Abstract: Processes for preparing azacitidine. Further included are processes for the preparation of crystalline azacitidine crystalline Form (I) and mixtures of azacitidine crystalline Forms (I) and (II).

Abstract: A method and device for causing a predetermined physiological change in a mammalian tissue. The method includes irradiating the tissue with a radiation having a power density in the tissue substantially larger than an activation threshold power density, the tissue being irradiated under conditions suitable to cause the predetermined physiological change. The device can emit raditation and forms to the anatomy of a patient. The device can both cool the patient and treatment head using one cooling system.

Abstract: Pharmaceutical formulations comprising amorphous pemetrexed or its salts, and processes to prepare the formulations.

Abstract: The present invention relates to substituted pyrazoline compounds, methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animal.

Abstract: The invention relates to a process for the production of alginate-containing porous or sponge-like moulded articles, and to the moulded articles obtainable thereby and their use.

Abstract: A method controls a friction clutch disposed between an internal combustion engine and a change speed transmission. The friction clutch is controlled in such a way that it transmits an average coupling torque of the internal combustion engine and does not transmit periodically occurring peak values of the coupling torque. In addition, a control unit is programmed to carry out the method.

Abstract: A knot tying apparatus for tying a pair of fishing lines to one another is provided. The apparatus includes a tubular body having a through passage extending between opposite first and second ends with a slot extending from the first end toward the second end. Further, the apparatus has an actuator coupled to the tubular body for sliding movement between the first and second ends. The actuator is moveable between the first and second ends via application of an external force to removed loops of the one of the lines from the tubular body onto the other of the lines.

Abstract: A coupled axle drive system for a vehicle has a first axle drive device for driving a first axle of the vehicle by a connected engine and a second axle drive device for driving a second axle of the vehicle. The second axle drive device has an electric machine for driving at least one wheel of the axle.

Abstract: A drivetrain has at least one drive machine (2, 3) with a drive output shaft (6) that can be coupled via a transmission (10) to at least one drive wheel. The transmission (10) is mounted on the drive machine (2, 3) and has a planetary gear set (18). To reduce the expenditure for the development and/or manufacture of the drivetrain, the transmission (10) has different mounting positions rotated relative to the drive output shaft (6) of the drive machine (2, 3).

Abstract: Processes for the preparation of amorphous pemetrexed disodium, and removal of residual solvents from amorphous pemetrexed disodium.

Abstract: The invention relates to an air nozzle for conducting an air flow from an air feed shaft or an air feed duct in a heating, a ventilating or an air-conditioning installation, particularly for passenger compartments in motor vehicles, consisting of a hollow-cylindrical housing with a front air outflow opening and a rear air inflow opening as well as an insert, which is mounted in the housing and by which the direction and/or the intensity of the of the air flow issuing from the air nozzle is or are variable. For improved mounting and easier assembly the insert has an outer surface which is spherical at least in sections and is supported at the inner surface of the housing by way of at least two bearing points of matching contour, wherein a spring element is associated with at least one bearing point.

Abstract: A method for operation of a hybrid vehicle is provided. The hybrid vehicle has a first drive apparatus for driving the wheels on a first axle by an internal combustion engine, a second drive apparatus having two electrical machines for driving the wheels on a second axle, and at least one electrical energy store that can be discharged when an electrical machine is being operated as a motor and can be charged when an electrical machine is being operated as a generator. The method includes operating at least one driver-operated control for causing at least one of the electrical machines to output additional electrical drive torque to the axle that is not driven by the internal combustion engine.

Abstract: A method is provided for operating a braking system of a hybrid vehicle that can be driven by an internal combustion engine and an electrical machine. A brake pressure for a mechanical brake in the braking system is reduced during braking with recuperation, in comparison to the brake pressure during braking without recuperation. A braking system and a vehicle having a braking system that functions in accordance with the method also are provided.

Abstract: A control system (1) for a vehicle (10) with two axle drive devices (5, 12) has an engine control device (28) for controlling a first axle drive device (5) for driving a first axle of the vehicle (10) by a connected combustion engine (14) in a two-wheel drive mode and by a four-wheel drive mode. The control system (1) also has a control device (26) for controlling a second electric axle drive device (12) for driving a second axle of the vehicle in a four-wheel drive mode. The control device (26) is connected to the engine control device (28) for passing on at least one characteristic diagram to the engine control device (28).

Abstract: A method and a device are provided for specifying a boost control strategy of a hybrid vehicle drive. The method includes predefining a driving track (R) with a multiplicity of track sections (G1-G4; K1-K4); determining a dependency of a lap time gain (?t) on a boost energy quantity (Eboost) used, proceeding from a vehicle-specific lap time without boost assistance from the electric motor (G1, G2) for a plurality of predetermined track sections (G1-G4); and defining a respective partial boost energy quantity (EBoost1, EBoost2, EBoost3, EBoost4) for each track section (G1-G4) based on the determined dependencies, with a sum of the partial boost energy quantities (EBoost1, EBoost2, EBoost3, EBoost4) corresponding to a predefined available total boost energy quantity (EBoostm).

Abstract: A vehicle having an electric drive device and an energy storage device which is arranged in a housing is disclosed. The energy storage device is formed from a plurality of cells. The housing includes a plurality of partitioning devices, with the result that at least one partitioning device is positioned between two cells. The housing of the energy storage device is connected both to a cooling air intake duct, having an inlet opening, and to a cooling air outflow duct, having an outlet opening. At least one partitioning device is configured in such a way that a plurality of cooling ducts are formed between the cells, and cooling air can flow through the cooling ducts in order to cool the energy storage device.

Abstract: A drive arrangement for an electric vehicle has an axle drive device of a portal design with two electric machines for driving the wheels of an axle of the electric vehicle, and at least one electric energy store that can be discharged when an electric machine is operated as a motor and/or can be charged when an electric machine is operated as a generator. The drive arranged is characterized in that the two electric machines (11) of the axle drive device (10) are combined with a respectively assigned transmission (12) in an electric axle to drive the individually suspended wheels (2) of the axle by means of, in each case, one articulated shaft flange (13) via a respective articulated shaft. Frequency converters assigned respectively to the two electric machines are combined in a converter unit.

Abstract: A hybrid vehicle has a first drive apparatus for driving wheels on a first axle by an internal combustion engine and a second electrical drive apparatus with two electrical machines for driving wheels on a second axle. At least one electrical energy store can be discharged when the two electrical machines are operated as a motor and can be charged when the electrical machines are operated as a generator. The two electrical machines of the electrical drive apparatus are combined with a respectively associated gearbox in an electrical axle to drive the individually suspended wheels on the first axle via universally jointed shafts. Two electrical converters are associated respectively with the two electrical machines and are combined in one converter unit, such that a basic module has the mechanical link to a bodywork structure, the link to a cooling circuit and the electrical link to an electrical energy store.

Abstract: A forward structure of a motor vehicle, particularly of a passenger car, includes a bumper cross member and an energy absorption element, particularly a foam-type impact absorbing element, disposed in front of the bumper cross member in the driving direction. A plurality of recesses are shaped into the forward-side outer contour of the energy absorption element. To ensure optimal energy reduction while the mounting space is reduced, and thereby a best-possible protective function with respect to a leg impact, at least several of the recesses completely penetrate the energy absorption element along its entire depth, whereby a plurality of breakthroughs are arranged in the energy absorption element.

Abstract: The present invention relates to Cycloalkane-substituted substituted pyrazoline compounds of formula (I), methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animals.