Abstract: A drug reservoir loading and unloading mechanism for drug delivery device using unidirectional rotated lead screw and method thereof are disclosed. The drug reservoir loading/unloading mechanism allows exchanging the drug reservoir quickly with very few steps and with more safety. The invention neither requires rewinding of the drive system either automatically or manually while replacing the drug reservoir nor requires an additional adapter to secure the drug reservoir.

Abstract: A drug delivery device drive that includes a single shape memory alloy wire actuator to advance a lead screw via a ratcheting mechanism and method thereof are disclosed. In one embodiment, a shape memory alloy wire is operably connected to one of a pair of ratchet wheels and configured to drive incrementally the rotation of the connected ratchet wheel via a contraction, which in turn drives the rotation of the other ratchet wheel about a rotational axis which moves a lead screw and advances a plunger to dispense a liquid drug from a drug container. A drug delivery device using the shape memory alloy wire actuator in combination with the ratcheting mechanism to incrementally rotate a shaft, a lead screw or a sleeve provides for a more compact an less complicated design.

Abstract: A system and a method for monitoring individual metabolic responses and generating nutritional feedback based on the monitored responses in a qualified subject are disclosed. Measurements of glucose level in the subject are consecutively performed by a measuring device to generate corresponding first data. Subsequently, data is transmitted to an analysis device, where second data representing glycemic responses is generated from a time-series of glucose level measurements represented by the first data. In a next step, the second data is compared with a predetermined individual glycemic response budget for the subject which represents a total amount of individual glycemic responses allowable for a certain time period. Finally, feedback corresponding to the result of the comparison is provided by an output device.

Abstract: The invention provides a device and methods for analyzing body fluids wherein the device is implanted in the body and provides for both the delivery of substances into the body and for the testing of body fluids.

Abstract: Administering device for infusing or injecting a product, comprising a housing (1, 2) with a receiver (3) for the product, a compartment (7) for a power source in order to supply the conveying mechanism (4) with electrical energy, a first contact spring (15) which is disposed in the compartment and places a terminal of the power source in an electrically conducting contact by means of a spring force when the power source is disposed in the compartment (7), and a second contact spring (16) for establishing an electrically conducting contact for an opposite terminal of the power source, likewise by means of spring force.

Abstract: A system including at least two distally separated devices that are in wireless communication with each other, wherein at least one of the two devices is provided with a warning mechanism configured to indicate an existing or imminent interruption or disturbance of communication. The inventive system may include a base unit and at least one mobile medical or pharmaceutical device in unidirectional communication or bidirectional communication with the base unit. A method for monitoring wireless communication between at least two devices is encompassed, wherein at least one of the two devices indicates an existing or imminent interruption or disturbance of the wireless communication by changing a type of the communication signal transmission.

Abstract: A device for administering doses of a substance, the device including a housing forming one of a product reservoir or a receiving seat for a product reservoir, a force sensor, a delivery mechanism which executes an axial output movement in a delivery direction to deliver a dose from the product reservoir, and which is supported via the sensor on the housing counter to the delivery direction, and a contact element on which the sensor is axially supported, at least one of the contact element and sensor forming a device for reducing play which, in an adjustment engagement with at least one of the housing or the delivery mechanism, is displaced into an adjustment position and axially secured in the adjustment position in such a way that axial play between the delivery mechanism and the housing is reduced.

Abstract: A port system including an implantable first fluid guiding system, an external second fluid guiding system with a connecting head at one end, a percutaneously implantable port for establishing a fluid connection between the fluid guiding systems, the port including a port casing which forms a first connecting element, and a connecting device which includes a second connecting element, wherein the connecting head is fastened to the port casing by a releasable, engagement of the connecting elements, several embodiments of which connecting elements are encompassed.

Abstract: A method for processing a chronological sequence of measurements of a time dependent parameter measured in or on a human body, in particular of a physiological glucose concentration, and a system thereof are disclosed. A database stores a plurality of chronological sequences of measurements of the time dependent parameter and computing and display equipment graphically displays on a user interface display at least three of the measurements of a stored sequence simultaneously. The method as well as the system enable a patient to improve self-management skills concerning a therapy that affects the behavior of the parameter.

Abstract: A device including a display for displaying operational and/or functional parameters of the device and a control unit with at least one control element for controlling the display and/or device, wherein the display is at least partly rotatable with respect to the device, and/or wherein the position of the at least one control element is modifiable or changeable with respect to the device. In some embodiments, the control functions of at least two control elements of the device are interchangeable. In some embodiments, the display is provided by data sent to the display at intervals, whereby the display is updated. In embodiments in which several display parts are rotatable, data is processed by a processing module prior to being sent to the display. A method of display and/or display and control manipulation is encompassed.

