Patents Assigned to E. R. Squibb & Sons, Inc.
  • Aminediol protease inhibitors
    Patent number: 5559256
    Abstract: Novel aminediol compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds in inhibiting retroviral protease, particularly useful in the treatment and/or prevention of HIV infection (AIDS).
    Type: Grant
    Filed: June 25, 1993
    Date of Patent: September 24, 1996
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Eric M. Gordon, Joel C. Barrish, Gregory S. Bisacchi, Chong-Qing Sun, Joseph A. Tino, Gregory D. Vite, Robert Zahler
  • Microbial reduction of benzazepines and benzothiazepine derivatives
    Patent number: 5559017
    Abstract: A novel process comprises reducing a benzazepine or benzothiazepine at the 3-position in d-cis configuration by treatment with reductase-supplying microorganisms or enzymes derived therefrom. The process can be catalyzed in a single stage by growing microbial cultures or in a two-stage fermentation/transformation by resting cell-suspensions. The enzymes derived from the microorganisms can be used in free state or immobilized form. The microorganisms and enzymes catalyzes the specific reduction with 90 to 99% conversion efficiency to 99% or greater optical purity of the desired enantiomer.
    Type: Grant
    Filed: November 19, 1990
    Date of Patent: September 24, 1996
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Ramesh N. Patel, Laszlo J. Szarka, Richard H. Mueller
  • Method for site-directed mutagenesis
    Patent number: 5556747
    Abstract: A method for site-directed mutagenesis using a third mutagenic primer in a polymerase chain reaction (PCR) based methodology.
    Type: Grant
    Filed: July 9, 1990
    Date of Patent: September 17, 1996
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Ramesh Kumar
  • Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase
    Patent number: 5552397
    Abstract: Compounds of the formula ##STR1## are disclosed as possessing inhibitory activity against angiotensin converting enzyme (ACE) and neutral endopeptidase (NEP) and thus being useful as cardiovascular agents. Processes for preparing these compounds are also disclosed.
    Type: Grant
    Filed: December 1, 1993
    Date of Patent: September 3, 1996
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Donald S. Karanewsky, Jeffrey A. Robl
  • Substituted stryl heterocyclic amido prostaglandin analogs
    Patent number: 5550248
    Abstract: Prostaglandin analogs useful in treating thrombotic and vasospastic disease having the structural formula ##STR1## wherein: C.sub.m H.sub.p is an alkylene chain wherein m is 0, 1, 2, or 3 and p=(2.times.m)-1, except that when m is 0, p is also 0;n is 0, 1, 2 or 3;R is CO.sub.2 R', CH.sub.2 OH, CONHSO.sub.2 R.sup.3, CONHR.sup.4, or --CH.sub.2 --5--tetrazolyl;R' is hydrogen, alkyl, or alkali metal;X is O or NH;Y is --O--, a single bond or vinylene, except that Y cannot be --O-- when n is 0;and the remaining symbols are as defined in the specification.
    Type: Grant
    Filed: November 29, 1990
    Date of Patent: August 27, 1996
    Assignee: E.R. Squibb & Sons, Inc.
    Inventor: Raj N. Misra
  • Coupling device for ostomy pouch
    Patent number: 5549588
    Abstract: The coupling device for an ostomy pouch includes a flexible, deflectable, annular force transmitter member joined to an abdominal mounting plate that has a coupling member. The force transmitter member can be pulled in a direction away from the mounting plate during coupling of an ostomy pouch. The force transmitter member can thus oppose and neutralize a coupling force that is directed to the mounting plate and protect the abdomen from receiving the pressure due to the coupling force.
    Type: Grant
    Filed: August 12, 1994
    Date of Patent: August 27, 1996
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Kenneth A. Johnsen
  • Ostomy device
    Patent number: 5545154
    Abstract: The hydrocolloid disk includes a polyethylene/PVDC film backing. The disk adheres to the acrylic adhesive layer of the collar over a large portion of the surface area of the disk. The collar is formed of a EVA/polyethylene perforated film on a polyethylene non-woven. In the one piece embodiment, the collar is secured directly to the pouch. In the two piece embodiment, the collar is secured directly to the coupling ring. Increased strength, better odor protection and improved breathability are achieved.
    Type: Grant
    Filed: December 28, 1994
    Date of Patent: August 13, 1996
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Gary E. Oberholtzer
  • Diol sulfonamide and sulfinyl renin inhibitors
    Patent number: 5545838
    Abstract: Compounds of the formula ##STR1## wherein Z is SO or SO.sub.2 possess renin inhibition activity and are useful in treating hypertension and other diseases where the reduction of the levels of circulating angiotensin II are beneficial.
