Patents Assigned to DSM
  • Patent number: 10308965
    Abstract: The present invention provides biological oils and methods and uses thereof. The biological oils are preferably produced by heterotrophic fermentation of one or more microorganisms using cellulose-containing feedstock as a main source of carbon. The present invention also provides methods of producing lipid-based biofuels and food, nutritional, and pharmaceutical products using the biological oils.
    Type: Grant
    Filed: August 16, 2016
    Date of Patent: June 4, 2019
    Assignee: DSM IP Assets B.V.
    Inventors: James Casey Lippmeier, Joseph W. Pfeifer, III, Jon Milton Hansen, III, Kirk E. Apt, William Robert Barclay, Paul Warren Behrens, David Christian Martin
  • Publication number: 20190160156
    Abstract: The invention relates to the use of at least one acid stable protease in poultry feed in combination with anti-coccidial vaccination of birds for increasing the performance of vaccinated animals. It has been found surprisingly that the additions of at least one acid stable protease according to the invention to the diet of “cocci”-vaccinated birds have a significant improvement of animal performance. The inventors found that especially the use of serine proteases improve the performance of vaccinated broiler chickens, in particular, the use of serine proteases increases weight gain and improves Feed Conversion Ratio (FCR) of cocci-vaccinated birds.
    Type: Application
    Filed: February 8, 2019
    Publication date: May 30, 2019
    Applicants: Novozymes A/S, DSM IP Assets B.V.
    Inventors: Nelson Ward, Inge Knap
  • Patent number: 10302819
    Abstract: The invention relates to a process of making an anti-reflective coating composition comprising the steps of 1) preparing an oil-in-water emulsion by mixing an apolar organic compound A; a cationic addition copolymer C as emulsion stabilizer; and aqueous medium of pH 2-6; at a mass ratio C/A of 0.1 to 2, to result in 1-50 mass % (based on emulsion) of emulsified droplets of average particle size 30-300 nm; and 2) providing an inorganic oxide shell layer to the emulsified droplets by adding to the emulsion obtained in step 1) at least one inorganic oxide precursor, to result in organic-inorganic core-shell nano-particles with mass ratio core/shell of from 0.2 to 25. An advantage of this process is that the dispersion of nano-particles obtained is stable under different conditions, and allows altering its concentration and solvent system, and addition of different binders and auxiliary components.
    Type: Grant
    Filed: November 24, 2014
    Date of Patent: May 28, 2019
    Assignee: DSM IP ASSETS B.V.
    Inventors: Michael Alphonsus Cornelis Johannes Van Dijck, Hermanus Adrianus Langermans, Jacobus Adriaan Antonius Vermeulen
  • Patent number: 10294467
    Abstract: The present invention relates to a polypeptide having proline-specific endoprotease activity, wherein the polypeptide has less than 70% residual activity when the polypeptide has been kept at a temperature of 65° C. for 15 min. The invention further relates to a polypeptide having proline-specific endoprotease activity comprising an amino acid sequence according to SEQ ID NO: 1, wherein SEQ ID NO: 1 comprises at least one amino acid substitution selected from the group consisting of P469A, P469C, P469D, P469E, P469F, P469G, P469H, P469I, P469K, P469L, P469M, P469N, P469Q, P469R, P469S, P469T, P469V, P469W, P469Y, a nucleic acid encoding a polypeptide having proline-specific endoprotease activity, a method of making a variant polypeptide having proline-specific endoprotease activity, a recombinant host cell and a method of producing the polypeptide and a process for the preparation of a food or feed product wherein the polypeptide is used.
    Type: Grant
    Filed: June 3, 2015
    Date of Patent: May 21, 2019
    Assignee: DSM IP ASSETS B.V.
    Inventors: Jan Metske Van Der Laan, Peter Jozef Ida Van De Vondervoort, Chantal Christis, Martine Spaans, Angela De Bruine-Paulus
  • Patent number: 10287610
    Abstract: The invention relates to an integrated process for alcohol production and organic acid production from lignocellulosic material.
