Abstract: Clinical information, molecular information and/or computer-generated morphometric information is used in a predictive model for predicting the occurrence of a medical condition. In an embodiment, a model predicts whether a patient is likely to have a favorable pathological stage of prostate cancer, where the model is based on features including one or more (e.g., all) of preoperative PSA, Gleason Score, a measurement of expression of androgen receptor (AR) in epithelial and stromal nuclei and/or a measurement of expression of Ki67-positive epithelial nuclei, a morphometric measurement of a ratio of area of epithelial nuclei outside gland units to area of epithelial nuclei within gland units, and a morphometric measurement of area of epithelial nuclei distributed away from gland units. In some embodiments, quantitative measurements of protein expression in cell lines are utilized to objectively assess assay (e.g.
Type:
Grant
Filed:
August 28, 2009
Date of Patent:
October 3, 2017
Assignee:
FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD
Inventors:
Michael Donovan, Faisal Khan, Jason Alter, Gerardo Fernandez, Ricardo Mesa-Tejada, Douglas Powell, Valentina Bayer Zubek, Stefan Hamann, Carlos Cordon-Cardo, Jose Costa
Abstract: A particle dispersion and the display devices in which the dispersion may be incorporated are provided. The particle dispersion includes a dispersion medium, one or more types of particle groups that are dispersed in the dispersion medium that may differ based on color and/or charge, and counter-ions oppositely charged than the one or more particle groups. The particle groups and counter-ions are moved in the dispersion medium according to an electric field formed in the dispersion medium. The one or more types of particle groups are configured such that the total amount of charges of one type of particle group (a) among the one or more types of particle groups is greater than a total amount of charges of the counter-ions that are charged with a polarity opposite to that of the particle group (a).
Abstract: An electro-optic display comprises, in order, a light-transmissive electrically-conductive layer; a layer of a solid electro-optic material; and a backplane (162) bearing a plurality of pixel electrodes, a peripheral portion of the backplane extending outwardly beyond the layer of solid electro-optic material and bearing a plurality of radiation generating means (166) and a plurality of radiation detecting means (168), the radiation generating means and radiation detecting means together being arranged to act as a touch screen.
Type:
Grant
Filed:
June 16, 2014
Date of Patent:
October 3, 2017
Assignee:
E Ink Corporation
Inventors:
Holly G. Gates, Robert W. Zehner, Russell J. Wilcox, Matthew J. Aprea
Abstract: A multi-color display device has front and rear electrodes on opposed sides of an electrophoretic medium. The device has a voltage controller configured to apply a first and a smaller second potential difference, of either polarity, between the electrodes. The electrophoretic medium has first, second, and third species of particles of differing colors and charge polarities. The first and second particles move independently of one another in response to the first potential difference, but upon application of the second potential difference form charged aggregates, moving as a unit, having an aggregate color different from the first and second colors.
Type:
Grant
Filed:
December 9, 2016
Date of Patent:
October 3, 2017
Assignee:
E Ink Corporation
Inventors:
Stephen J. Telfer, Richard J. Paolini, Jr., George G. Harris, Isaac W. Moran, Alain Bouchard
Abstract: The present invention is directed to an electrophoretic fluid which comprises additive particles. The concentration of the additive particles in the electrophoretic fluid is 2.5% to 25% by weight and the additive particles are not seen at the viewing side during operation of the display. The resulting fluid can improve optical performance of a display device, such as image stability and contrast ratio. The present invention is also directed to an electrophoretic display comprising the electrophoretic fluid.
Type:
Grant
Filed:
January 21, 2016
Date of Patent:
October 3, 2017
Assignee:
E INK CALIFORNIA, LLC
Inventors:
Ming Wang, Yu Li, Hui Du, Xiaojia Zhang, Haiyan Gu, Roman Ivanov, Robert A. Sprague, HongMei Zang
Abstract: Provided is a driving device of a display medium, including an application unit that applies a voltage with a pulse width corresponding to a density of a color to be displayed to each of plural pixels of a display medium in which plural kinds of particle groups having different movement starting voltages for movement between a pair of substrates according to an electric field and different colors are enclosed, and a controller that controls the application unit so that a first voltage with a pulse width corresponding to a density of a color of a first particle group finishes being applied to each of the plural pixels, and then a second voltage with a pulse width corresponding to a density of a color of a second particle group is applied thereto.
