Abstract: The present invention is directed to methods of disaggregating nanodiamond clusters, especially those clusters typically produced from detonation syntheses, the nanodiamond particles and dispersions produced from these disaggregation processes, and compositions derived from these nanodiamond particles and dispersions.

Abstract: A computational geometry technique is utilized to detect, diagnose, and/or mitigate fault detection during the execution of a software application. Runtime measurements are collected and processed to generate a geometric enclosure that represents the normal, non-failing, operating space of the application being monitored. When collected runtime measurements are classified as being inside or on the perimeter of the geometric enclosure, the application is considered to be in a normal, non-failing, state. When collected runtime measurements are classified as being outside of the geometric enclosure, the application is considered to be in an anomalous, failing, state. In an example embodiment, the geometric enclosure is a convex hull generated in N-dimensional Euclidean space. Appropriate action (e.g., restart the software, turn off access to a network port) can be taken depending on where the measurement values lie in the space.

Abstract: Degradable, polymeric fiber-based, three-dimensional braided scaffolds for use as graft materials in ligament and tendon repair, reconstruction and replacement are provided. Also provided are methods for preparing these scaffolds.

Abstract: A method for selecting the state of a reconfigurable antenna installed at either the receiver or transmitter of a communication system is provided. The proposed method uses online learning algorithm based on the theory of multi-armed bandit to perform antenna state selection. The selection technique utilizes the Post-Processing Signal-to-Noise Ratio (PPSNR) as a reward metric and maximizes the long-term average reward over time. The performance of the learning based selection technique is empirically evaluated using wireless channel data. The data is collected in an indoor environment using a 2×2 MIMO OFDM system employing highly directional metamaterial Reconfigurable Leaky Wave Antennas. the learning based selection technique shows performance improvements in terms of average PPSNR and regret over conventional heuristic policies.

Abstract: The invention includes a method of preventing or treating metastasis in a subject diagnosed with cancer, the method comprising determining whether at least one gene encoding one or more proteins is upregulated in a cancer tissue sample from the subject as compared to the level of expression of the at least one gene in a non-cancer control sample of the same tissue, and, if the at least one gene is upregulated in the cancer tissue sample from the subject, administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising one or more protein depleting agents.

Abstract: The present invention relates to an integrated Assisting Cooling (AC) device, system and method for use with PED devices, allowing use of biopolymers having higher melting points in the fabrication of 3D scaffolds. The AC device cools the filament as it is extruding from the nozzle via low flow convective cooling. The AC device allows for cooling in the +/? direction of motion on an XY plane. The AC device elevates with the material delivery chamber. The AC device allows for scaffold fabrication at applied temperatures as high as about 250° C.

Abstract: An artificial tissue including an internal mass transport network having a plurality of channels, wherein the channels are designed to substantially mimic naturally occurring vascular network and a method for creating an internal transport system within a tissue scaffold to improve circulation, diffusion, and mass transport properties by utilizing computer-aided tissue engineering (CATE). The artificial tissue has the internal mass transport network of channels embedded, deposited, or molded within a scaffold, wherein the channels are made from a biodegradable transporting material and the scaffold is made from a scaffold material. The artificial tissue of the invention includes a basic circulatory system embedded within the tissue scaffold. This system provides mass transport throughout the entire scaffold and degrades after the new circulatory system develops.

Abstract: A system and method are provided for automatically generating systematic reviews of received information in a field of science and technology, such as scientific literature, where the systematic review includes a systematic review of a research field in the scientific literature. The method includes the steps of constructing a time series networks of words, passages, documents, and citations and/or co-citations within received information into a synthesized network, decomposing the networks into clusters of fields or topics, performing part-of-speech tagging of text within the received information to provide tagged text, constructing semantic structures of concepts and/or assertions extracted from the source text, generating citation-based and content-based summaries of the clusters of fields or topics and the semantic structures, and generating structured narratives of the clusters of fields or topics and the summaries of the generated semantic structures.

Abstract: Methods of making a biologically active three-dimensional scaffold capable of supporting growth and differentiation of a cell are described. Biologically active three-dimensional scaffold made by the methods of the invention and an engineered tissue made from the scaffolds are described. Fibers of desired porosity can be obtained from non-structural ECM by lyophilization and/or electrospinning which can be useful for numerous tissue engineering applications requiring complex scaffolds, such as wound healing, artificial skin (burns), soft tissue replacement/repair and spinal cord injury.

Abstract: A piezoelectric microcantilever for sensing compounds or molecules. The piezoelectric microcantilever, may include at least one electrode, an insulation layer, a receptor, an immobilization layer, a non-piezoelectric layer and a piezoelectric layer. The sensor is capable of self actuation and detection. The piezoelectric layer may be constructed from a highly piezoelectric thin lead magnesium niobate-lead titanate film, a highly piezoelectric thin zirconate titanate film, a highly piezoelectric lead-free film. Methods of using the sensors and flow cells and arrays including the sensors are also described.

