Patents Assigned to DNAE GROUP HOLDINGS LIMITED
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Patent number: 10323275Abstract: Described is a method for sequencing a polynucleotide strand by sequencing by synthesis, the method including selecting a predetermined order of nucleotides to provide to a sequencing reaction, the order being selected to correlate with a predicted sequence for the polynucleotide strand; monitoring the reaction to detect incorporation of a nucleotide into a synthesized polynucleotide strand; wherein, in the event that nucleotide incorporation is detected, proceeding to provide the next nucleotide in the predetermined order. In the event that nucleotide incorporation is not detected, the predicted sequence for the polynucleotide strand may be revised and a new predetermined order of nucleotides selected, wherein the new predetermined order is selected to correlate with the revised predicted sequence. In this way, the sequencing reaction provides feedback to modify the order of nucleotides provided, thereby improving the efficiency of the sequencing reaction.Type: GrantFiled: April 27, 2015Date of Patent: June 18, 2019Assignee: DNAE Group Holdings LimitedInventor: Daniel Morley
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Patent number: 10316363Abstract: Provided is a sensing apparatus comprising a chip for integrated amplification and sequencing of a template polynucleotide in a sample. The apparatus comprises a chip with at least one ISFET in a well or chamber, amplification means for amplifying the template polynucleotide on a surface of said chip and comprising at least one heating means suitable for conducting amplification of the template polynucleotide at temperatures elevated with respect to room temperature, and sequencing means for sequencing the amplified template polynucleotide in said well or chamber. Methods of use are also provided.Type: GrantFiled: April 24, 2017Date of Patent: June 11, 2019Assignee: DNAE Group Holdings LimitedInventors: Zahid Ansari, Krishna Amin, Ginny Jorgensen, Kurt Kolb, Daniel Morley, Alpesh Patel, Samuel Reed, Leila Shepherd, Christofer Toumazou
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Patent number: 10288576Abstract: A device for sensing a property of a fluid comprising a first substrate having formed thereon a sensor configured in use to come into contact with a fluid in order to sense a property of the fluid, and a wireless transmitter for transmitting data over a wireless data link and a second substrate having formed thereon a wireless receiver for receiving data transmitted over said wireless link by said wireless transmitter. The first substrate is fixed to or within said second substrate. Additionally or alternatively, the device comprises a first substrate defining one or more microfluidic structures for receiving a fluid to be sensed and a second substrate comprising or having attached thereto a multiplicity of fluid sensors, the number of sensors being greater than the number of microfluidic structures.Type: GrantFiled: February 10, 2015Date of Patent: May 14, 2019Assignee: DNAE Group Holdings LimitedInventors: Sam Reed, Pantelakis Georgiou, Timothy G. Constandinou
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Publication number: 20190040463Abstract: An apparatus with a transducer having a first output signal and arranged to receive an electrical input. The transducer switches the first output signal between an ON and OFF state. The apparatus has a chemical sensing surface coupled to the transducer arranged to receive a chemical input. A signal generator oscillates one or more of said inputs to vary the switching point of the transducer. The oscillating input may be the chemical input and/or the electrical input. The output signal may be a pulse whose period ON or OFF is determined by the oscillating input modulated by the chemical input.Type: ApplicationFiled: October 2, 2018Publication date: February 7, 2019Applicant: DNAE Group Holdings LimitedInventors: Pantelis GEORGIOU, Samuel REED, Yan LIU, Christofer TOUMAZOU, Chung-Pei OU
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Patent number: 10144964Abstract: An apparatus with a transducer having a first output signal and arranged to receive an electrical input. The transducer switches the first output signal between an ON and OFF state. The apparatus has a chemical sensing surface coupled to the transducer arranged to receive a chemical input. A signal generator oscillates one or more of said inputs to vary the switching point of the transducer. The oscillating input may be the chemical input and/or the electrical input. The output signal may be a pulse whose period ON or OFF is determined by the oscillating input modulated by the chemical input.Type: GrantFiled: May 15, 2017Date of Patent: December 4, 2018Assignee: DNAE Group Holdings LimitedInventors: Pantelis Georgiou, Samuel Reed, Yan Liu, Christofer Toumazou, Chung-Pei Ou
