Patents Assigned to Doheny Eye Institute
-
Patent number: 11839430Abstract: In accordance with one aspect of the present invention, an optical coherence tomography-based ophthalmic testing center system includes an optical coherence tomography instrument comprising an eyepiece for receiving at least one eye of a user or subject; a light source that outputs light that is directed through the eyepiece into the user's or subject's eye, an interferometer configured to produce optical interference using light reflected from the user's/subject's eye, an optical detector disposed so as to detect said optical interference; and a processing unit coupled to the detector. The ophthalmic testing center system can be configured to perform a multitude of self-administered functional and/or structural ophthalmic tests and output the test data.Type: GrantFiled: February 17, 2021Date of Patent: December 12, 2023Assignee: Doheny Eye InstituteInventors: Alexander C. Walsh, Paul G. Updike, Srinivas R. Sadda
-
Publication number: 20230045859Abstract: Deep learning methods and systems for detecting biomarkers within optical coherence tomography volumes using such deep learning methods and systems are provided. Embodiments predict the presence or absence of clinically useful biomarkers in OCT images using deep neural networks. The lack of available training data for canonical deep learning approaches is overcome in embodiments by leveraging a large external dataset consisting of foveal scans using transfer learning. Embodiments represent the three-dimensional OCT volume by “tiling” each slice into a single two dimensional image, and adding an additional component to encourage the network to consider local spatial structure. Methods and systems, according to embodiments are able to identify the presence or absence of AMD-related biomarkers on par with clinicians. Beyond identifying biomarkers, additional models could be trained, according to embodiments, to predict the progression of these biomarkers over time.Type: ApplicationFiled: January 25, 2021Publication date: February 16, 2023Applicants: The Regents of the University of California, Doheny Eye InstituteInventors: Eran Halperin, Nadav Rakocz, Jeffrey Chiang, Muneeswar Gupta, Srinivas Sadda
-
Patent number: 11510567Abstract: In accordance with one aspect of the present invention, an optical coherence tomography-based ophthalmic testing center system includes an optical coherence tomography instrument comprising an eyepiece for receiving at least one eye of a user or subject; a light source that outputs light that is directed through the eyepiece into the user's or subject's eye, an interferometer configured to produce optical interference using light reflected from the user's/subject's eye, an optical detector disposed so as to detect said optical interference; and a processing unit coupled to the detector. The ophthalmic testing center system can be configured to perform a multitude of self-administered functional and/or structural ophthalmic tests and output the test data.Type: GrantFiled: September 14, 2021Date of Patent: November 29, 2022Assignee: Doheny Eye InstituteInventors: Alexander C. Walsh, Paul G. Updike, Srinivas R. Sadda
-
Systems, methods, and devices for optical coherence tomography multiple enface angiography averaging
Patent number: 11452443Abstract: The disclosure herein provides methods, systems, and devices for improving optical coherence tomography machine outputs through multiple enface optical coherence tomography angiography averaging techniques. The embodiments disclosed herein can be utilized in ophthalmology for employing optical coherence tomography (OCT) for in vivo visualization of blood vessels and the flow of blood in an eye of a patient, which is also known generally as optical coherence tomography angiography (OCTA).Type: GrantFiled: January 11, 2021Date of Patent: September 27, 2022Assignee: Doheny Eye InstituteInventors: SriniVas R. Sadda, Akihito Uji -
