Patents Assigned to Duquesne University
  • Tricyclic compounds having cytostatic and/or cytotoxic activity and methods of use thereof
    Patent number: 9422297
    Abstract: The present invention provides tricyclic compounds having cytostatic and cytotoxic activity in a single molecule having receptor tyrosine kinase(s), dihydrofolate reductase, thymidylate synthase and/or dihydroorotate dehydrogenase inhibitory activity, which are useful as anti-angiogenic and anti-tumor agents. Also provided are methods of utilizing these inhibitors to treat tumor cells and other proliferative diseases and disorders.
    Type: Grant
    Filed: September 25, 2014
    Date of Patent: August 23, 2016
    Assignee: Duquesne University of the Holy Ghost
    Inventor: Aleem Gangjee
  • SUBSTITUTED PYRROLO[2,3-D]DIPYRIMIDINES FOR SELECTIVELY TARGETING TUMOR CELLS WITH FR-ALPHA AND FR-BETA TYPE RECEPTORS
    Publication number: 20160229857
    Abstract: Pyrrolo[2,3-d]pyrimidine derivatives, and pharmaceutical acceptable salts thereof, useful in therapeutically treating patients with cancer are disclosed. These compounds selectively target folate receptors (FR) of cancerous tumor cells and inhibit purine synthesis and hence, DNA synthesis.
    Type: Application
    Filed: February 9, 2015
    Publication date: August 11, 2016
    Applicant: Duquesne University of The Holy Ghost
    Inventors: ALEEM GANGJEE, LARRY H. MATHERLY
  • Combination hormone replacement therapy (HRT) and melatonin to prevent and treat mammary cancer
    Patent number: 9370526
    Abstract: A combination hormone and melatonin therapy is provided to reduce the risk of developing, or to reduce the severity of, breast cancer by administering at least one estrogen hormone and optionally at least one progesterone-receptor-binding compound or composition and melatonin together, preferably at normal bed time.
    Type: Grant
    Filed: December 10, 2013
    Date of Patent: June 21, 2016
    Assignee: Duquesne University of the Holy Spirit
    Inventors: Paula A. Witt-Enderby, Vicki L. Davis
  • MERCURY SENSOR AND METHODS OF USE
    Publication number: 20160097754
    Abstract: The invention relates to non-fluorescent or low-fluorescent compounds for contact with mercury ions to produce fluorescent compounds as a detector for mercury. The fluorescence produced by the contact of the non-fluorescent or low-fluorescent compounds with mercury ions has an intensity greater than the intensity produced by the contact of the non-fluorescent or low-fluorescent compounds with other metals. The fluorescent compounds may be used as sensors/detectors for mercury ions in various samples. Methods for detecting and calculating the concentration of mercury ions in samples are also disclosed.
    Type: Application
    Filed: October 1, 2014
    Publication date: April 7, 2016
    Applicant: DUQUESNE UNIVERSITY OF THE HOLY GHOST
    Inventors: Partha BASU, Igor PIMKOV, Kristine DEIBLER
  • Composition, synthesis, and use of new substituted pyran and pterin compounds
    Patent number: 9266889
    Abstract: The present invention relates to substituted pterin compounds, their synthesis and use. In particular, the present invention relates to a new precursor compound and its analogs for synthesizing a new substituted pterin compound and its analogs. These new compounds are particularly suitable for treating molybdenum cofactor deficiency.
    Type: Grant
    Filed: December 23, 2014
    Date of Patent: February 23, 2016
    Assignee: Duquesne University of the Holy Ghost
    Inventors: Partha Basu, Igor Pimkov
  • Bicyclic and tricyclic pyrimidine tyrosine kinase inhibitors with antitubulin activity and methods of treating a patient
    Patent number: 9139590
    Abstract: Bicyclic and tricyclic pyrimidine tyrosine kinase inhibitors with antitubulin activity are provided in the present invention. The compositions of the present invention possess dual activity in a single agent of potent vascular endothelial growth factor receptor inhibitory activity as well as antitubulin activity. Water soluble salts of these compositions are also described. Methods of treating a patient having cancer, macular degeneration, and arthritis with the compositions and salts thereof of the present invention are disclosed.
    Type: Grant
    Filed: February 2, 2012
    Date of Patent: September 22, 2015
    Assignee: Duquesne University of the Holy Spirit
    Inventor: Aleem Gangjee
  • COMPOSITION, SYNTHESIS, AND USE OF A NEW CLASS OF ISONITRILES
    Publication number: 20150239835
    Abstract: This invention relates to novel isonitriles, including arylthio isonitriles, and methods for their preparation. The isonitriles include a conjugated ring system. The structure is designed with the flexibility to have multiple substitution patterns. The isonitriles may be used in applications including, but not limited to, pharmaceutical compositions.
