Patents Assigned to E. R. Squibb & Sons, Inc.
  • Ostomy coupling
    Patent number: 5261708
    Abstract: An ostomy coupling has first and second coupling elements. One has a flange carrying a wall upstanding therefrom, the free end of this wall having an inwardly or outwardly extending sealing and latching member. The other coupling element has an inner (second) annular wall surrounding a stomal orifice and, radially outwardly therefrom, a third annular wall. The second or the third annular wall carries a projection arranged to cooperate with the free end of the sealing and latching member. The inner or outer surface of the first annular wall as the case may be and a confronting surface of the second or the third annular wall are tapered in a complementary manner.
    Type: Grant
    Filed: March 27, 1991
    Date of Patent: November 16, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Peter L. Steer
  • Paramagnetic metalloporphyrins as contrast agents for magnetic resonance imaging
    Patent number: 5262532
    Abstract: Porphyrin-complex compounds useful as contrast agents in magnetic resonance imaging (MRI) having the formula ##STR1## where Y is a transition metal such as Fe.sup.III, Cr.sup.III, Mn.sup.III, Mn.sup.II and Cu.sup.II, X is a biologically well-tolerated metal complexing anion such as Cl.sup.-, CF.sub.3 SO.sub.3 or CF.sub.3 COO.sup.- and R is a nonionic water solubilizing moiety.
    Type: Grant
    Filed: July 22, 1991
    Date of Patent: November 16, 1993
    Assignee: E.R. Squibb & Sons, Inc.
    Inventors: Michael F. Tweedle, Lon J. Wilson, Joseph E. Bradshaw, Daniel W. Lee
  • Combination of pravastatin and nicotinic acid or related acid and method for lowering serum cholesterol using such combination
    Patent number: 5260305
    Abstract: A pharmaceutical combination is provided which includes an inhibitor of the enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, which is pravastatin and a pharmaceutical which reduces serum cholesterol and/or inhibits cholesterol biosynthesis by a mechanism other than inhibiting production of the enzyme HMG CoA reductase, namely, nicotinic acid (niacin) or related acid. A method for reducing serum cholesterol or inhibiting formation of or treating atherosclerosis using the above combination without causing drug-induced myopathy or rhabdomyolysis, is also provided.
    Type: Grant
    Filed: June 18, 1992
    Date of Patent: November 9, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Leonard G. Dennick
  • Method for preparing 7-oxabicycloheptyl substituted bromooxazole amide prostaglandin analog intermediates useful in the preparation of anti-thrombotic and anti-vasospastic compounds
    Patent number: 5260449
    Abstract: A method is provided for preparing bromooxazole intermediates of the structure ##STR1## wherein a vinyl compound of the structure ##STR2## wherein X.sup.1 and X.sup.2 are independently H and Br, is treated with a metal halide such as cupric bromide, and a base such as 1,8-diazabicyclo-[5.4.0]undec-7-ene (DBU). The resulting bromooxazole may be hydrolyzed and hydrogenolyzed to the final anti-thrombotic-anti-vasospastic compounds.
    Type: Grant
    Filed: August 12, 1992
    Date of Patent: November 9, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Janak Singh, Richard H. Mueller, Jagabandhu Das, Philip M. Sher
  • Method for preparing 7-oxabicycloheptyl substituted heterocyclic amide prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease
    Patent number: 5260448
    Abstract: A method is provided for preparing 7-oxabicycloheptyl substituted heterocyclic amide prostaglandin analogs which are thromboxane A.sub.2 (TXA.sub.2) receptor antagonists or combined thromboxane A.sub.2 receptor antagonists/thromboxane synthetase inhibitors useful, for example, in the treatment of thrombotic and/or vasospastic disease, wherein a vinyl bromide of the formula, for example, ##STR1## wherein m, n, R.sup.1 and R.sup.2 are as defined herein is treated with a cyclizing agent to form the corresponding oxazole.
    Type: Grant
    Filed: June 18, 1992
    Date of Patent: November 9, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Jagabandhu Das, David Kronenthal
  • Intermediates for the preparation of optically active cyclobutane nucleoside
    Patent number: 5256806
    Abstract: Novel intermediates useful in the preparation of the optically active antiviral compound [1R-(1.alpha.,2.beta.,3.alpha.)]-2-amino-9-[2,3-bis(hydroxymethyl)cyclobut yl]-1,9-dihydro-6H-purin-6-one are described.