Patent number: 11291364Abstract: In accordance with one aspect of the present invention, an optical coherence tomography instrument comprises an eyepiece for receiving at least one eye of a user is provided; a light source that outputs light that is directed through the eyepiece into the user's eye; an interferometer configured to produce optical interference using light reflected from the user's eye; an optical detector disposed so as to detect said optical interference; and electronics coupled to the detector. The electronics can be configured to perform a risk assessment analysis based on optical coherence tomography measurements obtained using the interferometer. An output device can be electrically coupled to the electronics, and may be configured to output the risk assessment to the user through the output device. The optical coherence tomography instrument can be self-administered, and the eyepiece can be a monocular system or a binocular system.Type: GrantFiled: August 26, 2016Date of Patent: April 5, 2022Assignee: Doheny Eye InstituteInventors: Alexander C. Walsh, Paul G. Updike, Srinivas R. Sadda
-
Patent number: 11154226Abstract: A medical sensor is described. In an example, the medical sensor includes a nanoscale tapered waveguide attached to a substrate. The nanoscale tapered waveguide includes a nanoscale channel that receives fluid and an excitation light and that outputs a response light. The excitation light propagates through the fluid. A receiving channel of the nanoscale channel is configured as a waveguide that receives and guides the excitation to a linearly tapered channel of the nanoscale channel. The linearly tapered channel has three dimensional linear tapering that focuses the excitation light guided from the receiving channel into an optical response channel of the nanoscale channel. In turn, the optical response channel is configured as a waveguide that outputs a response light in response to the excitation light focused from the linearly tapered channel. The response light corresponds to a response of an analyte of the fluid present in the optical response channel.Type: GrantFiled: June 10, 2016Date of Patent: October 26, 2021Assignees: California Institute of Technology, University of Southern California, Doheny Eye instituteInventors: Yu-Chong Tai, Hyuck Choo, Ramiro Magalhaes Ribeiro, Mark S. Humayun
-
Patent number: 10966738Abstract: Devices, systems and methods for ocular ultrasound are provided having therapeutic and/or diagnostic applications. In one aspect, an ocular probe is disclosed that is uniquely configured for use in the eye on the basis of shape and frequency. The ocular probe may be multi-functional, providing sensor, optical or other functionality in additional to ultrasound energy.Type: GrantFiled: July 17, 2017Date of Patent: April 6, 2021Assignee: DOHENY EYE INSTITUTEInventor: Mark S. Humayun
-
Patent number: 10945597Abstract: In accordance with one aspect of the present invention, an optical coherence tomography-based ophthalmic testing center system includes an optical coherence tomography instrument comprising an eyepiece for receiving at least one eye of a user or subject; a light source that outputs light that is directed through the eyepiece into the user's or subject's eye, an interferometer configured to produce optical interference using light reflected from the user's/subject's eye, an optical detector disposed so as to detect said optical interference; and a processing unit coupled to the detector. The ophthalmic testing center system can be configured to perform a multitude of self-administered functional and/or structural ophthalmic tests and output the test data.Type: GrantFiled: November 8, 2018Date of Patent: March 16, 2021Assignee: Doheny Eye InstituteInventors: Alexander C. Walsh, Paul G. Updike, Srinivas R. Sadda
-
Systems, methods, and devices for optical coherence tomography multiple enface angiography averaging
Patent number: 10918274Abstract: The disclosure herein provides methods, systems, and devices for improving optical coherence tomography machine outputs through multiple enface optical coherence tomography angiography averaging techniques. The embodiments disclosed herein can be utilized in ophthalmology for employing optical coherence tomography (OCT) for in vivo visualization of blood vessels and the flow of blood in an eye of a patient, which is also known generally as optical coherence tomography angiography (OCTA).Type: GrantFiled: September 18, 2019Date of Patent: February 16, 2021Assignee: Doheny Eye InstituteInventors: SriniVas R. Sadda, Akihito Uji -