Abstract: A vertical charge ordered transistor is disclosed. A thin charge ordered layer is employed as a tunnel barrier between two electrodes. A gate-induced accumulation of charge destabilizes the charge ordered state around the circumference of the device, opening up a parallel ohmic conduction channel, which leads to an exponential increase in source-drain current. VCOT devices have the potential to exhibit very large on/off ratios, low off-state currents, and sub-threshold slopes below 60 mV/dec.

Abstract: An optically transparent conformal polymer antenna and a method for producing the antenna from optically transparent conductive polymers. The method includes selecting an antenna design; providing an optically transparent conductive polymer material capable of being printed using an ink jet printer device; and printing layers of the polymer in the desired antenna design pattern onto a substrate. The surface tension of the polymer solution is adjusted to allow the material to pass through a printer head for printing on a flexible substrate. The material is modified to have a higher conductivity than regular conductive polymer materials so that a suitable antenna may be formed.

Abstract: Noise artifacts may be removed from a signal utilizing functional near infrared (fNIR) spectroscopy measurement techniques. The noise removal may be accomplished in field conditions, such as, for example, in an operating room setting. In an example configuration, to remove noise artifacts, independent component analysis (ICA) and principal component analysis (PCA) may be implemented in a procedure that utilizes a dark current measurement as a reference signal. The use of the combined ICA/PCA analysis and dark current measurement reference signal allows noise to be removed on a per channel basis, thus providing an effective noise removal procedure and allowing for a single active measurement channel.

Abstract: Blood pressure measurement devices comprising a transducer may have error introduced when the transducer is placed in mechanical communication with a vein or artery. This error may be based on alignment, applanation, calibration, and the contact based stress required to obtain a signal from pressure in a vein or artery. The present invention teaches isolating and removing this error from the blood pressure system which may increase the accuracy of the measurement. Calibration is also provided.

Abstract: Cantilever Sensors made of piezoelectric material may be structured with various configurations of asymmetric anchors as well as asymmetric electrodes. Such asymmetry enables measurement of resonant properties of the cantilever that are otherwise unmeasurable electrically, resulting in significant advantages for ease of measurement. In addition the asymmetry enables expression of torsional and/or lateral modes that are otherwise absent, and these modes also exhibit excellent mass-change sensitivity. The asymmetries may enable resonant mode impedance-coupling.

Abstract: Aspects of the present invention are related to methods comprising contacting an endothelial cell in an endothelial cell population with a non-thermal plasma to release an angiogenic growth factor. The released angiogenic growth factor may induce endothelial cell proliferation. In certain embodiments, the angiogenic growth factor is fibroblast growth factor-2. Preferably, the non-thermal plasma may be an atmospheric pressure dielectric barrier discharge. Additional aspects of the present invention are directed to methods for treating a disease comprising promoting angiogenesis by contacting an endothelial cell in a endothelial cell population with a non-thermal plasma to release an angiogenic growth factor. The angiogenic growth factor may induce endothelial cell proliferation.

Abstract: A magnetic delivery system for delivering a magnetizable particle to a location in a body, the device includes a magnetizable object implanted in the body, wherein the magnetizable object includes a plurality of segments distributed throughout the magnetizable object and wherein the segments are configured to provide a magnetic gradient for attracting the magnetizable particle and an external source of a magnetic field capable of (i) magnetizing the magnetizable particle and (ii) increasing a degree of magnetization of the magnetizable object and thereby creating the magnetic gradient. A drug delivery system including the magnetic delivery system and a magnetizable particle associated with a therapeutic agent and/or a cell. A cell delivery system based on the magnetic delivery system and a magnetizable particle associated with a cell. A method of using the magnetic delivery system for delivery of a therapeutic agent and/or a cell to a targeted location in a body.

Abstract: The Location Design and Routing problem asks to find a subset of “depot” nodes and a spanning forest of a graph such that every connected component in the forest contains at least one depot. This problem arises in a number of both logistical and computer networking problems, for example, in selecting the number and location of distribution centers in vehicle routing networks. This problem is functionally equivalent to that of supernode selection in peer-to-peer networks. A distributed algorithm approximates a solution to this problem that runs in a logarithmic number of communication rounds with respect to the number of nodes (independent of the topology of the network), and, under assumptions on the embedding of the edge weights, whose solutions are within a factor of 2 of optimal.

Abstract: A method for producing a multiple surface system that may be a two-mirror surface. The method involves first finding from a given primary curve an appropriate secondary curve. The method then uses ideas from exterior differential systems to grow from the primary curve and the secondary curve, primary and secondary mirror surfaces. The Cartan-Kähler theorem gives a strong indication of the existence of such solution surfaces.

Abstract: The invention relates to compositions and methods for treating C. difficile associated disease (CDAD) through the administration to a subject in need thereof at least one nucleic acid encoding at least a portion of at least one of toxin A and toxin B.