Abstract: Apparatus and methods are provided for treating diseases that produce elevated intraocular pressures, such as glaucoma, wherein the device includes a housing shell defining a cavity between a first end and a second end of the housing shell, and an elastic membrane disposed within the cavity to divide the cavity into a fluidic channel that permits a flow of fluid from the first end to the second end and a sealed cavity. The elastic membrane deforms to change the volume of the sealed cavity responsive to pressure fluctuations between the first and second ends, thereby varying the fluidic resistance of the flow of fluid through the fluidic channel.

Abstract: The invention relates to a nanoplasma switch device, comprising: —multiple electrically isolated electrodes; —a gap separating the two electrodes; wherein the gap has a width which is dimensioned to effect the generation of a plasma by electric-field electron emission.

Abstract: The present invention relates to a photodetector array for capturing image data, comprising: —photodetector cells arranged on a substrate, each including a single-photon avalanche diode, wherein the active areas of the photodetector cells are neighbored along a hexagonal grid; —microlenses, having a hexagonal or circular shape, each arranged on one photodetector cell to focus light onto the photodiode.

Abstract: A method and a setup for light detection and ranging are disclosed. The setup is configured to carry out the following method: generating signal radiation at multiple signal frequencies with an optical signal source, wherein the signal radiation exhibits random signal modulations preferably at each of the multiple signal frequencies, splitting the signal radiation into a target radiation part and a reference radiation part, directing the target radiation part towards a target, detecting a target signal, wherein the target signal is associated with a reflected portion of the target radiation part being reflected from the target, detecting a reference signal, wherein the reference signal is associated with the reference radiation part, and deriving at least one ranging information parameter from the target signal and the reference signal.

Abstract: The present disclosure relates to a microfluidic device comprising: a substrate; a culture chamber (130); a loading channel (170) in fluid communication with the culture chamber; at least one auxiliar channel (170-1, 5 170-2) extending from and in fluid communication with the loading channel, wherein the at least one auxiliary channel is so dimensioned such that a hydraulic resistance in the at least one auxiliary channel is higher than a hydraulic resistance in the loading channel; a test area (150) defined along the loading channel at a position between the loading channel and the at least one auxiliary channel; a first medium reservoir (110) in fluid communication with a first side of the test area; and a second medium reservoir (120) in fluid communication with a second side of the test area, the second side being different from the first side.

Abstract: A light microscope has a light source for illuminating a specimen, a sensor array comprised of photon-counting detector elements for measuring detection light coming from the specimen, and a control device for controlling the sensor array. The control device is configured for flexibly binning the photon-counting detector elements into one or more super-pixels.

Abstract: A system for privacy-preserving distributed training of a global model on distributed datasets has a plurality of data providers being communicatively coupled. Each data provider has a local model and a local training dataset for training the local model using an iterative training algorithm. Further it has a portion of a cryptographic distributed secret key and a corresponding collective cryptographic public key of a multiparty fully homomorphic encryption scheme. All models are encrypted with the collective public key. Each data provider trains its local model using the respective local training dataset, and combines the local model with the current global model into a current local model. A data provider homomorphically combines current local models into a combined model, and updates the current global model based on the combined model. The updated global model is provided to at least a subset of the other data providers.

Abstract: A photonic assembly, a laser setup having the photonic assembly and a method for performing frequency-modulated continuous-wave light detection and ranging using the laser setup are disclosed. The photonic assembly has an active photonic chip, a photonic modulator chip, and a tuning arrangement having a modulation element having a thickness of 10 micrometers or less. The active photonic chip and the photonic modulator chip are optically coupled such, that injection radiation at an optical feedback wavelength is generated, which defines at least one optical lasing wavelength at which the optical radiation is emitted by the active photonic chip. The modulation element is arranged such, that an actuation of the modulation element tunes the optical feedback wavelength via the Pockels effect, such, that a tuning of the optical feedback wavelength entails a tuning of the optical lasing wavelength.

Abstract: The invention relates to an image sensor comprising a photodetector array including neighboring photodetector elements, each photodetector element comprising: —a photodetector cell having a photodiode and a reset unit; —a cell control unit coupled with the photodetector cell and configured to reset the photodiode by means of the reset unit; wherein the cell control unit is configured to asynchronously effect resetting of the photodiode after a given dead time after detection of a photon.

Abstract: The invention relates to a scaffold material comprising a plurality of particles of a highly porous polymeric material, characterized in that said scaffold material becomes a shapeable paste once hydrated. The specific features of the particle material impart a special behavior to the scaffold, which can be easily shaped and even highly reversibly compressed, so that in certain aspects it can, if needed, be injected, said capacity to be shaped being maintained over a high range of hydration conditions. A particular aspect of the invention relates, therefore, to the use of such scaffold material for the manufacturing of shapeable body implants, such as breast implants, to the shapeable body implants themselves as well as to non-invasive methods for using thereof in creating or reconstructing a three-dimensional volume in a subject's body part.

Abstract: Apparatus and methods are provided for treating diseases that produce elevated intraocular pressures, such as glaucoma, wherein the device includes a housing shell defining a cavity between a first end and a second end of the housing shell, and an elastic membrane disposed within the cavity to divide the cavity into a fluidic channel that permits a flow of fluid from the first end to the second end and a sealed cavity. The elastic membrane deforms to change the volume of the sealed cavity responsive to pressure fluctuations between the first and second ends, thereby varying the fluidic resistance of the flow of fluid through the fluidic channel.

