Abstract: The invention relates to an eukaryotic cell expressing nucleotide sequences encoding the ara A, ara B and ara D enzymes whereby the expression of these nucleotide sequences confers on the cell the ability to use L-arabinose and/or convert L-arabinose into L-ribulose, and/or xylulose 5-phosphate and/or into a desired fermentation product such as ethanol. Optionally, the eukaryotic cell is also able to convert xylose into ethanol.
Type:
Application
Filed:
January 6, 2012
Publication date:
August 16, 2012
Applicant:
DSM IP ASSETS B.V.
Inventors:
Antonius Jeroen Adriaan VAN MARIS, Jacobus Thomas PRONK, Hendrik Wouter WISSELINK, Johannes Pieter VAN DIJKEN, Aaron Adriaan WINKLER, Johannes Hendrik DE WINDE
Abstract: Processes for the treatment of an aqueous mixture comprising a dipolar aprotic compound, comprise: a) an adsorption step, in which the aqueous mixture is brought into contact with a porous adsorbent, whereby the porous adsorbent is chosen such that the dipolar aprotic compound adsorbs to it more readily than water; b) a desorption step, in which the porous adsorbent is brought into contact with a desorbing agent, whereby a recovery solution is formed comprising the desorbing agent and the dipolar aprotic compound.
Abstract: In alternative embodiments, the invention provides phosphatidylinositol-specific phospholipase C (PI-PLC) enzymes, nucleic acids encoding them, antibodies that bind specifically to them, and methods for making and using them. Industrial methods and products comprising use of these phospholipases are also provided. In certain embodiments, provided herein are methods for hydration of non hydratable phospholipids (NHPs) within a lipid matrix. The methods enable migration of NHPs to an oil-water interface thereby allowing the NHPs to be reacted and/or removed from the lipids. In certain embodiments, provided is a method for removing NHPs, hydratable phospholipids, and lecithins from vegetable oils to produce a degummed oil or fat product that can be used for food production and/or non-food applications. In certain embodiments, provided herein are methods for hydration of NHPs followed by enzymatic treatment and removal of various phospholipids and lecithins.
Type:
Application
Filed:
October 8, 2010
Publication date:
August 16, 2012
Applicant:
DSM IP ASSETS B.V.
Inventors:
Nelson R. Barton, Tim S. Hitchman, Jonathan D. Lyon, Eileen O'Donaghue, Mark A. Wall
Abstract: Ascorbic acid compositions in the form of a powder and/or granules contain as principle components L-ascorbic acid and/or a pharmaceutically acceptable salt thereof, and a high molecular (300 kDalton or higher) pectin. The compositions are compressible into tablets with improved mechanical strength and hardness.
Abstract: The invention relates to a curable liquid resin composition comprising the following components (A), (B), and (C): (A) a urethane (meth)acrylate oligomer, (B) a monomer shown by the following formula (1), CH2?CR1COOR2 (1) wherein R1 represents a hydrogen atom or a methyl group and R2 represents a monovalent organic group, 40 wt % or more of the total amount of the component (B) being a monomer in which the R2 group in the formula (1) is a nonpolar organic group, and the monomer in the component (B) in which the R2 group in the formula (1) is a nonpolar organic group being hereinafter referred to as “nonpolar (meth)acrylate-containing monomer”, and (C) a polymerization initiator.
Type:
Grant
Filed:
March 15, 2005
Date of Patent:
August 14, 2012
Assignees:
DSM IP Assets B.V., JSR Corporation
Inventors:
Hiroshi Yamaguchi, Satoshi Kamo, Takeo Shigemoto, Zen Komiya
Abstract: The present invention relates to the use of a compound as effective agent for the prevention or treatment of diabetes mellitus in a mammal. Said compounds being selected from the group of phthalide derivatives and exhibit excellent blood glucose lowering effects and thus are effective agents in the prevention or treatment of diabetes mellitus in mammals.
Type:
Grant
Filed:
March 27, 2009
Date of Patent:
August 14, 2012
Assignee:
DSM IP Assets B.V.
