Patents Assigned to Duquesne University
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Publication number: 20250213479Abstract: The present invention is an improvement in Lipid Nanoparticles (LNPs) for re-routing their distribution from the liver and spleen (the non-target organs) to hard-to-deliver targets such as the brain and other tissues for drug delivery. Specifically, the invention derivatizes or otherwise modifies LNPs to provide the surface or constituency thereof with “Ionic Liquid” (IL) so that the IL-LNP incorporates an ionizable lipid such as a cationic ionizable lipid, an optional helper lipid, cholesterol and a (true) ionic liquid component. Among other benefits of the inclusion of “Ionic Liquid” is to decrease the delivery of LNPs to the body's filtering organ—the liver—and thereby re-route delivery to other target organs.Type: ApplicationFiled: December 6, 2024Publication date: July 3, 2025Applicant: Duquesne University of the Holy SpiritInventors: Purva Prasad Khare, Eden E.L. Tanner, Devika Soundara Manickam
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Publication number: 20250111088Abstract: The present invention is a personal security method and a writer's tool, in two or three modules, that assures generation of text by a user which cannot be identified has having been written by said user. The present invention uses Large Language Modules (LLMs such as but not limited to ChatGPT) principally to generated the document. Using an LLM together with the two or three modules of the present invention side-steps the author's (user's) features entirely by having the LLM generate the text, creating an authorship opaque document, and thus concealing and securing the identity of the writer.Type: ApplicationFiled: September 27, 2024Publication date: April 3, 2025Applicant: Duquesne University of the Holy SpiritInventor: Patrick M. Juola
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Publication number: 20250087008Abstract: The instant document converter transforms any text or text-predominant document, virtually immediately and automatically, to a list containing solely its culled, formatted references, together with one or more coordinated executables that launch the culled formatted references as a search query, when triggered, to a search engine for verification analysis.Type: ApplicationFiled: September 6, 2024Publication date: March 13, 2025Applicant: Duquesne University of the Holy SpiritInventor: Patrick Juola
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Publication number: 20250025414Abstract: The present invention is a ready-delivery oral dosage form for laboratory animals, for the testing of candidate active agents, that meets a number of design parameters. First, the oral dosage form is chewable but neither fragile nor sticky, so it does not fall apart or scatter in the living space in which it is administered—but also cannot become lodged in the animal's teeth or mouth. Second, the palatability profile is greater than the ordinary animal feed (such as rodent chow and so forth) and therefore will be consumed immediately and preferentially, when administered, prior to any other available food. Finally, the oral dosage form must be readily compounded such as with an automated tablet press without the need to add heat or volatile solvents, with inclusion of active agent added followed by optional refrigeration prior to administration.Type: ApplicationFiled: July 16, 2024Publication date: January 23, 2025Applicant: Duquesne University of the Holy SpiritInventors: Ira Shea Buckner, Rehana Khan Leak, Aleem Gangjee, Anuj Sunil Jamenis
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Publication number: 20240321132Abstract: The present invention is a modular electromechanical system for proctoring an online examination, as to a test-taker at a remote computer location, incorporating modules which collect and compare only motion-detected biometrics. The modules of the system include a computer keyboard or equivalent input device, a User Registration Database, a module for motion sensing (during testing) and data transmission that populates a Motion Capture Database, and a compiler for comparing or contrasting the User Registration Database and the Motion Capture Database, with the compiler's rendering its analytical data to a Secure Compilation Database Storage with User Output. The User Registration Database is populated in advance of the test to be proctored, in a secure setting.Type: ApplicationFiled: March 22, 2024Publication date: September 26, 2024Applicant: Duquesne University of the Holy SpiritInventor: Patrick Juola
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Publication number: 20240218419Abstract: In aspects, the present disclosure provides methods for quantifying microorganisms. In aspects, the present disclosure provides methods for identifying microorganisms. In aspects, the present disclosure provides methods of analyzing food. In aspects, the present disclosure provides methods of treating a human subject having an infection. In aspects, the present disclosure provides methods of analyzing environmental samples.Type: ApplicationFiled: August 6, 2021Publication date: July 4, 2024Applicants: The University of Chicago, Duquesne University of the Holy SpiritInventors: Melikhan Tanyeri, Jing Lin, Mustafa F. Abasiyanik, Yulder D. Angarita Marmolejo
