Abstract: A motor vehicle has a high-voltage battery and two separate electric machines. Each electric machine is associated with a power electronics unit, and each power electronics unit has a DC-to-DC converter. Each DC-to-DC converter is designed to reduce a high voltage of the high-voltage battery to a predetermined voltage. The two DC-to-DC converters of the two power electronics units are connected electrically in parallel and are set to different voltage values.

Abstract: The present invention provides a method for treating or preventing a condition or disease in a human or an animal subject wherein the condition or disease is associated with lipoprotein metabolism, the method comprising administering to the subject a composition comprising benzylamine compounds.

Abstract: A drive device (1) for motorized actuation of a functional element of a motor vehicle has an electric motor (2) with a motor shaft (3) and also has a worm shaft (4) of a worm gearing. A first end of the worm shaft is connected to the motor shaft (3) and a second end is received in a radial bearing (5). The radial bearing (5) has a bearing body (21) with an outer surface mounted in a housing (11) and at least one annular bearing element (24) is mounted to the worm shaft (4). The bearing element (24) is elastic at least in a partial region to ensure compensation for tolerances in the region of the radial bearing.

Abstract: Botulinum toxin is combined with colloidal silver particles to provide improved compositions for use in medical and cosmetic treatments.

Abstract: A brake disc having a friction ring and a hub produced as a separate element and arranged inside the friction ring according. Recesses are configured in the friction ring on the inside to connect the hub to the friction ring and corresponding projections are formed on the hub, which projections engage in the recesses of the friction ring in order to be able to transfer torque from the friction ring to the hub. The recesses have an undercut at least partially in a radial direction, as viewed looking inward from the outside. The disc is simple and cost-effective to manufacture and has an acoustically advantageous operating performance, in particular in the case of thermal expansion.

Abstract: A method for machining a surface of a metal component, in particular a connecting rod or a cam for a motor vehicle, including the following steps: providing a metal component which has a surface to be machined; premachining the surface to be machined; structuring the premachined surface by means of a laser beam in such a way that elevations but no depressions are formed as laser structures on the premachined surface with respect to the level thereof.

Abstract: A vehicular register apparatus includes an apparatus body having a ventilation path with a downstream end provided as a blow outlet to a vehicle room. Fins are arranged in the ventilation path. The fins are spaced to each other in a first direction intersecting with an airflow direction. Each of the fins extends in a second direction intersecting with the airflow direction and the first direction. The fins respectively have shaft parts for supporting the fins on the apparatus body. The apparatus body includes guide passages for swingably and slidably supporting the shaft parts. The guide passages are formed so as to be apart in the first direction from each other toward the vehicle room.

Abstract: The invention concerns a tool for machining of materials, specifically a grinding tool, which has a substantially rotationally symmetrical shape with respect to a rotation axis (R), the tool comprising an outer shell centered about the rotation axis and defining an internal space therein, wherein at least a part of a surface of the outer shell is provided with an abrasive coating or component, wherein the outer shell encases an internal skeleton structure in the internal space, the internal skeleton being integral with the outer shell and defining void volumes in the internal space thereby establishing material and void volumes of the internal space, and wherein the material to void ratio M/V is distributed substantially identically along each radius (r) centered around the rotation axis (R) and its corresponding symmetrical radius (r?). The invention also concerns a method for producing such tool.

Abstract: Clinical information, molecular information and/or computer-generated morphometric information is used in a predictive model for predicting the occurrence of a medical condition. In an embodiment, a model predicts whether a patient is likely to have a favorable pathological stage of prostate cancer, where the model is based on features including one or more (e.g., all) of preoperative PSA, Gleason Score, a measurement of expression of androgen receptor (AR) in epithelial and stromal nuclei and/or a measurement of expression of Ki67-positive epithelial nuclei, a morphometric measurement of a ratio of area of epithelial nuclei outside gland units to area of epithelial nuclei within gland units, and a morphometric measurement of area of epithelial nuclei distributed away from gland units. In some embodiments, quantitative measurements of protein expression in cell lines are utilized to objectively assess assay (e.g.