    Type: Application
    Filed: February 20, 2015
    Publication date: August 27, 2015
    Applicant: DUQUESNE UNIVERSITY OF THE HOLY GHOST
    Inventors: FRASER FERGUSSON FLEMING, Jesus Armando Lujan-Montelongo
  • COMPOSITION, SYNTHESIS, AND USE OF NEW ARYLSULFONYL ISONITRILES
    Publication number: 20150239833
    Abstract: This invention relates to novel isonitriles, including arylsulfonyl isonitriles, and methods for their synthesis. The isonitriles include a conjugated ring system. The structure is designed with the flexibility to have multiple substitution patterns. The isonitriles may be used in applications including, but not limited to, pharmaceutical compositions.
    Type: Application
    Filed: February 20, 2015
    Publication date: August 27, 2015
    Applicant: DUQUESNE UNIVERSITY OF THE HOLY GHOST
    Inventors: FRASER FERGUSSON FLEMING, Jesus Armando Lujan-Montelongo
  • COMPOSITION, SYNTHESIS, AND USE OF NEW SUBSTITUTED PYRAN AND PTERIN COMPOUNDS
    Publication number: 20150203497
    Abstract: The present invention relates to substituted pterin compounds, their synthesis and use. In particular, the present invention relates to a new precursor compound and its analogs for synthesizing a new substituted pterin compound and its analogs. These new compounds are particularly suitable for treating molybdenum cofactor deficiency.
    Type: Application
    Filed: December 23, 2014
    Publication date: July 23, 2015
    Applicant: DUQUESNE UNIVERSITY OF THE HOLY GHOST
    Inventors: Partha Basu, Igor Pimkov
  • Kinetic-based tool for biometric identification, verification, validation and profiling
    Publication number: 20150193653
    Abstract: A method for identifying an animal or human, including the steps of collecting and retaining an archive data set of measurements of two or more kinetic stylometrics of a first individual animal or human; collecting and retaining a test data set of measurements of the same two or more kinetic stylometrics of a test individual; and comparing archive and test data sets to determine similarity therefore, wherein similarity within any appropriate confidence interval confirms that the test individual and the first individual are the same. Using similar methods, social or other groups maybe kinetically stylometrically profiled for subsequent individual testing.
    Type: Application
    Filed: July 9, 2013
    Publication date: July 9, 2015
    Applicant: DUQUESNE UNIVERSITY OF THE HOLY SPIRIT
    Inventors: Patrick Juola, Michael Ryan
  • Tricyclic compounds having antimitotic and/or antitumor activity and methods of use thereof
    Patent number: 9056869
    Abstract: The present invention provides tricyclic compounds, pharmaceutically acceptable salts, prodrugs, solvates, or hydrates thereof, having antimitotic activity, anti-multidrug resistance activity, for example P-glycoprotein inhibition, and antitumor activity, and which inhibit paclitaxel sensitive and resistant tumor cells. Also provided are methods of utilizing these compounds for treating tumor cells and inhibiting mitosis of cancerous cells.
    Type: Grant
    Filed: June 2, 2011
    Date of Patent: June 16, 2015
    Assignee: Duquesne University of the Holy Spirit
    Inventor: Aleem Gangjee
  • Tricyclic compounds having antimitotic and/or antitumor activity and methods of use thereof
    Patent number: 9045489
    Abstract: The present invention provides tricyclic compounds, pharmaceutically acceptable salts, prodrugs, solvates, or hydrates thereof, having antimitotic activity, anti-multidrug resistance activity, for example P-glycoprotein inhibition, and antitumor activity, and which inhibit paclitaxel sensitive and resistant tumor cells. Also provided are methods of utilizing these compounds for treating tumor cells and inhibiting mitosis of cancerous cells.
    Type: Grant
    Filed: October 9, 2012
    Date of Patent: June 2, 2015
    Assignee: Duquesne University of the Holy Spirit
    Inventor: Aleem Gangjee
  • Methods of Using Selective Chemotherapeutic Agents for Targeting Tumor Cells
    Publication number: 20150126536
    Abstract: A method for treating cancer tumors, particularly ovarian cancer tumors, is described, where fused cyclic pyrimidine having a cancer treating ability is selectively delivered to an FR expressing cancerous tumor.
    Type: Application
    Filed: January 8, 2015
    Publication date: May 7, 2015
    Applicants: WAYNE STATE UNIVERSITY, DUQUESNE UNIVERSITY OF THE HOLY GHOST
    Inventors: Aleem Gangjee, Larry H. Matherly
  • Computer Security System and Method
    Publication number: 20150047037
    Abstract: The present invention is a computer security system and method in which the various algorithms not only do not search for or detect the presence of a steganographic or other hidden image in a data file or across data files, but also includes at least one or more combined approaches for altering and neutralizing any hidden messages without significantly detracting from the underlying integrity of the data file or files thus treated.