Inventors:
Daniel D'Orazio, Antoine De Saizieu, Goede Schueler, Daniel Raederstorff, Sandra Renata Teixeira, Ying Wang Schmidt, Peter Weber, Swen Wolfram
Abstract: An aqueous coating composition (which optionally can coat plastic substrates) the composition comprising a block copolymer and a polymer P; where the block copolymer comprises at least blocks [A]x[B]y; where at least block [A] is obtained by a controlled radical polymerisation of at least one ethylenically unsaturated monomer via a reversible addition-fragmentation chain transfer (RAFT) mechanism (optionally in solution in the presence of a control agent and a source of free radicals); and wherein block [A] comprises 20 to 100 mol % of ethylenically unsaturated monomer units bearing water-dispersing functional groups; wherein block [B] comprises 20 to 100 mol % of ethylenically unsaturated monomer units bearing plastic adhesion promoting functional groups; and wherein polymer P is prepared in the presence of blocks [A]x[B]y. The compositions may be used to coat plastic substrates, foam; surfaces having low surface energy, hydrophobic substrates and/or polyolefins.
Type:
Application
Filed:
April 4, 2012
Publication date:
August 2, 2012
Applicant:
DSM IP Assets B.V.
Inventors:
Michael Arnoldus Jacobus SCHELLEKENS, Gerardus Cornelis Overbeek, Tijs Nabuurs, John Geurts
Abstract: Extruder (1) for processing material, comprising an extruder barrel (3) containing a bore (5) and at least one extruder screw (11) positioned within said bore, the bore having an upstream inlet portion for feeding the material to be processed and a downstream outlet portion connectable to an extruder exit (7) for material processed through the extruder, the at least one extruder screw has a length:diameter ratio of less than 20:1, the extruder further comprising at least one recycling channel (13, 15) running through the barrel from the outlet portion of the bore and at least two recycling exits (19, 21, 23) that connect a recycling channel to the bore upstream of the outlet portion by and further comprising means for directing the material through the at least one recycling channel and the recycling exits and/or the extruder exit.
Abstract: The present invention relates to a recombinant host cell for the production of a compound of interest. The invention further relates to a method for the production of such host cell. The invention further relates to the production of a compound of interest. The invention further relates to isolated polynucleotides and vectors and host cells comprising said polynucleotides.
Type:
Application
Filed:
July 1, 2010
Publication date:
July 26, 2012
Applicant:
DSM IP ASSETS B.V.
Inventors:
Noël Nicolass Maria Elisabeth Van Peij, Herman Jan Pel, Thibaut José Wenzel, Adriana Marina Riemens, Ilse De Lange
Abstract: A process for obtaining a solvent borne polyurethane composition comprising preparing an isocyanate-terminated prepolymer A; reacting the isocyanate groups of isocyanate-terminated prepolymer A with 0.1 to 1.8 stoichiometric equivalents of at least one active-hydrogen containing chain-terminating compound and or chain-extending compound; optionally introducing an isocyanate-terminated compound B; and reacting the isocyanate groups of the isocyanate-terminated prepolymer obtained in the previous steps and isocyanate-terminated compound B with 0 to 1.2 stoichiometric equivalents of at least one active-hydrogen containing chain-terminating compound and or chain-extending compound.
Type:
Application
Filed:
April 5, 2012
Publication date:
July 26, 2012
Applicant:
DSM IP Assets B.V.
Inventors:
Ester PARRA PASTOR, Joan Tiana Ruiz, Urs Jürgen Frieden Hugel
Abstract: The present invention refers to carnosol and rosmanol for use (as medicament) in the treatment of a disorder connected to reduced neurotransmission, cognitive dysfunction and/or symptoms caused by headache and/or migraine, as well as to dietary and pharmaceutical compositions and their uses.
Type:
Grant
Filed:
November 22, 2007
Date of Patent:
July 24, 2012
Assignees:
DSM IP Assets B.V., Nestec S.A.
Inventors:
Ann Fowler, Regina Goralczyk, Claus Kilpert, Hasan Mohajeri, Daniel Raederstorff, Antoine De Saizieu, Goede Schueler, Ying Wang-Schmidt, Christof Wehrli
Abstract: Rosemary extracts are used in the treatment of disorders connected to reduced neurotransmission, as well as dietary and pharmaceutical compositions containing these rosemary extracts.
Type:
Application
Filed:
March 29, 2012
Publication date:
July 19, 2012
Applicant:
DSM IP ASSETS B.V.
