Patents Assigned to E. R. Squibb & Sons, Inc.
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Patent number: 6551794Abstract: Stable compositions containing biotinylated molecules, such as enzymes, are provided. The compositions include a biotinylated biomolecule, a biomolecule protectant, a buffer, a bulking agent selected from one or more water soluble, nonionic polymers and preferably a terminal sterilization protectant. The compositions can be utilized either as aqueous solutions or preferably in dried form, e.g., as a lyophilized, powder cake. They have applicability in any case where avidin/biotin technology is used and are particularly important as compositions containing a thrombin-like enzyme, e.g., for preparation of a fibrin monomer and fibrin monomer-based fibrin sealants.Type: GrantFiled: November 9, 1995Date of Patent: April 22, 2003Assignee: E. R. Squibb & Sons, Inc.Inventors: Steven James Burton, James C. Pearson, Peter A. D. Edwardson, Alan Menzies
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Patent number: 6387082Abstract: An ostomy appliance or wound drainage device having a receptacle side component including a receptacle for receiving and storing waste solids and fluids and a bodyside component for adhering to the patient's skin around the stoma in which the two components are releasably sealed together through a pealable, washable based coupling mechanism.Type: GrantFiled: September 1, 1999Date of Patent: May 14, 2002Assignee: E. R. Squibb & Sons, Inc.Inventor: Frank Freeman
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Patent number: 6284285Abstract: A method for isolating tissue repair promoting substances from human or animal blood, which method comprises collecting the human or animal blood from a single human or animal individual in a first container of a container system comprising at least first and second interconnected containers; centrifuging the container system containing said blood so as to separate the blood in various fractions including a plasma fraction; transferring at least part of the plasma fraction to said second container of the container system; subjecting the plasma fraction in said second container to a low temperature so as to obtain a precipitate comprising tissue repair promoting substances; concentrating said precipitate in said second container so as to obtain a first fraction comprising a major part of the non-precipitated material, and a second fraction comprising at least the major part of the precipitate and a minor part of the non-precipitated material; and separating said second fraction comprising the tissue repair proType: GrantFiled: December 29, 1992Date of Patent: September 4, 2001Assignee: E. R. Squibb & Sons, Inc.Inventor: Ulla Sivertsen Weis-Fogh
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Patent number: 6117885Abstract: Compounds of the formula ##STR1## wherein X, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, A, B, D and E are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore, for example, as antihypertensive agents.Type: GrantFiled: February 24, 1994Date of Patent: September 12, 2000Assignee: E. R. Squibb & Sons, Inc.Inventors: Denis Evan Ryono, John Lloyd
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Patent number: 6087349Abstract: A method is provided by blocking or preventing the prenylation of CAAX box containing proteins including ras oncogene products thereby preventing and/or treating ras-related tumors which includes the step of administering a therapeutically effective amount of a protein-prenyl transferase inhibitor.Type: GrantFiled: May 6, 1998Date of Patent: July 11, 2000Assignee: E. R. Squibb & Sons, Inc.Inventors: Scott A. Biller, Mariano Barbacid, Eric M. Gordon, David R. Magnin, Chester A. Meyers, Veeraswamy Manne
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Patent number: 6066773Abstract: A thin film device for medical applications such as a wound dressing including an occlusive layer having an edge portion about at least a portion of the thin film device and a non-continuous, hydrocolloid-containing polymeric support layer overlying the edge portion of the occlusive layer.Type: GrantFiled: August 25, 1995Date of Patent: May 23, 2000Assignee: E. R. Squibb & Sons, Inc.Inventor: Frank Freeman
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Patent number: 6046024Abstract: Compositions and methods for avidin immobilized on an inert support material, e.g. agarose, are disclosed. The compositions have high activity levels of avidin and may further include a bulking agent, e.g., maltose, and a protectant to maintain the stability and integrity of the avidin agarose during lyophilization and terminal sterilization processes. These compositions have applicability in any instance where avidin agarose and/or the avidin/biotin technology are useful. In particular, the present compositions are useful in an enzyme capture system to prepare fibrin monomer useful for fibrin sealants. The fibrin is prepared by subjecting a fibrinogen-containing composition to a biotinylated enzyme to convert the fibrinogen in the composition to a corresponding fibrin monomer. A fibrin monomer/biotinylated enzyme mixture is formed.Type: GrantFiled: August 1, 1997Date of Patent: April 4, 2000Assignee: E. R. Squibb & Sons, Inc.Inventors: Steven James Burton, James C. Pearson, Peter A. D. Edwardson
