Abstract: A position-measuring device includes a scale and a scanning unit movable relative to the scale in a measurement direction. The scale has an incremental measuring graduation and reference marks spaced apart from each other. The scale has a first marking track containing a first marking associated a reference mark and a second marking spaced apart from the first marking. The scanning unit has a first and a second detector spaced apart from each other. A distance between the detectors is greater than a length of the first marking and less than a length of the second marking. The scanning unit is configured to produce a reference pulse based on only the first detector of the two detectors generating a scanning signal, and to produce a switching signal when both the first detector and the second detector generate a scanning signal.

Abstract: The present invention relates to new imidazo[2,1-b]thiazole derivatives having a great affinity for sigma receptors, especially sigma-1 receptors, as well as to the process for the preparation thereof, to compositions comprising them, and to their use as medicaments.

Abstract: A seat depth adjustment device for a vehicle seat has a seat structure (3) that includes a support plate (6) that is displaceable relative to the seat structure (3) with the aid of a linear guide (7) of the seat structure (3). The seat structure (3) is designed for receiving an upholstery cover. The upholstery cover is pretensioned with the aid of a cover return (22), and wherein the cover return (22) is connected to the support plate (6). Accordingly, the cover return (22) is connected to the support plate (6) in a manner positionable infinitely variably.

Abstract: An internal combustion engine with an adjustable compression ratio has a switchover valve (10) for controlling hydraulic oil flow in chambers of an eccentric adjustment device. The switchover valve (10) has a switching element (12) and a sleeve-shaped connecting section (16) with a first bore (17) that connects to a first hydraulic line (18), a second bore (19) that connects to a second hydraulic line (20), and a venting bore (21) that connects to a vent (22). The switching element (12) can be displaced in the connecting section (16) between a first position (S1) where a groove in the switching element (12) connects the first hydraulic line (18) to the venting duct (22) or a second position (S2) where the groove (14) connects the second hydraulic line (20) to the venting duct (22). A pick-off element (30) extends through the connecting section (16) and interacts with the switching element (12).

Abstract: A transfer device for energy in a motor vehicle is designed for connection to a first vehicle electrical distribution system and a second vehicle electrical distribution system, which each comprise an associated energy store. In this case, the transfer device comprises a first sampling device for determining that the two energy stores have been filled sufficiently, a second sampling device for detecting an energy withdrawal from one of the vehicle electrical distribution systems, and a DC-to-DC converter for transferring energy between the vehicle electrical distribution systems. In addition, a control device is provided which is designed, in an automatic mode to control a transfer of energy from one of the vehicle electrical distribution systems into the other vehicle electrical distribution system on the basis of the signals of the sampling devices when energy is withdrawn from the other vehicle electrical distribution system.

Abstract: A lighting apparatus for a motor vehicle includes a daytime running light device, a low-beam, high-beam, or low- and high-beam light device, and a drive device operable to drive an illumination level of the daytime running light device. With the low-beam and/or high-beam light device switched off, the drive device drives the daytime running light device so as to have a first illumination level. With the low-beam and/or high beam light device switched on, the drive device drives the daytime running light device so as to have a second illumination level. With the low-beam and/or high-beam light device switched on and with poor weather conditions, the drive device drives the daytime running light device so as to have a third illumination level. The second illumination level is less than or equal to the first illumination level. The third illumination level is less than the second illumination level.

Abstract: A toothbrush having a head extending along a longitudinal axis. The toothbrush has a handle extending along the longitudinal axis. The toothbrush has a first set of bristle tufts arranged along a first row, all bristle tufts of the first set of bristle tufts attached to the head and oriented at a first angle leftward of a vertical position. The toothbrush has a second set of bristle tufts arranged along a second row, all bristle tufts of the second set of bristle tufts attached to the head and oriented in the vertical position. The toothbrush has a third set of bristle tufts arranged along a third row, all bristle tufts of the third set of bristle tufts attached to the head and oriented at a second angle rightward of the vertical position, and the second row is located between the first row and the third row.

Abstract: A drive module for a vehicle has a transmission (12) and an electric machine (11) that is coupled to an input shaft (16) of the transmission (12). An air-filled cavity (23) is formed between the electric machine (11) and the transmission (12). The electric machine (11) is an external-rotor motor with a rotor (24) that surrounds the stator (25). A fan impeller (31) rotates with the rotor (24) and draws air out of the air-filled cavity (23) in an axial direction, draws the air through windings (27) of the stator (25) for cooling, and subsequently conveys the air in the radial direction into a housing-side flow duct (34) in which heated air can be accumulated and via which the air can be returned toward the cavity (23). The heated air can be cooled in the region of the flow duct (34) and/or in the region of the cavity (23).

Abstract: The present invention relates to new 1,2,3-triazole-amine derivatives, having affinity for sigma receptors, especially sigma-1 receptor, as well as to the process for the preparation thereof, to compositions comprising them, and to their use as medicaments for the treatment of sigma receptor related diseases and disorders.

Abstract: A redundant brushless drive system, including a coil (12) having first and second phase windings operable independently of one another and first and second independently operable sensor groups for the rotational position of a rotor (11) and for commutation of the phase windings. The first and second sensor groups are positioned along the motor axle one-behind-the-other parallel to each other and symmetrical to the motor axle (10). An encoder circuit board (7) is configured such that an association of the sensor groups (G1, G2) to a phase winding (W1, W2) is configurable such that either the first sensor group (G1) is used for controlling the first phase winding (W1) and the second sensor group (G2) for controlling the second phase winding (W2), or the first sensor group (G1) is used for controlling the second phase winding (W2) and the second sensor group (G2) for controlling the first phase winding (W1).