Inventors:
Antoine De Saizieu, Ann Fowler, Regina Goralczyk, Claus Kilpert, Goede Schueler
Abstract: The invention relates to a process for the preparation of a fermentation product from ligno-cellulosic material, comprising the following steps: a) optionally pre-treatment b) optionally washing; c) enzymatic hydrolysis; d) fermentation; and e) optionally recovery of a fermentation product; wherein in step c) an enzyme composition is used that has a temperature optimum of 55 degrees C. or more, the hydrolysis time is 40 hours or more and the temperature is 50 degrees C. or more.
Type:
Application
Filed:
October 5, 2010
Publication date:
July 19, 2012
Applicant:
DSM IP ASSETS B.V.
Inventors:
Johannes Petrus Smits, Elisabeth Maria Gierveld, Fop Cornelis Van Der Hor
Abstract: A tube bundle falling film microreactor for performing gas-liquid reactions, which has: a) at least one vertical tube with b) a device for distributing the liquid on the inside of the tube and c) a liquid collecting system, and d) a device for gas supply and removal, and use thereof.
Type:
Grant
Filed:
May 29, 2008
Date of Patent:
July 17, 2012
Assignee:
DSM Fine Chemicals Austria NFG GmbH & Co KG
Inventors:
Florian Seebauer, Peter Poechlauer, Sascha Braune, Stefan Steinhofer
Abstract: The invention relates to a process for the culturing of cells, preferably E1-immortalized HER cells, more preferably PER.C6 cells in a reactor in suspension in a cell culture medium, wherein the cells produce a biological substance, preferably an antibody, wherein at least one cell culture medium component is fed to the cell culture and wherein the cell culture comprising the cells, the biological substance and cell culture medium is circulated over a separation system and wherein the separation system separates the biological substance from substances having a lower molecular weight than the biological substance and wherein the biological substance is retained in or fed back into the reactor. Preferably part of the substances of lower molecular weight is continuously removed from the cell culture.
Type:
Grant
Filed:
February 13, 2012
Date of Patent:
July 17, 2012
Assignee:
DSM IP Assets B.V.
Inventors:
Gerben Meile Zijlstra, Robert Patrick Hoff, Jacob Schilder
Abstract: Waste reduction, including hazardous waste reduction in photoimaging processes can be accomplished by improving diffusional resolution of cationic curable compositions. The addition of fluorinated polymers including fluorinated surfactants provides improved diffusional resolution in cationic and/or radical based photoimaging formulations allowing for image accuracy improvements, and reduced product and process waste quantity and disposal cost. These fluorinated surfactants also allow for increased cure speed, and non-hazardous constituent formulations that result in less wasted material and time.
Type:
Application
Filed:
March 20, 2012
Publication date:
July 12, 2012
Applicant:
DSM IP ASSETS
Inventors:
John LAWTON, Jigeng Xu, John Southwell, Gordon Smith, Willem D. Weenink
Abstract: The invention provides a process for the conversion of cystine to cystein and/or glutathione comprising contacting cystine with a microorganism. The invention also relates to a yeast extract comprising at least 1.8 mg/g cystein and a yeast autolysate comprising at least 1.3 mg/g cystein.
Abstract: The present invention relates to a method for preparing a soy-based fermented food product using L. delbrueckii and a strain capable of stimulating growth of L. delbrueckii, and a food product obtainable by such method. The invention also provides for a culture comprising said strains, and the use thereof for preparing said fermented food product.
Type:
Application
Filed:
September 10, 2010
Publication date:
July 12, 2012
Applicant:
DSM IP ASSETS B.V.
Inventors:
Franciscus Adrianus Maria De Bok, Patrick Wilhelmus Maria Janssen, Jan Sikkema, Eilt Johannes Smid
Abstract: Topical composition for use especially as a skin lightener, characterized in that it contains an effective amount of at least one compound of general formula (I) or a mixture of such compounds and/or an acid addition salt thereof: in which X is NH or a direct bond and n is 2, 3 or 4, preferably 2 or 3, and its use for lightening skin colour, for depigmenting liver spots and for evening out non-uniformities in skin colouration. The invention further relates to dermatologically effective compositions containing at least one disulfide of general formula (I) and at least one additional skin care ingredient.
Type:
Application
Filed:
March 21, 2012
Publication date:
July 12, 2012
Applicant:
DSM IP ASSETS B.V.
Inventors:
Hugo ZIEGLER, Peter Wikstroem, Martin Stöckli