Patents Assigned to Duke University
  • Interventional ultrasound probe
    Patent number: 11432801
    Abstract: A method and system are provided for guiding a needle to a target location within a subject. The system comprises a probe and a needle guide. The probe includes two or more transducers that are arranged to direct sound waves toward a target location on a subject. The needle guide can be detachably coupled to the probe, and may be used to maintain the needle within viewing planes of the transducers while the needle is inserted into the subject. To facilitate guidance of the needle, a real-time image of the target region can be produced by overlaying images produced by the two or more transducers. Such a system may provide a more adaptive and reliable way to guide the insertion of a needle, allowing for more sophisticated and fool-proof viewing planes, improved versatility, and more ergonomic needle control.
    Type: Grant
    Filed: April 6, 2018
    Date of Patent: September 6, 2022
    Assignee: DUKE UNIVERSITY
    Inventor: Charles Y. Kim
  • COMPOSITIONS AND METHODS FOR DECREASING INTRAOCULAR PRESSURE
    Publication number: 20220273694
    Abstract: Provided herein are methods and compositions for decreasing intraocular pressure in a subject. Also provided are methods and compositions for treating or preventing glaucoma.
    Type: Application
    Filed: August 7, 2020
    Publication date: September 1, 2022
    Applicant: Duke University
    Inventors: Pedro GONZALEZ, Coralia C. LUNA
  • Compositions and methods for promoting hematopoietic stem cell regeneration
    Patent number: 11426389
    Abstract: Described is a method for promoting regeneration of hematopoietic stem and progenitor cells in a subject in need thereof. The method comprises administering to the subject a composition comprising a Ca2+/calmodulin (CaM)-dependent protein kinase kinase 2 (CaMKK2) inhibitor. The CaMKK2 inhibitor may be a small molecule inhibitor, such as 7H-benzimidazo(2,1-a)benz(de)isoquinoline-7-one-3-carboxylic acid (STO-609).
    Type: Grant
    Filed: July 27, 2018
    Date of Patent: August 30, 2022
    Assignee: Duke University
    Inventor: Luigi Racioppi
  • Compositions and methods of improving specificity in genomic engineering using RNA-guided endonucleases
    Patent number: 11427817
    Abstract: Disclosed herein are optimized guide RNAs (gRNAs) that have increased target binding specificity and reduced off-target binding. Further disclosed herein are methods of designing and using the optimized gRNAs.
    Type: Grant
    Filed: August 25, 2016
    Date of Patent: August 30, 2022
    Assignee: Duke University
    Inventors: Eric Josephs, Dewran Kocak, Piotr Marszalek, Charles A. Gersbach
  • Motion planning for autonomous vehicles and reconfigurable motion planning processors
    Patent number: 11429105
    Abstract: A system for motion planning for autonomous vehicles can include a plurality of sensors, a plurality of detectors in electrical communication with the plurality of sensors, and a motion planning module in electrical communication with the plurality of detectors and a computing system of an autonomous vehicle. The motion planning module stores a planning graph with each node representing, explicitly or implicitly, time and variables defining a state of the autonomous vehicle, an operating environment, or both the state of the autonomous vehicle and the operating environment. A reconfigurable processor can include a collision detection module and, optionally, a shortest path module. Pre-computed collision data and planning graph data reflecting logical/physical node mapping can be communicated to the processor during a programming phase and used during runtime.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: August 30, 2022
    Assignees: DUKE UNIVERSITY, BROWN UNIVERSITY
    Inventors: Daniel J. Sorin, George D. Konidaris, William Floyd-Jones, Sean Murray
  • Implantable mesh and method of use
    Patent number: 11426267
    Abstract: A method of using an implantable mesh for repairing a tissue defect or reconstructing tissue, wherein the implantable mesh has a mesh body and at least two mesh extensions comprised of mesh extending therefrom, includes positioning the mesh body of the implantable mesh such that the mesh body extends across the tissue defect or tissue to be reconstructed and passing at least one mesh extension through tissue adjacent to the tissue defect or tissue to be reconstructed so as to anchor the implantable mesh to the tissue and resist high tension without dehiscing or migrating from the tissue defect or tissue to be reconstructed.
    Type: Grant
    Filed: November 19, 2019
    Date of Patent: August 30, 2022
    Assignee: Duke University
    Inventor: Howard Levinson
  • Methods for predicting tumor response to immunotherapy
    Patent number: 11428691
    Abstract: Methods of testing tumor samples for mutational burden and/or for expression profiles permit the prediction of responsiveness of an individual to immunotherapy comprising PVSRIPO. Those predicted to respond are treated with PVSRIPO and those predicted not to respond are treated with other agents.
