Abstract: The present invention relates to prodrug derivatives of pentamidine, their use in the treatment and/or prophylaxis of diseases such as tumor diseases, as well as leishmaniasis, trypanosomiasis, pneumocystis carinii pneumonia (PcP), and malaria.

Abstract: The invention relates to a method for improving the bioavailability of pharmaceutical substances and for allowing the pharmaceutical substances to permeate the blood-brain barrier, the pharmaceutical substances having at least one or more amidine, guanidine, N-hydroxyamidine (amidoxime) or N-hydroxyguanidine functions. The invention also relates to medicaments containing the correspondingly modified pharmaceutical substances.

Abstract: An ion-conductive thermoplastic compositions contains a partially acetalated polyvinyl alcohol, at least one support electrolyte and at least one plasticizer. The partially acetalated polyvinyl alcohol contains two different acetal units. Electrochromic laminated glass systems produced using the ion-conductive compositions and a method for producing the systems are also provided.

Abstract: The invention relates to polymerizates that can be obtained by a) reacting at least one polyisocyanate with at least one polyol and optionally at least one radically curable monomer A with groups reactive toward isocyanate in at least one radically curable monomer B to form polyurethane particles having an average diameter of less than 40 nm, preferably less than 20 nm, and especially preferably less than 10 nm and an average number of radically curable functionalities in a range of 2 to 4, preferably 2 to 3, and b) emulsion polymerizing the product obtained under a). By means of the emulsion polymerization, larger cross-linked polyurethane/polymer hybrid dispersions are produced, in which the nanoparticles act as a connecting member between the polymer areas and the polyurethane components.

Abstract: 4-amino-3-arylamino-6-arylpyrazolo[3,4-d]pyrimidine derivatives of general formula (I), pharmaceutically acceptable salts thereof, method for preparation of the aforesaid compounds and their use as antiviral agents.

Abstract: The invention relates to a high-frequency lamp with a glass bulb and a device for supplying a high-frequency signal. High-frequency lamps known in the prior art either have been limited to a narrow selection of substances in the glass bulb or have relied on a heating process using a spiral-wound filament or the like. The aim of the invention is to provide an inexpensive and more efficient high-frequency lamp. This is to be achieved in particular in that the glass bulb is made, for example from window glass, so as to be heatable by the heat losses of the high-frequency signal in the glass bulb such that even metal halogenides for example can be evaporated without an additional heating process.

Abstract: The present invention relates to prodrug derivatives of dabigatran, their use in the treatment and/or prophylaxis of diseases, in particular thrombotic diseases, stroke, cardiac infarction and/or atrial fibrillation and cardiac arrhythmia, as well as oncological diseases of any pathogenesis.

Abstract: An exchanger device for transferring mass and/or energy between a first medium and a second medium includes a chamber having a first inlet and first outlet of the first medium and through which the first medium can flow. The chamber is equipped with at least one, preferably a plurality, of one mass- and/or energy-permeable exchanger hollow fibers connected at one end to a second inlet and at the other end to a second outlet of the second medium. The second medium can flow through the fiber(s) and the first medium can flow around the fiber(s). The chamber is equipped with at least one pump element for displacing the first medium in and out of the chamber in a pulsing manner. The pump element has an elastically deformable element, is connected to a third inlet of a third medium used as a driving medium, and is expandable by the third medium.

Abstract: The invention relates to a method for improving bioavailability of pharmaceutical substances and for allowing the pharmaceutical substances to permeate the blood-brain barrier, the pharmaceutical substances having at least one or more amidine, guanidine, N-hydroxyamidine (amidoxime) or N-hydroxyguanidine functions. The invention also relates to medicaments containing the correspondingly modified pharmaceutical substances.

Abstract: A process is provided for producing a polycrystalline layer. This process includes the steps of: applying to a substrate a layer sequence comprising at least one amorphous starting layer provided with impurities, a metallic activator layer, and a cleaning layer based on titanium or titanium oxide arranged between the starting layer and the activator layer for withdrawing the impurities from the starting layer; and carrying out a heat treatment after the layer sequence has been applied for forming a polycrystalline end layer.

