Patents Assigned to Doheny Eye Institute
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Patent number: 10117776Abstract: Several embodiments disclosed herein relate to the delivery of therapeutic nucleic acids to an ocular tissue in order to provide a therapeutic effect to reduce symptoms of or otherwise alleviate an ocular disorder. In particular embodiments, plasmid DNA is delivered to the cells of the trabecular meshwork in order to ameliorate increasing intraocular pressure. Devices and systems to accomplish this delivery are also disclosed.Type: GrantFiled: October 26, 2016Date of Patent: November 6, 2018Assignee: DOHENY EYE INSTITUTEInventor: Chee Hian Tan
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Patent number: 10076242Abstract: Systems and methods for classifying abnormalities within optical coherence tomography images of the eye are presented. One embodiment of the present invention is the classification of pigment epithelial detachments (PEDs) based on characteristics of their internal reflectivity, size and shape. The classification can be based on selected subsets of the data located within or surrounding the abnormalities. Training data can be used to generate the classification scheme and the classification can be weighted to highlight specific classes of particular clinical interest.Type: GrantFiled: December 7, 2015Date of Patent: September 18, 2018Assignees: DOHENY EYE INSTITUTE, UNIVERSITY OF SOUTHERN CALIFORNIA, CARL ZEISS MEDITEC, INC.Inventors: SriniVas R. Sadda, Paul F. Stetson
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Patent number: 10076359Abstract: Various adjustable cannula systems are provided. The systems can include an adjustable cannula capable of expansion and/or contraction having an elongate body with a distal end and a proximal end. The adjustable cannula can be coupled to an upper housing and a lower housing such that rotation of the upper housing results in expansion or contraction of the adjustable cannula. The adjustable cannula can also have a proximal end having a lumen larger than a distal end lumen. A plurality of flanges can be formed in the elongate body by a plurality of slits that span a majority of a length of the cannula, including along or proximate to its proximal end and distal end.Type: GrantFiled: November 13, 2015Date of Patent: September 18, 2018Assignee: DOHENY EYE INSTITUTEInventors: Ralph Kerns, Prashant Bhadri, Matthew McCormick, Anderson Gustavo Teixeira Pinto, Mark Humayun, Luis Arana
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Patent number: 10070934Abstract: A surgical apparatus for use by a surgeon can include a tray and a plurality of surgical instruments. The tray can have a plurality of structures located on an upper side of the tray for receiving the plurality of surgical instruments. The tray can receive a separate control unit. The tray can also have a fluid reservoir receiver for receiving a bottle or container of fluid, such as balanced salt solution. The fluid reservoir receiver can include one or more features, including, a spike, an air vent, and a light. A separate container can be used to place the bottle or container of fluid into the fluid reservoir receiver on the tray. This separate container can include a collapsible section.Type: GrantFiled: October 3, 2016Date of Patent: September 11, 2018Assignee: Doheny Eye InstituteInventors: Ralph Kerns, Mark Humayun, Matthew T. McCormick, Trent Spencer Wells, Lawrence Chong, Jaw Chyng Lue
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Systems, methods, and devices for optical coherence tomography multiple enface angiography averaging
Patent number: 10010249Abstract: The disclosure herein provides methods, systems, and devices for improving optical coherence tomography machine outputs through multiple enface optical coherence tomography angiography averaging techniques. The embodiments disclosed herein can be utilized in ophthalmology for employing optical coherence tomography (OCT) for in vivo visualization of blood vessels and the flow of blood in an eye of a patient, which is also known generally as optical coherence tomography angiography (OCTA).Type: GrantFiled: March 21, 2018Date of Patent: July 3, 2018Assignee: Doheny Eye InstituteInventors: SriniVas R. Sadda, Akihito Uji -
Patent number: 9999542Abstract: A cannula insertion system configured to divide a cannula insertion process into a two-step process. The first step advances a needle portion a first distance and the second step advances the needle portion a second distance. The first step and the second step may be at different angles. At least one of the angles may be less than 90°. At least one of the steps may be mechanically assisted.Type: GrantFiled: July 8, 2015Date of Patent: June 19, 2018Assignee: DOHENY EYE INSTITUTEInventors: Mark Humayun, Jaw-Chyng Lormen Lue
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Publication number: 20170348147Abstract: An implantable medical device is described. The implantable medical device includes a small molecule generator, a small molecule diffusor, and a cannula that connects the two. The small molecule generator includes an electrolyte reservoir and a set of electrodes. A first portion of the electrolyte reservoir is impermeable to a predetermined class of small molecules. A second portion of the electrolyte reservoir is permeable to the small molecules. The set of electrodes is disposed inside the electrolyte reservoir and is configured to facilitate electrolysis of the small molecules based on an electric power application to the set of electrodes and on presence of electrolyte inside the electrolyte reservoir. At least a portion of the small molecule diffusor is permeable to the small molecules.Type: ApplicationFiled: August 24, 2017Publication date: December 7, 2017Applicants: California Institute of Technology, University of Southern California, Doheny Eye InstituteInventors: Yu-Chong Tai, Nicholas E. Scianmarello, Karthik Murali, Mark S. Humayun, Ramiro Magalhaes Ribeiro
