Patents Assigned to Drug Delivery Systems Inc.
  • Patent number: 5591123
    Abstract: A transdermal drug applicator (100) for application to a living body for the delivery of at least one drug through the skin (144) into the bloodstream comprising an applicator (100) including at least one drug reservoir (182A,182B) containing the drug for delivering same through the skin (144) by physico/chemical mass transfer. A mounting structure (138, 140) is removably mounted to the body for holding the applicator (100) to the skin (144), with the applicator (100) removably connected to the mounting structure (138,140). A power supply (166) for the applicator (100) and a circuit transmitting electrical power from the power supply (166) to the applicator (100) is disclosed, wherein an electric circuit is created between the applicator (100) and the skin (144).
    Type: Grant
    Filed: January 30, 1995
    Date of Patent: January 7, 1997
    Assignee: Drug Delivery Systems Inc.
    Inventors: Dan Sibalis, Sanford Rosen
  • Patent number: 5372579
    Abstract: An electrophoretic/electro-osmotic transdermal drug delivery system for passing at least one drug, or therapeutic compound, through the skin membrane of a patient by way of a drug reservoir or gel for delivery to the systemic blood of a patient in selected, periodic pulsations. The system can be varied to accommodate various types of therapeutic compounds having varied characteristics and purposes. The system includes a current oscillator that applies periodic electrical variations to the system in order to trigger rhythmical variations of the potential and resistance of the skin membrane so as to cause oscillatory electro-osmotic streaming of the liquid with the therapeutic compound across the skin membrane in synchronization with the oscillator to the systemic blood of the patient in response to the rhythmical variations.
    Type: Grant
    Filed: March 2, 1994
    Date of Patent: December 13, 1994
    Assignee: Drug Delivery Systems, Inc.
    Inventor: Dan Sibalis
  • Patent number: 5358483
    Abstract: An electrically/battery powered transdermal drug applicator comprising a flexible nonconductive substrate with a plurality of conductive coated areas, the conductive coated areas forming drug reservoir electrodes, and a plurality of drug reservoirs separated by occlusive adhesive dams and in electrical contact with said drug reservoir electrodes. The battery is connected to the electrodes of the drug reservoirs and said applicator including electrical current conditioning means, with a conformal cover adhesively secured to said transdermal drug applicator and with a release liner covering and protecting said plurality of drug reservoirs until use.
    Type: Grant
    Filed: September 23, 1992
    Date of Patent: October 25, 1994
    Assignee: Drug Delivery Systems Inc.
    Inventor: Dan Sibalis
  • Patent number: 5336168
    Abstract: An electrophoretic/electro-osmotic transdermal drug delivery system for passing at least one drug, or therapeutic compound, through the skin membrane of a patient by way of a drug reservoir or gel for delivery to the systemic blood of a patient in selected, periodic pulsations. The system can be varied to accommodate various types of therapeutic compounds having varied characteristics and purposes. The system includes a current oscillator that applies periodic electrical variations to the system in order to trigger rhythmical variations of the potential and resistance of the skin membrane so as to cause oscillatory electro-osmotic streaming of the liquid with the therapeutic compound across the skin membrane in synchronization with the oscillator to the systemic blood of the patient in response to the rhythmical variations.
    Type: Grant
    Filed: April 7, 1992
    Date of Patent: August 9, 1994
    Assignee: Drug Delivery Systems Inc.
    Inventor: Dan Sibalis
  • Patent number: 5328453
    Abstract: An electrical transdermal drug applicator provides enhanced drug flow to the bloodstream of the subject by delivering a primary drug into a subject's circulatory system for therapeutic purposes, and delivering from the same or other reservoir a non-therapeutic counteracting agent to the skin of the patient which induces flow enhancement and allows delivery of the primary drug systemically over a longer period of time and in greater quantity than heretofore appeared possible using electric current.
    Type: Grant
    Filed: February 12, 1992
    Date of Patent: July 12, 1994
    Assignee: Drug Delivery Systems Inc.
