Patents Assigned to Dow Pharmaceutical Sciences, Inc.
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Patent number: 11478498Abstract: An aqueous formulation for topical application to the skin comprising water, a water-miscible organic solvent, and benzoyl peroxide, wherein the concentration of the organic solvent is sufficient to provide a stable suspension of benzoyl peroxide in the aqueous formulation without the inclusion of a surfactant in the formulation, wherein the ratio of concentrations of water and organic solvent in the formulation is sufficient to maintain the benzoyl peroxide in saturated solubility in the formulation following application to the skin, and wherein the concentration of benzoyl peroxide in the formulation is less than 5.0% and at least 1.0% w/w. The formulation may further contain a chemical compound in addition to benzoyl peroxide that is effective in the treatment of acne. The aqueous formulations of the invention are useful in the treatment of acne and acne rosacea.Type: GrantFiled: April 20, 2020Date of Patent: October 25, 2022Assignee: Dow Pharmaceutical Sciences, Inc.Inventors: Yunik Chang, Gordon J. Dow, Radhakrishnan Pillai
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Patent number: 10828293Abstract: The present invention provides methods for treating onychomycosis. In certain embodiments, the methods comprise comprising applying a pharmaceutically acceptable formulation containing 10% efinaconazole once a day for a treatment period of at least 36 weeks to the treatment area of an onychomycosis patient (a) without debriding the nail or nail-associated tissue initially or during the treatment period and/or (b) without removing the formulation from the treatment area during the treatment period. In certain embodiments, the formulation also comprises, water, cyclomethicone, diisopropyl adipate, alcohol, C12-15 alkyl lactate, butylated hydroxytoluene, citric acid anhydrous, and disodium edetate.Type: GrantFiled: March 14, 2019Date of Patent: November 10, 2020Assignee: DOW PHARMACEUTICAL SCIENCES, INC.Inventors: Radhakrishnan Pillai, Gordon Dow
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Patent number: 10828369Abstract: Methods and compositions for treating disorders of the nail and nail bed. Such compositions contain a vehicle in which all components of the composition are dissolved, suspended, dispersed, or emulsified, a non-volatile solvent, a wetting agent, and a pharmaceutically active ingredient that is soluble in the non-volatile solvent and/or a mixture of the vehicle and the non-volatile solvent, which composition has a surface tension of 40 dynes/cm or less and has continuing spreadability, and which composition is effective in treating a disorder of the nail or nail bed.Type: GrantFiled: September 12, 2018Date of Patent: November 10, 2020Assignee: DOW PHARMACEUTICAL SCIENCES, INC.Inventors: Gareth Winckle, Gregory T. Fieldson
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Patent number: 10624918Abstract: An aqueous formulation for topical application to the skin comprising water, a water-miscible organic solvent, and benzoyl peroxide, wherein the concentration of the organic solvent is sufficient to provide a stable suspension of benzoyl peroxide in the aqueous formulation without the inclusion of a surfactant in the formulation, wherein the ratio of concentrations of water and organic solvent in the formulation is sufficient to maintain the benzoyl peroxide in saturated solubility in the formulation following application to the skin, and wherein the concentration of benzoyl peroxide in the formulation is less than 5.0% and at least 1.0% w/w. The formulation may further contain a chemical compound in addition to benzoyl peroxide that is effective in the treatment of acne. The aqueous formulations of the invention are useful in the treatment of acne and acne rosacea.Type: GrantFiled: October 26, 2018Date of Patent: April 21, 2020Assignee: Dow Pharmaceutical Sciences, Inc.Inventors: Yunik Chang, Gordon J. Dow, Radhakrishnan Pillai
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Patent number: 10512640Abstract: Methods and compositions for treating disorders of the nail and nail bed. Such compositions contain a vehicle in which all components of the composition are dissolved, suspended, dispersed, or emulsified, a non-volatile solvent, a wetting agent, and a pharmaceutically active ingredient that is soluble in the non-volatile solvent and/or a mixture of the vehicle and the non-volatile solvent, and which composition is effective in treating a disorder of the nail or nail bed.Type: GrantFiled: December 20, 2017Date of Patent: December 24, 2019Assignee: Dow Pharmaceutical Sciences, Inc.Inventors: Gareth Winckle, Gregory T. Fieldson
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Patent number: 10478502Abstract: Pharmaceutical compositions for topical application to skin are provided. In some embodiments, the pharmaceutical compositions comprise a corticosteroid and further comprise a liquid oil component comprising one or more dicarboxylic acid esters and/or monocarboxylic acid esters.Type: GrantFiled: June 6, 2017Date of Patent: November 19, 2019Assignee: Dow Pharmaceutical Sciences, Inc.Inventors: Arturo Angel, Gordon Dow