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Patent number: 10000557Abstract: The present invention generally relates to methods of generating antibodies against a species of pathogen that involve identifying the pathogen that is most genetically representative of member of pathogen species and using the identified pathogen to generate an antibody.Type: GrantFiled: December 18, 2013Date of Patent: June 19, 2018Assignee: DNAE Group Holdings LimitedInventors: Colin Dykes, Sergey A. Dryga, Lisa-Jo Ann Clarizia, Eddie W. Adams, Meghan Norvell
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Patent number: 9995742Abstract: The invention generally relates to methods and devices for transferring a sample into a cartridge for processing. Methods of the invention include providing a vessel containing a sample, coupling the sample to a cartridge configured to process the sample at an interface, in which the interface is configured to provide communication between the vessel and the cartridge, introducing a fluid, capture particles, or both from the cartridge into the vessel, and transferring the sample, fluid, and capture particles from the vessel and into the cartridge for processing.Type: GrantFiled: December 18, 2013Date of Patent: June 12, 2018Assignee: DNAE Group Holdings LimitedInventor: James H. Macemon
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Patent number: 9970931Abstract: The invention generally relates to methods of using compositions that include sets of magnetic particles, members of each set being conjugated to an antibody specific for a pathogen, and magnets to isolate a pathogen from a body fluid sample.Type: GrantFiled: October 24, 2016Date of Patent: May 15, 2018Assignee: DNAE Group Holdings LimitedInventors: Sergey A. Dryga, Victor C. Esch, Lisa-Jo Ann Clarizia, Eddie W. Adams, Thearith H. Ung, Ravil A. Sitdikov
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Patent number: 9902949Abstract: The invention generally relates to methods for universal target capture.Type: GrantFiled: September 1, 2016Date of Patent: February 27, 2018Assignee: DNAE Group Holdings LimitedInventor: Colin Dykes
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Patent number: 9869671Abstract: The invention generally relates to conducting an assay on a sample that isolates a pathogen from the sample and allows for analysis of the pathogen with minimal (i.e., at most 24 hrs of culturing) or no culturing of the pathogen. In certain embodiments, the invention provides methods for identifying a pathogen from a sample that involve obtaining a sample including a pathogen, conducting an assay that isolates the pathogen from the sample, culturing the isolated pathogen for at most about 24 hrs, and analyzing the pathogen.Type: GrantFiled: April 25, 2017Date of Patent: January 16, 2018Assignee: DNAE Group Holdings LimitedInventors: Sergey A. Dryga, Lisa-Jo Ann Clarizia, Eddie W. Adams, Victor C. Esch
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Patent number: 9863940Abstract: The invention generally relates to methods of using compositions that include sets of magnetic particles, members of each set being conjugated to an antibody specific for a pathogen, and magnets to isolate a pathogen from a body fluid sample.Type: GrantFiled: May 30, 2017Date of Patent: January 9, 2018Assignee: DNAE Group Holdings LimitedInventors: Sergey A. Dryga, Victor C. Esch, Lisa-Jo Ann Clarizia, Eddie W. Adams, Thearith H. Ung, Ravil A. Sitdikov
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Patent number: 9840733Abstract: An apparatus for monitoring amplification of a nucleic acid by providing a pH sensor or pH indicator, a nucleic acid in an amplification mixture, and an isothermal amplification enzyme.Type: GrantFiled: September 30, 2016Date of Patent: December 12, 2017Assignee: DNAE GROUP HOLDINGS LIMITEDInventors: Maurizio Lamura, Angel Chan-Ju Wang, Alpesh Patel
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Publication number: 20170321272Abstract: An apparatus with a transducer having a first output signal and arranged to receive an electrical input. The transducer switches the first output signal between an ON and OFF state. The apparatus has a chemical sensing surface coupled to the transducer arranged to receive a chemical input. A signal generator oscillates one or more of said inputs to vary the switching point of the transducer. The oscillating input may be the chemical input and/or the electrical input. The output signal may be a pulse whose period ON or OFF is determined by the oscillating input modulated by the chemical input.Type: ApplicationFiled: May 15, 2017Publication date: November 9, 2017Applicant: DNAE Group Holdings LimitedInventors: Pantelis GEORGIOU, Samuel REED, Yan LIU, Christofer TOUMAZOU, Chung-Pei OU
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Patent number: 9804069Abstract: Methods for degrading contaminant nucleic acid. The methods use combinations of metal ions and peroxide ions to produce a variety of oxidative species that degrade nucleic acid. Methods of the invention are useful for decontaminating laboratory equipment or solutions. After the equipment or solutions have been decontaminated, the metal ion and peroxide ion solution can be deactivated by raising the temperature to dissociate the peroxide or by binding the metal ions, e.g., with a chelating agent.Type: GrantFiled: December 16, 2013Date of Patent: October 31, 2017Assignee: DNAE Group Holdings LimitedInventor: Sergey A. Dryga