    Inventor: Dan Sibalis
  • Patent number: 5328452
    Abstract: A transdermal applicator for attachment to the skin having at least one drug reservoir containing at least one drug, and having an electrical connection formed at a surface interface between said reservoir upon contact with said skin; means for causing said at least one drug to move through said interface transdermally and for maintaining said transdermal movement for an extended time period. The means for causing and maintaining transdermal movement including a source of varying electrical potential, said source having one terminal electrically connected to said at least one reservoir at a location away from said skin surface interface and an other terminal in circuit with said skin surface at a location away from said reservoir/skin surface interface.
    Type: Grant
    Filed: February 25, 1993
    Date of Patent: July 12, 1994
    Assignee: Drug Delivery Systems Inc.
    Inventor: Dan Sibalis
  • Patent number: 5328454
    Abstract: An electrophoretic/electro-osmotic transdermal drug delivery system for passing at least one drug, or therapeutic compound, through the skin membrane of a patient by way of a drug reservoir or gel for delivery to the systemic blood of a patient in selected, periodic pulsations. The system can be varied to accommodate various types of therapeutic compounds having varied characteristics and purposes. The system includes a current oscillator that applies periodic electrical variations to the system in order to trigger rhythmical variations of the potential and resistance of the skin membrane so as to cause oscillatory electro-osmotic streaming of the liquid with the therapeutic compound across the skin membrane in synchronization with the oscillator to the systemic blood of the patient in response to the rhythmical variations.
    Type: Grant
    Filed: April 7, 1992
    Date of Patent: July 12, 1994
    Assignee: Drug Delivery Systems Inc.
    Inventor: Dan Sibalis
  • Patent number: 5224928
    Abstract: A transdermal drug applicator (100) for application to a living body for the delivery of at least one drug through the skin (144) into the bloodstream comprising an applicator (100) including at least one drug reservoir (182A,182B) containing the drug for delivering same through the skin (144) by physico/chemical mass transfer. A mounting structure (138, 140) is removably mounted to the body for holding the applicator (100) to the skin (144), with the applicator (100) removably connected to the mounting structure (138,140). A power supply (166) for the applicator (100) and a circuit transmitting electrical power from the power supply (166) to the applicator (100) is disclosed, wherein an electric circuit is created between the applicator (100) and the skin (144).
    Type: Grant
    Filed: June 6, 1991
    Date of Patent: July 6, 1993
    Assignee: Drug Delivery Systems Inc.
    Inventors: Dan Sibalis, Sanford Rosen
  • Patent number: 5167617
    Abstract: An electrically powered transdermal drug applicator a flexible, non-conductive substrate with a plurality of conductive coated areas forming drug reservoir electrodes with a plurality of drug reservoirs separated by occlusive dams are in electrical contact with the drug reservoir electrodes. Flexible mounting means support and removably holding the drug applicator to a limb of a body and form together therewith a combined dual assembly structure conformable to that part of said body and skin to which the drug applicator is attached. The mounting means has programmable computer means including a power source connected in an electrical circuit with the electrodes of the drug reservoirs for electrically powering the applicator and transmitting the drug programmably through the skin. A conformal cover is secured to said transdermal drug applicator and a release liner covers and protects the drug reservoirs until use.
    Type: Grant
    Filed: July 14, 1989
    Date of Patent: December 1, 1992
    Assignee: Drug Delivery Systems Inc.
    Inventor: Dan Sibalis
  • Patent number: 5163899
    Abstract: An electro-osmotic transdermal drug delivery system for passing a drug to the systemic blood of a patient through the skin. The delivery system includes a semi-dry drug patch containing a water solute with the drug and a selected level of current delivered to the semi-dry patch. Water from the semi-dry patch is limited in movement from the patch to the skin particularly in lateral movement relative to the skin so that the sweat and sebaceous ducts and glands, which ordinarily are filled with liquid, namely the solute, and act as electrical shunts for osmotic delivery of the drug, are starved of liquid so that the electrical current is diverted to the stratum corneum along with the electro-osmotic movement of the liquid carrying the drug. This result greatly increases the total drug delivery area of the skin.