Abstract: Peptides that specifically bind erythrocytes are described. These are provided as peptidic ligands having sequences that specifically bind, or as antibodies or fragments thereof that provide specific binding, to erythrocytes. The peptides may be prepared as molecular fusions with therapeutic agents, tolerizing antigens, or targeting peptides. Immunotolerance may be created by use of the fusions and choice of an antigen on a substance for which tolerance is desired.

Abstract: The invention describes a composition containing a) a functionalized polymer (10) that comprises at least one polymer segment (13) and at least two polymer aggregating segments (11,12) capable of forming non-covalent bonds based on a supramolecular interaction, b) an aggregating additive (20) that comprises at least one additive aggregating segment (21) capable of forming non-covalent bonds based on the same supramolecular interaction as the polymer aggregating segments (11,12), wherein the polymer aggregating segments (11,12) and the additive aggregating segment (21) are ditopic, wherein the polymer aggregating segments (11,12) and the additive aggregating segment (21) are designed such that they can form aggregates (31) that contain polymer aggregating segments (11,12) and additive aggregating segments (21), and wherein the aggregating additive (20) has a molecular weight of from 50 g/mol to 2000 g/mol.

Abstract: A device (100) is provided for treating diseases that produce elevated intraocular pressures, such as glaucoma, wherein the device (100) includes a housing shell (101) defining a cavity (107) between a first end (102) and a second end (104) of the housing shell (101), and an elastic membrane (110) disposed within the cavity (107) to divide the cavity (107) into a fluidic channel (106) that permits a flow of fluid from the first end (102) to the second (104) end and a sealed cavity (112). The elastic membrane (110) deforms to change the volume of the sealed cavity (107) responsive to pressure fluctuations between the first and second ends (102, 104), thereby varying the fluidic resistance of the flow of fluid through the fluidic channel (106).

Abstract: A method for characterizing a dynamic occupancy of a space by two opposing teams of a game, including a movable sporting accessory, such as a ball, a puck or a shuttlecock, each team including at least one player. The method makes it possible to determine, for each player and for all or some of the points on the pitch, a value representative of how far in advance the player is to the point of the pitch, the representative value being computed by a comparison between the duration of movement of the player to the point of the pitch and the duration of movement of a distinct player and/or of the sporting accessory to the same point. A system is also provided for characterizing a dynamic occupancy of a space by two opposing teams of a game, implementing the method.

Abstract: The simplification of neural network models is described. For example, a method for simplifying a neural network model includes providing the neural network model to be simplified, defining a first temporal filter for the conveyance of input from a neuron to an other spatially-extended neuron along the arborized projection, defining a second temporal filter for the conveyance of input from yet another neuron to the spatially-extended neuron along the arborized projection, replacing, in the neural network model, the first, spatially-extended neuron with a first, spatially-constrained neuron and the arborized projection with a first connection extending between the first, spatially-constrained neuron and the second neuron, wherein the first connection filters input from the second neuron in accordance with the first temporal filter and a second connection extending between the first spatially-constrained neuron and the third neuron.

Abstract: This disclosure relates to a rail pad including a pad matrix having a first material and at least one damping element at least partially encapsulated or embedded in the pad matrix. The damping element includes a second material. The second material includes at least one damping element having a damping factor tan delta greater than or equal to 0.5 in the audible frequency of 1000 Hz. Methods for producing the rail pad are also disclosed.

Abstract: Peptides that specifically bind erythrocytes are described. These are provided as peptidic ligands having sequences that specifically bind, or as antibodies or fragments thereof that provide specific binding, to erythrocytes. The peptides may be prepared as molecular fusions with therapeutic agents, tolerizing antigens, or targeting peptides. Immunotolerance may be created by use of the fusions and choice of an antigen on a substance for which tolerance is desired. Fusions with targeting peptides direct the fusions to the target, for instance a tumor, where the erythrocyte-binding ligands reduce or entirely eliminate blood flow to the tumor by recruiting erythrocytes to the target.

Abstract: The present invention relates to a bicistronic expression vector for silencing a gene specifically in astrocytes and neurons, comprising two expression cassettes comprising a first and a second silencer sequence, respectively, wherein the expression of said first silencer sequence within astrocytes is regulated by an astrocyte-specific promoter and the expression of said second silencer sequence within neurons is regulated by a neuron-specific promoter. In a preferred embodiment, said first and second silencer sequences are SOD1 silencer sequences. Pharmaceutical composition comprising said bicistronic vector and the use of the same in the treatment of motoneuron diseases are further described.

Abstract: A spring (3, 3?) comprising a plurality of elements (30), each element (3) comprising a rigid portion (31) and a flexible beam (32), the extremities (320, 321) of the flexible beam being supported by the rigid portion (31), the flexible beam (32) having a single stable position, so that the flexible beam can be deformed when a pressure is exerted between said extremities in the direction of the rigid portion (31), and returns to said single stable position when the pressure is released, and wherein the rigid portion (31) of at least one element (30) is in contact with the flexible beam (32) of the next element between said extremities (320, 321) of the flexible beam (32), so that the spring has a negative stiffness over an operating range. The arrangement ensures a pure radial compression/expansion of the spring.