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Patent number: 9739743Abstract: A plug side surface of a plug housing is provided with a claw portion. The claw portion includes a plug lock surface facing in a direction away from a connector mounting surface. Each assistant fitting of a receptacle connector includes a receptacle lock surface that faces in a direction approaching the connector mounting surface and is opposed to the plug lock surface in a mated state. The plug lock surface includes a lock maintaining surface and an unlocking surface. Assuming that an angle formed between a reference plane and the lock maintaining surface is a lock maintaining angle and an angle formed between the reference plane and the unlocking surface is an unlocking angle, the lock maintaining angle is smaller than the unlocking angle.Type: GrantFiled: March 28, 2013Date of Patent: August 22, 2017Assignee: DNAE GROUP HOLDINGS LIMITEDInventors: Panteleimon Athanasiou, Alpesh Patel, David Whitaker, Hua Bai, John Palmer-Felgate, Daniel Coomber-Alford, Jessica Fisher, Chad Schneider, Alex Flamm, Ben Lane, Sam Reed
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Publication number: 20170226579Abstract: Provided is a sensing apparatus comprising a chip for integrated amplification and sequencing of a template polynucleotide in a sample. The apparatus comprises a chip with at least one ISFET in a well or chamber, amplification means for amplifying the template polynucleotide on a surface of said chip and comprising at least one heating means suitable for conducting amplification of the template polynucleotide at temperatures elevated with respect to room temperature, and sequencing means for sequencing the amplified template polynucleotide in said well or chamber. Methods of use are also provided.Type: ApplicationFiled: April 24, 2017Publication date: August 10, 2017Applicant: DNAE Group Holdings LimitedInventors: Zahid ANSARI, Krishna AMIN, Ginny JORGENSEN, Kurt KOLB, Daniel MORLEY, Alpesh PATEL, Samuel REED, Leila SHEPHERD, Christofer TOUMAZOU
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Patent number: 9696302Abstract: The invention generally relates to methods of using compositions that include sets of magnetic particles, members of each set being conjugated to an antibody specific for a pathogen, and magnets to isolate a pathogen from a body fluid sample.Type: GrantFiled: September 5, 2014Date of Patent: July 4, 2017Assignee: DNAE Group Holdings LimitedInventors: Sergey A. Dryga, Victor C. Esch, Lisa-Jo Ann Clarizia, Eddie W. Adams, Thearith H. Ung, Ravil A. Sitdikov
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Patent number: 9683260Abstract: An apparatus with a transducer having a first output signal and arranged to receive an electrical input. The transducer switches the first output signal between an ON and OFF state. The apparatus has a chemical sensing surface coupled to the transducer arranged to receive a chemical input. A signal generator oscillates one or more of said inputs to vary the switching point of the transducer. The oscillating input may be the chemical input and/or the electrical input. The output signal may be a pulse whose period ON or OFF is determined by the oscillating input modulated by the chemical input.Type: GrantFiled: October 28, 2011Date of Patent: June 20, 2017Assignee: DNAE GROUP HOLDINGS LIMITEDInventors: Pantelis Georgiou, Sam Reed, Yan Liu, Christofer Toumazou, Chung-Pei Ou
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Patent number: 9671395Abstract: The invention generally relates to conducting an assay on a sample that isolates a pathogen from the sample and allows for analysis of the pathogen with minimal (i.e., at most 24 hrs of culturing) or no culturing of the pathogen. In certain embodiments, the invention provides methods for identifying a pathogen from a sample that involve obtaining a sample including a pathogen, conducting an assay that isolates the pathogen from the sample, culturing the isolated pathogen for at most about 24 hrs, and analyzing the pathogen.Type: GrantFiled: April 21, 2011Date of Patent: June 6, 2017Assignee: DNAE Group Holdings LimitedInventors: Sergey A. Dryga, Lisa-Jo Ann Clarizia, Eddie W. Adams, Victor C. Esch
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Publication number: 20170106371Abstract: A system, device, and method for receiving, preparing and identifying a biological sample. Some parts may be user held and actuated. The sample may be detected by an array of sensors. The system may comprise reusable and disposable components arranged to be connected together. The biological sample may contain nucleic acids, proteins, or other molecules to be detected.Type: ApplicationFiled: December 30, 2016Publication date: April 20, 2017Applicant: DNAE GROUP HOLDINGS LIMITEDInventors: Panteleimon ATHANASIOU, Alpesh PATEL, David WHITAKER, Hua BAI, John PALMER-FELGATE, Daniel COOMBER-ALFORD, Jessica FISHER, Chad SCHNEIDER, Alex FLAMM, Ben LANE, Samuel REED