    Type: Grant
    Filed: December 12, 1989
    Date of Patent: November 17, 1992
    Assignee: Drug Delivery Systems Inc.
    Inventor: Dan Sibalis
  • Patent number: 5135478
    Abstract: A transdermal application for attachment to the skin having at least one drug reservoir containing at least one drug, and having an electrical connection formed at a surface interface between said reservoir upon contact with said skin; means for causing said at least one drug to move through said interface transdermally and for maintaining said transdermal movement for an extended time period. The means for causing and maintaining transdermal movement including a source of varying electrical potential, said source having one terminal electrically connected to said at least one reservoir at a location away from said skin surface interface and an other terminal in circuit with said skin surface at a location away from said reservoir/skin surface interface.
    Type: Grant
    Filed: May 10, 1989
    Date of Patent: August 4, 1992
    Assignee: Drug Delivery Systems Inc.
    Inventor: Dan Sibalis
  • Patent number: 5135479
    Abstract: A transdermal drug applicator (100) for application to a living body for the delivery of at least one drug through the skin (144) into the bloodstream comprising an applicator (100) including at least one drug reservoir (182A, 182B) containing the drug for delivering same through the skin (144) by physico/chemical mass transfer. A mounting structure (138, 140) is removably mounted to the body for holding the applicator (100) to the skin (144), with the applicator (100) removably connected to the mounting structure (138, 140). A power supply (166) for the applicator (100) and a circuit transmitting electrical power from the power supply (166) to the applicator (100) is disclosed, wherein an electric circuit is created between the applicator (100) and the skin (144).
    Type: Grant
    Filed: June 6, 1991
    Date of Patent: August 4, 1992
    Assignee: Drug Delivery Systems, Inc.
    Inventors: Dan Sibalis, Sanford Rosen
  • Patent number: 5088977
    Abstract: An electrical transdermal drug applicator provides enhanced drug flow to the bloodstream of the subject by delivering a primary drug into a subject's circulatory system for therapeutic purposes, and delivering from the same or other reservoir a non-therapeutic counteracting agent to the skin of the patient which induces flow enhancement and allows delivery of the primary drug systemically over a longer period of time and in greater quantity than heretofore appeared possible using electric current.
    Type: Grant
    Filed: December 21, 1988
    Date of Patent: February 18, 1992
    Assignee: Drug Delivery Systems Inc.
    Inventor: Dan Sibalis
  • Patent number: 5087240
    Abstract: An improved transdermal drug applicator for application to a living body for the migration of at least one medicament through the skin into the blood stream embodying at least two electrode elements forming the applicator and with the electrodes separated from each other by insulating means. A reservoir means, in at least one of said electrode elements of said applicator, containing said medicament; and a circuit, including a power source, for supplying electric power to said electrodes and such reservoir means. Suitable cover means partially enclosed at least said reservoir means, and adhesive means affixes the applicator to the skin, so as to complete an electrical circuit through the skin when the applicator is affixed thereto, thus creating at least one physico/chemical mass transfer phenomenon which causes said medicament to migrate through the skin.
    Type: Grant
    Filed: October 30, 1989
    Date of Patent: February 11, 1992
    Assignee: Drug Delivery Systems Inc.
    Inventor: Dan Sibalis
  • Patent number: 5032109
    Abstract: The invention comprises in combination:(a) a polypeptide having from about three to about 20 peptide units in aqueous solution or suspension, and(b) an electrolytic device for transdermal transport of the polypeptide to the bloodstream of the patient.It may be useful to enhance the transdermal delivery of the polypeptide by adding an aqueous cosolute/cosolvent with negative Setschenow constants.The electrolytic device preferably comprises a hydrophilic reservoir containing a supply of the aqueous polypeptide solution or suspension, an electric battery, two extended contacts, and optionally a semipermeable membrane between the reservoir and the patient's skin.Representative polypeptides include oxytocin, angiotensin I, II, and III, substance P, vasopressin, lypressin, desmopressin, leuprolide acetate, antripeptin, and the like.