Abstract: Methods and compositions for modulating shoot apical meristem size are provided. Methods are provided for modulating the expression of fea3 sequence in a host plant or plant cell to modulate agronomic characteristics such as altered size and number of organs, including plant seeds.
Type:
Application
Filed:
June 2, 2017
Publication date:
September 28, 2017
Applicants:
E I Du Pont De Nemours and Company, Cold Spring Harbor Laboratory
Inventors:
Stephen M. Allen, David Peter Jackson, Byoung IL Je, Mai Komatsu, Young Koung Lee, Hajime Sakai
Abstract: This invention relates to polynucleotide sequences encoding genes that can confer resistance to the plant pathogen Colletotrichum, which causes anthracnose stalk rot, leaf blight and top dieback in corn and other cereals. It further relates to plants and seeds of plants carrying chimeric genes comprising said polynucleotide sequences, which enhance or confer resistance to the plant pathogen Colletotrichum, and processes of making said plants and seeds. The invention further presents sequences that can be used as molecular markers that in turn can be used to identify the region of interest in corn lines resulting from new crosses and to quickly and efficiently introgress the genes from corn lines carrying said genes into other corn lines that do not carry said genes, in order to make them resistant to Colletotrichum and resistant to stalk rot.
Abstract: Shoe having a transversal air passageway comprising a shoe sole (4) and an upper (1) and a lower (3) pliable parts for enclosing a foot of the user of the shoe, wherein the shoe further comprises a peripheral band (2) formed in the shape of a closed line and formed in a resilient material, wherein the upper and lower parts are attached by their outer edges to opposing faces of said peripheral band along its length, and wherein the lower part is attached to the shoe sole in both the front and back parts of the shoe, but not in a part between the front and back parts of the shoe, such that a transversal air passageway (5) is formed from the medial part to the lateral part of the shoe, between the front and the back parts of the shoe, and between the shoe sole and the lower part.
Type:
Application
Filed:
April 22, 2015
Publication date:
September 28, 2017
Applicant:
SFI Brand - Comercio E Distribuicao, LDA
Abstract: The present invention relates to an industrialized construction process of at least part of a structure (1) to be constructed, by applying it, for example, to bridge decks, in which the filling material (8) is poured in situ on empty segments (3) prefabricated ex situ.
Type:
Application
Filed:
July 29, 2015
Publication date:
September 28, 2017
Applicant:
PGPI - MARCAS E PATENTES, S.A
Inventors:
Pedro Alvares Ribeiro DO CARMO PACHECO, David Fernandes MARTINS RAMOS, Diogo Teixeira GRACA MOURA, Hugo Edgar Norberto SOARES COELHO, Pedro Henrique BAPTISTA BORGES
Abstract: A display apparatus includes a light permeable substrate, dummy pixels, a peripheral wiring layer and a display element layer. The dummy pixels are disposed on the light permeable substrate. Each of the dummy pixels includes a dummy pattern controlling layer. The peripheral wiring layer is disposed on the light permeable substrate for applying voltages having the same polarity to the dummy pattern controlling layers. The display element layer covers the light permeable substrate and the dummy pixels. The peripheral wiring layer and the dummy pattern controlling layer are spaced apart by a gap. The gap allows light to be reflected from the display element layer to the light permeable substrate.
Abstract: Processes for producing low nitrogen, essentially nitride-free chromium or chromium plus niobium-containing nickel-based alloys include charging elements or compounds which do not dissolve appreciable amounts of nitrogen in the molten state to a refractory crucible within a vacuum induction furnace, melting said elements or compounds therein under reduced pressure, and effecting heterogeneous carbon-based bubble nucleation in a controlled manner. The processes also include, upon cessation of bubble formation, adding low nitrogen chromium or a low nitrogen chromium-containing master alloy with a nitrogen content of below 10 ppm to the melt, melting and distributing said added chromium or chromium-containing master alloy throughout the melt, bringing the resulting combined melt to a temperature and surrounding pressure to permit tapping, and tapping the resulting melt, directly or indirectly, to a metallic mold and allowing the melt to solidify and cool under reduced pressure.
