Abstract: The particle (1) is suitable for the manufacture of an implantable soft tissue engineering material and comprises: a three-dimensionally warped and branched sheet (2) where (i) the three-dimensionally warped and branched sheet (2) is made from a biocompatible material having a Young's modulus of 1 kPa to 1 GPa; (ii) the three-dimensionally warped and branched sheet (2) has an irregular shape which is encompassed in a virtual three-dimensional envelope (3) having a volume VE; (iii) the three-dimensionally warped and branched sheet (2) has a mean sheet thickness T; iv) the three-dimensionally warped and branched sheet (2) has a volume VS; (v) the particle (1) has a Young's modulus of 100 Pa to 15 kPa; and (vi) the particle (1) further comprises a number of protrusions where the three-dimensionally warped and branched sheet (2) reaches the envelope (3); (vii) the particle (1) has a number of interconnected channel-type conduits (5) defined by the branching of the sheet (2) and/or by voids in the sheet (2); and (

Abstract: A light pulse source and method for generating repetitive optical pulses are described. The light pulse source includes a continuous wave cw laser device, an optical waveguide optically coupled with the laser device, an optical microresonator, and a tuning device. The optical microresonator coupling cw laser light via the waveguide into the microresonator, which, may include, a light field in a soliton state with soliton shaped pulses coupled out of the microresonator for providing the repetitive optical pulses. The laser device includes a chip based semiconductor laser, the microresonator and/or the waveguide may reflect an optical feedback portion of light back to the semiconductor laser, which may provide self-injection locking relative to a resonance frequency of the microresonator. The tuning device is arranged for tuning at least one of a driving current and a temperature of the semiconductor laser such that the microresonator may provide the soliton state.

Abstract: The present invention relates to a free-standing single crystalline diamond part and a single crystalline diamond part production method. The method includes the steps of: —providing a single crystalline diamond substrate or layer; —providing a first adhesion layer on the substrate or layer; —providing a second adhesion layer on the first adhesion layer: —providing a mask layer on the second adhesion layer; —forming at least one indentation or a plurality of indentations through the mask layer and the first and second adhesion layers to expose a portion or portions of the single crystalline diamond substrate or layer; and—etching the exposed portion or portions of the single crystalline diamond substrate or layer and etching entirely through the single crystalline diamond substrate or layer.

Abstract: The present invention relates to systems and methods for planning and/or providing neuromodulation. An example system includes a first data input module for stimulation related basic data, a second data input module for stimulation related response data, a transfer module configured and arranged such that the stimulation related basic data received by the data input module are linked and/or translated into and/or with the response data and/or artificial response data created by the transfer module, wherein the data generated by the transfer module are transfer data, the transfer data comprising link data and/or translation data and/or artificial response data, and a mapping module configured and arranged such that based on the stimulation related basic data and stimulation related response data and the transfer data a digital characteristic map is generated, which describes an interrelation between the stimulation related basic data and the stimulation related response data and the transfer data.

Abstract: Sensor system comprising a frame supporting a force-sensing tip arranged to generate a signal based upon a force applied by said force-sensing tip to a material to be tested, the system further comprising: an input drum mounted in said frame such that it can rotate about an input axis of rotation; an output lever supported by said frame by means of an output revolute joint defining an output axis of rotation; wherein said force-sensing tip is mounted on said output lever such that said force-sensing tip is arranged to be brought into contact with a material to be tested; and wherein said sensor system comprises a mechanical transmission arranged to kinematically link said input drum to said output lever such that a rotation of said input drum about said input axis of rotation causes said output lever to pivot in an oscillatory manner about said output axis of rotation.

Abstract: The invention discloses a system and method to obtain a set of corrected projected patterns from an integrated 3D measurement system so that the solidification of the formed object appears at the same time in a volumetric printer such as a tomographic back-projection or multi-beam printer, hence ensuring that the object is formed with the highest fidelity and spatial resolution.

Abstract: The present invention relates to a Semiconductor device including a first electrode, a second electrode and at least one semiconductor material or layer between the first and second electrode. The semiconductor device further includes at least one field plate structure for increasing a breakdown voltage of the semiconductor device. The at least one field plate structure comprises at least two recesses in the at least one semiconductor material or layer, the at least two recesses defining a semiconductor region therebetween, and a third electrode contacting or provided on the semiconductor region.

Abstract: The present invention provides compositions and methods for down-modulating the expression and/or the immuno-suppressive activity of i) the FMRP protein, ii) an mRNA encoding the FMRP protein, and/or iii) the FMR1 gene for the treatment and/or prevention of primary cancer and/or cancer metastasis in a subject in need thereof.

Abstract: Data transformer apparatus comprising at least a dispatcher module (D), a reader module (R), a converter module (C) and a writer module (W). The dispatcher module (D) is configured to: receive a data transformation request (DTR) including: a first information item (X1) associated to a memory address where data to be transformed (Data1) are stored and to a type attribute (T) of said data to be transformed (Data1); a second information item (X2) indicating a memory address where transformed data (Data2), obtained from said data to be transformed (Data1), have to be written. The reader module (R) is configured to: retrieve the data to be transformed, according to said first information item (X1); obtain the type attribute (T) of the data to be transformed (Data1), based on said first information item (X1); send the data to be transformed (Data1) and the type attribute (T) thereof to the converter module (C).

