Abstract: A drug reservoir loading and unloading mechanism for drug delivery device using unidirectional rotated lead screw and method thereof are disclosed. The drug reservoir loading/unloading mechanism allows exchanging the drug reservoir quickly with very few steps and with more safety. The invention neither requires rewinding of the drive system either automatically or manually while replacing the drug reservoir nor requires an additional adapter to secure the drug reservoir.

Abstract: Devices for the automatic release of liquid medicaments are disclosed. In particular, a flexible container for storing a liquid medicament, a port for such a flexible container, and a device for the automated release of a liquid medicament are disclosed. A flexible container for storing a medicament comprises sealed top and bottom flexible sheets and at least one port mounted to a wall of the flexible container. The at least one port comprises a flange attached to the wall and an inner conduit connecting the inner storage volume and the exterior of the flexible container. The port comprises an adapter protruding through a hole in the top flexible sheet and a base plate having at least one drain channel connected to the inner conduit via an inner opening on the base plate. A device for the automated release of a medicament comprises at least one flexible container.

Abstract: A drug delivery device drive that includes a single shape memory alloy wire actuator to advance a lead screw via a ratcheting mechanism and method thereof are disclosed. In one embodiment, a shape memory alloy wire is operably connected to one of a pair of ratchet wheels and configured to drive incrementally the rotation of the connected ratchet wheel via a contraction, which in turn drives the rotation of the other ratchet wheel about a rotational axis which moves a lead screw and advances a plunger to dispense a liquid drug from a drug container. A drug delivery device using the shape memory alloy wire actuator in combination with the ratcheting mechanism to incrementally rotate a shaft, a lead screw or a sleeve provides for a more compact an less complicated design.

Abstract: A method and system for optimizing post prandial blood glucose excursions for persons with diabetes via computation of time-varying optimal insulin profiles are disclosed. The method builds upon a mathematical model based on the physiologic description of the human glucoregulatory system. Model parameter values are specific for each patient and meal type, and are determined from measured data by minimizing differences between both measurements and model predictions, and which are used to provide the optimal insulin profiles that are useful to diabetics in managing their chronic disease.

Abstract: A medical infusion system with pulse width modulation and a safety circuit and a method thereof are disclosed. Embodiments of the system include a switching device and a pump motor, wherein the pump motor and the switching device are connected in series and constitute a power supply circuit to be connected to a power supply. Embodiments of the system further includes a control signal generator configured to generate a control signal e.g. PWM, and which is connected to input of the safety circuit. Output of the safety circuit is connected to a control input of the switching device such that the pump motor will not operate if there is no control signal applied to the input of the safety circuit.

Abstract: Methods for setting a basal rate profile for an insulin pump with an input unit and a calculation unit are disclosed. A number of interpolation nodes for the basal rate profile are defined by means of the input unit of the insulin pump. A continuous function with respect to the interpolation nodes, which images the interpolation nodes and any previously stored basal rates, is formed using the calculation unit of the insulin pump, and a temporal sequence of basal rates to be released by the insulin pump during specific time intervals is generated from the continuous function using the calculation unit of the insulin pump.

Abstract: A system and a method for monitoring individual metabolic responses and generating nutritional feedback based on the monitored responses in a qualified subject are disclosed. Measurements of glucose level in the subject are consecutively performed by a measuring device to generate corresponding first data. Subsequently, data is transmitted to an analysis device, where second data representing glycemic responses is generated from a time-series of glucose level measurements represented by the first data. In a next step, the second data is compared with a predetermined individual glycemic response budget for the subject which represents a total amount of individual glycemic responses allowable for a certain time period. Finally, feedback corresponding to the result of the comparison is provided by an output device.

Abstract: The invention provides a device and methods for analyzing body fluids wherein the device is implanted in the body and provides for both the delivery of substances into the body and for the testing of body fluids.

Abstract: A dosing device for an infusion system comprises a dosing unit having a variable volume and at least one opening in fluid connection with the variable volume, through which opening the variable volume can be filled with a substance or the substance can be dispensed from the variable volume. The dosing device is operable in a first state for filling the substance from a supply conduit, in a second state for preventing filling and dispensing, or in a third state for dispensing through a dispensing conduit. No direct fluid connection exists between the supply conduit and the dispensing conduit at any time. Methods for dosing a substance with the dosing device.

Abstract: Embodiments of an assessment method for processing a signal corresponding to a glucose concentration and performing a retrospective analysis comprises the steps of: a) initiating a first trigger, wherein the first trigger defines the beginning of a segment of a continuous measurement of glucose concentration or defines the first of a series of spot measurements of glucose concentration; b) collecting data of the continuous measurement or the series of spot measurements of glucose concentration to be analyzed, wherein the collected data relates to a glucose concentration excursion corresponding to a reaction to a relevant event such as a meal or physical activity; c) analyzing the collected data initiated by a second trigger, wherein the second trigger defines the end of the collected data to be analyzed, wherein a measure for a grading of the excursion is determined from the collected data, and d) displaying the results of the analysis.