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Patent number: 6030794Abstract: The present invention provides mice which are deficient in the normal expression of one or more members of the RAR or RXR class of receptors, mice which are heterozygous for such deficiency, and to cell lines, preferably pluripotent or totipotent cell lines, which are heterozygous or homozygous for such deficiency. The present invention further provides the use of any of the above mice and cell lines in situations where the absence of at least one RAR or RXR receptor(s), or the normal expression thereof, is desirable.Type: GrantFiled: June 27, 1995Date of Patent: February 29, 2000Assignees: Institut National de la Sante et de la Recherche Medicale, Centre National de la Recherche Scientifique, Universite Louis Pasteur, E. R. Squibb & Sons, Inc.Inventors: Pierre Chambon, Thomas Lufkin, David Lohnes, Manuel Mark, Andree Dierich, Philippe Gorry, Philippe Kastner, Marianne Lemeur, Cathy Mendelsohn
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Patent number: 5968024Abstract: An ostomy appliance or wound drainage device having a lower end with an adhesive composition thereon so that when the lower end is folded upon itself, the drainage opening is closed off, or, alternatively, the lower end is made of a material having intrinsic adhesive properties.Type: GrantFiled: February 24, 1998Date of Patent: October 19, 1999Assignee: E. R. Squibb & Sons, Inc.Inventor: Frank Freeman
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Patent number: 5942406Abstract: Compositions and methods for avidin immobilized on an inert support material, e.g., agarose, are disclosed. The compositions have high activity levels of avidin and may further include a bulking agent, e.g., maltose, and a protectant to maintain the stability and integrity of the avidin agarose during lyophilization and terminal sterilization processes. A dry composition, and wet compositions such as a gel, slurry or suspension having avidin immobilized on an inert support material are disclosed. The dry composition has at least 1000 biotin binding units of activity, and the wet compositions have at least 50 units of binding activity. These compositions have applicability in any instance where avidin agarose and/or the avidin/biotin technology are useful. In particular, the present compositions are useful in an enzyme capture system to prepare fibrin monomer useful for fibrin sealants.Type: GrantFiled: August 1, 1997Date of Patent: August 24, 1999Assignee: E. R. Squibb & Sons, Inc.Inventors: Steven James Burton, James C. Pearson, Peter A. D. Edwardson
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Patent number: 5859239Abstract: Compounds of the formula ##STR1## wherein X.sub.1 is ##STR2## are disclosed. These compounds possess inhibitory activity against angiotensin converting enzyme and neutral endopeptidase and thus useful as cardiovascular agents.Type: GrantFiled: September 30, 1997Date of Patent: January 12, 1999Assignee: E. R. Squibb & Sons, Inc.Inventors: Donald S. Karanewsky, Jeffrey A. Robl
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Patent number: 5859187Abstract: Inhibition of UL42 stimulation of herpesvirus DNA polymerase activity is exhibited by novel compounds of the formulasW'--A.sub.1 --A.sub.2 --A.sub.3 --A.sub.4 --A.sub.5 --A.sub.6 --A.sub.7 --A.sub.8 --A.sub.9 --A.sub.10 --A.sub.11 --X ?SEQ. ID NO: 1!andY'--A.sub.12 --A.sub.13 --A.sub.14 --A.sub.15 --A.sub.16 --A.sub.17 --Z ?SEQ. ID NO: 2!that are useful as antiviral agents.Type: GrantFiled: January 29, 1992Date of Patent: January 12, 1999Assignee: E. R. Squibb & Sons, Inc.Inventors: James T. Matthews, Katerina Leftheris, Robert K. Hamatake, John T. Stevens, Mary L. Haffey
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Patent number: 5856476Abstract: Processes are disclosed for preparing the azepine intermediates of the formula ##STR1## These intermediates can be reacted with acylmercaptocarboxylic acids of the formula ##STR2## to give the pharmaceutically active products.Type: GrantFiled: October 8, 1997Date of Patent: January 5, 1999Assignee: E. R. Squibbs & Sons, Inc.Inventor: Jeffrey A. Robl