    Type: Grant
    Filed: January 27, 1992
    Date of Patent: August 13, 1996
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Michael A. Poss
  • Process for the preparation of intermediates useful in the preparation of pyranyl cyanoguanidine derivatives
    Patent number: 5536833
    Abstract: A process for preparing compounds of the formula ##STR1## where a, b, c, R.sub.1, R.sub.2, and R.sub.3 are as defined herein including the step of alkylating a phenol of formula ##STR2## with an acetylene of formula ##STR3## where X is chlorine; bromine; --OC(O)--R.sub.5, where R.sub.5 is alkyl, aryl or substituted aryl; or --OCO.sub.2 R.sub.6, where R.sub.6 is alkyl or ##STR4## in the presence of a catalytic amount of a cuprous or cupric salt. The compounds of formula I are intermediates useful in the preparation of pyranyl cyanoguanidine derivatives.
    Type: Grant
    Filed: May 26, 1995
    Date of Patent: July 16, 1996
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Jollie D. Godfrey, Jr., Richard H. Mueller, Thomas C. Sedergran, Nachimuthu Soundararajan
  • Pseudomonas fluorescens lipase
    Patent number: 5534427
    Abstract: Nucleic acid sequences, particularly DNA sequences, coding for all or part of a lipase of Pseudomonas fluorescens, wherein said lipase has the amino acid sequence encoded by the nucleotide sequence of the BamHI/HindIII insert of the plasmid pRJ-Ltac1 from Escherichia coli BL21/pRJ-Ltac1 deposited with the American Type Culture Collection, expression vectors containing the DNA sequences, host cells containing the expression vectors, and methods utilizing these materials. The invention also concerns polypeptide molecules comprising all or part of a lipase of Pseudomonas fluorescens, wherein said lipase has the amino acid sequence encoded by the nucleotide sequence of the plasmid pRJ-Ltac1 from Escherichia coli BL21/pRJ-Ltac1 BamHI/HindIII insert of deposited with the American Type Culture Collection, and methods for producing these polypeptides.
    Type: Grant
    Filed: July 31, 1992
    Date of Patent: July 9, 1996
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Robert M. Johnston, Steven L. Goldberg, Paul M. Cino
  • Male incontinence device
    Patent number: 5531725
    Abstract: An improved male incontinence comprises a condom located within a hollow tubular applicator open at both ends, in which a strip of tape having a medical grade adhesive on one surface and a release layer strip on the other surface is arranged in a helically wound configuration within the condom with the adhesive engaging the inner surface of the condom and the release layer strip located radially inwardly of the adhesive, there being a pull-cord or equivalent attached to a free end of the release layer strip so that upon removal thereof, the adhesive is exposed and can be brought into contact with the penis of the wearer in order to securely attach the device.
    Type: Grant
    Filed: February 2, 1995
    Date of Patent: July 2, 1996
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Graham E. Steer
  • Callus cell induction from partially submerged explant tissue in liquid medium for preparation of taxanes
    Patent number: 5527702
    Abstract: A method for the induction of callus cells capable of producing taxanes from explant tissue by partially submerging the explant tissue in a liquid culture medium on a membrane raft, resulting in callus formation. The induction of callus cells by this method provides direct transfer of the cells formed to a liquid medium for a suspension cell culture preparation of taxanes. Thus, there is no need of a separate growth or proliferation step in the method of this invention. Furthermore, callus cells can be produced by the method; and also disclosed is a method for the use of the callus cells so produced in a suspension cell culture preparation for taxanes.
    Type: Grant
    Filed: February 23, 1994
    Date of Patent: June 18, 1996
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Paul M. Cino, Steven R. Schwarz, Dana L. Cazzulino
  • Process for the preparation of an antiviral agent
    Patent number: 5525726
    Abstract: Racemic Feist's acid is treated with (R)-(+) -.alpha.-methylbenzylamine to yield (1R-trans)-3-methylene -cyclopropane-1,2-dicarboxylic acid, (R)-.alpha.-methylbenzyl-amine (1:1) salt. This salt can then be converted to (1R-trans)-3-methylene-1,2-cyclopropanedicarboxylic acid, dimethyl ester which is an intermediate in the preparation of the antiviral agent [1R-(1.alpha.,2.beta.,3.alpha.)]-2-amino-9-[2,3-bis(hydroxymethyl)cyclobut yl]-1,9-dihydro-6H-purin-6-one. The improved process also enables the recovery of racemic Feist's acid from the resolution.