Abstract: Administering device for infusing or injecting a product, comprising a housing (1, 2) with a receiver (3) for the product, a compartment (7) for a power source in order to supply the conveying mechanism (4) with electrical energy, a first contact spring (15) which is disposed in the compartment and places a terminal of the power source in an electrically conducting contact by means of a spring force when the power source is disposed in the compartment (7), and a second contact spring (16) for establishing an electrically conducting contact for an opposite terminal of the power source, likewise by means of spring force.

Abstract: A system including at least two distally separated devices that are in wireless communication with each other, wherein at least one of the two devices is provided with a warning mechanism configured to indicate an existing or imminent interruption or disturbance of communication. The inventive system may include a base unit and at least one mobile medical or pharmaceutical device in unidirectional communication or bidirectional communication with the base unit. A method for monitoring wireless communication between at least two devices is encompassed, wherein at least one of the two devices indicates an existing or imminent interruption or disturbance of the wireless communication by changing a type of the communication signal transmission.

Abstract: An insulin pump comprises a pump device, a control for the pump device, a memory, an operating element for operating the insulin pump and a method for controlling a user interface of the insulin pump are disclosed. The control is designed and programmed such that options for the user of the insulin pump are displayed by the user interface as a function of a user-specific preference profile stored in the memory and as a function of a current time and are provided for selection by using the operating element. The insulin pump can be designed in an auto-adaptive fashion, such that the control continuously updates the user-specific preference profile based on analyzing operating inputs of the user. Embodiments of the invention allow a large range of functions and simple operation, even in the case of miniaturized pumps.

Abstract: A device for administering doses of a substance, the device including a housing forming one of a product reservoir or a receiving seat for a product reservoir, a force sensor, a delivery mechanism which executes an axial output movement in a delivery direction to deliver a dose from the product reservoir, and which is supported via the sensor on the housing counter to the delivery direction, and a contact element on which the sensor is axially supported, at least one of the contact element and sensor forming a device for reducing play which, in an adjustment engagement with at least one of the housing or the delivery mechanism, is displaced into an adjustment position and axially secured in the adjustment position in such a way that axial play between the delivery mechanism and the housing is reduced.

Abstract: A port system including an implantable first fluid guiding system, an external second fluid guiding system with a connecting head at one end, a percutaneously implantable port for establishing a fluid connection between the fluid guiding systems, the port including a port casing which forms a first connecting element, and a connecting device which includes a second connecting element, wherein the connecting head is fastened to the port casing by a releasable, engagement of the connecting elements, several embodiments of which connecting elements are encompassed.

Abstract: A method for processing a chronological sequence of measurements of a time dependent parameter measured in or on a human body, in particular of a physiological glucose concentration, and a system thereof are disclosed. A database stores a plurality of chronological sequences of measurements of the time dependent parameter and computing and display equipment graphically displays on a user interface display at least three of the measurements of a stored sequence simultaneously. The method as well as the system enable a patient to improve self-management skills concerning a therapy that affects the behavior of the parameter.

Abstract: The present invention generally relates to a universal interface for an infusion system. Specifically it relates to a new carrier system for an infusion system with improved wearing comfort and handling.

Abstract: A device including a display for displaying operational and/or functional parameters of the device and a control unit with at least one control element for controlling the display and/or device, wherein the display is at least partly rotatable with respect to the device, and/or wherein the position of the at least one control element is modifiable or changeable with respect to the device. In some embodiments, the control functions of at least two control elements of the device are interchangeable. In some embodiments, the display is provided by data sent to the display at intervals, whereby the display is updated. In embodiments in which several display parts are rotatable, data is processed by a processing module prior to being sent to the display. A method of display and/or display and control manipulation is encompassed.

Abstract: A catheter head, for introduction of a fluid into an organic tissue, including a cannula housing with a cannula, a connector element with a fluid inlet, a guide and a fixing device. The guide device has several selectable discrete rotational positions for positioning the connector element relative to the cannula housing about a longitudinal axis of the cannula. The connector element, positioned in a rotational position, is detachably connected to the cannula housing in the selected position by means of the fixing device.

Abstract: A micro perfusion device including a casing, a perfusate supply, an inner cannula forming an inner lumen between a front cannula opening which is distal when the device is subcutaneously positioned and a rear cannula opening, the inner lumen being connected or connectable to the perfusate supply via the rear cannula opening, a perfusion cannula projecting from a lower side of the casing and surrounding the inner cannula, an outer lumen between the inner cannula and the perfusion cannula, a collecting container for the perfusate, and a perfusate outlet connecting the outer lumen to the collecting container, wherein the collecting container has a variable volume and a partial vacuum with respect to a pressure prevailing in the perfusate supply may be generated in the collecting container.