Patents Assigned to Drexel University
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Patent number: 9054423Abstract: A magnetic permeability enhanced metamaterial is used to enhance the antenna array of a Multiple Input Multiple Output (MIMO) communication system. A rectangular patch antenna array is formed including a stack of a plurality of unit cells, where each unit cell includes an inductive loop of magnetic permeability enhanced metamaterials embedded in a host dielectric substrate. The use of such metamaterials permits the antenna arrays to be made smaller, and have less mutual coupling, when using a metamaterial substrate. The measured channel capacities of the antenna arrays are similar for the metamaterial and conventional substrates; however, the capacity improvement when using MIMO relative to single antenna communication systems is greater for antennas on metamaterial substrates.Type: GrantFiled: August 8, 2014Date of Patent: June 9, 2015Assignee: Drexel UniversityInventors: Kapil R. Dandekar, Prathaban Mookiah
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Patent number: 9039921Abstract: A method to produce low-temperature sinterable powders which are then subsequently used to fabricate freestanding piezoelectric films with very large electric-field-enhanced piezoelectric response is provided. The ?d31 coefficient for PMN-PT layers can be as high as 2000 pm/V, larger than that of commercial single crystalline PMN-PT bulk materials, at 10 kV/cm (or 20 V over the 20-micron film thickness). In contrast to single crystals, the polycrystalline freestanding films are easy to fabricate and can be made into any size. The films are also easily miniaturized. The method can be applied to nearly any piezoelectric material.Type: GrantFiled: May 20, 2010Date of Patent: May 26, 2015Assignee: Drexel UniversityInventors: Wei-Heng Shih, Hongyu Luo, Christian Martorano, Wan Y. Shih
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Patent number: 9040488Abstract: Imino sugars, such as deoxynojirimycin (DNJ), are glucose analogues that selectively inhibit cellular ?-glucosidase I and II (enzymes that process N-linked glycans in glycoprotein) and exhibit broad spectrum antiviral activities against many enveloped viruses. Previously we have reported a novel DNJ derivative, OSL-95II, with antiviral activity and reduced cytotoxicity. In order to develop imino sugars with more potent antiviral activity as well as improved toxicity profile, OSL-95II was modified by diversifying the nitrogen linked alkylated side chain. The antiviral activities were initially tested in bovine viral diarrhea virus (BVDV) infected MDBK cells, yielding several imino sugar derivatives with novel structure and superior antiviral activity and toxicity profile. Furthermore, these new compounds were shown to be active against Dengue virus (DV) and West Nile virus (WNV) infection in BHK cells where potent anti-DV activity having submicromolar EC50 values and SI of greater than 900.Type: GrantFiled: September 2, 2009Date of Patent: May 26, 2015Assignees: Baruch S. Blumberg Institute, Drexel UniversityInventors: Timothy M. Block, Jinhong Chang, Xiaodong Xu
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Patent number: 9035831Abstract: A bi-directional antenna includes a plurality of unit cells stacked in two perpendicular planes (Y-X and Z-X planes) to form cube shaped unit cells whereby inductive loops are placed on four faces corresponding to the Y-X and Z-X planes. Each unit cell includes a magnetic permeability enhanced metamaterial. The resulting antenna has the ability to couple magnetic fields oriented in both the X and Y directions with increased permeabilities and can be used to realize a variety of different antenna architectures that do not have their magnetic field confined in a single direction.Type: GrantFiled: June 24, 2011Date of Patent: May 19, 2015Assignee: Drexel UniversityInventors: Prathaban Mookiah, Kapil Dandekar
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Publication number: 20150135293Abstract: Channel based authentication schemes for intrusion detection that operates at the physical layer are described that apply the capabilities of a pattern re-configurable antenna for improved performance. Performance gains are achieved by the schemes as a function of the number of antenna modes. The first scheme relies on a channel based fingerprint for differentiating between transmitters whereas another scheme poses the intruder detection problem as a generalized likelihood ratio (GLR) test problem that operates on the channel realizations corresponding to different modes present in a reconfigurable antenna. The benefits of these two schemes over single element antennas are demonstrated. General guidelines are provided on how to choose the different elements of the decision metric in order to realize better performance for physical layer based authentication schemes based on any diversity scheme.Type: ApplicationFiled: September 7, 2012Publication date: May 14, 2015Applicant: Drexel UniversityInventors: Prathaban Mookiah, Kapil R. Dandekar, John MacLaren Walsh, Rachel Greenstadt