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Patent number: 11897886Abstract: A compound of Formula II, or optionally a salt or a hydrate of the compound of Formula II is provided: wherein R1 is selected from the group consisting of a hydrogen, an alkyl group having from one to six carbon atoms, an aryl group, and a heteroaryl group; R2 is selected from the group consisting of an alkyl group having from one to six carbon atoms, a hydrogen, a NRaRb group wherein Ra is either a hydrogen or an alkyl group having from one to six carbon atoms and Rb is either a hydrogen or an alkyl group having from one to six carbon atoms, an aryl group, a heteroaryl group, and a halogen; R is an alkyl group having from one to six carbon atoms; and Ar is selected from the group consisting of an alkyl group having from one to six carbon atoms, a substituted aryl, and a substituted heteroaryl.Type: GrantFiled: November 2, 2020Date of Patent: February 13, 2024Assignee: Duquesne University of The Holy SpiritInventor: Aleem Gangjee
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Publication number: 20240041767Abstract: The present invention is a composition, and a method for making and administering, a pharmaceutical in unit dosage form in which mitochondria-enriched extracellular vesicles are delivered, “as is” or with an optional suitable carrier, after increasing the mitochondria content of the vesicles by generating the vesicles from a human brain endothelial cell line in the presence of one or more suitable promoting agents. Such mitochondria-enriched vesicles are effective to treat tissues needing amelioration of mitochondrial dysfunction or boosting of mitochondrial function. The EVs intrinsically are able to cross the blood-brain barrier and thus are particularly well suited for treating compromised tissues of the brain in situ. as well as other tissues under stress and in need of treatment not limited to neurologic tissues, and are typically administered parenterally.Type: ApplicationFiled: July 27, 2023Publication date: February 8, 2024Applicant: Duquesne University of the Holy SpiritInventor: Devika Soundara Manickam
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Patent number: 11840539Abstract: The present invention provides substituted pyrrolo-, furano-, and cyclopentylpyrimidine bicyclic pharmaceutical compositions comprising compounds of Formula IV, and pharmaceutically acceptable salts, solvates, and hydrates thereof, having antimitotic activity, anti-multidrug resistance activity, such as for example P-glycoprotein inhibition, and antitumor activity, and which inhibit paclitaxel sensitive and resistant tumor cells. Also provided are methods of utilizing these compounds and pharmaceutical compositions for treating tumor cells and inhibiting mitosis of cancerous cells.Type: GrantFiled: February 3, 2021Date of Patent: December 12, 2023Assignee: Duquesne University of the Holy SpiritInventor: Aleem Gangjee
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Patent number: 11629370Abstract: A method of detecting a species, strain or type of bacteria includes mixing a labeled bacteriophage including a label that is detectible via a detection system with a bacterial culture including the species, strain or type of bacteria to which the labeled bacteriophage selectively binds and using the detection system to detect the labeled bacteriophage bound to the species, strain or type of bacteria.Type: GrantFiled: March 16, 2021Date of Patent: April 18, 2023Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, Duquesne University of the Holy SpiritInventors: John Alston Kellum, John D. Hempel, Robert Hugh Edgar, John Andrew Viator
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Patent number: 11605055Abstract: Novel distractorless authorship verification technology optionally combines with novel algorithms to solve authorship attribution as to an open set of candidates—such as without limitation by analyzing the voting of “mixture of experts” and outputting the result to a user using the following: if z (z=pi?pj? pi+pj?(pi?pj)2/n) is larger than a first predetermined threshold then author j cannot be the correct author; or if z (z=pi?pj? pi+pj?(pi?pj)2/n) is smaller than a second predetermined threshold then author i cannot be the correct author; or if no author garners significantly more votes than all other contenders then none of the named authors is the author of a document in question—in a number of novel applications. Personality profiling and authorship attribution may also be used to verify user identity to a computer.Type: GrantFiled: April 16, 2020Date of Patent: March 14, 2023Assignee: Duquesne University of the Holy SpiritInventors: Patrick Juola, James Orlo Overly, John Isaac Noecker, Michael Ryan, Christine Gray
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Patent number: 11572363Abstract: This invention provides substituted bicyclic pyrimidine compounds of the following formula: or a pharmaceutically acceptable salt thereof, wherein R is selected from the group consisting of a straight or a branched chain alkyl group having from 1 to 10 carbon atoms, wherein the alkyl group is partially or completely saturated. Methods of treating a patient diagnosed with cancer are disclosed comprising administering to the patient a therapeutically effective amount of the substituted bicyclic pyrimidine compounds, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: December 22, 2020Date of Patent: February 7, 2023Assignee: Duquesne University of The Holy SpiritInventor: Aleem Gangjee
