Abstract: Disclosed is a calendar holder for allowing a calendar to be hung on its regular position for a long time without any problem such as deformation or wrinkling. The calendar holder is applied to a band-type calendar support including a band-type calendar support body, a calendar mounting groove prepared in a lower portion of the support body, an elastic press having an elastic groove and a pressing portion, and a hanging member formed in an upper portion of the support body. The calendar holder includes a calendar holder body having a plate shape inserted into a space in the calendar mounting groove to combine the calendar along the band-type calendar support; a hooking protrusion integrally formed with the calendar holder body to be inserted into a hanging hole formed in the calendar; and combining portions combined along the elastic groove to prevent drooping or deviation of the calendar holder body.
Abstract: The invention relates to a therapeutic composition for broad spectrum dermal disease and in particular, to a composition comprising principal lipid components of skin, preferably having about 30 to 90% by weight of a carrier for applying to skin; 0.01 to 5.0% by weight of sphingolipid long-chain base; 0.001 to 1.0% by weight of lysophosphatidic acid; and 1 to 40% by weight of organic or inorganic additives. The composition is useful for the treatment and improvement of atopic dermatitis, psoriasis, acne, ichthyosis, infectious dermatitis, pruritus, erythema derived from pruritus, vulnus, chapping of skin and ulcer, etc.
Type:
Grant
Filed:
September 12, 2003
Date of Patent:
November 15, 2005
Assignee:
Doosan Corporation
Inventors:
Chang Seo Park, Jin Wook Kim, Jin Hee Choi, Ui Chan Koh
Abstract: Lysophosphatidylethanolamine has skin whitening ability and thus a composition containing lysophosphatidylethanolamine as an active ingredient can be used to relieve hyperpigmentation or discoloration. The composition containing lysophosphatidylethanolamine can also induce moisturizing effect on skin, is very safe, and very stable.
Type:
Application
Filed:
January 29, 2003
Publication date:
June 9, 2005
Applicant:
Doosan Corporation
Inventors:
Guk Hoon Chung, Young Sei Park, Wang Keun Choi, Chang Seo Park
Abstract: Disclosed herein is a method for purifying the lysophosphatidylethanolamine with high purity by treating the phospholipid mixture with enzymes, followed by solvent fractionaltion without the column purification. The method of the present invention comprises hydrolyzing phospholipid mixture containing 10-99 weight % of phosphatidylethanolamine with phospholipase A2 to produce lysophospholipid; and treating the lysophospholipid with the solvent mixture comprising water and one or more organic solvents selected from the group consisting of low alcohol, hydrocarbon and alkylester to eliminate impurities except lysophosphatidylethanolamine.
Abstract: Expression cassettes for transforming Pichia ciferrii and their use are disclosed. The present invention relates to expression cassettes containing Pichia ciferrii ribosomal DNA fragment, CYHr gene resistant to cycloheximide, and a desired gene. Expression cassette further comprising Pichia ciferrii GAPDH promoter gene which allows an increase in the expression of the desired gene also provided. Moreover, the present invention provides a process for producing tetraacetyl phytosphingosine using transformed Pichia ciferrii cells with the expression cassettes in a higher yield.
Type:
Grant
Filed:
July 17, 2001
Date of Patent:
October 28, 2003
Assignees:
Doosan Corporation, Korea Institute of Science and Technology
Inventors:
Sang Ki Rhee, Jung Hoon Bae, Eui Sung Choi, Jung Hoon Sohn, Hyun Ah Kang, Chang Seo Park
Abstract: The present invention discloses improved lysophospholipids composition having water-solubility in order to solve a conventional problem accompanying only the use of LPE as an anti-aging lysophospholipid caused by water-insoluble property thereof, comprising subsidiary lysophospholipid components, that is, LPI and LPC other than LPE to inhibit aging processional lysophospholipids, thereby forming an enhanced water-soluble lysophospholipids composition conveniently useable in plants and/or animals applications.
Type:
Grant
Filed:
December 7, 2001
Date of Patent:
August 26, 2003
Assignee:
Doosan Corporation
Inventors:
GukHoon Chung, Young-Lae Yang, Ui C Koh
Abstract: The present invention discloses improved lysophospholipids composition having water-solubility in order to solve a conventional problem accompanying only the use of LPE as an anti-aging lysophospholipid caused by water-insoluble property thereof, comprising subsidiary lysophospholipid components, that is, LPI and LPC other than LPE to inhibit aging processional lysophospholipids, thereby forming an enhanced water-soluble lysophospholipids composition conveniently useable in plants and/or animals applications.