    Type: Grant
    Filed: January 23, 2019
    Date of Patent: August 30, 2022
    Assignee: Duke University
    Inventors: David Ashley, Darell Bigner, Matthias Gromeier, Smita Nair
  • Compositions and methods for the repair of myelin
    Patent number: 11426419
    Abstract: Described are oxysterols, pharmaceutical compositions including the oxysterols, and methods of using the oxysterols and compositions for treating diseases and/or disorders related to myelin injury, such as neonatal brain injury, traumatic brain injury, spinal cord injury, cerebral palsy, seizures, cognitive delay, multiple sclerosis, stroke, autism, leukodystrophy, schizophrenia and bipolar disorder.
    Type: Grant
    Filed: June 24, 2020
    Date of Patent: August 30, 2022
    Assignee: Duke University
    Inventor: Eric J. Benner
  • DEVICES, SYSTEMS, AND METHODS FOR PROMOTING VOIDING IN SUBJECTS WITH UNDERACTIVE BLADDERS
    Publication number: 20220266010
    Abstract: This present disclosure provides devices, systems, and methods for the treatment of conditions pertaining to bladder control. In particular, the present disclosure provides devices, systems, and methods directed to the application of electrical stimulation to the proximal urethra and associated nervous tissue to elicit voiding contractions that normalize bladder function.
    Type: Application
    Filed: July 30, 2020
    Publication date: August 25, 2022
    Applicant: Duke University
    Inventors: Bradley POTTS, Matthew FRASER
  • Acid-alpha glucosidase variants and uses thereof
    Patent number: 11421211
    Abstract: The present invention relates to variants of acid-alpha glucosidase and uses thereof. Said variants are sequence-optimized and/or are linked to a heterogenous signal peptide.
    Type: Grant
    Filed: September 12, 2017
    Date of Patent: August 23, 2022
    Assignees: GENETHON, SORBONNE UNIVERSITÉ, DUKE UNIVERSITY
    Inventors: Federico Mingozzi, Giuseppe Ronzitti, Dwight D. Koeberl, Sang-Oh Han
  • Bispecific molecules that are immunoreactive with immune effector cells that express an activating receptor and an antigen expressed by a cell infected by a virus and uses thereof
    Patent number: 11421031
    Abstract: The present invention relates to bispecific molecules that are capable of localizing an immune effector cell that expresses an activating receptor to a virally infected cell, so as to thereby facilitate the killing of the virally infected cell. In a preferred embodiment, such localization is accomplished using bispecific molecules that are immunoreactive with an activating receptor of an immune effector cell and to an antigen expressed by a cell infected with a virus wherein the antigen is detectably present on the cell infected with the virus at a level that is greater than the level at which the antigen is detected on the virus by the bispecific molecules, and to the use of such bispecific molecules in the treatment of latent viral infections.
    Type: Grant
    Filed: June 22, 2020
    Date of Patent: August 23, 2022
    Assignees: MacroGenics, Inc., Duke University
    Inventors: Scott Koenig, Leslie S. Johnson, Chia-Ying Kao Lam, Liqin Liu, Jeffrey Lee Nordstrom, Barton F. Haynes, Guido Ferrari
  • Platforms for single cell analysis
    Patent number: 11420204
    Abstract: Provided herein are devices, systems, and methods for analysis of objects, such as cells. The devices, systems, and methods organize a plurality of objects in a plurality of partitions by trapping an object in a trap and transferring the object to an adjacent partition. The devices, systems, and methods provide for parallel analysis of a plurality of objects.
    Type: Grant
    Filed: January 12, 2017
    Date of Patent: August 23, 2022
    Assignee: Duke University
    Inventors: Benjamin B. Yellen, Roozbeh Abedini-Nassab, Korine A. Ohiri, David M. Murdoch, Kris Wood
  • Systems, methods, and techniques for waste processing
    Patent number: 11420891
    Abstract: A waste processing system includes a reactor including an inlet end and an outlet end configured to discharge reactor effluent. The inlet end includes a mixing unit having an oxidizing material input and a waste stream input. The reactor oxidizing material input is configured to receive reactor oxidizing material at a temperature greater than 200° C. and at a pressure greater than 60 atm. A second waste stream input is positioned between the reactor inlet end and the reactor outlet end.
    Type: Grant
    Filed: October 19, 2018
    Date of Patent: August 23, 2022
    Assignee: Duke University
    Inventors: Yaacov Nagar, Kathleen Jooss, Marc Deshusses, Kurabachew Duba
  • Genome engineering with type I CRISPR systems in eukaryotic cells
    Patent number: 11421251
    Abstract: Disclosed herein are Type I Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated (Cas) system related compositions and methods of using said Type I CRISPR/Cas system related compositions for altering gene expression and genome engineering. The invention relates to compositions comprising Type I CRISPR-Cas polypeptides and CRISPR array nucleic acids designed for genome modification in eukaryotic cells and for targeted killing of eukaryotic cells.