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Patent number: 11124520Abstract: The present invention provides a compound of Formula III, and salts thereof, and a pharmaceutical composition comprising a compound of Formula III: wherein R1 is selected from the group consisting of: wherein R2 is H or an alkyl group having from one to ten carbon atoms; R3 is H or an alkyl group having from one to ten carbon atoms; and R4 is H or an alkyl group having from one to ten carbon atoms. Methods of treating a patient with cancer with these compounds are also provided.Type: GrantFiled: December 4, 2019Date of Patent: September 21, 2021Assignee: Duquesne University of the Holy SpiritInventor: Aleem Gangjee
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Patent number: 11111252Abstract: The present invention discloses a compound of the formula: and optionally comprising a pharmaceutically acceptable salt or hydrate thereof. A method of treating a patient having cancer or a disease comprising administering to a patient an effective amount of the compound or pharmaceutically acceptable salt or hydrate thereof.Type: GrantFiled: August 11, 2020Date of Patent: September 7, 2021Assignee: Duquesne University of The Holy SpiritInventor: Aleem Gangjee
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Patent number: 11091500Abstract: The present invention provides tricyclic compounds, and pharmaceutically acceptable salts thereof, having antimitotic activity, anti-multidrug resistance activity, for example P-glycoprotein inhibition, and antitumor activity, and which inhibit paclitaxel sensitive and resistant tumor cells. Also provided are methods of utilizing these compounds for treating tumor cells and inhibiting mitosis of cancerous cells.Type: GrantFiled: August 2, 2019Date of Patent: August 17, 2021Assignee: Duquesne University of the Holy SpiritInventor: Aleem Gangjee
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Patent number: 11078214Abstract: The present invention provides a compound of Formula XXVII: wherein X is CH2 or O, and R1 is H or CH3; or a salt or a hydrate of the compound, and further provides a pharmaceutical composition comprising the compound of Formula XXVII and one or more acceptable pharmaceutical carriers. A method of treating a patient having cancer comprising administering a therapeutically effective amount of a compound of Formula XXVII, or a pharmaceutical composition comprising a compound of Formula XXVII and one or more acceptable pharmaceutical carriers to the patient is disclosed.Type: GrantFiled: September 16, 2019Date of Patent: August 3, 2021Assignee: Duquesne University of The Holy SpiritInventor: Aleem Gangjee
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Patent number: 11053252Abstract: Fused cyclic pyrimidine compounds, including tautomers thereof, and pharmaceutically acceptable salts, prodrugs, solvates and hydrates thereof, are disclosed having the general Formula I: These compounds are useful in methods for treating cancer, selectively targeting cancerous cells via the proton coupled folate transporter, folate receptor alpha, and/or folate receptor beta pathways, inhibiting GARFTase in cancerous cells, and selectively targeting activated macrophages in a patient having an autoimmune disease, such as rheumatoid arthritis.Type: GrantFiled: February 26, 2020Date of Patent: July 6, 2021Assignees: Duquesne University of the Holy Spirit, Wayne State UniversityInventors: Aleem Gangjee, Larry H. Matherly
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Patent number: 11001595Abstract: The present invention discloses a compound of the formula: wherein R is hydrogen or an alkyl group having from one to ten carbon atoms, or a compound of the formula wherein the S is replaced by CH2 or O, and optionally comprising a pharmaceutically acceptable salt or hydrate thereof. A method of treating a patient having cancer or a disease comprising administering to a patient an effective amount of the compound or pharmaceutically acceptable salt or hydrate thereof.Type: GrantFiled: August 11, 2020Date of Patent: May 11, 2021Assignee: Duquesne University of The Holy SpiritInventor: Aleem Gangjee
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Patent number: 10961557Abstract: A system for identifying at least one species, strain or type of bacteria in a sample including at least one a labeled bacteriophage which binds selectively to the species, strain or type of bacteria, the at least one labeled bacteriophage comprising a label attached thereto, the system further comprising a detection system adapted to detect the labeled bacteriophage bound to the species of bacteria.Type: GrantFiled: December 19, 2019Date of Patent: March 30, 2021Assignees: University of Pittsburgh Of the Commonwealth System of Higher Education, Duquesne University of the Holy SpiritInventors: John Alston Kellum, John D. Hempel, Robert Hugh Edgar, John Andrew Viator
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Patent number: 10947246Abstract: The present invention provides substituted pyrrolo-, furano-, and cyclopentylpyrimidine bicyclic compounds of Formula III, and Formula IV, and pharmaceutically acceptable salts, solvates, and hydrates thereof, having antimitotic activity, anti-multidrug resistance activity, such as for example P-glycoprotein inhibition, and antitumor activity, and which inhibit paclitaxel sensitive and resistant tumor cells. Also provided are methods of utilizing these compounds and pharmaceutical compositions for treating tumor cells and inhibiting mitosis of cancerous cells.Type: GrantFiled: August 7, 2018Date of Patent: March 16, 2021Assignee: Duquesne University of the Holy SpiritInventor: Aleem Gangjee