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Patent number: 9763825Abstract: An implantable medical device is described. The implantable medical device includes a small molecule generator, a small molecule diffusor, and a cannula that connects the two. The small molecule generator includes an electrolyte reservoir and a set of electrodes. A first portion of the electrolyte reservoir is impermeable to a predetermined class of small molecules. A second portion of the electrolyte reservoir is permeable to the small molecules. The set of electrodes is disposed inside the electrolyte reservoir and is configured to facilitate electrolysis of the small molecules based on an electric power application to the set of electrodes and on presence of electrolyte inside the electrolyte reservoir. At least a portion of the small molecule diffusor is permeable to the small molecules.Type: GrantFiled: September 9, 2016Date of Patent: September 19, 2017Assignees: California Institute of Technology, University of Southern California, Doheny Eye InstituteInventors: Yu-Chong Tai, Nicholas E. Scianmarello, Karthik Murali, Mark S. Humayun, Ramiro Magalhaes Ribeiro
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Patent number: 9750639Abstract: Electric vitrectomy handpieces are provided. The handpiece includes a motor, a clutch mechanism, an oscillating drive mechanism, a cutting tip and a handle. The motor is attached to the clutch, and the clutch is attached to the oscillating drive mechanism. When the motor is operational, the clutch expands to engage the oscillating drive mechanism and the oscillating drive mechanism converts the rotational motion of the clutch to the reciprocating motion of the cutting tip. When the motor is at rest, the clutch retracts to allow aspiration.Type: GrantFiled: April 18, 2014Date of Patent: September 5, 2017Assignee: Doheny Eye InstituteInventors: Aaron Barnes, Charles DeBoer, Matthew McCormick
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Patent number: 9730833Abstract: A biological tissue cutting and fluid aspiration system provides a plurality of surgical instruments operable independent of an external control console. In some embodiments, each surgical instrument may include all sensors and controls directly applicable to the surgical instrument, and may be used independently. In some embodiments, instruments communicate status information to each other, and adjust operating parameters based on the communications.Type: GrantFiled: November 27, 2013Date of Patent: August 15, 2017Assignee: Doheny Eye InstituteInventors: Mark Humayun, Charles DeBoer, Ralph Kerns, Matthew McCormick, Prashant Bhadri, Lawrence Chong
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Publication number: 20170071785Abstract: An implantable medical device is described. The implantable medical device includes a small molecule generator, a small molecule diffusor, and a cannula that connects the two. The small molecule generator includes an electrolyte reservoir and a set of electrodes. A first portion of the electrolyte reservoir is impermeable to a predetermined class of small molecules. A second portion of the electrolyte reservoir is permeable to the small molecules. The set of electrodes is disposed inside the electrolyte reservoir and is configured to facilitate electrolysis of the small molecules based on an electric power application to the set of electrodes and on presence of electrolyte inside the electrolyte reservoir. At least a portion of the small molecule diffusor is permeable to the small molecules.Type: ApplicationFiled: September 9, 2016Publication date: March 16, 2017Applicants: California Institute of Technology, University of Southern California, Doheny Eye InstituteInventors: Yu-Chong Tai, Nicholas E. Scianmarello, Karthik Murali, Mark S. Humayun, Ramiro Magalhaes Ribeiro
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Patent number: 9526580Abstract: A sterile surgical tray includes structure for receiving a plurality of surgical instruments. The sterile surgical tray also may include electrical input and output connectors attached to tray.Type: GrantFiled: January 27, 2014Date of Patent: December 27, 2016Assignee: Doheny Eye InstituteInventors: Mark Humayun, Charles DeBoer, Matthew McCormick, Prashant Bhadri, Joel Cicchella, Ralph Kerns
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Patent number: 9492079Abstract: In accordance with one aspect of the present invention, an optical coherence tomography-based ophthalmic testing center system includes an optical coherence tomography instrument comprising an eyepiece for receiving at least one eye of a user or subject; a light source that outputs light that is directed through the eyepiece into the user's or subject's eye, an interferometer configured to produce optical interference using light reflected from the user's/subject's eye, an optical detector disposed so as to detect said optical interference; and a processing unit coupled to the detector. The ophthalmic testing center system can be configured to perform a multitude of self-administered functional and/or structural ophthalmic tests and output the test data.Type: GrantFiled: August 28, 2014Date of Patent: November 15, 2016Assignee: Doheny Eye InstituteInventors: Alexander C. Walsh, Paul G. Updike, Srinivas R. Sadda