    Type: Grant
    Filed: November 12, 1992
    Date of Patent: October 26, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Gregory S. Bisacchi, Toomas Mitt
  • Sulfur-containing HMG-COA reductase inhibitors
    Patent number: 5256692
    Abstract: Novel sulfur-containing compounds which inhibit the activity of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, having a sulfur-containing side-chain bonded to a hydrophobic anchor group through an acetylenic or ethylenic linkage. Pharmaceutical compositions, and methods of use for the treatment or prevention of hypercholesterolemia, atheroschlerosis, hyperlipoproteinaemia and hyperlipidemia are provided, as are novel methods for preparation and intermediate compounds.
    Type: Grant
    Filed: January 7, 1992
    Date of Patent: October 26, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Eric M. Gordon, Jelka Pluscec
  • Method for inhibiting myocardial cell necrosis and preserving heart function during myocardial ischemia and/or reperfusion
    Patent number: 5256688
    Abstract: A method is provided for inhibiting myocardial cell necrosis and improving myocardial function during myocardial ischemia and/or reperfusion by locally administering to the heart a potent potassium channel activator such as pinacidil or cromakalim.
    Type: Grant
    Filed: October 29, 1991
    Date of Patent: October 26, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Gary J. Grover, Karnail Atwal
  • Acyl amidine and acyl guanidine substituted biphenyl derivatives
    Patent number: 5256695
    Abstract: Novel compounds are disclosed having the formula ##STR1## where A is ##STR2## and wherein R.sub.1, R.sub.2 and R.sub.3 are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore, for example, as antihypertensive agents.
    Type: Grant
    Filed: September 16, 1992
    Date of Patent: October 26, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Michael A. Poss
  • Hydroxyphosphinyl phosphonate squalene synthetase inhibitors and method
    Patent number: 5254544
    Abstract: Hydroxyphosphinyl phosphonate compounds are provided which inhibit the enzyme squalene synthetase and thereby inhibit cholesterol biosynthesis. These compounds have the formula ##STR1## wherein R.sup.2, R.sup.3 and R.sup.4 are independently H, alkyl, metal ion or a prodrug ester; and R.sup.1 is a lipophilic group which contains at least 6 carbons and is alkyl, alkenyl, alkynyl, mixed alkenylalkynyl, a hetero-containing moiety as defined herein, or a phenylalkyl or phenylalkenyl group including those containing a biphenyl group.
    Type: Grant
    Filed: September 25, 1992
    Date of Patent: October 19, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Scott A. Biller, John K. Dickson, Jr.
  • Heteroaryl derivatives of monocyclic beta-lactam antibiotics
    Patent number: 5250691
    Abstract: Compounds having the formula ##STR1## exhibiting antibacterial activity.
    Type: Grant
    Filed: September 9, 1991
    Date of Patent: October 5, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Henner Straub, Jakob-Matthias Drossard
  • Ostomy bag with filter combination
    Patent number: 5250042
    Abstract: An ostomy bag having a stomal aperture to receive a stoma in one wall of the bag and a gas venting aperture in the bag with a filter element covering the gas venting aperture, the bag including an intervening membrane disposed between the front rear walls of the bag and between the stomal aperture and the gas venting aperture. The intervening membrane is liquid impermeable and gas permeable and supports an adequate flow rate of gas for ostomy bag applications. The intervening membrane preferably comprises a polytetrafloroethylene, microporous semi-permeable membrane laminated to a thermoplastic film layer which is heat sealable to the walls of the bag.
    Type: Grant
    Filed: February 20, 1990
    Date of Patent: October 5, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Anil M. Torgalkar, Frank S. Castellana
  • Aminoalkylphosphonic acid esters of natural 4-methoxy-5-methyl-pyran-3-ol and derivatives thereof
    Patent number: 5248790
    Abstract: Antibiotic substances having the general formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are as defined herein.
    Type: Grant
    Filed: June 30, 1992
    Date of Patent: September 28, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Uwe D. Treuner
  • Process for preparing a cis oxabicyclo olefinic acid and ester from an oxabicyclo pyranol
    Patent number: 5245055
    Abstract: A compound having the structure ##STR1## is reacted with Ph.sub.3 P.dbd.CH(CH.sub.2).sub.3 Y wherein Y is --CO.sub.2 .sup..crclbar. M.sup..sym. or --C.tbd.N to form ##STR2## which is aminated and esterified to form ##STR3## which may be used to form [1S-[1.alpha.,2.alpha.(Z),3.alpha., 4.alpha.[[-7-[3-[[[[1-oxoheptyl) -amino]acetyl]amino]methyl]-7-oxabicyclo-[2.2.1]-hept-2-yl]-5-heptenoic acid.