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Publication number: 20150112299Abstract: A magnetic delivery system for delivering a magnetizable particle to a location in a body, the device includes a magnetizable object implanted in the body, wherein the magnetizable object includes a plurality of segments distributed throughout the magnetizable object and wherein the segments are configured to provide a magnetic gradient for attracting the magnetizable particle and an external source of a magnetic field capable of (i) magnetizing the magnetizable particle and (ii) increasing a degree of magnetization of the magnetizable object and thereby creating the magnetic gradient. A drug delivery system including the magnetic delivery system and a magnetizable particle associated with a therapeutic agent and/or a cell. A cell delivery system based on the magnetic delivery system and a magnetizable particle associated with a cell. A method of using the magnetic delivery system for delivery of a therapeutic agent and/or a cell to a targeted location in a body.Type: ApplicationFiled: October 28, 2014Publication date: April 23, 2015Applicant: Drexel UniversityInventors: Zachary Graham Forbes, Benjamin Biron Yellen, Kenneth Andrew Barbee, Gennady Friendman
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Patent number: 9010360Abstract: A flow valve assembly includes a valve operable between an open position and a closed position and a controller operatively coupled to the valve to operate the valve between the open position and the closed position. A mechanically or electrically operated assembly is provided to determine an amount of fluid flow through the valve when the valve is in the open position. A mechanically or electrically operated mechanism moves the valve from the open position to the closed position when the amount of fluid flow exceeds a predetermined value. A method of operating the valve is also provided.Type: GrantFiled: September 3, 2014Date of Patent: April 21, 2015Assignee: Drexel UniversityInventors: John Older, Bakhtier Farouk, La'Shell Jones, Jared Kern, Matthew Scholl
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Patent number: 9011697Abstract: A method for the treatment of fluid including the step of exposing the fluid to a pulsed plasma discharge. The pulsed plasma discharge will be generated using a suitable electrode configuration to generate the plasma discharge in the fluid. Apparatus useful in the method may include a vessel, at least two electrodes for generating a plasma discharge in water, and a flow inlet and a flow outlet to allow water to be passed through the vessel. Also described is an in-line water treatment, where a pulsed plasma discharge is used in a pipe carrying moving water. Plasma based fluid treatment system may have many advantages in comparison to other treatment methods, such as very minimal maintenance, low operating power, and minimal pressure loss through the device.Type: GrantFiled: June 15, 2007Date of Patent: April 21, 2015Assignee: Drexel UniversityInventors: Christopher A. Campbell, Young I. Cho, Alexander F. Gutsol, Alexander Fridman, Frank T. Snyder, Vincent Szarko, Erik Yelk, Jesse Zanolini, Victor Vasilets
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Patent number: 9006194Abstract: The invention relates to compositions and methods for preventing and diminishing virus infection. The invention further relates to compositions and methods for diminishing inflammation associated with viral infection. The invention also relates to compositions and methods for interfering with TLR activation, and thereby diminishing inflammation associated with viral infection.Type: GrantFiled: December 17, 2009Date of Patent: April 14, 2015Assignee: Drexel UniversityInventors: Peter D. Katsikis, Alina C. Boesteanu, Sefik S. Alkan
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Patent number: 8999640Abstract: Detection of miniscule amounts of nucleic acid is accomplished via binding of target nucleic acid to probe material, composed of nucleic acid, which is bound to a sensor configured to sense mass. The sensor is prepared by immobilizing a probe material to a surface of the sensor, wherein the probe material is known to bind to the target nucleic acid. The prepared sensor is exposed to the target nucleic acid. The target nucleic acid binds to the probe material. The mass accumulated on the sensor reflects the amount of target nucleic acid bound to the probe material.Type: GrantFiled: July 31, 2013Date of Patent: April 7, 2015Assignee: Drexel UniversityInventors: Rajakkannu Mutharasan, Kishan Rijal, David R. Maraldo, Gossett Augustus Campbell