    Type: Grant
    Filed: January 27, 2016
    Date of Patent: May 14, 2019
    Assignee: DSM IP ASSETS B.V.
    Inventor: Johannes Petrus Smits
  • Patent number: 10287592
    Abstract: The invention provides Bacillus host cell deficient in the production of a neutral protease and of a alkaline protease which host cell comprises a nucleic acid construct, wherein the nucleic acid construct comprises a polynucleotide encoding a compound of interest or encoding a compound involved in the synthesis of a compound of interest operably linked to a promoter sequence allowing for expression of the polynucleotide in the host cell, wherein the promoter comprises a bacteriophage promoter sequence, more preferably a bacteriophage SPO1 promoter sequence. Said host cell can advantageously be used in a method of production of a compound of interest.
    Type: Grant
    Filed: February 6, 2015
    Date of Patent: May 14, 2019
    Assignee: DSM IP Assets B.V.
    Inventors: Evert Tjeerd Van Rij, Martine Spaans, Hendrikus Bernardus Carolus Hillebrand
  • Patent number: 10280532
    Abstract: Suture containing filaments of ultra-high molecular weight polyethylene (UHMwPE), characterized in that the suture contains a multi-filament yarn that is obtained by a process comprising the steps of: a) Providing a mixture containing UHMwPE, a spinning solvent and a pigment b) Spinning a multi-filament yarn from the mixture by the gel spinning process.
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: May 7, 2019
    Assignee: DSM IP ASSETS B.V.
    Inventors: Joseph Arnold Paul Maria Simmelink, Claudia C. Vaz
  • Patent number: 10280439
    Abstract: The present invention relates to a method for a dicarboxylic acid, which method comprises fermenting fungal cells in a vessel comprising a suitable fermentation medium, wherein a least a portion of the fungal cells are reused in the presence of a vitamin and/or a trace element.
    Type: Grant
    Filed: July 18, 2014
    Date of Patent: May 7, 2019
    Assignees: DSM IP ASSESTS B.V., ROQUETTE FRERES SA
    Inventors: Mickel Leonardus August Jansen, René Verwaal, Laurent Segueilha, Mélanie Louchart, Tania Veiga Dos Inocentes
  • Patent number: 10273519
    Abstract: The present invention relates to a method for the production of a diterpene or a glycosylated diterpene, which method comprises: a. fermenting a recombinant microorganism of the genus Yarrowia in a suitable fermentation medium at a temperature of about 29° C. or higher, wherein the microorganism comprises one or more nucleotide sequence(s) encoding: a polypeptide having ent-copalyl pyrophosphate synthase activity; a polypeptide having ent-Kaurene synthase activity; a polypeptide having ent-Kaurene oxidase activity; and a polypeptide having kaurenoic acid 13-hydroxylase activity and whereby expression of the nucleotide sequence(s) confer(s) on the microorganism the ability to produce at least steviol; and b. recovering the diterpene or glycosylated diterpene.
    Type: Grant
    Filed: July 23, 2014
    Date of Patent: April 30, 2019
    Assignee: DSM IP ASSETS B.V.
    Inventors: Nicolette Jasmijn Broers, Viktor Marius Boer, Adam G. Lawrence
  • Patent number: 10273507
    Abstract: The invention relates to a cell capable of converting one or more pentose sugar and one or more hexose sugar into fermentation product constitutively expressing one or more heterologous or homologous polypeptide having the amino acid sequence set out in SEQ ID NO: 20, or a variant polypeptide thereof having at least 45% identity to SEQ ID NO 20. In an embodiment the heterologous polypeptide has glyoxalase activity.
    Type: Grant
    Filed: October 15, 2013
    Date of Patent: April 30, 2019
    Assignee: DSM IP ASSETS B.V.
