Patents Assigned to E. R. Squibb and Sons, Inc.
  • Trifluoromethyl mercaptan and mercaptoacyl derivatives and method of using same
    Patent number: 5414013
    Abstract: Compounds of the formula ##STR1## wherein Z is ##STR2## proline, pipecolic acid, an indolecarboxylic acid or an isoquinolinecarboxylic acid. These compounds are useful as cardiovascular agents.
    Type: Grant
    Filed: March 26, 1993
    Date of Patent: May 9, 1995
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Norma G. Delaney, George C. Rovnyak, Melanie J. Loots
  • Process for selecting an enantiomer of a hydroxy lactone using pseudomonas lipase
    Patent number: 5413935
    Abstract: An enantiomerically pure compound of the formula ##STR1## is prepared when the associated racemic mixture is reacted with an acrylating agent R.sup.3 --C(O)--O--R in the presence of a microorganism or enzyme derived therefrom capable of catalyzing transesterification of an alcohol. X.sup.1 and X.sup.2 are each independently halogen, R is alkyl, R.sup.1 and R.sup.2 are each independently alkyl, cycloalkyl, aralkyl or aryl and R.sup.3 is alkyl, cycloalkyl, aryl or aralkyl.
    Type: Grant
    Filed: March 24, 1993
    Date of Patent: May 9, 1995
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Ramesh N. Patel, Clyde G. McNamee, Laszlo J. Szarka
  • Process for preparing diprotected 2,3-hydroxymethyl cyclobutanol
    Patent number: 5412134
    Abstract: The protected cyclobutanone of the formula ##STR1## is treated with a dialkylaluminum chloride, an alkylaluminum dichloride, a trialkylaluminum compound, diphenylsilane in the presence of tris(triphenylphosphine) rhodium (I) chloride, or iridium tetrachloride to yield the corresponding diprotected cyclobutanol. This compound is useful as an intermediate in the preparation of antiviral agents.
    Type: Grant
    Filed: May 26, 1992
    Date of Patent: May 2, 1995
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Janak Singh, Gregory S. Bisacchi, Richard H. Mueller
  • Retractile penis device
    Patent number: 5409475
    Abstract: A retractile penis device comprises an apertured plate carrying an inflatable toroid ring, the ring being substantially aligned with the aperture and acting in use when inflated to apply pressure to the base of the penis and the surrounding skin area of the wearer.
    Type: Grant
    Filed: March 10, 1994
    Date of Patent: April 25, 1995
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Peter L. Steer
  • Methods for detecting candida albicans
    Patent number: 5405745
    Abstract: Isolated nucleic acid molecules capable of hybridizing to sequences of Candida albicans along with methods utilizing such probes for the detection of Candida albicans in clinical and other biological samples.
    Type: Grant
    Filed: December 17, 1991
    Date of Patent: April 11, 1995
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Jessica A. Gorman, Catherine A. Bingham
  • Indane and quinoline derivatives
    Patent number: 5401848
    Abstract: Novel indane and quinoline derivatives, useful, for example, as antiischemic agents, having the formula ##STR1## where A, X, R.sub.1 -R.sub.7 are as defined herein, are disclosed.
    Type: Grant
    Filed: October 15, 1991
    Date of Patent: March 28, 1995
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Karnail Atwal
  • Stereoselective preparation of halophenyl alcohols from ketones
    Patent number: 5393663
    Abstract: A process is described for selectively preparing a compound of the formula ##STR1## wherein: R.sup.1 is halogen;R.sup.2 is halogen, alkyl, cycloalkyl, aryl or ##STR2## and R.sup.3 hydrogen, alkyl, cycloalkyl, aryl, ##STR3## wherein the process comprises treating the associated ketone with an oxido-reductase or a microorganism comprising an oxidoreductase. Compounds prepared by this process are useful antipsychotic agents or useful intermediates therefor.