Type:
Application
Filed:
December 7, 2001
Publication date:
March 27, 2003
Applicant:
Doosan Corporation
Inventors:
GukHoon Chung, Young-Lae Yang, Ui C. Koh
Abstract: Disclosed is a method for preparing an aqueous phytosphingosine solution containing as much as 5-10 weight % of phytosphingosine without using any solvents other than water. A high content of phytosphingosine is dissolved in water and lactic acid with the help of a willow bark extract. In addition to being clear, the aqueous phytosphingosine solution is able to recover damaged skin with activity against bacteria and inflammation. Also, when being applied for cosmetics, the aqueous phytosphingosine solution allows them to contain as much as 1-2 weight % of phytosphingosine by virtue of its high content of phytosphingosine. Further, the phytosphingosine solution is greatly improved in compatibility with cosmetic components so that it can be readily applied for aqueous cosmetics such as skin lotions, essence lotions, aqueous pack products, body essence compositions, etc., for which phytosphingosine has not yet been applied, thus far.
Type:
Grant
Filed:
October 18, 2000
Date of Patent:
June 11, 2002
Assignee:
Doosan Corporation
Inventors:
Chang Seo Park, Jin Wook Kim, Jee Hean Jeong
Abstract: Disclosed are compositions for skin care and their medicinal uses. The compositions are identical in lipid constituents and structural properties to that of human stratum corneum. They comprise the major constituents for the lipid lamellar of the stratum corneum, including ceramides, cholesterol and fatty acids, the major constituents for epidermal cell membranes, including phospholipids, and physiologically active substances, including phytosphingosine and its derivatives. Without causing side effects, the cream composition for skin care is of much better skin penetration and water-retention capacity than are conventional compositions comprised of ceramide and other components in forms different from those of human skin. In addition to providing inhibitory activity against skin microorganisms, the cream composition brings about an improvement in the wrinkle condition of the skin, so that it can be applied to cosmetics.
Type:
Grant
Filed:
October 18, 2000
Date of Patent:
April 16, 2002
Assignee:
Doosan Corporation
Inventors:
Chang Seo Park, Jin Wook Kim, Jee Hean Jeong
Abstract: The present invention relates to a process for preparing lysophospholipid using enzyme, more specifically, a process for preparing lysophospholipid from glycerol-3-phosphate derivative using lipase based upon esterification or transesterification reaction.
Type:
Grant
Filed:
July 21, 1998
Date of Patent:
July 31, 2001
Assignee:
Doosan Corporation
Inventors:
Guk Hoon Chung, Sun Ki Kim, Joon Shick Rhee, Jeong Joon Han
Abstract: The present invention relates to a microbiological process for preparing sphingolipids, especially, tetraacetylphytosphingosine(TAPS), using novel yeast cell Pichia ciferrii DSCC 7-25 under optimal fermentation conditions. Further, this invention concerns a novel yeast cell Pichia ciferrii DSCC 7-25 and it's isolation method from wild type of Pichia ciferrii strain.
Type:
Grant
Filed:
June 11, 1999
Date of Patent:
February 27, 2001
Assignee:
Doosan Corporation
Inventors:
Chang Seo Park, Ji Hean Jeong, Sung Yong Hong, Woo Seok Choi
Abstract: The present invention relates to a fermentation process for preparing erythritol with high productivity using Trichosporonoides madida DS 911, more specifically, for preparing erythritol by optimizing the culture conditions such as pH, temperature, aeration rate and agitation speed, and by developing the process of fed-batch culture such as feeding strategy of substrate and composition of feeding substrate.
Type:
Grant
Filed:
August 27, 1998
Date of Patent:
May 9, 2000
Assignee:
Doosan Corporation
Inventors:
Jin Byung Park, Byung Cheol Seo, Jung Ryul Kim
Abstract: The present invention relates to a microbiological process for preparing sphingolipids, especially, tetraacetylphytosphingosine(TAPS), using novel yeast cell Pichia ciferrii DSCC 7-25 under optimal fermentation conditions. Further, this invention concerns a novel yeast cell Pichia ciferrii DSCC 7-25 and it's isolation method from wild type of Pichia ciferrii strain.
Type:
Grant
Filed:
July 21, 1998
Date of Patent:
September 28, 1999
Assignee:
Doosan Corporation
Inventors:
Chang Seo Park, Ji Hean Jeong, Sung Yong Hong, Woo Seok Choi