Abstract: The present invention relates to a recombinant host cell which is capable of producing a dicarboxylic acid and which comprises a mutant malate dehydrogenase resulting in an increased production of the dicarboxylic acid. The invention also relates to a process for producing a dicarboxylic acid, which method comprises fermenting said recombinant host cell in a suitable fermentation medium and producing the dicarboxylic acid.
Type:
Application
Filed:
July 11, 2017
Publication date:
July 25, 2019
Applicant:
DSM IP ASSETS B.V.
Inventors:
Alrik Pieter LOS, Rene Marcel DE JONG, Remko Tsjibbe WINTER, Ben DEN DULK
Abstract: The invention relates to a radiation curable resin composition comprising a cationically polymerizable component, a cationic photoinitiator, a hydroxy component, an impact modifier and wherein the resin composition after full cure has a modulus of >2 GPa; a yield stress <70 MPa; and a K1c value >1.3 MPa·(m)1/2 or an Izod value >0.45 J/cm. The resin composition can preferably be used in the preparation of three dimensional objects.
Type:
Grant
Filed:
May 4, 2017
Date of Patent:
July 23, 2019
Assignee:
DSM IP ASSETS, B.V.
Inventors:
Paulus Antonius Maria Steeman, Beert Jacobs Keestra, Marco Marcus Matheus Driessen, Debra Lynn Fish Repko, Melvin Zussman
Abstract: Methods for treating/preventing conditions associated with an increased level of eotaxin in a human with 25-hydroxyvitamin D3 (calcifediol) are provided. Optionally, vitamin D3 may be used together with 25-hydroxyvitamin D3.
Type:
Grant
Filed:
December 28, 2016
Date of Patent:
July 23, 2019
Assignee:
DSM IP ASSETS B.V.
Inventors:
Stephanie Krammer-Lukas, Elisabeth Stoecklin, Joseph Schwager, Swen Wolfram
Abstract: The invention relates to a preformed sheet comprising mono-layers from a fibrous network with fibers having a tensile strength of at least about 1.2 GPa and preferably a binder, and a separating film on at least one of its outer surfaces, the separating film having an areal density of between 1 and 10 g/m2 and a surface tension of less than 35 mN/m at the surface faced to the fibrous network and the separating film has a crystallinity of between 50 and 90%.
Abstract: Processes are disclosed for obtaining a lipid from a cell by lysing the cell to form a lysed cell composition, adding an acid to lower the pH of the lysed cell composition, and demulsify the lysed cell composition, and obtaining the lipid from the demulsified lysed cell composition. Also disclosed are lipids prepared by the processes of the present invention wherein the lipids have a particular anisidine value, peroxide value, and/or phosphorus content.
Type:
Grant
Filed:
December 19, 2014
Date of Patent:
July 9, 2019
Assignee:
DSM IP Assets B.V.
Inventors:
Mark Barker, Nasrin Tabayehnejad, Ginger Shank, Neil Leininger, Kirt Lyvell Matthews, Sr.
Abstract: The invention relates to a process for the preparation of a fermentation product from lignocellulosic material, comprising the following steps: a) optionally, pretreatment of the lignocellulosic material, b) optionally, washing of the optionally pretreated lignocellulosic material, c) enzymatic hydrolysis of the optionally washed and/or optionally pretreated lignocellulosic material using an enzyme composition comprising at least two cellulases and whereby the enzyme composition at least comprises LPMO, and optionally purifying the hydrolysed lignocellulosic material, d) fermentation of the hydrolysed lignocellulosic material to produce a fermentation product, and e) optionally, recovery of a fermentation product, wherein the amounts of formed hydrolysed oxidation products at the end of the enzymatic hydrolysis by the oxidation by LPMO of the lignocellulosic material containing cellulose and/or cello-oligosaccharides is kept between 3 to 80 g/kg glucan present in the lignocellulosic material by adding a s
Type:
Grant
Filed:
April 29, 2015
Date of Patent:
July 2, 2019
Assignee:
DSM IP ASSETS B.V.