Patent number: 10874552Abstract: Ocular lens cutting devices and methods for cutting and removing tissue such as lens fragments from an eye of a patient are disclosed. In one embodiment, an ocular lens cutting device includes an outer member and an inner member positioned within the outer member. The outer member and the inner member can each include at least one cutting edge. The at least one cutting edge of the outer member and the at least one cutting edge of the inner member can cooperate to form a cutting structure as the inner member moves with respect to the outer member. The ocular lens cutting device can also be connected to a vacuum source which can allow the ocular lens cutting device to grasp the tissue to be cut and remove the cut fragments from the surgical area.Type: GrantFiled: July 5, 2012Date of Patent: December 29, 2020Assignee: DOHENY EYE INSTITUTEInventors: Trent Spencer Wells, Matthew T. McCormick, Ralph Kerns, Mark S. Humayun
-
Patent number: 10780272Abstract: The present invention is a fitting system with a graphical interface with specific interface screens for specific functions. Methods and devices for fitting a visual prosthesis are described. In one of the methods, threshold levels and maximum levels for the electrodes of the prosthesis are determined and a map of brightness to electrode stimulation levels is later formed. A fitting system for a visual prosthesis is also discussed, together with a computer-operated system having a graphical user interface showing visual prosthesis diagnostic screens and visual prosthesis configuration screens.Type: GrantFiled: August 20, 2012Date of Patent: September 22, 2020Assignees: Second Sight Medical Products, Inc., Doheny Eye InstituteInventors: Matthew J. McMahon, Arup Roy, Scott Greenwald, Ione Fine, Alan Matthew Horsager, Avraham I. Caspi, Kelly Hobart McClure, Robert Jay Greenberg
-
Patent number: 10743896Abstract: Devices, systems and methods for ocular ultrasound are provided having therapeutic and/or diagnostic applications. In one aspect, an ocular probe is disclosed that is uniquely configured for use in the eye on the basis of shape and frequency. The ocular probe may be multi-functional, providing sensor, optical or other functionality in additional to ultrasound energy.Type: GrantFiled: December 13, 2016Date of Patent: August 18, 2020Assignee: DOHENY EYE INSTITUTEInventor: Mark S. Humayun
-
Patent number: 10667404Abstract: Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, or cortical stimulation many purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow. Common flexible circuit fabrication techniques generally require that a flexible circuit electrode array be made flat. Since neural tissue is almost never flat, a flat array will necessarily apply uneven pressure. Further, the edges of a flexible circuit polymer array may be sharp and cut the delicate neural tissue. By applying the right amount of heat to a completed array, a curve can be induced.Type: GrantFiled: October 28, 2007Date of Patent: May 26, 2020Assignees: Second Sight Medical Products, Inc., Doheny Eye InstituteInventors: Robert Greenberg, Neil Talbot, Jordan Neysmith, Dilek Guven, James Little, Brian Mech, Mark Humayun
-
Systems, methods, and devices for optical coherence tomography multiple enface angiography averaging
Patent number: 10456031Abstract: The disclosure herein provides methods, systems, and devices for improving optical coherence tomography machine outputs through multiple enface optical coherence tomography angiography averaging techniques. The embodiments disclosed herein can be utilized in ophthalmology for employing optical coherence tomography (OCT) for in vivo visualization of blood vessels and the flow of blood in an eye of a patient, which is also known generally as optical coherence tomography angiography (OCTA).Type: GrantFiled: May 29, 2018Date of Patent: October 29, 2019Assignee: Doheny Eye InstituteInventors: SriniVas R. Sadda, Akihito Uji -
Patent number: 10363165Abstract: A biological tissue cutting and fluid aspiration system provides a plurality of surgical instruments operable independent of an external control console. In some embodiments, each surgical instrument may include all sensors and controls directly applicable to the surgical instrument, and may be used independently. In some embodiments, instruments communicate status information to each other, and adjust operating parameters based on the communications.Type: GrantFiled: July 21, 2017Date of Patent: July 30, 2019Assignee: DOHENY EYE INSTITUTEInventors: Mark Humayun, Charles DeBoer, Ralph Kerns, Matthew McCormick, Prashant Bhadri, Lawrence Chong
-