Abstract: A catheter head, for introduction of a fluid into an organic tissue, including a cannula housing with a cannula, a connector element with a fluid inlet, a guide and a fixing device. The guide device has several selectable discrete rotational positions for positioning the connector element relative to the cannula housing about a longitudinal axis of the cannula. The connector element, positioned in a rotational position, is detachably connected to the cannula housing in the selected position by means of the fixing device.

Abstract: A micro perfusion device including a casing, a perfusate supply, an inner cannula forming an inner lumen between a front cannula opening which is distal when the device is subcutaneously positioned and a rear cannula opening, the inner lumen being connected or connectable to the perfusate supply via the rear cannula opening, a perfusion cannula projecting from a lower side of the casing and surrounding the inner cannula, an outer lumen between the inner cannula and the perfusion cannula, a collecting container for the perfusate, and a perfusate outlet connecting the outer lumen to the collecting container, wherein the collecting container has a variable volume and a partial vacuum with respect to a pressure prevailing in the perfusate supply may be generated in the collecting container.

Abstract: An insertion aid for inserting a cannula of a catheter head into organic tissue, in particular a catheter head for administering a liquid active substance, wherein the insertion aid includes a guide needle that is fixed to a grip section for removably inserting and stabilising the cannula during insertion into the organic tissue and a needle shield, having at least two sections, which is secured in a pivotable manner to the grip section and which encases and shields the guide needle when the insertion aid is separated from the catheter head.

Abstract: A system for recommending insulin bolus quantities to an insulin user includes a display unit and memory unit coupled to a control circuit with a user blood glucose target stored in the memory unit. The control circuit is programmed to receive the user's current blood glucose value, to determine and display via the display unit a recommended correction insulin bolus quantity if the current blood glucose value exceeds the blood glucose target, to compute a difference value as the current blood glucose value less the blood glucose target, and to produce a modified blood glucose target as a sum of the blood glucose target and the difference value for a lock-out time period if the difference value is positive. Additional correction insulin bolus quantities may be recommended during the lock-out time period if the user's current blood glucose value exceeds the modified blood glucose target.

Abstract: A membrane with at least one passage extending through an elastic material of the membrane, wherein when a cannula is inserted in the passage, the passage is expanded and the elastic material presses against the cannula and surrounds the cannula in a seal, wherein the membrane can be compressed relative to the passage, and wherein, in one embodiment, the passage exhibits a cross-sectional area having a long main axis and a short main axis perpendicular to the long main axis. The invention encompasses a membrane-cannula combination for biological and medical uses, and a membrane-connecting device combination for connecting a fluid guide and a catheter.

Abstract: A cannula, for introduction into a body tissue, the cannula flexible after introduction, and rigid below a critical temperature and flexible above the critical temperature. In a method for the introduction of the cannula into the body tissue, the cannula is cooled to a temperature below the critical temperature and introduced into the body tissue. After being introduced, the cannula is brought to a temperature above the critical temperature by warming and thus becomes flexible.

Abstract: A device for administering an injectable product in doses including a casing, a container for the product, accommodated by the casing, from which container product is delivered through an opening of the container by moving a piston accommodated in the container toward the opening, and a drive for causing the delivery of the product wherein the drive moves the container relative to the casing and the piston.

Abstract: A device for the dosed output of a substance, the device involving hydrogel-based osmotic drive, wherein output characteristics of the device, including a time profile, may be adjusted by a user. In some embodiments, the device may be used once and, in other embodiments, it may be used several times.

Abstract: A system for removing or tranferring a pharmaceutical product from a reservoir including an ampoule with a moveable piston therein and an adaptor which includes, generally along a longitudinal axis, a reservoir connector and an ampoule connector for coupling to the ampoule, wherein the ampoule connector includes at least one locking mechanism which, in a side wall, includes a resilient element generally corresponding to a portion of the side wall which extends along the periphery thereof and, at opposing ends, merges with the side wall.

Abstract: A system for positioning and inserting insertion means into tissue includes an insertion head and an inserter. The insertion head includes a base with a lower side positionable on tissue; and an insertion means movably mounted by the base, which is movable from a protective position where a free end of the insertion means is short of the lower side, into an insertion position where the free end protrudes beyond the lower side of the base. The inserter includes an inserter casing having a lower side with an opening for the insertion head; a holding means, coupled to the inserter casing for holding the insertion head in an initial position; a drive configured to move the insertion head out of the initial position in an advancing direction; and an activating member movable relative to the holding means and operable such that the insertion means is moved into the insertion position.