Inventors:
Bertus Noordam, Loes Elizabeth Bevers, Rudy Francois Maria Jozef Parton, Michael Petrus Jozef Berkhout
Abstract: Novel biaromatic compounds, which are vitamin D analogs, processes for their preparation and cosmetic, dermatological and pharmaceutical preparations containing one or more of these compounds.
Type:
Grant
Filed:
December 14, 2016
Date of Patent:
July 2, 2019
Assignee:
DSM IP ASSETS B.V.
Inventors:
Igor Bendik, Piero Geotti-Bianchini, Marc Heidl, Eileen Jackson, Alexander Schlifke-Poschalko
Abstract: There is described a low number average molecular weight (MN<10 kD) and high glass transition temperature (>75° C.) copolymer (optionally a solid grade oligomer (SGO)) that comprises (a) at least 20 wt-% of itaconate functional monomer(s), (b) not more than 40% of a hydrophilic monomer, preferably an acid functional monomer(s) in an amount sufficient to achieve an acid value from 65 to 325 mg KOH per g of solid polymer; (c) optionally not more than 70% of other monomers not being either (a) or (b), having a max content of vinyl aromatic monomer(s) of 40 wt-% and/or max content of methacrylate(s) of 40 wt-%; where the weight percentages of monomers (a), (b) and (c) are calculated as a proportion of the total amount of monomers in the copolymer being 100%.
Abstract: The invention relates to a one component heat-curable powder coating composition comprising a resin containing reactive unsaturations and wherein all said reactive unsaturations are carbon carbon double bonds connected directly to an electron withdrawing group, a thermal initiation system comprising a transition metal catalyst and a peroxide, wherein the peroxide is chosen from the group of peroxyesters, mono-peroxycarbonates and mixtures thereof and a co-crosslinker chosen from the group of vinylethers, vinylesters, vinylamides, itaconates, enamines and mixtures thereof.
Type:
Grant
Filed:
September 18, 2015
Date of Patent:
June 25, 2019
Assignee:
DSM IP ASSETS B.V.
Inventors:
Johan F. G. A. Jansen, Jan Pieter Drijfhout
Abstract: The present invention provides a method for extracting lipids from microorganisms without using organic solvent as an extraction solvent. In particular, the present invention provides a method for extracting lipids from microorganisms by lysing cells and removing water soluble compound and/or materials by washing the lysed cell mixtures with aqueous washing solutions until a substantially non-emulsified lipid is obtained.
Type:
Grant
Filed:
July 6, 2017
Date of Patent:
June 25, 2019
Assignee:
DSM IP Assets B.V.
Inventors:
Craig M. Ruecker, Swithwin Patrick Adu-Peasah, Brian S. Engelhardt, George T Veeder, III
Abstract: Proline containing dipeptides are disclosed for up-regulating of genes involved in collagen fiber maturation and thus for revitalizing, strengthening and increasing the integrity of collagen fibers. These proline containing dipeptides are furthermore particularly suitable for improving the skin firmness, texture and elasticity as well as reducing the pore size and increasing skin moisturization.
Type:
Grant
Filed:
December 9, 2016
Date of Patent:
June 25, 2019
Assignee:
DSM IP ASSETS B.V.
Inventors:
Remo Campiche, Dominik Imfeld, Alexandre Rio
Abstract: A variant polypeptide having alpha-amylase activity, wherein the variant has an amino acid sequence which, when aligned with the alpha-amylase comprising the sequence set out in SEQ ID NO: 2, comprises at least one substitution of an amino acid residue. Such a variant polypeptide may be used in the preparation of a baked product.
Type:
Grant
Filed:
September 26, 2017
Date of Patent:
June 25, 2019
Assignee:
DSM IP ASSETS B.V.
Inventors:
Rene Marcel De Jong, Hanna Elsabet Abbas, Evert Tjeerd Van Rij
Abstract: The invention relates to a one component heat curable powder coating composition comprising a resin containing reactive unsaturations and wherein all said reactive unsaturations are carbon carbon double bonds connected directly to an electron withdrawing group, a thermal initiation system comprising a peroxide chosen from the group of compounds represented by formula (1) wherein R1 and R2 each independently stand for an optionally substituted alkyl of 1 to 30 C-atoms, wherein the 1 to 30 C-atoms do not include the C-atoms of the substituents or for an optionally substituted aryl of 6 to 18 C-atoms, wherein the 6 to 18 C-atoms do not include the C-atoms of the substituents, and a co-crosslinker chosen from the group of vinylethers, vinyletherurethanes, vinylesters, vinylamides, itaconates, enamines, vinylureas and mixtures thereof.
