Patents Assigned to DNAE GROUP HOLDINGS LIMITED
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Patent number: 11879116Abstract: A method of analysing nucleic acid using apparatus comprising a reaction chamber and plurality of sensors located in the base of the chamber, with each sensor preferably located within a respective well. The method comprises flowing a fluid containing the nucleic acid or fragments thereof into the reaction chamber. While the chamber is fully or at least partially sealed, amplification of the nucleic acid or said fragments is performed within the chamber using an amplification primer or primers whilst detecting the generation of amplicons using said sensors. Sequencing or hybridisation is then performed on the amplicons, and sequencing or hybridisation is detected using said sensors.Type: GrantFiled: January 14, 2022Date of Patent: January 23, 2024Assignee: DNAe Group Holdings LimitedInventors: Christofer Toumazou, David Davidson, Samuel Reed
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Patent number: 11603400Abstract: The present invention generally relates to methods of generating antibodies against a species of pathogen that involve identifying the pathogen that is most genetically representative of member of pathogen species and using the identified pathogen to generate an antibody.Type: GrantFiled: June 18, 2018Date of Patent: March 14, 2023Assignee: DNAE Group Holdings LimitedInventors: Colin Dykes, Sergey A. Dryga, Lisa-Jo Ann Clarizia, Eddie W. Adams, Meghan E. Norvell
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Patent number: 11448646Abstract: The invention generally relates to using magnetic particles and magnets to isolate a target analyte from a body fluid sample. In certain embodiments, methods of the invention involve introducing magnetic particles including a target-specific binding moiety to a body fluid sample in order to create a mixture, incubating the mixture to allow the particles to bind to a target, applying a magnetic field to capture target/magnetic particle complexes on a surface, and washing with a wash solution that reduces particle aggregation, thereby isolating target/magnetic particle complexes.Type: GrantFiled: January 12, 2018Date of Patent: September 20, 2022Assignee: DNAE Group Holdings LimitedInventors: Lisa-Jo Ann Clarizia, Eddie W. Adams, Sergey A. Dryga
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Publication number: 20220195355Abstract: A method of analysing nucleic acid using apparatus comprising a reaction chamber and plurality of sensors located in the base of the chamber, with each sensor preferably located within a respective well. The method comprises flowing a fluid containing the nucleic acid or fragments thereof into the reaction chamber. While the chamber is fully or at least partially sealed, amplification of the nucleic acid or said fragments is performed within the chamber using an amplification primer or primers whilst detecting the generation of amplicons using said sensors. Sequencing or hybridisation is then performed on the amplicons, and sequencing or hybridisation is detected using said sensors.Type: ApplicationFiled: January 14, 2022Publication date: June 23, 2022Applicant: DNAe Group Holdings LimitedInventors: Christofer TOUMAZOU, David DAVIDSON, Samuel REED
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Patent number: 11312930Abstract: A method of analysing nucleic acid using apparatus comprising a reaction chamber and plurality of sensors located in the base of the chamber, with each sensor preferably located within a respective well. The method comprises flowing a fluid containing the nucleic acid or fragments thereof into the reaction chamber. While the chamber is fully or at least partially sealed, amplification of the nucleic acid or said fragments is performed within the chamber using an amplification primer or primers whilst detecting the generation of amplicons using said sensors. Sequencing or hybridisation is then performed on the amplicons, and sequencing or hybridisation is detected using said sensors.Type: GrantFiled: April 27, 2015Date of Patent: April 26, 2022Assignee: DNAe Group Holdings LimitedInventors: Christofer Toumazou, David Davidson, Samuel Reed
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Patent number: 11073513Abstract: The invention generally relates to using magnetic particles and alternating magnet fields to separate a target analyte from a sample. In certain embodiments, methods of the invention involve contacting a sample with magnetic particles including first moieties specific for a target analyte, thereby forming target/particle complexes in the sample, flowing the sample through a channel including second moieties attached to at least one surface of the channel, applying alternating magnetic fields to the flowing sample to result in target/particle complexes being brought into proximity of the surface to bind the second moieties and unbound particles remaining free in the sample, binding the target/particle complexes to the second moieties, and washing away unbound particles and unbound analytes of the sample.Type: GrantFiled: July 11, 2016Date of Patent: July 27, 2021Assignee: DNAE Group Holdings LimitedInventors: Sergey A. Dryga, Victor C. Esch, Richard G. Saul, Andrew F. McDowell
