrast agents for nuclear magnetic resonance imaging.

Abstract: Compounds of formula (I) both in the racemic and optically active forms, are used in MRI diagnostic imaging.

Abstract: A process for the preparation of S-N,N′-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)amino]-2,4,6-triiodo-1,3-benzenedicarboxamide, comprising the formation of S-N,N′-bis[2-hydro-xy-1-(hydroxymethyl)ethyl]-5-[(2-(acetyloxy)-1-oxopro-pyl)amino]-2,4,6-triiodo-1,3-benzenedicarboxamide star-ting from S-(−)-5-[[2-(acetyloxy)-1-oxopropyl]amino]-2,4,6-triiodo-1,3-benzenedicarboxylic acid dichloride and 2-amino-1,3-propanediol in a solvent, characterized in that the solvent is selected from the group consisting of: lower alcohols, monoalkyl ether glycols and straight or branched cyclic alkyl ethers.

Abstract: Equipment and procedures for regenerating ion exchange resin mixed beds, used for the desalination of water or of aqueous solutions from industrial processes (process solutions), that use two columns: the first treatment column (C1), containing a mixed bed of ion exchange resins, in which the cation exchange resins are regenerated, and a second column (C2) into which the anion exchange resins are transferred and regenerated, to be then reintroduced from the bottom into the above mentioned first column (C1), where they rise through the cation exchange resins and intimately mix with the anionic exchange resins.

Abstract: Compounds of formulae (I) and (II) wherein the R, R1, R2, R3 and R4 groups have the meanings defined in the disclosure, are useful chelants for metal ions. The complexes of compounds (I) and (II) with paramagnetic ions are useful as contrast agents for M.R.I. imaging.

Abstract: A process for the preparation of 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid and the salts thereof of formula (I) ##STR1## which comprises the following steps: a) carboxymethylation reaction of a suitable precursor in water, with a haloacetic acid,b) hydrolysis reaction in basic conditions by addition of the base added at the previous step.

Abstract: The present invention relates to the novel compound, 1,4,7,10-tetraazabicyclo[8.2.2]tetradecan-2-one of formula (I), its preparation and the use thereof for the preparation of tetraazamacrocycles .

Abstract: A novel a process for the preparation of the chelating agent of formula (I) ##STR1## 4-carboxy-5,8,11-tris(carboxymethyl)-1-phenyl-2-oxa-5,8,11-triazatridecan- 13-oic acid, commonly named BOPTA.

Abstract: Procedures for preparing compounds of formula (I) ##STR1## in which n, p and q or independently 0 or 1, are prepared according to the reaction scheme: ##STR2##

Abstract: Compounds of formulae (I) and (II) ##STR1## wherein the R, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 groups have the meanings defined in the disclosure, are useful chelants for metal ions. The complexes of compounds (I) and (II) with paramagnetic ions are useful as contrast agents for M.R.I. imaging.

Abstract: A process for the preparation of tetraazamacrocycles of general formula (I) ##STR1## wherein n, p and q can independently be 0 or 1, comprising the following steps:a): condensation of polyamines with a glyoxal derivative;b): condensation of the resulting compound with an alkylating agent;c): oxidation of the resulting compound with an oxidizing agent, to give a mixture of oxidated products which is submitted tod): hydrolysis in acid aqueous solution, to give the compound of formula (I).

Abstract: A process for the preparation of 3-amino-1,2-propanediol, commonly known as isoserinol, having an organic impurities content lower than 0.1% and an inorganic impurities content lower than 0.05%.

Abstract: Compounds which can chelate paramagnetic bi- and trivalent metal ions, their chelates with said metal ions and their use as contrast agents in magnetic resonance imaging (MRI), the compounds having formula (I) ##STR1## wherein R is a --(CH.sub.2).sub.m --O--R.sub.2 group or hydrogen,R.sub.2 is a (C.sub.6 -C.sub.10) aryl, or an alkyl(C.sub.1 -C.sub.5)-aryl(C.sub.6 -C.sub.10) group, substituted or not by a group L corresponding to a OH group or a OR.sub.3 group, wherein R.sub.3 is a linear or branched (C.sub.1 -C.sub.5) alkyl group; or L is NH.sub.2, halogen, COOH or CONR.sub.4 R.sub.5 wherein R.sub.4 and R.sub.5 are independently hydrogen, or a linear or branched (C.sub.1 -C.sub.5) alkyl which can be substituted by 1-6 hydroxy groups and/or 1-6 alkoxy groups,R.sub.1 can have the same meanings as R, independently from it, except for hydrogen,Z is independently OH or OR.sub.6, or NR.sub.4 R.sub.5 wherein R.sub.4 and R.sub.5 are as previously defined, and R.sub.6 is a (C.sub.1 -C.sub.

Abstract: A process based on ion exchange with separated beds is disclosed for the deionization of substances that are not stable in the presence of strongly acidic cation exchangers, wherein the solution to be deionized is contacted with a first bed consisting of a basic anion exchanger in the form of hydrogen carbonate and subsequently with a second bed, connected in series, consisting of a weakly acidic cation exchanger in hydrogen form.

Abstract: A process for the preparation of 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid and the salts thereof of formula (I) ##STR1## which comprises the following steps: a) carboxymethylation reaction of a suitable precursor in water, with a haloacetic acid,b) hydrolysis reaction in basic conditions by addition of the base added at the previous step.