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Patent number: 9463070Abstract: A surgical apparatus for use by a surgeon can include a tray and a plurality of surgical instruments. The tray can have a plurality of structures located on an upper side of the tray for receiving the plurality of surgical instruments. The tray can receive a separate control unit. The tray can also have a fluid reservoir receiver for receiving a bottle or container of fluid, such as balanced salt solution. The fluid reservoir receiver can include one or more features, including, a spike, an air vent, and a light. A separate container can be used to place the bottle or container of fluid into the fluid reservoir receiver on the tray. This separate container can include a collapsible section.Type: GrantFiled: September 24, 2013Date of Patent: October 11, 2016Assignee: Doheny Eye InstituteInventors: Ralph Kerns, Mark Humayun, Matthew T. McCormick, Trent Spencer Wells, Lawrence Chong, Jaw Chyng Lue
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Publication number: 20160183783Abstract: Systems and methods for classifying abnormalities within optical coherence tomography images of the eye are presented. One embodiment of the present invention is the classification of pigment epithelial detachments (PEDs) based on characteristics of their internal reflectivity, size and shape. The classification can be based on selected subsets of the data located within or surrounding the abnormalities. Training data can be used to generate the classification scheme and the classification can be weighted to highlight specific classes of particular clinical interest.Type: ApplicationFiled: December 7, 2015Publication date: June 30, 2016Applicant: Doheny Eye Institute -University of Southern CaliforniaInventors: SriniVas R. SADDA, Paul F. STETSON
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Patent number: 9274095Abstract: Disclosed herein are generally to methods and systems that facilitate imaging of cells on a substrate and more particularly to pre-implantation (in vitro) and post-implantation (in vivo) imaging of cell-seeded substrates implanted in target tissues in the context of stem cell therapy.Type: GrantFiled: July 2, 2015Date of Patent: March 1, 2016Assignees: University of Southern California, Doheny Eye InstituteInventors: Mark Humayun, Ashish Ahuja, Charles Le Pere
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Patent number: 9198797Abstract: Various adjustable cannula systems are provided. The systems can include an adjustable cannula capable of expansion and/or contraction having an elongate body with a distal end and a proximal end. The adjustable cannula can be coupled to an upper housing and a lower housing such that rotation of the upper housing results in expansion or contraction of the adjustable cannula. The adjustable cannula can also have a proximal end having a lumen larger than a distal end lumen. A plurality of flanges can be formed in the elongate body by a plurality of slits that span a majority of a length of the cannula, including along or proximate to its proximal end and distal end.Type: GrantFiled: September 21, 2010Date of Patent: December 1, 2015Assignee: Doheny Eye InstituteInventors: Ralph Kerns, Prashant Bhadri, Matthew McCormick, Anderson Gustavo Teixeira Pinto, Mark Humayun, Luis Arana
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Patent number: 9149182Abstract: In accordance with one aspect of the present invention, an optical coherence tomography instrument comprises an eyepiece for receiving at least one eye of a user is provided; a light source that outputs light that is directed through the eyepiece into the user's eye; an interferometer configured to produce optical interference using light reflected from the user's eye; an optical detector disposed so as to detect said optical interference; and electronics coupled to the detector. The electronics can be configured to perform a risk assessment analysis based on optical coherence tomography measurements obtained using the interferometer. An output device can be electrically coupled to the electronics, and may be configured to output the risk assessment to the user through the output device. The optical coherence tomography instrument can be self-administered, and the eyepiece can be a monocular system or a binocular system.Type: GrantFiled: December 17, 2012Date of Patent: October 6, 2015Assignee: Doheny Eye InstituteInventors: Alexander C. Walsh, Paul G. Updike, Srinivas R. Sadda
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Publication number: 20150273197Abstract: An implantable oxygenator may have a configuration that is suitable for implantation within a human body be implanted within a human body, such as within a human eye. The implantable oxygenator may include an electrolyte reservoir having a configuration suitable for storing electrolyte and an electrolysis system having a configuration that performs electrolysis on a portion of the electrolyte, thereby producing oxygen in the region of the electrolysis system.Type: ApplicationFiled: October 7, 2013Publication date: October 1, 2015Applicants: UNIVERSITY OF SOUTHERN CALIFORNIA, CALIFORNIA INSTITUTE OF TECHNOLOGY, DOHENY EYE INSTITUTEInventors: Mark S. Humayun, Karthik Murali, Ramiro Magalhaes Ribeiro, Yu-chong Tai, Nicholas Scianmarello
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Patent number: 9089600Abstract: Disclosed herein are generally to methods and systems that facilitate imaging of cells on a substrate and more particularly to pre-implantation (in vitro) and post-implantation (in vivo) imaging of cell-seeded substrates implanted in target tissues in the context of stem cell therapy.Type: GrantFiled: April 27, 2012Date of Patent: July 28, 2015Assignees: University of Southern California, Doheny Eye InstituteInventors: Mark Humayun, Ashish Ahuja, Charles Le Pere