    Type: Grant
    Filed: April 1, 2020
    Date of Patent: August 23, 2022
    Assignees: Duke University, North Carolina State University
    Inventors: Charles A. Gersbach, Adrian Pickar Oliver, Chase Beisel
  • Methods and Systems for Sterilizing Surgical Drains
    Publication number: 20220257814
    Abstract: Systems and methods for decontaminating a surgical drain and its reservoir are provided. An apparatus is provided in the form of a container having an interior chamber and an expansible opening to the interior chamber for insertion of a surgical drain therethrough. Ultraviolet light emitters are disposed within the interior chamber to emit beams of ultraviolet radiation at the surgical drain and/or its reservoir, thereby killing or neutralizing bacteria and fungus on the drain. Walls forming the expansible opening are collapsible to abut a portion of the inserted drain when inserted into the apparatus, and a fluid tight seal is formed between the drain and the apparatus.
    Type: Application
    Filed: March 3, 2022
    Publication date: August 18, 2022
    Applicant: DUKE UNIVERSITY
    Inventors: Charlotte Lynne Sawyer, Yitaek Azariah Hwang, Michaela Jane Walker, Vaibhav Bajaj, Scott Thomas Hollenbeck
  • Spatial coherence feedback for adaptive clutter filtering
    Patent number: 11415693
    Abstract: An ultrasound system that includes a transducer configured to acquire ensemble channel/echo data and a filter bank configured to receive the echo data from the transducer, wherein the echo data is passed through a plurality of clutter filters within the filter bank to realize a plurality of echo data outputs. A processor calculates a spatial coherence value from each of the plurality of echo data outputs, compares the spatial coherence values of each filter, and selects the filter that yields a best spatial coherence for subsequent velocity estimation used to generate an output image for clinical use, where the best spatial coherence value is a highest and best spatial coherence value among the set of spatial coherence values.
    Type: Grant
    Filed: October 26, 2020
    Date of Patent: August 16, 2022
    Assignee: Duke University
    Inventors: Willie J. Long, Gregg E. Trahey
  • COMPOSITIONS AND METHODS FOR BONE REPAIR AND BONE HEALTH
    Publication number: 20220249533
    Abstract: The present disclosure relates to polymer-based biomaterials for the systemic or localized delivery of osteoanabolic molecules, and their use in methods for treating and/or preventing bone degeneration and for promoting bone regeneration. In one aspect, the present invention provides a biomaterial comprising a polymer and a bioactive molecule binding moiety. In certain embodiments of the first aspect of the invention, the bioactive molecule binding moiety is an osteoanabolic molecule binding moiety.
    Type: Application
    Filed: June 3, 2020
    Publication date: August 11, 2022
    Applicant: DUKE UNIVERSITY
    Inventors: Shyni Varghese, Yu Ru Shih, Jiaul Hoque
  • Ultrasound transducers for constructive shear wave interference and related methods and systems
    Patent number: 11406360
    Abstract: A transducer array includes at least one annular shear wave generation transducer that defines an interior area, the at least one annular shear wave generation transducer being configured to generate a shear wave excitation to a region of interest such that the shear wave excitation excites at least a part of a corresponding cylindrical portion of the region of interest and shear waves propagating from the cylindrical portion of the region of interest constructively interfere in an interior region of the cylindrical portion of the region of interest: and at least one tracking transducer positioned in the interior area of the at least one annular shear wave generation transducer, the at least one tracking transducer being configured to detect a shear wave in the interior region of the region of interest.
    Type: Grant
    Filed: June 22, 2017
    Date of Patent: August 9, 2022
    Assignee: Duke University
    Inventors: Peter J. Hollender, Mark Palmeri
  • Oncolytic poliovirus for human tumors
    Patent number: 11406677
    Abstract: Human clinical use of a chimeric poliovirus construct has demonstrated excellent anti-tumor effect. The mechanism of action is believed to involve both viral oncolysis as well as immune recruitment, both of which lead to necrosis in the area of the tumor. No adverse effects have been observed.
    Type: Grant
    Filed: September 10, 2020
    Date of Patent: August 9, 2022
    Assignee: Duke University
    Inventors: Matthias Gromeier, John H. Sampson, Darell D. Bigner, Annick Desjardins, Henry S. Friedman
  • Systems and methods for psycho-signal processing
    Patent number: 11399930
    Abstract: Systems and methods for psycho-signal processing. According to an aspect, a method includes receiving a visual representation of a subject. The method also includes performing a structured motion operation on the received visual representation to generate a modified visual representation of the subject. The method further includes presenting, via a user interface, the modified visual representation.
    Type: Grant
    Filed: January 23, 2018
    Date of Patent: August 2, 2022
    Assignee: Duke University
    Inventor: Sina Farsiu