    Type: Grant
    Filed: December 18, 1990
    Date of Patent: September 14, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: David Kronenthal, Robert Waltermire
  • Heterocyclic amido prostaglandin analogs
    Patent number: 5238951
    Abstract: Prostaglandin analogs useful in treating thrombotic and vasospastic disease having the structural formula ##STR1## wherein: m is 1, 2, or 3;n is 0, 1, 2 or 3;R is CO.sub.2 R', CH.sub.2 OH, CONHSO.sub.2 R.sub.hu 3, CONHR.sup.4, or --CH.sub.2 -5-tetrazolyl;R' is hydrogen, alkyl, or alkali metal;X is O or NH;Y is --O--, a single bond or vinylene, except that Y cannot be --O-- when n is 0 and if Y is vinylene, then n=0; ##STR2## and the remaining symbols are as defined in the specification.
    Type: Grant
    Filed: August 20, 1992
    Date of Patent: August 24, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Philip M. Sher
  • Process for the preparation of an antiviral agent
    Patent number: 5237096
    Abstract: Racemic Feist's acid is treated with (R)-(+)-.alpha.-methylbenzylamine to yield (1R-trans)-3-methylenecyclopropane-1,2-dicarboxylic acid, (R)-.alpha.-methylbenzylamine (1:1) salt. This salt can then be converted to (1R-trans)-3-methylene-1,2-cyclopropanedicarboxylic acid, dimethyl ester which is an intermediate in the preparation of the antiviral agent [1R-(1.alpha.,2.beta.,3.alpha.)]-2-amino-9-[2,3-bis(hydroxymethyl)cyclobut yl]-1,9-dihydro-6H-purin-6-one. The improved process also enables the recovery of racemic Feist's acid from the resolution.
    Type: Grant
    Filed: October 16, 1992
    Date of Patent: August 17, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Jollie D. Godfrey, Jr., Richard H. Mueller, Thomas P. Kissick, Janak Singh
  • Oxadiazinone substituted indole and benzimidazole derivatives
    Patent number: 5236916
    Abstract: Novel compounds having the formula ##STR1## wherein X, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore, for example, as antihypertensive agents.
    Type: Grant
    Filed: May 26, 1992
    Date of Patent: August 17, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Harold N. Weller, III, Michael A. Poss
  • Process for the preparation of an antiviral agent
    Patent number: 5237095
    Abstract: Racemic Feist's acid is treated with (R)-(+)-.alpha.-methylbenzylamine to yield (1R-trans)-3-methylenecyclopropane-1,2-dicarboxylic acid, (R)-.alpha.-methylbenzylamine (1:1) salt. This salt can then be converted to (1R-trans)-3-methylene-1,2-cyclopropanedicarboxylic acid, dimethyl ester which is an intermediate in the preparation of the antiviral agent [1R-(1.alpha.,2.beta.,3.alpha.)]-2-amino-9-[2,3-bis(hydroxymethyl)cyclobut yl]-1,9-dihydro-6H-purin-6-one. The improved process also enables the recovery of racemic Feist's acid from the resolution.
    Type: Grant
    Filed: October 16, 1992
    Date of Patent: August 17, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Jollie D. Godfrey, Jr., Richard H. Mueller, Thomas P. Kissick, Janak Singh
  • Method for treating Parkinson's disease employing quinine
    Patent number: 5236932
    Abstract: A method is provided for treatment of Parkinson's disease or controlling movement of a Parkinsonian patient by administering an ATP-sensitive potassium channel blocker, such as a sulfonyl urea, (for example, tolbutamide), or quinine.
    Type: Grant
    Filed: November 18, 1991
    Date of Patent: August 17, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Susan A. Greenfield, Denyse Levesque
  • Substitute indole and benzimidazole derivatives
    Patent number: 5234923
    Abstract: Novel compounds are disclosed having the formula ##STR1## or its isomer ##STR2## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and X are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore, for example, as antihypertensive agents.
    Type: Grant
    Filed: December 16, 1991
    Date of Patent: August 10, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Michael A. Poss, Karnail S. Atwal