Abstract: A tank ventilation valve has a housing (21), a closing member (4), a sealing seat (5) and a first space (17). A second space (18) is connected to the first space (17) via a control opening (19) that surrounds the sealing seat (5). A spring (6) pretensions the closing member (4) against the sealing seat (5) and closes the control opening (19). The closing member (4) opens as a function of a pressure difference between the first and second spaces (17, 18). The opened closing member (4) opens the control opening (19) so that the first space (17) is connected to a first line (2) connects to fresh air. The second space (18) is connected to a second line (3) that is attachable to a filter. Structure is provided to exert a further negative pressure on the closing member (4) to move the closing member (4) into the open position.

Abstract: The application provides formulations for the topical administration of an active agent comprising at least one steroid, in the form of topical sprays that are propellant-free, and/or substantially non-foaming, and/or alcohol-free. The present application also provides processes for preparing such compositions and methods of using them in management of skin diseases or disorders such as psoriasis, dermatoses, and other associated skin diseases or disorders.

Abstract: Method for operating an electrical network including a first subnetwork and a second subnetwork which are connected to one another via a transformer and are DC-isolated from one another by the latter. A primary side of the transformer with a first number of turns is assigned to the first subnetwork and a secondary side of the transformer with a second number of turns is assigned to the second subnetwork. The first subnetwork has a multi-level converter having a plurality of individual modules, and each individual module has an electrical energy store. The multi-level converter provides at least one first incoming electrical AC voltage which is modulated with at least one second incoming electrical AC voltage. A resulting electrical voltage is made available to the transformer and is transformed by the transformer to an outgoing electrical voltage which is made available to the second subnetwork.

Abstract: A method controls an internal combustion engine having a drive output shaft that is coupled to an input shaft of a transmission. The internal combustion engine and the transmission are encompassed by a drivetrain for the drive of a motor vehicle. The method includes determining a rotational speed of the drive output shaft of the internal combustion engine and determining a rotational acceleration of the drive output shaft based on the rotational speed of the drive output shaft. A dynamic torque of the internal combustion engine is determined as a product of the rotational acceleration and a dynamic moment of inertia of the internal combustion engine. A maximum combustion torque of the internal combustion engine is determined from a sum of a predetermined maximum torque at the input shaft of the transmission and the dynamic load torque of the internal combustion engine.

Abstract: A length-measuring device includes a scale and a mounting element. The mounting element has a first fastening portion by which the mounting element is stationarily attached to the scale and a second fastening portion configured to be stationarily attached to a support. An arrangement of a plurality of flexible struts is provided between the first fastening portion and the second fastening portion which, through flexure, allows the first fastening portion to move relative to the second fastening portion perpendicularly to the longitudinal direction. The arrangement of struts is configured to compensate for a flexure-induced change in length of the struts in such a way that no movement will result from the flexure-induced change in length between the first fastening portion and the second fastening portion in the longitudinal direction.

Abstract: The present application relates to a series of substituted pyrazolo[1,5-a]pyridine compounds, their use as tropomyosin receptor kinase (Trk) family protein kinase inhibitors, method of making and pharmaceutical compositions comprising such compounds.

Abstract: An optical position measuring instrument including a scale and a scanning unit, wherein the scanning unit and the scale are movable with respect to one another. The scanning unit includes a detector unit, and a reflector unit that has a first and second wave front correctors and a beam direction inverter. The reflector unit is disposed so that beams first pass through the scale and the first wave front corrector, then a back-reflection of partial beams is effected in a direction of the scale, and the partial beams then pass through the scale and the second wave front corrector before the partial beams then arrive at the detector unit, wherein it is ensured that wave front deformations of the partial beams are converted into wave front deformations that compensate for resultant wave front deformations of the partial beams upon a second diffraction at the scale.