    Type: Grant
    Filed: April 14, 1993
    Date of Patent: February 28, 1995
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Ramesh N. Patel, Mark Liu, Amit Banerjee, Laszlo J. Szarka
  • Quinoxaline biphenyl angiotensin II inhibitors
    Patent number: 5380719
    Abstract: Angiotensin II inhibition is exhibited by ##STR1## wherein: X is --CH.sub.2 -- or O;R is hydrogen, alkyl, aryl, cycloalkyl, aralkyl, or cycloalkylalkyl;R.sup.1 and R.sup.2 are each independently O or absent;R.sup.3 is hydrogen, alkyl, alkenyl, alkoxy, cycloalkyl, aryl, aralkyl, cycloalkylalkyl, halo, haloalkyl, or haloalkoxy;R.sup.4 is hydrogen, alkyl, alkenyl, alkoxy, aryl, cycloalkyl, aralkyl, cycloalkylalkyl, --R.sup.8 --OH, or --R.sup.8 CO.sub.2 R.sup.9 ;and the remaining symbols are as defined in the specification.
    Type: Grant
    Filed: April 28, 1992
    Date of Patent: January 10, 1995
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Kyoung S. Kim
  • Flushable ostomy pouch with mechanical coupling
    Patent number: 5380309
    Abstract: The ostomy pouch has a coupling member that can be removed from the pouch envelope to permit flush disposal of the envelope without the coupling member. Flushability of the pouch is further enhanced by forming the pouch with converging side walls. Thus when the pouch is deposited in a toilet bottom end first in a carrier sleeve, the pouch can flow in streamlined fashion through the passages of a toilet and any sewer pipe or septic line connected to the toilet. Depending upon the flush capacity of the toilet and the flow rate of water through the toilet and sewer line, the ostomy pouch can be deposited in the toilet without a carrier sleeve.
    Type: Grant
    Filed: June 9, 1994
    Date of Patent: January 10, 1995
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Denis E. Keyes, Kenneth Johnsen
  • Non-peptidic angiotensin-II-receptor-antagonists
    Patent number: 5378704
    Abstract: Novel compounds having the formula ##STR1## wherein R.sub.1, R.sub.2, X and Y are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore, for example, as antihypertensive agents.
    Type: Grant
    Filed: April 15, 1992
    Date of Patent: January 3, 1995
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Harold N. Weller, III
  • Aryl and heteroaryl(phosphinylmethyl)phosphonate squalene synthetase inhibitors and method
    Patent number: 5374628
    Abstract: Phosphonic acid squalene synthetase inhibitors are provided which are effective in lowering serum cholesterol and have the formula ##STR1## wherein m is 0 to 3, n is 1 to 5, Y.sup.1 and Y.sup.2 are H or halogen, R.sup.2, R.sup.3 and R.sup.4 are H, metal ion, C.sub.1 to C.sub.8 alkyl, C.sub.3 to C.sub.12 alkenyl, or prodrug ester, and R.sup.1 is a substituted or unsubstituted heteroaryl group or a substituted phenyl group.
    Type: Grant
    Filed: October 18, 1993
    Date of Patent: December 20, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Scott A. Biller
  • Aryl urea (thiourea) and cyanoguanidine derivatives
    Patent number: 5374643
    Abstract: Novel compounds useful, for example, in the treatment of ischemic conditions and arrhythmia having the formula I ##STR1## wherein X is oxygen, sulfur or --NCN and the R groups are as defined herein.
    Type: Grant
    Filed: August 12, 1993
    Date of Patent: December 20, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Karnail S. Atwal, George C. Rovnyak
  • Indole- and benzimidazole-substituted imidazole and benzimidazole derivatives
    Patent number: 5374615
    Abstract: Novel compounds are disclosed having the formula ##STR1## wherein X, R.sub.1, R.sub.2, R.sub.3, R.sub.4, and R.sub.5 are substituents. These compounds inhibit the action of angiotensin II and are useful, therefore, for example, as antihypertensive agents.
    Type: Grant
    Filed: February 7, 1992
    Date of Patent: December 20, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Michael A. Poss
  • Ostomy pouch
    Patent number: 5370638
    Abstract: The ostomy pouch is formed of a flexible plastic material with a waste inlet opening and a gas outlet opening proximate the waste inlet opening. The gas outlet opening is of a configuration and size that resists entry of outside water into the pouch through the gas outlet opening. A filter aligned with the gas outlet opening is bonded at a peripheral zone surrounding the gas outlet opening, leaving an unbonded area that communicates with the gas outlet opening. A free face of the filter is gas impermeable. Gases within the pouch pass through an exposed, gas permeable peripheral edge of the filter toward the center and exit into the unbonded section for evacuation through the gas outlet opening.