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Publication number: 20150094859Abstract: A cutting device is configured to attach to a boom arm. The cutting device includes a saw assembly with a cutting portion configured to cut into a target surface. The cutting device also includes a motor assembly coupled to the saw assembly. The motor assembly has at least two motors configured to rotate the saw assembly about two different axes. The cutting device further comprises a control system operatively coupled to the motor assembly. The control system has at least two sensors coupled to the saw assembly and the control system is configured to position the saw assembly to cut a target surface based on feedback from the at least sensors.Type: ApplicationFiled: May 8, 2012Publication date: April 2, 2015Applicant: Drexel UniversityInventors: Jonathan Awerbuch, Tein-Min Tan, Adam C. Carlson, William Scott Goehinger, Clayton Powers, Jordan H. Shenk, David M. Synder, Marnus G. Van Zyl
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Patent number: 8992518Abstract: Non-thermal plasma is a partly ionized gas, which can be generated by a high-voltage electric field at a low pressure. Disclosed herein are apparatuses and methods for treating an enteric disease in vivo using non-thermal plasma. The disclosed apparatuses have a first conduit comprising a lumen and a tip; a first electrode disposed within the lumen of the first conduit; a second electrode comprised of a metal conduit disposed within the first conduit; an insulator disposed within the lumen of the first conduit, the insulator configured to electrically insulate the first electrode from the second electrode; and a gas channel disposed between the outer surface of the metal conduit and the inner surface of the first conduit, the gas channel being capable of feeding a gas from a gas source to the tip, wherein when the potential is applied, the gas is ionized to produce the non-thermal plasma.Type: GrantFiled: March 16, 2010Date of Patent: March 31, 2015Assignee: Drexel UniversityInventors: Gregory Fridman, Danil V. Dobrynin, Alexander Fridman, Gennady Friedman, Kalyan Chakravarthy, Sreekant Murthy
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Patent number: 8990962Abstract: The invention is directed to a cervical spine protection apparatus one or more composite bands attached to provide restraint of one or more motions of the cervical spine of a wearer. The apparatus is designed to protect a wearer from incurring cervical spinal injuries, and/or to reduce the severity of cervical spine injuries without substantially compromising the normal functional range of motion of the wearer's cervical spine.Type: GrantFiled: February 6, 2014Date of Patent: March 31, 2015Assignee: Drexel UniversityInventors: Sorin Siegler, Mary Milone, Yoganand Ghati
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Publication number: 20150079607Abstract: The present invention relates to methods useful to monitor central and peripheral nervous system neuron/axon destruction resulting from an increase in acute phase inflammatory enzymes. The methods have applicability to monitoring the progress of neurological diseases, including multiple sclerosis and Alzheimer's disease, as well as neuroinflammatory damage that results from sports injuries, vigorous physical activity or any form of physical abuse. The invention further relates to methods of treating multiple sclerosis or other diseases with an inflammatory component related to phospholipase A2.Type: ApplicationFiled: June 5, 2014Publication date: March 19, 2015Applicant: Philadelphia Health and Education Corporation, d/b/a Drexel University College of MedicineInventors: Timothy J. Cunningham, Lihua Yao
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Patent number: 8979287Abstract: The invention relates to a reflective surface substantially perpendicular to a vector field described by the equation: W(x,y,z)=T(proj(x,v,z))?(x,v,z)+proj(x,v,z)?(x,v,z)?T(proj(x,y,z))?(x,y,z)? ?proj(x,y,z)?(x,y,z)? and a method for forming the reflective surface. The reflective surface is capable of providing a non-reversed, substantially undistorted direct reflection.Type: GrantFiled: June 11, 2010Date of Patent: March 17, 2015Assignee: Drexel UniversityInventor: Robert Andrew Hicks