Abstract: A high-frequency lamp (10) for low-pressure and high-pressure applications, and a method for the operation thereof, that is particularly suitable for improving the characteristics with regard to efficiency, emission spectrum, cost, and long life, in that the use of an ignition unit is no longer necessary, even at very low high-frequency power, due to an impedance transformer (26) connected downstream of a power amplifier (20), because the application of as high a voltage as possible to an ionization chamber (16) is successfully achieved by the impedance transformation.

Abstract: The present invention relates to prodrug derivatives of pentamidine, their use in the treatment and/or prophylaxis of diseases such as tumor diseases, as well as leishmaniasis, trypanosomiasis, pneumocystis carinii pneumonia (PcP), and malaria.

Abstract: A method for determining a position change of a handheld tool in space includes: alignment of an initial tool position with a reference position to determine at least a first position vector of the tool, at least one component of the first position vector being determined by measurement of a component of the gravitational acceleration in the direction of a predetermined axis of the tool; establishing a modification of the tool position during an actual position change by determining at least one angular discrepancy of a second position vector of at least one temporally preceding position vector, at least one component of the second position vector being determined after the position change by measuring the component of the gravitational acceleration in the direction of the predetermined axis of the tool; and providing information relating to the orientation of the tool established from the at least one angular discrepancy.

Abstract: A hand-held tool and tool control includes: an orientation determination unit, which is configured to determine an orientation of the tool as orientation data or orientation-specific data, an output unit, which is operatively connected to the orientation determination unit and can transmit data to the tool control via an interface suitable for communication, wherein the orientation determination unit and/or the output unit is suitable for determining at least one control parameter, in particular a multitude of control parameters, after comparing the orientation data or the orientation-specific data to comparison variables, it being possible to transmit the at least one control parameter to the tool control for controlling the tool.

Abstract: A device is provided for transferring mass and/or exchanging energy between two media, particularly between blood and a gas/gas mixture. The device includes a chamber (2), through which the first medium flows and inside which at least one mass-permeable and/or energy-permeable hollow fiber (5), preferably a plurality of mass-permeable and/or energy-permeable hollow fibers (5), is/ are arranged. The second medium can flow through the at least one hollow fiber (5), while the first medium can flow therearound. At least one pumping element (5), which allows the first medium to be displaced from the chamber (2) and/or to be sucked into the chamber (2), is disposed in the chamber (2) of the device.

Abstract: The present invention relates to prodrug derivatives of dabigatran, their use in the treatment and/or prophylaxis of diseases, in particular thrombotic diseases, stroke, cardiac infarction and/or atrial fibrillation and cardiac arrhythmia, as well as oncological diseases of any pathogenesis.

Abstract: A semiconductor component is provided having a substrate and at least one semiconductor layer realized to be polycrystalline on one side of the substrate. The polycrystalline semiconductor layer contains the crystal nuclei.

Abstract: Described are oligotetracenes of formula I which may either be unsubstituted or carry one or more substituents R and R? which are selected from the group comprising halogen, CN, alkyl or alkoxy radicals containing 1 to 18 carbon atoms, aryl radicals containing up to 10 carbon atoms which may also contain one or more heteroatoms, and/or fluorinated or perfluorinated alkyl or alkoxy radicals containing 1 to 18 carbon atoms, where n is an integer from 1 to 20, preferably 1 to 6, very particularly preferably 1 or 2, and X stands for a single bond, an alklyene group containing 1 to 6 carbon atoms, a hydrocarbon chain having one or more conjugated double bonds, an aryl group, or a system composed of one or more condensed aromatic rings. In the oligotetracenes according to the invention, one or more of the condensed aromatic six-atom rings may be substituted by a five-atom ring which may also contain a heteroatom.

Abstract: An ion-conductive thermoplastic compositions contains a partially acetalated polyvinyl alcohol, at least one support electrolyte and at least one plasticizer. The partially acetalated polyvinyl alcohol contains two different acetal units. Electrochromic laminated glass systems produced using the ion-conductive compositions and a method for producing the systems are also provided.

Abstract: The invention relates to ion-conductive thermoplastic compositions consisting of a partially acetalated polyvinyl alcohol, at least one support electrolyte and at least one softener, the partially acetalated polyvinyl alcohol containing two different acetal units. The invention also relates to electrochromic laminated glass systems produced using the ion-conductive compositions and to a method for producing said systems.