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Patent number: 10342875Abstract: The present invention provides compositions containing efinaconazole, butylated hydroxytoluene, a salt of ethylenediaminetetraacetic acid, and optional citric acid. The compositions exhibit stable color profiles and are useful in the treatment of fungal infections.Type: GrantFiled: May 29, 2017Date of Patent: July 9, 2019Assignee: Dow Pharmaceutical Sciences, Inc.Inventors: Varsha Bhatt, Nayan Desai, Radhakrishnan Pillai
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Patent number: 10245257Abstract: The present invention provides methods for treating onychomycosis. In certain embodiments, the methods comprise comprising applying a pharmaceutically acceptable formulation containing 10% efinaconazole once a day for a treatment period of at least 36 weeks to the treatment area of an onychomycosis patient (a) without debriding the nail or nail-associated tissue initially or during the treatment period and/or (b) without removing the formulation from the treatment area during the treatment period. In certain embodiments, the formulation also comprises, water, cyclomethicone, diisopropyl adipate, alcohol, C12-15 alkyl lactate, butylated hydroxytoluene, citric acid anhydrous, and disodium edetate.Type: GrantFiled: November 24, 2014Date of Patent: April 2, 2019Assignee: Dow Pharmaceutical Sciences, Inc.Inventors: Radhakrishnan Pillai, Gordon Dow
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Patent number: 10220049Abstract: An aqueous formulation for topical application to the skin comprising water, a water-miscible organic solvent, and benzoyl peroxide, wherein the concentration of the organic solvent is sufficient to provide a stable suspension of benzoyl peroxide in the aqueous formulation without the inclusion of a surfactant in the formulation, wherein the ratio of concentrations of water and organic solvent in the formulation is sufficient to maintain the benzoyl peroxide in saturated solubility in the formulation following application to the skin, and wherein the concentration of benzoyl peroxide in the formulation is less than 5.0% and at least 1.0% w/w. The formulation may further contain a chemical compound in addition to benzoyl peroxide that is effective in the treatment of acne. The aqueous formulations of the invention are useful in the treatment of acne and acne rosacea.Type: GrantFiled: February 6, 2017Date of Patent: March 5, 2019Assignee: Dow Pharmaceutical Sciences, Inc.Inventors: Yunik Chang, Gordon J. Dow
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Patent number: 10166235Abstract: The solubility of kinetin and/or of zeatin is increased when either or both are combined in a formulation that includes a polyoxyalkylene-n-glycerol dicarboxylate component and a fatty acid component. These two components provide a synergistic increase in the solubility of kinetin and/or zeatin that is greater than that which would be expected based on the solubility of kinetin and zeatin in the individual components.Type: GrantFiled: March 26, 2018Date of Patent: January 1, 2019Assignee: Dow Pharmaceutical Sciences, Inc.Inventors: Pramod P. Sarpotdar, Sarmistha Basu, Varsha D. Bhatt, Yunik Chang, Gordon J. Dow
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Patent number: 10137142Abstract: An aqueous formulation for topical application to the skin comprising water, a water-miscible organic solvent, and benzoyl peroxide, wherein the concentration of the organic solvent is sufficient to provide a stable suspension of benzoyl peroxide in the aqueous formulation without the inclusion of a surfactant in the formulation, wherein the ratio of concentrations of water and organic solvent in the formulation is sufficient to maintain the benzoyl peroxide in saturated solubility in the formulation following application to the skin, and wherein the concentration of benzoyl peroxide in the formulation is less than 5.0% and at least 1.0% w/w. The formulation may further contain a chemical compound in addition to benzoyl peroxide that is effective in the treatment of acne. The aqueous formulations of the invention are useful in the treatment of acne and acne rosacea.Type: GrantFiled: October 24, 2016Date of Patent: November 27, 2018Assignee: Dow Pharmaceutical Sciences, Inc.Inventors: Yunik Chang, Gordon J. Dow, Radhakrishnan Pillai
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Patent number: 10105444Abstract: Methods and compositions for treating disorders of the nail and nail bed. Such compositions contain a vehicle in which all components of the composition are dissolved, suspended, dispersed, or emulsified, a non-volatile solvent, a wetting agent, and a pharmaceutically active ingredient that is soluble in the non-volatile solvent and/or a mixture of the vehicle and the non-volatile solvent, which composition has a surface tension of 40 dynes/cm or less and has continuing spreadability, and which composition is effective in treating a disorder of the nail or nail bed.Type: GrantFiled: November 29, 2017Date of Patent: October 23, 2018Assignee: Dow Pharmaceutical Sciences, Inc.Inventors: Gareth Winckle, Gregory T. Fieldson
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Patent number: 9925194Abstract: The solubility of kinetin and/or of zeatin is increased when either or both are combined in a formulation that includes a polyoxyalkylene-n-glycerol dicarboxylate component and a fatty acid component. These two components provide a synergistic increase in the solubility of kinetin and/or zeatin that is greater than that which would be expected based on the solubility of kinetin and zeatin in the individual components.Type: GrantFiled: April 10, 2017Date of Patent: March 27, 2018Assignee: Dow Pharmaceutical Sciences, Inc.Inventors: Pramod P. Sarpotdar, Sarmistha Basu, Varsha D. Bhatt, Yunik Chang, Gordon J. Dow