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Publication number: 20210164935Abstract: An array of pixels, wherein each pixel comprises: a CHEMFET sensor; and a sigma delta ADC.Type: ApplicationFiled: February 11, 2021Publication date: June 3, 2021Applicant: DNAe Group Holdings LimitedInventors: David Michael Garner, Darya Mohtashemi, Tuck Weng Poon
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Patent number: 11016086Abstract: The invention generally relates to methods and devices for transferring a sample into a cartridge for processing. Methods of the invention include providing a vessel containing a sample, coupling the sample to a cartridge configured to process the sample at an interface, in which the interface is configured to provide communication between the vessel and the cartridge, introducing a fluid, capture particles, or both from the cartridge into the vessel, and transferring the sample, fluid, and capture particles from the vessel and into the cartridge for processing.Type: GrantFiled: June 11, 2018Date of Patent: May 25, 2021Assignee: DNAE Group Holdings LimitedInventor: James H. Macemon
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Patent number: 10948453Abstract: An array of pixels, wherein each pixel comprises: a CHEMFET sensor; and a sigma delta ADC.Type: GrantFiled: November 2, 2017Date of Patent: March 16, 2021Assignee: DNAe Group Holdings LimitedInventors: David Michael Garner, Darya Mohtashemi, Tuck Weng Poon
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Patent number: 10745763Abstract: The invention generally relates to a system for isolating or separating a target from a sample. In certain aspects, processes performed by the target capture system include introducing a plurality of magnetic particles, in which a plurality of the particles include at least one binding moiety specific to a target, into a sample to form at least one target/particle complex and applying a magnetic field to isolate the magnetic particle/target complexes from the sample. The process starts at inputting a sample into the system and ends at delivering a capture target or nucleic acids of the target into a container for further analysis.Type: GrantFiled: March 20, 2017Date of Patent: August 18, 2020Assignee: DNAE Group Holdings LimitedInventors: Ravil A. Sitdikov, Eddie W. Adams, Magdalena A. Torrance, David K. Aley, Erik J. Smith, Victor C. Esch
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Patent number: 10697011Abstract: An apparatus with a transducer having a first output signal and arranged to receive an electrical input. The transducer switches the first output signal between an ON and OFF state. The apparatus has a chemical sensing surface coupled to the transducer arranged to receive a chemical input. A signal generator oscillates one or more of said inputs to vary the switching point of the transducer. The oscillating input may be the chemical input and/or the electrical input. The output signal may be a pulse whose period ON or OFF is determined by the oscillating input modulated by the chemical input.Type: GrantFiled: October 2, 2018Date of Patent: June 30, 2020Assignee: DNAE Group Holdings LimitedInventors: Pantelis Georgiou, Samuel Reed, Yan Liu, Christofer Toumazou, Chung-Pei Ou
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Patent number: 10677789Abstract: The invention generally relates to conducting an assay on a sample that isolates a pathogen from the sample and allows for analysis of the pathogen with minimal (i.e., at most 24 hrs of culturing) or no culturing of the pathogen. In certain embodiments, the invention provides methods for identifying a pathogen from a sample that involve obtaining a sample including a pathogen, conducting an assay that isolates the pathogen from the sample, culturing the isolated pathogen for at most about 24 hrs, and analyzing the pathogen.Type: GrantFiled: January 10, 2018Date of Patent: June 9, 2020Assignee: DNAE Group Holdings LimitedInventors: Sergey A. Dryga, Lisa-Jo Ann Clarizia, Eddie W. Adams, Victor C. Esch
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Publication number: 20200131572Abstract: Provided is a sensing apparatus comprising a chip for integrated amplification and sequencing of a template polynucleotide in a sample. The apparatus comprises a chip with at least one ISFET in a well or chamber, amplification means for amplifying the template polynucleotide on a surface of said chip and comprising at least one heating means suitable for conducting amplification of the template polynucleotide at temperatures elevated with respect to room temperature, and sequencing means for sequencing the amplified template polynucleotide in said well or chamber. Methods of use are also provided.Type: ApplicationFiled: January 2, 2020Publication date: April 30, 2020Applicant: DNAE Group Holdings LimitedInventors: Zahid ANSARI, Krishna AMIN, Ginny JORGENSEN, Kurt KOLB, Daniel MORLEY, Alpesh PATEL, Samuel REED, Leila SHEPHERD, Christofer TOUMAZOU