Abstract: The invention provides a pharmaceutical composition for intranasal administration comprising a salt of sumatriptan or a physiologically acceptable solvate thereof, an alkyl glycoside or saccharide alkyl ester and optionally at least one pharmaceutically acceptable excipient, wherein the said composition provides Tmax value of less than 30 minutes upon said administration. Other aspects and embodiments are contemplated and described. The invention also provides a pharmaceutical composition for intranasal administration comprising a triptan, a pharmaceutically acceptable vehicle and a mucosal permeation enhancer, wherein upon said administration said composition provides a Tmax substantially equivalent to subcutaneous administration of said triptan. Other aspects and embodiments are contemplated and described.

Abstract: A sealing element (10) for sealing battery cells (18) of a battery module (34) for the purely electric drive of a motor vehicle has a first sealing disk (12) for a seal-forming attachment between a housing (32) and a first attachment frame (44), a second sealing disk (14) spaced from the first sealing disk (12) for a seal-forming attachment between the housing (32) and a second attachment frame (46), and receptacle pockets (16), connecting the first and second sealing disks (12, 14) for accommodating battery cells (18) therein. The first and second sealing disks (12, 14) and the receptacle pockets (16) are manufactured in one piece from a common sealing material. Thus, the battery cells (18) can be sealed with respect to a cooling medium that flows through the housing (32) thereby avoiding the risk of electrical short-circuits via the cooling medium.

Abstract: A method for serial data transmission between a position-measuring device and subsequent electronics over a bidirectional data channel includes transmitting data in data frames and in encoded form in accordance with a data transmission code. The data transmission in each case is initiated by an interface unit at a transmitter end with a start sequence having an encoding scheme that at least partially differs from an encoding scheme of a remainder of the data frames. After a reversal of data direction, an interface unit at a receiver end detects a beginning of the data transmission in each case by detection of the start sequence.

Abstract: A rollover protection element (4) having a rollover element (5, 10, 110, 210) of elongate configuration and a bumper element (6, 11, 111, 211) connected at a free end of the rollover element (5, 10, 110, 210). The bumper element (6, 11, 111, 211) extends in a width direction of the rollover element (5, 10, 110, 210). The bumper element (6, 11, 111, 211) has a circumferential-side wall and webs that are arranged within the wall, a lower-side region of the wall of the bumper element (6, 11, 111, 211) is connected to the rollover element (5, 10, 110, 210). The webs are arranged in a curved and/inclined manner such that none of the webs lies perpendicularly on the lower-side region of the wall.

Abstract: Described is a protective solution for avoiding ischemic, storage or ischemia/reperfusion to organs, or to isolated cell systems, or to tissue components after perfusion, surgery, transplantation, or cryopreservation and subsequent reperfusion, which contains alkali ions, and if need be also alkaline earth ions as the electrolyte, a buffer e.g. on a histidine derivation basis, as well as a polyol and/or a saccharide, has an osmolarity of about 290 mosm/l to about 350 mosm/l, as well as a pH value of about 6.8 to about 7.4, and to which hydroxamic acid, and/or one or more hydroxamic acid derivatives are added.

Abstract: The invention relates to a method for rapid immunogen selection (RIS) based on the binding a library of recombinant viruses containing randomized HIV gp120 variants of a surface polypeptide displayed to said neutralizing antibodies. The invention relates as well to the use of the HIV gp120 immunogens isolated according to the RIS method of the invention in medicine for the treatment of diseases caused by a virus and in diagnosis for the identification of neutralizing antibodies in a patient.

Abstract: The invention relates to a measuring method for determining biometric data of human feet, comprising the following steps providing a reference object, which has at least one reference pattern, providing a freely moveable image recording device, automatically detecting the relative position and the alignment of the image recording device relative to the reference object using the at least one reference pattern, automatically recording of several images by the image recording device, wherein each individual image is only recorded, when the relative position and the alignment of the image recording device relative to the reference object corresponds to a triggering position predetermined for the respective image, determining biometric data of the at least one foot by means of the recorded images. Furthermore, the present invention relates to a measuring system as well as a pedestal for determining biometric data of human feet.

Abstract: An injection member penetrates an elastic septum of a device defining a sealed, empty, sterile chamber in fluid communication with the septum. During penetrating, an annular interface is formed between the septum and the injection member extending axially between a penetration point on an interior surface of the septum in fluid communication with the sterile chamber, and an exterior surface of the septum engaging the injection member. The injection member is de-contaminated by (i) friction between the septum and injection member at the annular interface, and (ii) elongation of the septum at the annular interface. A substance is introduced through the injection member and into the sterile chamber of the device, the injection member is then withdrawn from the septum, the septum reseals itself at the resulting penetration aperture, and the chamber is maintained sterile throughout the foregoing steps.

Abstract: Systems, kits and methods for transferring heat with a portion of a mammal are provided. Aspects of the subject systems include a negative pressure device configured to apply negative pressure to a portion of a mammal, and a temperature modulation device configured to contact the portion of the mammal under negative pressure in a manner sufficient to transfer heat with the contacted portion of the mammal, e.g., either remove heat or introduce heat into the contacted portion of the mammal. The disclosed systems and methods find use in a variety of different applications, including both therapeutic and non-therapeutic applications.