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Patent number: 5856477Abstract: The azepine intermediates of the formula ##STR1## wherein R.sub.6 and R.sub.7 are other than hydrogen are disclosed. These intermediates can be reacted with acylmercaptocarboxylic acids of the formula ##STR2## to give the pharmaceutically active products.Type: GrantFiled: July 30, 1996Date of Patent: January 5, 1999Assignee: E. R. Squibb & Sons, Inc.Inventor: Jeffrey A. Robl
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Patent number: 5830200Abstract: It would be desirable to have improved designs of ostomy couplings which embody a springy or resilient split ring as a locking ring.In an ostomy coupling, first and second coupling members 50, 60 are held together by a springy flexible split locking ring 70. A plurality of tabs 71 symmetrically arranged on each limb of the locking ring 70, can be withdrawn generally radially outwardly by an upward pull on the locking ring to permit separation of the two coupling members. The ring 70 is generally circular in its unstressed condition.Type: GrantFiled: April 12, 1996Date of Patent: November 3, 1998Assignee: E. R. Squibb & Sons, Inc.Inventors: Peter L. Steer, Keith G. M. Hollands, Graham Emery Steer, Ronald A. Plass, Howard Barratt
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Patent number: 5827868Abstract: Thromboxane receptor antagonist activity is exhibited by compounds of the formula ##STR1## wherein: V is --(CH.sub.2).sub.m --, --O--, or ##STR2## but if V is --O--or ##STR3## R.sup.3 and R.sup.4 must complete an aromatic ring; W is --(CH.sub.2).sub.2 --, --CH.dbd.CH-- or phenylene;X is a single bond, --CH.dbd.CH--, --(CH.sub.2).sub.n --, or --O--(CH.sub.2).sub.n --; or X is branched alkylene or --O--branched alkylene wherein W is linked to Y through a chain n carbon atoms long;Y is --CO.sub.2 H, --CO.sub.2 alkyl, --CO.sub.2 alkali metal, --CH.sub.2 OH, --CONHSO.sub.2 R.sup.5, --CONHR.sup.6, or --CH.sub.2 -5-tetrazolyl;Z is O or NH;R.sup.3 and R.sup.4 are each independently hydrogen or alkyl or R.sup.3 and R.sup.4 together complete a ring optionally substituted through a ring carbon with a halo, lower alkyl, phenyl, halo (lower alkyl), halophenyl, oxo or hydroxyl group; and the remaining symbols are as defined in the specification.Type: GrantFiled: October 7, 1991Date of Patent: October 27, 1998Assignee: E. R. Squibb & Sons, Inc.Inventors: Raj N. Misra, Jagabandhu Das, Steven E. Hall, Wen-Ching Han, Philip M. Sher, Philip D. Stein
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Patent number: 5811292Abstract: Methods for the enzymatic resolution of mixtures of enantiomers, such as .beta.-lactam compounds, which may be employed as intermediates in the preparation of taxanes such as taxol, the latter useful in the pharmaceutical field.Type: GrantFiled: August 1, 1996Date of Patent: September 22, 1998Assignee: E. R. Squibb & Sons, Inc.Inventors: Ramesh N. Patel, Laszlo J. Szarka, Richard A. Partyka
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Patent number: 5789197Abstract: Nucleic acid sequences, particularly DNA sequences, coding for all or part of the high molecular weight subunit of microsomal triglyceride transfer protein, expression vectors containing the DNA sequences, host cells containing the expression vectors, and methods utilizing these materials. The invention also concerns polypeptide molecules comprising all or part of the high molecular weight subunit of microsomal triglyceride transfer protein, and methods for producing these polypeptide molecules. The invention additionally concerns novel methods for preventing, stabilizing or causing regression of atherosclerosis and therapeutic agents having such activity. The invention concerns further novel methods for lowering serum liquid levels and therapeutic agents having such activity.Type: GrantFiled: June 7, 1995Date of Patent: August 4, 1998Assignee: E. R. Squibb & Sons, Inc.Inventors: John R. Wetterau, II, Daru Young Sharp, Richard E. Gregg
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Patent number: 5776933Abstract: Novel aminediol compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds in inhibiting retroviral protease, particularly useful in the treatment and/or prevention of HIV infection (AIDS).Type: GrantFiled: May 31, 1995Date of Patent: July 7, 1998Assignee: E. R. Squibb & Sons, Inc.Inventors: Eric M. Gordon, Joel C. Barrish, Gregory S. Bisacchi, Chong-Qing Sun, Joseph A. Tino, Gregory D. Vite, Robert Zahler
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Patent number: 5760036Abstract: Novel aminediol compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds in inhibiting retroviral protease, particularly useful in the treatment and/or prevention of HIV infection (AIDS).Type: GrantFiled: May 31, 1995Date of Patent: June 2, 1998Assignee: E. R. Squibb & Sons, Inc.Inventors: Eric M. Gordon, Joel C. Barrish, Gregory S. Bisacchi, Chong-Oing Sun, Joseph A. Tino, Gregory D. Vite, Robert Zahler