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Patent number: 8968286Abstract: The present invention is direct to a nano-probe corona tool and uses thereof. A nano-probe corona tool is disclosed having a tip with a diameter in the nano-scale, typically around 100 nm. The nano-probe corona tool is constructed of electrically conductive material. On the other end of the tool, a pulsed voltage source outputs a pulsed voltage to generated a pulsed electrical potential at the tip. The pulsed electrical potential at the tip causes a plasma discharge corona to occur. Uses of the corona discharge include, but are not limited to, optical emission spectroscopy, in the enhancement of deposition of coatings and nanoscale welding, e.g., nanotube or nanowires to a contact pad and welding two nanowires together, and in nanoscale surgery. For example, a nano-probe comprising CNTs may be inserted into cell membranes. The resulting corona discharge may be used to destroy tumors within the cell.Type: GrantFiled: August 19, 2009Date of Patent: March 3, 2015Assignee: Drexel UniversityInventors: David Staack, Alexander Gutsol, Alexander Fridman, Yury Gogotsi, Gennady Friedman
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Publication number: 20150044714Abstract: A device and method for determining the presence or absence, or the level of, sPLA2 activity in a fluid sample. The device includes an absorbent matrix that defines a flow path for a fluid sample, a first region of the absorbent matrix for applying a fluid sample, where one of the components selected from a bioactive sPLA2 substrate and a label is dried onto or within the first region of the absorbent matrix, a second region of the absorbent matrix downstream of, and in fluid communication with, the first region for detecting an aggregated reaction product, where the other component not present in the first region is dried onto or within the second region of the absorbent matrix.Type: ApplicationFiled: June 5, 2012Publication date: February 12, 2015Applicant: Philadelphia Health & Education Corporation d/b/a Drexel University College of MedicineInventors: Timothy J. Cunningham, Katherine Marie Kollins Callaghan, Lihua Yao
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Patent number: 8951963Abstract: The invention provides a peptide triazole conjugate and derivatives thereof, and methods of its use. The invention also provides an antibody to the peptide triazole conjugate. The invention further provides a method of identifying an HIV-1 entry inhibitor candidate.Type: GrantFiled: March 27, 2013Date of Patent: February 10, 2015Assignee: Drexel UniversityInventors: Irwin M. Chaiken, Umashankara Muddegowda, Karyn McFadden
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Publication number: 20150038584Abstract: Aspects of the present subject matter are directed to a method comprising contacting an fluid, optionally containing an added organic material, with a non-thermal plasma to form a disinfection composition, wherein the disinfection composition is a liquid, and contacting a surface with the disinfection composition, wherein the surface is at least partially disinfected upon contact with the disinfection composition. Additional aspects of the present subject matter are directed to a method comprising forming a disinfection composition by contacting an organic material with a non-thermal plasma, wherein the disinfection composition is a liquid. A further aspect of the present subject matter is directed to a disinfection composition comprising an organic material contacted by a non-thermal plasma, wherein the disinfection composition is a liquid.Type: ApplicationFiled: August 3, 2011Publication date: February 5, 2015Applicants: Philadelphia Health & Education Corporation d/b/a Drexel University College of Medicine, DREXEL UNIVERSITYInventors: Gregory Fridman, Sin Park, Natalie Shainsky, Danil V. Dobrynin, Alexander Rabinovich, Gennady Friedman, Alexander Fridman, Moogega Cooper, Ari D. Brooks, Suresh G. Joshi, Alexander E. Poor, Utku K. Ercan, Mark Ingerman
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Publication number: 20150038812Abstract: Described herein are fNIR-based brain computer interfaces. Training of individuals to intentionally control neural activity in specific cortical areas, thereby up-regulating and down-regulating oxygenation levels in specific locations in the brain is also provided herein. Further, continuous and/or binary control over computing environments using fNIR brain computer interfaces. Further still, a scale for brain interface index for oxygenation of a portion of the brain is provided herein.Type: ApplicationFiled: March 23, 2012Publication date: February 5, 2015Applicant: Drexel UniversityInventors: Hasan Ayaz, Patricia A. Shewokis, Scott C. Bunce, Banu Onaral