    Type: Grant
    Filed: November 1, 1989
    Date of Patent: July 16, 1991
    Assignee: Drug Delivery Systems Inc.
    Inventor: Dan Sibalis
  • Patent number: 5013293
    Abstract: An electrophoretic/electro-osmotic transdermal drug delivery system for passing at least one drug, or thereapeutic compound, through the skin membrane of a patient by way of a drug reservoir or gel for delivery to the systemic blood of a patient in selected, periodic pulsations. The system can be varied to accommodate various types of therapeutic compounds having varied characteristics and purposes. The system includes a current oscillator that applies periodic electrical variations to the system in order to trigger rhythmical variations of the potential and resistance of the skin membrane so as to cause oscillatory electro-osmotic streaming of the liquid with the therapeutic compound across the skin membrane in synchronization with the oscillator to the systemic blood of the patient in response to the rhythmical variations.
    Type: Grant
    Filed: November 13, 1989
    Date of Patent: May 7, 1991
    Assignee: Drug Delivery Systems Inc.
    Inventor: Dan Sibalis
  • Patent number: 4921475
    Abstract: A transdermal drug patch for delivering at least one drug to a patient through the skin comprises:(a) at least two electrodes forming the patch and separated from each other by an insulator;(b) a circuit including an electrical power source for supplying power to and electrically connected to the electrodes at a conductive element; and(c) drug reservoir means in the form of a plurality of microtubes separated from and insulated from each other extending from a conductive element at one end to the surface of the patch interfacing with the patient at the other end of the microtube.
    Type: Grant
    Filed: May 20, 1988
    Date of Patent: May 1, 1990
    Assignee: Drug Delivery Systems Inc.
    Inventor: Dan Sibalis
  • Patent number: 4919648
    Abstract: A transdermal drug patch for delivering at least one drug to a patient through the skin comprises:(a) At least two electrode constructions separated from each other;(b) Drug reservoir means in at least one of the electrode constructions;(c) An electrical circuit including a power source, electrodes constructions with conductive elements, and reservoir means connected together;(d) Optional cover means; and(e) Adhesive means for affixing the patch to the patient's skin, augmented by a plurality of isolated spots of high tack gel, either in arrays or random positions, whereby the patch is more easily removed and replaced than if the adhesive means were homogeneous.
    Type: Grant
    Filed: May 20, 1988
    Date of Patent: April 24, 1990
    Assignee: Drug Delivery Systems Inc.
    Inventor: Dan Sibalis
  • Patent number: 4900414
    Abstract: A commercial electrokinetic separation system extracts charged particles from fluids and separates the particles into discrete separation bands. An electrokinetic column of extended length has a plurality of alternatingly spaced layers of electrokinetic material and electrodes along its length. A traveling wave electrical field is established by applying an electrical potential between two adjacent or nearly adjacent electrodes at one end of the column and by moving the connections progressively to electrodes further along the column, working toward the other end. A fluid containing particles for separation is introduced in a chamber at said one end of the column where the traveling wave is initiated and particles having a phoretic speed equal or greater than the velocity of the traveling wave move from one end to the other end of the column, leaving behind all particles which have lesser phoretic speeds. The electrical source can be either AC or DC.
    Type: Grant
    Filed: August 19, 1988
    Date of Patent: February 13, 1990
    Assignee: Drug Delivery Systems Inc.
    Inventor: Dan Sibalis
  • Patent number: 4883457
    Abstract: Applicators for the electrophoretic and/or electro-osmostic dispensing of a medicament across the skin and into the bloodstream of a patient. Each applicator includes two electrodes in electrical contact with the skin with at least one of the electrodes being a drug reservoir, at least one battery, a flexible, non-conductive substrate having an electrically conductive coating extending to electrical contact with each electrode and to the terminals of the battery, the substrate being folded into at least two layers, a cover adhesively secured to the applicator, and a release liner covering and protecting the drug reservoir or reservoirs until use.
    Type: Grant
    Filed: June 5, 1987
    Date of Patent: November 28, 1989
    Assignee: Drug Delivery Systems Inc.
    Inventor: Dan Sibalis