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Patent number: 10634642Abstract: An assay device (10) is provided. The device comprises an integrated circuit (IC) (16) comprising a plurality of ISFETs (18); an over-moulded layer (17) which partially covers the IC, such that the plurality of ISFETs remain uncovered; and a film (20) provided across substantially the entire IC. The film acts as a passivation and/or sensing layer for each of the ISFETs. In addition, the film acts as a barrier layer to encase the over-moulded layer.Type: GrantFiled: May 15, 2017Date of Patent: April 28, 2020Assignee: DNAE GROUP HOLDINGS LIMITEDInventor: Zahid Ansari
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Patent number: 10584329Abstract: The invention generally relates to methods for universal target capture.Type: GrantFiled: February 26, 2018Date of Patent: March 10, 2020Assignee: DNAE Group Holdings LimitedInventor: Colin Dykes
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Patent number: 10557168Abstract: Provided is a sensing apparatus comprising a chip for integrated amplification and sequencing of a template polynucleotide in a sample. The apparatus comprises a chip with at least one ISFET in a well or chamber, amplification means for amplifying the template polynucleotide on a surface of said chip and comprising at least one heating means suitable for conducting amplification of the template polynucleotide at temperatures elevated with respect to room temperature, and sequencing means for sequencing the amplified template polynucleotide in said well or chamber. Methods of use are also provided.Type: GrantFiled: April 24, 2019Date of Patent: February 11, 2020Assignee: DNAE Group Holdings LimitedInventors: Zahid Ansari, Krishna Amin, Ginny Jorgensen, Kurt Kolb, Daniel Morley, Alpesh Patel, Samuel Reed, Leila Shepherd, Christofer Toumazou
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Patent number: 10527574Abstract: A system, device, and method for receiving, preparing and identifying a biological sample. Some parts may be user held and actuated. The sample may be detected by an array of sensors. The system may comprise reusable and disposable components arranged to be connected together. The biological sample may contain nucleic acids, proteins, or other molecules to be detected.Type: GrantFiled: December 30, 2016Date of Patent: January 7, 2020Assignee: DNAE GROUP HOLDINGS LIMITEDInventors: Panteleimon Athanasiou, Alpesh Patel, David Whitaker, Hua Bai, John Palmer-Felgate, Daniel Coomber-Alford, Jessica Fisher, Chad Schneider, Alex Flamm, Ben Lane, Samuel Reed
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Patent number: 10416155Abstract: The invention generally relates to methods of using compositions that include sets of magnetic particles, members of each set being conjugated to an antibody specific for a pathogen, and magnets to isolate a pathogen from a body fluid sample.Type: GrantFiled: May 2, 2018Date of Patent: September 17, 2019Assignee: DNAE Group Holdings LimitedInventors: Sergey A. Dryga, Victor C. Esch, Lisa-Jo Ann Clarizia, Eddie W. Adams, Thearith H. Ung, Ravil A. Sitdikov
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Publication number: 20190249246Abstract: Provided is a sensing apparatus comprising a chip for integrated amplification and sequencing of a template polynucleotide in a sample. The apparatus comprises a chip with at least one ISFET in a well or chamber, amplification means for amplifying the template polynucleotide on a surface of said chip and comprising at least one heating means suitable for conducting amplification of the template polynucleotide at temperatures elevated with respect to room temperature, and sequencing means for sequencing the amplified template polynucleotide in said well or chamber. Methods of use are also provided.Type: ApplicationFiled: April 24, 2019Publication date: August 15, 2019Applicant: DNAE Group Holdings LimitedInventors: Zahid ANSARI, Krishna AMIN, Ginny JORGENSEN, Kurt KOLB, Daniel MORLEY, Alpesh PATEL, Samuel REED, Leila SHEPHERD, Christofer TOUMAZOU
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Patent number: 10379113Abstract: The invention generally relates to methods for indicating whether an assay for isolating targets is properly isolating and detecting targets. Methods of the invention involve obtaining a sample suspected of a containing target, introducing a detectable marker into the sample, conducting an assay using magnet particles to isolate the detectable marker and the target if it is present in the sample, determining the presence or absence of the target; and confirming that the assay functioned properly by determining presence or absence of the detectable marker.Type: GrantFiled: January 23, 2017Date of Patent: August 13, 2019Assignee: DNAE Group Holdings LimitedInventor: Meghan E. Norvell