Abstract: A system and method for determining a subject's attentional response to a stimulus. The method includes measuring microsaccadic eye movement dynamics of the subject, detecting whether a microsaccadic signature (a suppression in microsaccadic rate) is present in the measured microsaccadic eye movement relative to a time of the stimulus, and correlating the subject's attentional response to the stimulus based on the detection. The method further includes determining that the stimulus was sensed if the microsaccadic signature is present and determining that the stimulus was not sensed if the microsaccadic signature is absent.

Abstract: Various embodiments of a system and method for the treatment of brain cancer using a subdurally-implanted alternating electric field generation apparatus are disclosed herein.

Abstract: Embodiments for a cerebrospinal fluid flow detector for detecting the flow of cerebrospinal fluid are disclosed. In some embodiments, the cerebrospinal fluid flow detector includes a casing with a rotatable wheel having a plurality of radially extending arms disposed therein. The rotatable wheel is in communication with a channel having a distal end in communication with an inlet port and a proximal end in communication with an outlet port such that the flow of cerebrospinal fluid through the channel causes the rotatable wheel to rotate. In some embodiments, each radially extending arm includes at least one radiopaque marker in which movement of the rotatable wheel caused by fluid flow through the channel allows an X-ray imaging apparatus to detect the difference in position of a respective radiopaque marker at multiple times caused by rotation of the rotatable wheel.

Abstract: The invention relates to a composition and use of the composition in the treatment of a disorder, for example, a neurological disease associated with retinoid signaling. The invention also includes the use of a retinoid encapsulated in nanoparticles. The retinoid encapsulated nanoparticles are adapted to increasing lifespan and conferring neuroprotective effects such as preserving motor units, reducing motor impairment, or reducing neuroinflammation in a subject.

Abstract: A medical device is disclosed including a needle guide. The needle guide includes abase, a guide member, and a handle arrangement. The base defines a base channel and the guide member includes a guide member channel in communication with one another and configured for receiving a flexible needle. The guide member includes a non-linear portion and is generally flexible to accommodate passage of a flexible needle through a corresponding portion of the guide member channel. The handle arrangement is configured to accommodate stabilization of the needle guide during deployment.

Abstract: Systems, devices, and methods are provided for reducing a risk of unintentional falls in a subject that is at risk for falls. The device includes a sensor and a stimulator. The sensor is configured to be positioned adjacent a body portion of the user that changes orientation when the user sits and stands. The sensor is also configured to emit an activation signal when the user stands and to emit a deactivation signal when the user sits or lies down. The stimulator is in communication with the sensor and is configured to be positioned adjacent one of a calf and a lower back of the user. The stimulator is configured to vibrate at a frequency that stimulates proprioceptors of the user without inducing muscle contractions upon receipt of the activation signal from the sensor and to cease vibration upon receipt of the deactivation signal from the sensor.

Abstract: Various embodiments of a pedicle screw assembly disclosed herein include a pedicle screw configured for engaging with bone tissue. The pedicle screw includes a body defining a plurality of channels through the body of the screw and in communication with a plurality of respective distal openings defined along the screw body. The pedicle screw assembly further includes an anchor defining a plurality of anchor members which are configured to be received at least partially through the plurality of channels and the plurality of respective distal openings to further engage the pedicle screw to the bone tissue.

Abstract: The present disclosure generally relates to a table-mounted retractor system for open-spine surgery. The table-mounted retractor system includes a frame, wherein the frame is situated lateral to the patient. The table-mounted retractor system further comprises a plurality of retractor hooks wherein each of the plurality of retractor hooks are in operative association with one of a plurality of tension lines, wherein each of the plurality of tension lines is engaged with the frame. Each one of the plurality of retractor hooks are operable to engage with the flesh of a patient as each of the tension lines pull the flesh back laterally towards the frame along each side of the patient.

Abstract: A system and method for bending a surgical rod using an automated bending system includes receiving an indication of a plurality of line segments defined on the rod and an indication of an angle measurement to be formed between at least two adjacent ones of the plurality of line segments. Bending parameters to perform on the rod to form the angle measurement between the at least two adjacent ones of the plurality of line segments are determined and operation of the automated bending system is controlled using the bending parameters to create an angle having the angle measurement between the at least two adjacent ones of the plurality of line segments.