    Inventors: Maria Bernedina Elizabeth Jonkers, Paul Klaassen, Aloysius Wilhelmus Rudolphus Hubertus Teunissen, Rene Marcel De Jong
  • Patent number: 10272060
    Abstract: The invention is directed to microbial oils containing omega-3 polyunsaturated fatty acids comprising docosahexaenoic acid, eicosapentaenoic acid, and optionally docosapentaenoic acid and dosage forms containing such oils.
    Type: Grant
    Filed: February 6, 2018
    Date of Patent: April 30, 2019
    Assignee: DSM IP Assets B.V.
    Inventors: Kirk E. Apt, Paul Warren Behrens, Jon Milton Hansen, Joseph W. Pfeifer, III, Tracey Lynn Stahl, Ross Zirkle
  • Patent number: 10266365
    Abstract: The invention concerns an improved yarn package and a method winding a package of high Young's modulus yarn. The package has a low normalized standard deviation in unwinding tension and hence is very suitable for converting into a range of yarn constructions and particularly medical products.
    Type: Grant
    Filed: July 27, 2017
    Date of Patent: April 23, 2019
    Assignee: DSM IP ASSETS B.V.
    Inventors: Evert Florentinus Florimondus De Danschutter, Herbert Rabe, Carsten Goerke
  • Patent number: 10266676
    Abstract: The invention relates to a plastic engine cover, as well as to a process for making the plastic engine cover and to an engine comprising the plastic engine cover. The plastic engine cover is made of a glass fiber reinforced thermoplastic polymeric material comprising a polyamide with units derived from terephthalic acid and from diamino butane.
    Type: Grant
    Filed: May 1, 2013
    Date of Patent: April 23, 2019
    Assignee: DSM IP ASSETS B.V.
    Inventors: James Beam Conkey, Peter Clinton Schmieg
  • Patent number: 10260075
    Abstract: The present invention relates to a process for the production of one or more fermentation product from a sugar composition, comprising the following steps: a) fermentation of the sugar composition in the presence of a yeast belonging to the genera Saccharomyces, Kluyveromyces, Candida, Pichia, Schizosaccharomyces, Hansenula, Kloeckera, Schwanniomyces or Yarrowia, and b) recovery of the fermentation product, wherein the yeast comprises the genes araA, araB and araD and the sugar composition comprises glucose, galactose and arabinose.
    Type: Grant
    Filed: January 17, 2017
    Date of Patent: April 16, 2019
    Assignee: DSM IP ASSETS B.V.
    Inventors: Paul Klaassen, Gijsberdina Pieternella Van Suylekom, Bianca Elisabeth Maria Gielesen, Nicolette Jasmijn Broers, Beate Wiedemann, Wilhelmus Theodorus Antonius Maria De Laat
  • Patent number: 10252962
    Abstract: The present invention relates to a new process for the production of D-sorbitol.
    Type: Grant
    Filed: July 14, 2016
    Date of Patent: April 9, 2019
    Assignee: DSM IP ASSETS B.V.
    Inventors: Mae Joanne Aguila, Hans Peter Hohmann, Laurent Lefort, Jonathan Alan Medlock, Guenter Pappenberger
  • Patent number: 10253305
    Abstract: A variant polypeptide having chymosin activity, wherein the variant has an amino acid sequence which, when aligned with the chymosin comprising the sequence set out in SEQ ID NO: 2, comprises at least one substitution of an amino acid residue corresponding to any of amino acids 2, 22, 40, 48, 50, 51, 53, 61, 62, 76, 88, 98, 99, 109, 112, 117, 125, 126, 135, 144, 160, 161, 163, 187, 189, 194, 200, 201, 202, 203, 221, 223, 240, 242, 244, 254, 267, 271, 273, 278, 280, 284, 289, 292, 294 or 295 said positions being defined with reference to SEQ ID NO: 2 and wherein the variant has one or more altered properties as compared with a reference polypeptide having chymosin activity. Such a variant polypeptide may be used in the preparation of a cheese.