    Type: Grant
    Filed: December 22, 1992
    Date of Patent: December 6, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Denis E. Keyes
  • Hydroxymethyl cyclobutyl purines
    Patent number: 5369098
    Abstract: Antiviral activity is exhibited by compounds having the formula ##STR1## and their pharmaceutically acceptable salts. R.sub.1 is ##STR2## R.sub.2 is hydrogen, --PO.sub.3 H.sub.2, ##STR3## wherein R.sub.3 is hydrogen, alkyl, substituted alkyl, or aryl, and R.sub.4 is alkyl.
    Type: Grant
    Filed: June 16, 1989
    Date of Patent: November 29, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: William A. Slusarchyk
  • Nitrogen-substituted mevinic acid derivatives useful as HMG-CoA reductase inhibitors
    Patent number: 5369123
    Abstract: Novel nitrogen-substituted mevinic acid derivatives which inhibit the activity of HMG-CoA reductase. Pharmaceutical compositions, and methods of use for the treatment or prevention of hypercholesterolemia, atherosclerosis, hyperlipoproteinaemia and hyperlipidemia are provided, as are novel methods for preparation and intermediate compounds.
    Type: Grant
    Filed: October 9, 1992
    Date of Patent: November 29, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Dinos P. Santafianos, Kathleen M. Poss, Eric M. Gordon, Peggy J. McCann
  • Method for inhibiting myocardial cell necrosis and preserving heart function during myocardial ischemia and/or reperfusion
    Patent number: 5354764
    Abstract: A method is provided for inhibiting myocardial cell necrosis and improving myocardial function during myocardial ischemia and/or reperfusion by locally administering to the heart a potent potassium channel activator such as pinacidil or cromakalim.
    Type: Grant
    Filed: November 2, 1992
    Date of Patent: October 11, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Gary J. Grover, Karnail Atwal
  • Membrane, e.g. for use in an ileostomy bag
    Patent number: 5352316
    Abstract: A method of making a gas-permeable liquid-impermeable membrane includes the steps of perforating a film of linear low density polyethylene (or other suitable polyolefin) in such a way as to yield an array of holes each having an average diameter of approximately 350, microns and then solution coating the needled film with a porous polyurethane material having pores of a pore size of 1 to 10 microns.Such a film is advantageously embodied in an ileostomy bag, and is fixed to a bag wall thereof in a location to prevent faecal material contacting the bag filter, by a heat or RF welding operation by which the polyolefin is welded to the bag wall which carries the filter. In use, the polyurethane is exposed to the bag contents, and permits gases to pass but prevents any liquid reaching the filter.
    Type: Grant
    Filed: August 19, 1991
    Date of Patent: October 4, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Graham E. Steer
  • Monoclonal antibodies which bind (E)-5- (2-bromovinyl)-arabinofuranosyluracil and diagnostic methods based thereon
    Patent number: 5352584
    Abstract: Monoclonal antibodies which bind (E)-5-(2-bromovinyl)-arabinofuranosyluracil and/or immunologically related compounds, hybrid cell lines which produce these monoclonal antibodies, and immunoassay methods for detecting (E)-5-(2-bromovinyl)-arabinofuranosyluracil and/or immunologically related compounds using these monoclonal antibodies.
    Type: Grant
    Filed: January 22, 1990
    Date of Patent: October 4, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Edward M. Croze, Jan-I Tu, Marc D. Ogan
  • Dihydropyrimidine derivatives
    Patent number: 5350752
    Abstract: Novel A-II receptor antagonists have the formula ##STR1## or its isomer ##STR2## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, and R.sub.6, are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore, for example, as antihypertensive agents.
    Type: Grant
    Filed: December 16, 1991
    Date of Patent: September 27, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Michael A. Poss, John Lloyd, Karnail S. Atwal