Type:
Grant
Filed:
September 25, 2015
Date of Patent:
June 25, 2019
Assignee:
DSM IP ASSETS B.V.
Inventors:
Johan F.G.A. Jansen, Jan Pieter Drijfhout
Abstract: The present invention relates to a method of purification of compound of formula (I) which comprises the step of crystallization of compound of formula (I) from a composition comprising the compound of formula (I) and the compound of formula (II) and a specific solvent system containing ethanol, 1-propanol, 2-propanol, 2-methyl-1-propanol, 1-butanol or 2-butanol.
Abstract: The invention relates to a polypeptide having hemicellulase activity. The invention features the full length coding sequence of the novel gene as well as the amino acid sequence of the full-length functional protein and functional equivalents of the gene or the amino acid sequence. The invention also relates to methods for using the polypeptide in industrial processes. Also included in the invention are cells transformed with a polynucleotide according to the invention suitable for producing these proteins.
Type:
Grant
Filed:
April 25, 2018
Date of Patent:
June 11, 2019
Assignee:
DSM IP ASSETS B.V.
Inventors:
Alrik Pieter Los, Rene Marcel De Jong, Maaike Appeldoorn
Abstract: The invention relates to a process for the manufacture of a multilayer material sheet comprising unidirectional high performance fibers, the process comprising the steps of positioning the fibers in a parallel fashion, consolidation of the fibers to obtain a monolayer, stacking at least two monolayers such that the fiber direction in one monolayer is at an angle ? to the direction of the fibers in an adjacent monolayer and fixation whereby the stack of at least two monolayers is subjected to a pressure and temperature treatment for a duration of a least 2 seconds, followed by cooling the stack under pressure to a temperature of 120° C. or lower. The invention furthermore relates to the multilayer material sheet obtainable with the process according to the invention. This multilayer material sheet has a reduced uptake of liquids.
Type:
Grant
Filed:
December 16, 2010
Date of Patent:
June 11, 2019
Assignee:
DSM IP ASSETS B.V.
Inventors:
Koen van Putten, Johannes Maria Mathias Wilms, Ernst Jan van Klinken, Harm van der Werff, Leonard Josef Arnold Nielaba, Roelof Marissen
Abstract: Disclosed are compositions and methods related to eukaryotic microorganisms that can produce unsaturated fatty acids which can be purified and used.
Type:
Application
Filed:
September 17, 2018
Publication date:
June 6, 2019
Applicant:
DSM NUTRITIONAL PRODUCTS AG
Inventors:
Adam M BURJA, Helia RADIANINGTYAS, Colin James BARROW, Anthony James WINDUST
Abstract: The invention provides hydrolases, polynucleotides encoding them, and methods of making and using these polynucleotides and polypeptides. In one aspect, the invention is directed to polypeptides, e.g., enzymes, having a hydrolase activity, e.g., an esterase, acylase, lipase, phospholipase (e.g., phospholipase A, B, C and D activity, patatin activity, lipid acyl hydrolase (LAH) activity) or protease activity, including thermostable and thermotolerant hydrolase activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The hydrolase activities of the polypeptides and peptides of the invention include esterase activity, lipase activity (hydrolysis of lipids), acidolysis reactions (to replace an esterified fatty acid with a free fatty acid), transesterification reactions (exchange of fatty acids between triglycerides), ester synthesis, ester interchange reactions, phospholipase activity and protease activity (hydrolysis of peptide bonds).
Type:
Grant
Filed:
October 7, 2015
Date of Patent:
June 4, 2019
Assignee:
DSM IP ASSETS B.V.
Inventors:
Uwe T. Bornscheuer, David Weiner, Tim Hitchman, Jonathan Lyon, Sirirung Wongsakul