    Type: Application
    Filed: May 1, 2014
    Publication date: February 12, 2015
    Applicant: DUQUESNE UNIVERSITY OF THE HOLY SPIRIT
    Inventor: Charles Wood
  • Authorship Technologies
    Publication number: 20150046346
    Abstract: Novel distractorless authorship verification technology optionally combines with novel algorithms to solve authorship attribution as to an open set of candidates—such as without limitation by analyzing the voting of “mixture of experts” and outputting the result to a user using the following: if z (z=pi?pj?pi+pj?(pi?pj)2/n) is larger than a first predetermined threshold then author j cannot be the correct author; or if z (z=pi?pj?pi+pj?(pi?pj)2/n) is smaller than a second predetermined threshold then author i cannot be the correct author; or if no author garners significantly more votes than all other contenders then none of the named authors is the author of a document in question—in a number of novel applications. Personality profiling and authorship attribution may also be used to verify user identity to a computer.
    Type: Application
    Filed: May 4, 2012
    Publication date: February 12, 2015
    Applicant: Duquesne University of the Holy Spirit
    Inventors: Patrick Juola, James Orlo Overly, John Isaac Noecker, JR., Michael Ryan, Christine Gray
  • Methods of using selective chemotherapeutic agents for targeting tumor cells
    Patent number: 8952019
    Abstract: A method for treating cancer tumors, particularly ovarian cancer tumors, is described, where fused cyclic pyrimidine having a cancer treating ability is selectively delivered to an FR expressing cancerous tumor.
    Type: Grant
    Filed: September 6, 2013
    Date of Patent: February 10, 2015
    Assignees: Duquesne University of The Holy Ghost, Wayne State University
    Inventors: Aleem Gangjee, Larry H. Matherly
  • Substituted pyrrolo, -furano, and cyclopentylpyrimidines having antimitotic and/or antitumor activity and methods of use thereof
    Patent number: 8946239
    Abstract: The present invention provides substituted pyrrolo-, furano-, and cyclopentylpyrimidine bicyclic compounds of formula III, and 5,6-saturated and unsaturated and pharmaceutically acceptable salts, prodrugs, solvates, and hydrates thereof, having antimitotic activity, anti-multidrug resistance activity, such as for example P-glycoprotein inhibition, and antitumor activity, and which inhibit paclitaxel sensitive and resistant tumor cells. Also provided are methods of utilizing these compounds for treating tumor cells and inhibiting mitosis of cancerous cells.
    Type: Grant
    Filed: July 10, 2008
    Date of Patent: February 3, 2015
    Assignee: Duquesne University of the Holy Spirit
    Inventor: Aleem Gangjee
  • Composition, synthesis, and use of new substituted pyran and pterin compounds
    Patent number: 8946450
    Abstract: The present invention relates to substituted pterin compounds, their synthesis and use. In particular, the present invention relates to a new precursor compound and its analogs for synthesizing a new substituted pterin compound and its analogs. These new compounds are particularly suitable for treating molybdenum cofactor deficiency.
    Type: Grant
    Filed: January 7, 2013
    Date of Patent: February 3, 2015
    Assignee: Duquesne University of the Holy Ghost
    Inventors: Partha Basu, Igor Pimkov
  • Tricyclic compounds having cytostatic and/or cytotoxic activity and methods of use thereof
    Patent number: 8871776
    Abstract: The present invention provides tricyclic compounds having cytostatic and cytotoxic activity in a single molecule having receptor tyrosine kinase(s), dihydrofolate reductase, thymidylate synthase and/or dihydroorotate dehydrogenase inhibitory activity, which are useful as anti-angiogenic and anti-tumor agents. Also provided are methods of utilizing these inhibitors to treat tumor cells and other proliferative diseases and disorders.
    Type: Grant
    Filed: October 10, 2012
    Date of Patent: October 28, 2014
    Assignee: Duquesne University of the Holy Ghost
    Inventor: Aleem Gangjee
  • Substituted Cyclopenta Pyrimidine Bicyclic Compounds Having Antitmitotic And/Or Antitumor Activity And Methods Of Use Thereof
    Publication number: 20140303188
    Abstract: The present invention provides substituted cyclopenta and cyclopentyl pyrimidine bicyclic compounds of Formula III, and 5,6-saturated and unsaturated and pharmaceutically acceptable salts, prodrugs, solvates, and hydrates thereof, having antimitotic activity, anti-multidrug resistance activity, such as for example P-glycoprotein inhibition, and antitumor activity, and which inhibit paclitaxel sensitive and resistant tumor cells. Also provided are methods of utilizing these compounds for treating tumor cells and inhibiting mitosis of cancerous cells.
    Type: Application
    Filed: April 3, 2014
    Publication date: October 9, 2014
    Applicant: DUQUESNE UNIVERSITY OF THE HOLY SPIRIT
    Inventor: Aleem Gangjee