Type:
Grant
Filed:
November 5, 2014
Date of Patent:
September 26, 2017
Assignee:
Companhia Brasileira de Metalurgia e Mineração
Abstract: Compositions comprising cellulase and at least one poly alpha-1,3-glucan ether compound having a degree of substitution with an organic group of about 0.05-3.0 are disclosed. Such compositions can be dry or aqueous, the latter of which can have a viscosity of at least about 10 cPs. The disclosed composition can be in the form of a personal care product, household product, or industrial product, for example. Also disclosed are a method for preparing an aqueous composition comprising cellulase and a poly alpha-1,3-glucan ether compound, and a method of treating a material such as fabric by contacting it with this aqueous composition.
Type:
Grant
Filed:
June 17, 2015
Date of Patent:
September 26, 2017
Assignee:
E I DU PONT DE NEMOURS AND COMPANY
Inventors:
Kevin D Nagy, Perry G Caimi, T Joseph Dennes, Susan Marie Hennessey, Ayrookaran J. Poulose, Jayme L Paullin
Abstract: A stamped resistive element for use in electrical equipment, manufacturing process of stamped resistive element and apparatus equipped with stamped resistive element are provided. The stamped resistive element is produced from a stamping process and is intended to be used in replacement of conventional helical electrical resistances, whether in hair dryers and similar equipment or in other types of heating equipment. The stamped resistive element is produced as a blank from a metal sheet presenting a known resistive coefficient.
Type:
Application
Filed:
June 6, 2017
Publication date:
September 21, 2017
Applicant:
ACTION TECHNOLOGY INDUSTRIA E COMERCIO DE ELETROEL ETRONICOS LTDA.
Abstract: A vertical takeoff and landing aircraft (101) for transporting persons or loads, including a plurality of preferably equivalent and redundant electric motors (3) and propellers (2), substantially arranged in one surface, wherein each propeller is assigned an individual electric motor to drive the propeller, the aircraft being characterized in that at least one attitude sensor is provided for attitude control of the aircraft (101) in an active signal connection to at least one signal processing unit which is designed or set up to automatically perform the attitude control based on measurement data from the attitude sensor by regulating the speed of at least some of the electric motors (3), preferably with signal actions of the speed controller assigned to each electric motor such that the aircraft (101) is positioned in space with the surface defined by the propeller (2) substantially horizontal at all times, without control input by a pilot or a remote control.
Type:
Application
Filed:
May 29, 2017
Publication date:
September 21, 2017
Applicant:
e-volo GmbH
Inventors:
Thomas Senkel, Stephan Wolf, Alexander Zosel
Abstract: An enhanced septic system includes a storage tank having an inlet that receives liquid gray water from a standard septic system having at least one digester and a pump located in the storage tank. The pump is coupled to an actuator to selectively provide power to the pump from a power supply to pump the gray water from the storage tank when the gray water reaches a predetermined level within the storage tank. The system also includes an outlet pipe coupled to the storage tank and to receive gray water pumped from the storage tank by the pump, at least one ultraviolet light in communication with the outlet pipe, and a detector to determine when the pump is actuated and to turn on the at least one ultraviolet light upon actuation of the pump.
Abstract: A tendon stripper includes a stripping device and a rod. The stripping device includes a stripping member and at least one coupling member coupling to the stripping member. The stripping member has a blade portion and a separating portion separating the stripping member into several parts. The rod has a handle end and a coupling end opposite to the handle end. The coupling end couples to the coupling member of the stripping device. The separating portion allows the stripping member to be divided into first and second parts, and the first and second parts can be combined to each other to jointly receive the tendon. This avoids the generation of the incisions during the tendon transplantation. In addition, since the tendon stripper does not require any instrument for retaining the free end of the tendon, a convenient surgical procedure is provided.