    Type: Grant
    Filed: November 12, 1993
    Date of Patent: June 11, 1996
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Jollie D. Godfrey, Jr., Richard H. Mueller, Thomas P. Kissick, Janak Singh
  • Self-aligning ostomy device
    Patent number: 5520670
    Abstract: The ostomy device includes a waste collection pouch and an adhesive faceplate adapted to mount the pouch to the body, adjacent the stoma. To attach the pouch to the faceplate, coupling rings, mounted respectively on each part, are aligned and snapped together. A hook member provided on the vertical centerline of the faceplate has a planar top surface which cooperates with a laterally extending elongated element located on the vertical centerline of the pouch to allow the pouch to swing to a position where the couplng rings are aligned to facilitate coupling of the rings. The hook may also have a mechanism to lock the pouch element, acting as an auxilary connection.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: May 28, 1996
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: John L. Blum
  • Dispensing device for dispensing at least two fluids
    Patent number: 5520658
    Abstract: A dispensing device for dispensing at least two fluids comprises a housing (12,22) of a pistol-like configuration having an integral handle (50), in which a spring-biased trigger (60) is received. Within the housing (12,22) of the dispensing device (10), two syringes (80,81) are received and fixated, which syringes contain respective fluids to be accurately dispensed. Provided a cover (22) of the housing is closed, the motion of the trigger (60) relative to the handle (50) is transmitted to a toothed rack which cooperates with a propeller body (70) in a ratchet-like manner. The ratchet-like cooperation allows a uni-directional motion of the propeller body (70) and prevents a motion of the propeller body (70) in the opposite direction.
    Type: Grant
    Filed: December 12, 1994
    Date of Patent: May 28, 1996
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Niels E. Holm
  • Process for preparing [IR-(1.alpha.,2.beta.-3.alpha.)]-2-amino-9-[2,3-bis(hydroxymethyl)cyclob utyl]-1,9-dihydro-6H-purin-6-one
    Patent number: 5516903
    Abstract: The protected cyclobutanone of the formula ##STR1## is treated with a dialkylaluminum chloride, an alkylaluminum dichloride, a trialkylaluminum compound, hydrogen in the presence of the catalysts ruthenium black or ruthenium on alumina, diphenyl-silane in the presence of tris(triphenylphosphine) rhodium (I) chloride, or iridium tetrachloride to yield the corresponding diprotected cyclobutanol. This compound is useful as an intermediate in the preparation of antiviral agents.
    Type: Grant
    Filed: November 4, 1994
    Date of Patent: May 14, 1996
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Janak Singh, Gregory S. Bisacchi, Richard H. Mueller
  • Aminocarbonyl (thiocarbonyl) and cyanoguanidine derivatives of quinoline and indoline
    Patent number: 5514690
    Abstract: Novel compounds having potassium channel activating activity and useful, for example, as antiischemic agents are disclosed. These compounds have the general formula ##STR1## wherein A is ##STR2## or a single bond to complete an indoline nucleus; X is --O--, --S-- or --NCN; and the R groups are as defined herein.
    Type: Grant
    Filed: August 24, 1993
    Date of Patent: May 7, 1996
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Karnail S. Atwal, Francis N. Ferrara
  • Pyridine anchors for HMG-CoA reductase inhibitors
    Patent number: 5506219
    Abstract: Compounds which are useful as inhibitors of cholesterol biosynthesis and thus as hypocholesterolemic agents are provided which have a quinoline or a pyridine anchor attached by means of a linker to a binding domain sidechain, which compounds inhibit the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
    Type: Grant
    Filed: March 7, 1995
    Date of Patent: April 9, 1996
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Jeffrey A. Robl
  • Hydrocolloid wound gel
    Patent number: 5503847
    Abstract: A hydrocolloid wound gel composition useful for cleansing an debriding wounds and having some capacity for absorbing wound exudate and a method of treating wounds comprising applying the hydrocolloid wound gel to a wound.The composition includes sodium carboxymethylcellulose, pectin, propylene glycol and water.
    Type: Grant
    Filed: April 15, 1993
    Date of Patent: April 2, 1996
    Assignee: E. R. Squibb and Sons, Inc.
    Inventors: Douglas Queen, Lesley A. Chambers, Simon M. Adams, Hugh Delargy
  • Kit for administering radiologic material to an ostomate and method of use
    Patent number: 5503625
    Abstract: A radiology kit for use with a catheter includes a first connection member 20 for attachment to the skin of the patient around the stomal orifice and a second connection member 30 (a cap) constructed for releasable attachment to a first connection means, i.e. a rib 23, on the first connection member. The cap has an end wall 33 with a hole 39 therein through which a catheter 40 can be threaded. A third connection member 50 of the kit is attached to a drainage sleeve 52 and constructed for releasable attachment to a second connection means, i.e. a rib 25 on the first connection member 20.
    Type: Grant
    Filed: October 31, 1994
    Date of Patent: April 2, 1996
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Ronald A. Plass