Abstract: A biosensor includes a source element; a drain element; a semiconductor channel element between the source element and the drain element for forming an electrically conductive channel with adjustable conductivity between the source and drain elements; a first gate element configured to be electrically biased to set a given operational regime of the sensor with given electrical conductivity of the channel; and a second gate element, physically separate from the first gate element, configured to contact a solution comprising analytes allowed to interact with a gate contact surface of the second gate element to generate a surface potential change dependent on the concentration of the analytes in the solution. The channel element is substantially fully depleted allowing the first and second gate elements to be electrostatically coupled such that the surface potential change at the second gate element is configured to modify the electrical conductivity of the channel.

Abstract: The present relates to a carbon material having a 3D structure and made of graphene oxide and carbon nanotubes, characterized in that the 3D structure consists in that the carbon nanotubes are located with some agglomeration between the graphene oxide layers so as to extend the spacing between the graphene oxide layers.

Abstract: A fully wearable system used for communication and information transfer between two users or between a user and a machine to render an effective and intuitive physical interface for combined input and output functions, the fully wearable system including a bidirectional wearable skin including distributed actuator and sensing elements, the actuator and sensing elements including a multimodal actuation layer and a sensing layer, the bidirectional wearable skin being flexible and stretchable, and a portable control device for controlling the distributed actuator and sensing elements, and reading signals from the sensing layer, the portable control device is configured to perform pixilated actuation for both micro- and macrostimulation of a body of a wearer by an actuation frequency and stimulation amplitude.

Abstract: The present invention concerns an elongated capacitive sensor for fluid monitoring. The sensor comprising: a fibre support made of a dielectric material or dielectric composite material; and a first electrode and a second electrode arranged longitudinally along the fibre support, the first and second electrodes forming together with the fibre support a capacitive sensing element whose capacitance is dependent upon one or more electrical properties of one or more materials inside the support and/or outside the support, and/or is dependent upon a change of materials configuration and associated overall change of one or more electrical properties inside the support and/or outside the support.

Abstract: The invention concerns an ophthalmic lens having an increased resistance to thermal and hygroscopic stresses, said ophthalmic lens comprising a substrate, at least one main face of which is coated with a siloxane-based anti-abrasion hardcoat, characterized in that said ophthalmic lens further comprises at least one protective layer of an organic-inorganic material directly in contact with said hardcoat, said protective layer of organic-inorganic material having a Young's modulus higher than 20 GPa, preferably of at least 25 GPa.

Abstract: A method for producing a three-dimensional object comprising computing a sequence of back-projections describing the three-dimensional object to be formed from different orientation angles of the object, defining a sequence of patterns of light using the back-projections, and irradiating with each of the patterns of light at the respective corresponding orientation angle. According to the defined sequence, a photoresponsive material is capable of altering its material phase, upon irradiation by light, thereby creating a three-dimensional distribution of alterations within the photoresponsive medium which physically reproduces the three-dimensional object, thereby creating the three-dimensional object.

Abstract: Systems and methods are provided for that use noninvasively measured physiologic parameters to predict in real time noninvasively unobservable cardiovascular parameters by employing a one-dimensional arterial tree numerical model calibrated with representative patient data. The numerical model further may be trained and calibrated on a larger database that includes synthetic data using machine-learning algorithms to provide a robust generalized estimator for multiple cardiovascular and hemodynamic parameters.

Abstract: The present relates to a Metal hydride compressor control method for generating a variable output pressure P_desired_outPut, comprising a first step of inflowing gaseous hydrogen into a metal hydride compartment at a constant temperature and then stopping the gaseous hydrogen inflow, a second step of heating the metal hydride to a predetermined temperature which corresponds to a temperature which passes through the ?+? phase at the desired output pressure P_desired_output, a third step of opening the output connection of the compressor and keeping it at a constant pressure by regulating the temperature to keep a constant output pressure P_desired_outPut until the system completely leaves the ?+? phase.

Abstract: A polymer-based optoelectronic interface comprises an elastomeric substrate (10) and a plurality of discrete photovoltaic pixel elements (20) disposed on top of the substrate. Each pixel element comprises at least one active layer comprising a semiconducting polymer or polymer mixture. The pixel elements are excitable by light to generate an electric signal via a photovoltaic process. For mechanically protecting the pixel elements, an elastomeric encapsulation layer (30) can be disposed on top of the substrate, the encapsulation layer defining access openings (31) for the pixel elements (20). Pillar-like structures (40) can be disposed on the pixel elements. Methods for fabricating such an optoelectronic interface are also disclosed. The optoelectronic interface can be used as a retinal prosthesis.

Abstract: A method and system for deriving particle characteristics is described. The method comprises imaging the movement of at least one free-floating particle in a liquid environment at at least one moment in time, determining for at least one moment in time a movement parameter based on the imaged movement of the free-floating particles in the liquid environment, and deriving from the movement parameter a characteristic of the at least one particle.

Abstract: An actuator (22) comprises at least one actuator body (32) of dielectric elastomeric material and two electrodes (34, 36) being attached to opposite surfaces of the actuator body (32), respectively. At least one of the actuator body (32) and at least one of the electrodes (34, 36) is at least partly covered at its outer side with a protective layer (38a, 38b) of polymer material, wherein a mechanical stiffness of the protective layer (38a, 38b) is at least three times lower than a mechanical stiffness of the actuator body (32). Moreover, a valve actuator unit comprises such an actuator (22) and a housing, wherein the actuator (22) is arranged within the housing and the remainder of the housing is filled with a gas. Additionally, a valve comprises such a valve actuator unit and a valve element, wherein the valve element is movable by the valve actuator unit.