Abstract: Systems and methods for detecting onset, presence, and progression of particular states, including intoxication, include observing eye movements of a subject and correlating the observed movements to known baseline neurophysiological indicators of intoxication. A detection system may record eye movement data from a user, compare the eye movement data to a data model comprising threshold eye movement data samples, and from the comparison make a determination whether or not intoxication or impairment is present. The detection system may alert the user to take corrective action if onset or presence of a dangerous condition is detected. The eye movements detected include saccadic and intersaccadic parameters such as intersaccadic drift velocity. Measurements may be collected in situ with a field testing device. An interactive application may be provided on a user device to provoke the desired eye movements during recording.

Abstract: The present disclosure generally relates to a sacroiliac joint coupler having a base plate and an angled plate for respective engagement with the sacrum and ilium are described herein. The sacroiliac joint coupler includes a bolt having a threaded distal end extending from a top face of the base plate and a fastener that couples the distal end of the bolt to the angled plate. In addition, the fastener may include a hinge or a locking ball.

Abstract: Provided herein are systems, devices, and methods for improved treatment of tissue, such as brain tissue. The improved treatment described herein can result in improved tissue penetration of various compounds and chemicals, such as stains and immunohistochemistry reagents. For example, provided herein is a pressurizing device that may include a chamber body having an opening in one of a top and a sidewall of the body, and may also include a chamber lid covering the opening and releasably coupled to the chamber body proximate the opening. The chamber lid and chamber body form an air-tight cavity. The pressurizing device may also have an inlet passing through one of the chamber body and the chamber lid and into the air-tight cavity. The device may also include a retainer coupled inside the air-tight cavity and configured to releasably couple to at least one tissue sample receptacles.

Abstract: The present invention relates to methods of diagnosing samples as well as various microfluidic, microcentrifuge and microfilter devices. In one embodiment, the present invention provides a method of diagnosing neurodegenerative diseases using mitochondrial and/or platelet samples. In another embodiment, the present invention provides a microfluidic device that selectively captures and analyzes a desired amount of target biological particle.

Abstract: A soft-inflatable exosuit for knee rehabilitation is fabricated in two different beam-like structures (I and O cross-section actuators) and mechanically characterized for their torque performance in knee-extension assistance. The fabrication procedure of both types of actuators is presented as well as their integration into a light-weight, low-cost and body-conforming interface. To detect the activation duration of the device during the gait cycle, a soft-silicone insole with embedded force-sensitive resistors (FSRs) is used. In evaluation studies, the soft inflatable exosuit device is tested for its ability to reduce muscle activity during the swing phase of the knee. Using sEMG (surface electromyography) sensors, the rectus femoris muscle group of a healthy individual is recorded while walking on a treadmill at a constant speed, with and without the soft device.

Abstract: Methods and apparatus are provided for increasing compliance with the discard volume method of blood drawing. The method includes attaching an initial discard container for discarding an initial amount of blood drawn to a standard blood culture bottle. The apparatus, detachable and configurable with a variety of standard blood culture containers, may act as a physical reminder and a convenient handling arrangement for drawing blood according to the preferred discard volume method that reduces sample contamination and false positives. These methods and apparatus may be compatible or retrofit with existing standard blood culture bottles or kits.

Abstract: Apparatus and methods for measuring a concentration of a target molecule from a biological sample are disclosed. In one example, the apparatus includes a porous pad, which is impregnated with a solution containing at least one agent and which contains an unfilled capillary matrix, a housing for the porous pad, and a membrane that covers the porous pad.

Abstract: A soft robotic spinal orthosis includes a control system having at least one processor, a plurality of adjustable pressure fluid bladders to provide at least one variable supporting force to a torso of a user, a plurality of supports to secure the fluid bladders to the torso, at least one sensor to detect a position of the torso, and at least one pressure device to increase and decrease a fluid pressure of the fluid bladders.

Abstract: Methods and systems for distinguishing an astrocytic human brain tumor from a non-astrocytic human brain tumor. In one embodiment, a method includes the steps of staining tumor tissue from a subject suspected of having a brain tumor with SR101 and visualizing the tissue stained with SR101 with a fluorescence imaging device to confirm an astrocytic or non-astrocytic tumor type. Advantageously, tumor tissue from a subject is stained ex vivo, and the staining and visualizing steps are performed intraoperatively so as to guide the surgeon and thereby minimize or eliminate the need for a subsequent surgery.

Abstract: Provided herein are compounds, compositions, and methods for treating cancer in a subject in need thereof.

Abstract: Described herein are methods, systems and compositions for the diagnosis, prognosis and treatment of dementia and Alzheimer's disease. Also described are methods, systems and compositions to distinguish between Alzheimer's disease and Parkinson's disease. In various embodiments levels of PACAP and/or SIRT3 are analyzed for the diagnosis, prognosis and treatment of dementia and Alzheimer's disease.