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Patent number: 9877955Abstract: Methods and compositions for treating disorders of the nail and nail bed. Such compositions contain a vehicle in which all components of the composition are dissolved, suspended, dispersed, or emulsified, a non-volatile solvent, a wetting agent, and a pharmaceutically active ingredient that is soluble in the non-volatile solvent and/or a mixture of the vehicle and the non-volatile solvent, and which composition is effective in treating a disorder of the nail or nail bed.Type: GrantFiled: October 24, 2016Date of Patent: January 30, 2018Assignee: Dow Pharmaceutical Sciences, Inc.Inventors: Gareth Winckle, Gregory T. Fieldson
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Patent number: 9861698Abstract: Methods and compositions for treating disorders of the nail and nail bed. Such compositions contain a vehicle in which all components of the composition are dissolved, suspended, dispersed, or emulsified, a non-volatile solvent, a wetting agent, and a pharmaceutically active ingredient that is soluble in the non-volatile solvent and/or a mixture of the vehicle and the non-volatile solvent, which composition has a surface tension of 40 dynes/cm or less and has continuing spreadability, and which composition is effective in treating a disorder of the nail or nail bed.Type: GrantFiled: September 19, 2014Date of Patent: January 9, 2018Assignee: DOW PHARMACEUTICAL SCIENCES, INC.Inventors: Gareth Winckle, Gregory T. Fieldson
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Patent number: 9744150Abstract: Powder containing benzoyl peroxide is readily wetted by contacting the powder with a liquid containing water and one or more water-soluble organic solvents in a concentration sufficient to reduce the surface tension of the liquid to 64 dynes/cm or less. The benzoyl peroxide can then be subjected to a micronization treatment to obtain a suspension containing micronized benzoyl peroxide.Type: GrantFiled: October 15, 2010Date of Patent: August 29, 2017Assignee: Dow Pharmaceutical Sciences Inc.Inventor: Gordon Jay Dow
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Patent number: 9693988Abstract: An aqueous formulation for topical application to the skin comprising water, a water-miscible organic solvent, and benzoyl peroxide, wherein the concentration of the organic solvent is sufficient to provide a stable suspension of benzoyl peroxide in the aqueous formulation without the inclusion of a surfactant in the formulation, wherein the ratio of concentrations of water and organic solvent in the formulation is sufficient to maintain the benzoyl peroxide in saturated solubility in the formulation following, application to the skin, and wherein the concentration of benzoyl peroxide in the formulation is less than 5.0% and at least 1.0% w/w. The formulation may further contain a chemical compound in addition to benzoyl peroxide that is effective in the treatment of acne. The aqueous formulations of the invention are useful in the treatment of acne and acne rosacea.Type: GrantFiled: September 13, 2012Date of Patent: July 4, 2017Assignee: DOW PHARMACEUTICAL SCIENCES, INC.Inventors: Yunik Chang, Gordon J. Dow
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Patent number: 9662394Abstract: The present invention provides compositions containing efinaconazole, butylated hydroxytoluene, a salt of ethylenediaminetetraacetic acid, and optional citric acid. The compositions exhibit stable color profiles and are useful in the treatment of fungal infections.Type: GrantFiled: October 2, 2014Date of Patent: May 30, 2017Assignee: Dow Pharmaceutical Sciences, Inc.Inventors: Varsha Bhatt, Nayan Desai, Radhakrishnan Pillai
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Patent number: 9616132Abstract: The solubility of kinetin and/or of zeatin is increased when either or both are combined in a formulation that includes a polyoxyalkylene-n-glycerol dicarboxylate component and a fatty acid component. These two components provide a synergistic increase in the solubility of kinetin and/or zeatin that is greater than that which would be expected based on the solubility of kinetin and zeatin in the individual components.Type: GrantFiled: March 17, 2014Date of Patent: April 11, 2017Assignee: Dow Pharmaceutical Sciences, Inc.Inventors: Pramod Sarpotdar, Sarmistha Basu, Varsha D. Bhatt, Yunik Chang, Gordon J. Dow
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Patent number: 9566272Abstract: Methods and compositions for treating disorders of the nail and nail bed. Such compositions contain a vehicle in which all components of the composition are dissolved, suspended, dispersed, or emulsified, a non-volatile solvent, a wetting agent, and a pharmaceutically active ingredient that is soluble in the non-volatile solvent and/or a mixture of the vehicle and the non-volatile solvent, and which composition is effective in treating a disorder of the nail or nail bed.Type: GrantFiled: June 30, 2015Date of Patent: February 14, 2017Assignee: DOW PHARMACEUTICAL SCIENCES, INC.Inventors: Gareth Winckle, Gregory T. Fieldson