Patent number: 10342698Abstract: An implantable medical device is described. The implantable medical device includes a small molecule generator, a small molecule diffusor, and a cannula that connects the two. The small molecule generator includes an electrolyte reservoir and a set of electrodes. A first portion of the electrolyte reservoir is impermeable to a predetermined class of small molecules. A second portion of the electrolyte reservoir is permeable to the small molecules. The set of electrodes is disposed inside the electrolyte reservoir and is configured to facilitate electrolysis of the small molecules based on an electric power application to the set of electrodes and on presence of electrolyte inside the electrolyte reservoir. At least a portion of the small molecule diffusor is permeable to the small molecules.Type: GrantFiled: August 24, 2017Date of Patent: July 9, 2019Assignees: CALIFORNIA INSTITUTE OF TECHNOLOGY, UNIVERSITY OF SOUTHERN CALIFORNIA, DOHENY EYE INSTITUTEInventors: Yu-Chong Tai, Nicholas E. Scianmarello, Karthik Murali, Mark S. Humayun, Ramiro Magalhaes Ribeiro
-
Patent number: 10247719Abstract: Disclosed herein are generally to methods and systems that facilitate imaging of cells on a substrate and more particularly to pre-implantation (in vitro) and post-implantation (in vivo) imaging of cell-seeded substrates implanted in target tissues in the context of stem cell therapy.Type: GrantFiled: January 22, 2016Date of Patent: April 2, 2019Assignees: UNIVERSITY OF SOUTHERN CALIFORNIA, DOHENY EYE INSTITUTEInventors: Mark Humayun, Ashish Ahuja, Charles Le Pere
-
Patent number: 10219695Abstract: A first light source producing a first light beam with a first intensity and a second light source producing a second light beam with a second intensity. A light filter device receives the first light beam and transmits a filtered portion of the first light beam. A first angling device reflects the filtered portion of the first light beam in a first angled direction and a second angling device reflects the second light beam in a second angled direction. A mirror receives and in turn reflects the filtered portion of the first light beam reflected by the first angling device and the second light beam reflected by the second angling device to form a converged light beam with a third intensity.Type: GrantFiled: August 18, 2017Date of Patent: March 5, 2019Assignee: DOHENY EYE INSTITUTEInventors: Prashant Bhadri, James Lescoulie, Sophia Fang, Matthew McCormick, Ralph Kerns, Mark Humayun, Aaron Barnes
-
Patent number: 10188843Abstract: The present disclosure described methods, systems, and techniques for applying contrast-enhanced ultrasound to locate areas of blockage within retinal vessels and to break up clots that are causing damage. In addition to identifying the damaged area, the researchers anticipate that the initial image may serve as a baseline for monitoring the effect of treatment on the vessel, which may be achieved in multiple ways. The vibration effect of the ultrasound itself may suffice to dislodge clots. The microbubbles may also be coated or filled with medication, with ultrasonic shock waves activating the coating or causing mini explosions to release the medicine. Loading the microbubbles with a therapeutic agent, visualizing their presence at the diseased site using the ultrasound diagnostic mode, and then activating the microbubbles to release their contents at the targeted lesion could be a powerful and effective way to reverse occlusion without harming other areas of the eye or body.Type: GrantFiled: March 8, 2017Date of Patent: January 29, 2019Assignees: UNIVERSITY OF SOUTHERN CALIFORNIA, DOHENY EYE INSTITUTEInventors: Amani Fawzi, Hossein Ameri, Mark S. Humayun
-
Patent number: 10165941Abstract: In accordance with one aspect of the present invention, an optical coherence tomography-based ophthalmic testing center system includes an optical coherence tomography instrument comprising an eyepiece for receiving at least one eye of a user or subject; a light source that outputs light that is directed through the eyepiece into the user's or subject's eye, an interferometer configured to produce optical interference using light reflected from the user's/subject's eye, an optical detector disposed so as to detect said optical interference; and a processing unit coupled to the detector. The ophthalmic testing center system can be configured to perform a multitude of self-administered functional and/or structural ophthalmic tests and output the test data.Type: GrantFiled: November 11, 2016Date of Patent: January 1, 2019Assignee: Doheny Eye InstituteInventors: Alexander C. Walsh, Paul G. Updike, Srinivas R. Sadda