Patents Assigned to DNA Sciences Laboratories, Inc.
  • Genotyping the human UDP-glucuronosyl transferase 1 (UGT1) gene
    Publication number: 20030157517
    Abstract: Genetic polymorphisms are identified in the human UGT1 gene that alter UGT1-dependent drug metabolism. Nucleic acids comprising the polymorphic sequences are used to screen patients for altered metabolism for UGT1 substrates, potential drug-drug interactions, and adverse/side effects, as well as diseases that result from environmental or occupational exposure to toxins. The nucleic acids are used to establish animal, cell and in vitro models for drug metabolism.
    Type: Application
    Filed: September 18, 2002
    Publication date: August 21, 2003
    Applicant: DNA Sciences Laboratories, Inc.
    Inventors: Laura Penny, Margaret Galvin
  • Genotyping the human UDP-glucuronosyltransferase 2B7 (UGT2B7) gene
    Patent number: 6586175
    Abstract: Genetic polymorphisms are identified in the human UGT2B4, UGT2B7 and UGT2B15 genes that alter UGT2B activity. Nucleic acids comprising the polymorphic sequences are used to screen patients for altered metabolism for UGT2B substrates, potential drug-drug interactions, and adverse/side effects, as well as diseases that result from environmental or occupational exposure to toxins. The nucleic acids are used to establish animal, cell and in vitro models for drug metabolism.
    Type: Grant
    Filed: July 20, 1999
    Date of Patent: July 1, 2003
    Assignee: DNA Sciences Laboratories, Inc.
    Inventors: Margaret Galvin, Andrew Miller, Laura Penny, Michael Riedy
  • Genetic typing of the human cytochrome P450 2A6 gene and related materials and methods
    Publication number: 20030105314
    Abstract: Disclosed are novel polymorphisms in the human cytochrome P450 2A6 gene and the use of those polymorphisms as predictive sequences for altered metabolism or occurrence of disease.
    Type: Application
    Filed: August 30, 2002
    Publication date: June 5, 2003
    Applicant: DNA Sciences Laboratories, Inc.
    Inventors: Marco Guida, Jeff Hall
  • Genotyping human UDP-glucuronsyltransferase 2B15 (UGT2B15) genes
    Publication number: 20030099977
    Abstract: Genetic polymorphisms are identified in the human STP2 gene that alter STP2-dependent drug metabolism. Nucleic acids comprising the polymorphic sequences are used to screen patients for altered metabolism for STP2 substrates, potential drug-drug interactions, and adverse/side effects, as well as diseases that result from environmental or occupational exposure to toxins. The nucleic acids are used to establish animal, cell and in vitro models for drug metabolism.
    Type: Application
    Filed: July 26, 2002
    Publication date: May 29, 2003
    Applicant: DNA Sciences Laboratories, Inc.
    Inventors: Marco Guida, Janice Kurth
  • Genotyping of human CYP3A4
    Publication number: 20030059800
    Abstract: Genetic polymorphisms are identified in the human CYP3A4 gene that alter CYP3A4-dependent drug metabolism. Nucleic acids comprising the polymorphic sequences are used to screen patients for altered metabolism for CYP3A4 substrates, potential drug-drug interactions, and adverse/side effects, as well as diseases that result from environmental or occupational exposure to toxins. The nucleic acids are used to establish animal, cell and in vitro models for drug metabolism.
    Type: Application
    Filed: May 14, 2002
    Publication date: March 27, 2003
    Applicant: DNA Sciences Laboratories, Inc.
    Inventors: Jay B. Lichter, Marco Guida
  • Genetic typing of the human cytochrome P450 2A6 gene and related materials and methods
    Patent number: 6492115
    Abstract: Disclosed are novel polymorphisms in the human cytochrome P450 2A6 gene and the use of those polymorphisms as predictive sequences for altered metabolism or occurrence of disease.
    Type: Grant
    Filed: June 2, 2000
    Date of Patent: December 10, 2002
    Assignee: DNA Sciences Laboratories, Inc.
    Inventors: Marco Guida, Jeff Hall
  • Genotyping the human UDP-glucuronosyltransferase 1 (UGT1) gene
    Patent number: 6479236
    Abstract: Genetic polymorphisms are identified in the human UGT1 gene that alter UGT1-dependent drug metabolism. Nucleic acids comprising the polymorphic sequences are used to screen patients for altered metabolism for UGT1 substrates, potential drug-drug interactions, and adverse/side effects, as well as diseases that result from environmental or occupational exposure to toxins. The nucleic acids are used to establish animal, cell and in vitro models for drug metabolism.
    Type: Grant
    Filed: May 5, 1999
    Date of Patent: November 12, 2002
    Assignee: DNA Sciences Laboratories, Inc.
    Inventors: Laura Penny, Margaret Galvin
  • Genotyping the human phenol sulfotransferbase 2 gene STP2
    Patent number: 6448003
    Abstract: Genetic polymorphisms are identified in the human STP2 gene that alter STP2-dependent drug metabolism. Nucleic acids comprising the polymorphic sequences are used to screen patients for altered metabolism for STP2 substrates, potential drug-drug interactions, and adverse/side effects, as well as diseases that result from environmental or occupational exposure to toxins. The nucleic acids are used to establish animal, cell and in vitro models for drug metabolism.
    Type: Grant
    Filed: June 8, 1999
    Date of Patent: September 10, 2002
    Assignee: DNA Sciences Laboratories, Inc.
    Inventors: Marco Guida, Janice Kurth
  • Isolated CYP3A4 nucleic acid molecules and detection methods
    Patent number: 6432639
    Abstract: Genetic polymorphisms are identified in the human CYP3A4 gene that alter CYP3A4-dependent drug metabolism. Nucleic acids comprising the polymorphic sequences are used to screen patients for altered metabolism for CYP3A4 substrates, potential drug-drug interactions, and adverse/side effects, as well as diseases that result from environmental or occupational exposure to toxins. The nucleic acids are used to establish animal, cell and in vitro models for drug metabolism.
    Type: Grant
    Filed: August 31, 1998
    Date of Patent: August 13, 2002
    Assignee: DNA Sciences Laboratories, Inc.
    Inventors: Jay B. Lichter, Marco Guida