    Type: Grant
    Filed: October 12, 2017
    Date of Patent: April 9, 2019
    Assignee: DSM IP ASSETS B.V.
    Inventors: Petrus Jacobus Theodorus Dekker, Rene Marcel De Jong, Cornelis Marinus Muijlwijk
  • Patent number: 10244771
    Abstract: The present invention provides a method for the construction of a bacteriophage-insensitive mutant of a Streptococcus thermophilus parent strain whereby the bacteriophage insensitivity is not based on the CRISPR resistance mechanism but based on another mechanism. The method provides a protocol by which this can be achieved by inactivating one or more of the CRISPR systems present in a given strain. The invention also provides the bacteriophage-insensitive mutants as well as their use in a process for making a dairy product.
    Type: Grant
    Filed: July 23, 2015
    Date of Patent: April 2, 2019
    Assignee: DSM IP ASSETS B.V.
    Inventors: Roelof Hendrik Matthijs Kouwen, Laurens Leendert Hanemaaijer, Douwe Van Sinderen, Brian McDonnell, Jennifer Mahony
  • Publication number: 20190090517
    Abstract: The present invention is directed towards the use of granules in beverages, wherein the granules comprise (i) a milled carotenoid selected from the group consisting of lutein and zeaxanthin and any mixture thereof having the following particle size distribution: D [3,2] in the range of from 0.6 to 1.5 ?m, and D [v, 0.5] in the range of from 1.1 to 3.5 ?m, and (ii) a matrix comprising at least one modified food starch, a glucose syrup and sucrose, (iii) a water-soluble antioxidant, wherein the granules have the following particle size distribution: D [3,2] in the range of from 200 to 300 ?m, and D [v, 0.5] in the range of from 220 to 320 ?m, all D values as measured by laser diffraction according to the Fraunhofer scattering model, whereby the milled carotenoid is encapsulated by the matrix. The present invention is also directed towards the beverages and the granules as such, as well as to a process for the manufacture of the granules. Preferably the carotenoid is lutein, zeaxanthin or any mixture thereof.
    Type: Application
    Filed: April 3, 2017
    Publication date: March 28, 2019
    Applicant: DSM IP Assets B.V.
    Inventors: Markus BECK, Antonio ESTRELLA, Elger FUNDA, Andrea HITZFELD, Christian SCHAEFER, Bernd SCHLEGEL, Kai URBAN
  • Patent number: 10238767
    Abstract: The invention relates provides synthetic medical adhesives which exploit plant derivatives to form covalent bonds with amines and thiols on tissue surfaces.
    Type: Grant
    Filed: July 25, 2013
    Date of Patent: March 26, 2019
    Assignee: DSM IP ASSETS, B.V.
    Inventors: John L. Murphy, Jeffrey L. Dalsin, Arinne N. Lyman, Laura L. Bremer, Joel L. Broussard, Neil Winterbottom, Justin T. Koepsel
  • Patent number: 10233287
    Abstract: The invention relates to a process for preparing a salt from diamine and dicarboxylic acid, the process comprising contacting a diamine gas, having a gas temperature T-gas, with a dicarboxylic acid, thereby forming a reaction mixture comprising diamine/dicarboxylic acid salt, wherein the dicarboxylic acid and the reaction mixture are kept at a temperature T-mixture of at least 10° C. below the lowest of the melting temperature of the dicarboxylic acid (Tm-acid) and the melting temperature of the resulting diamine/dicarboxylic acid salt (Tm-salt). The invention also relates to a process for preparing a polyamide comprising preparing a salt from diamine and dicarboxylic acid.
    Type: Grant
    Filed: January 30, 2014
    Date of Patent: March 19, 2019
    Assignee: DSM IP ASSETS B.V.
    Inventors: Rudy Rulkens, Renier Henricus Maria Kierkels, Geert Adelina Rudolf Vanden Poel, Theo Joseph Cuypers, Eric Grolman