Patents Assigned to Ecole Polytechnique Federale de Lausanne (EPFL)
  • Patent number: 10984563
    Abstract: A method of displaying an image on a see-through display comprises: obtaining a first electro-magnetic radiation matrix of radiation intensity values of an object; dividing the first matrix into a second matrix representing a first subset of the radiation intensity values, and a third matrix representing a second subset of the radiation intensity values; generating a first histogram for the second matrix; equalizing the first histogram to obtain an equalised second histogram; generating a first grayscale image representing the first subset of the radiation intensity values; colouring the first grayscale image with a first colourmap to obtain a first colour image; generating a second grayscale image representing the second subset of the radiation intensity values; colouring the second grayscale image with a second colourmap to obtain a second colour image; combining the first colour image and the second colour image; and displaying the combined colour image on the see-through display.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: April 20, 2021
    Assignee: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)
    Inventors: Adrien Birbaumer, Martinus Bosch, Jason Racine, Sabine Süsstrunk
  • Patent number: 10981004
    Abstract: The present disclosure refers to systems for electrical neurostimulation of a spinal cord of a subject in need of nervous system function support. In one example, a system comprises a signal processing device configured to receive signals from the subject and operate signal-processing algorithms to elaborate stimulation parameter settings; one or more multi-electrode arrays suitable to cover a portion of the spinal cord of the subject; and an Implantable Pulse Generator (IPG) configured to receive the stimulation parameter settings from the signal processing device and simultaneously deliver independent current or voltage pulses to the one or more multiple electrode arrays, wherein the independent current or voltage pulses provide multipolar spatiotemporal stimulation of spinal circuits and/or dorsal roots. Such system advantageously enables effective control of nervous system functions in the subject by stimulating the spinal cord, such as the dorsal roots of the spinal cord, with spatiotemporal selectivity.
    Type: Grant
    Filed: July 10, 2019
    Date of Patent: April 20, 2021
    Assignee: Ecole Polytechnique Federale De Lausanne (EPFL)
    Inventors: Jocelyne Bloch, Grégoire Courtine, Nikolaus Wenger, Silvestro Micera, Marco Capogrosso
  • Patent number: 10985253
    Abstract: The present invention relates, for example, to a semiconductor structure containing multiple parallel channels in which several parallel conductive channels are formed within the semiconductor structure. Electric contact or electrostatic control over all these channels is done by three-dimensional electrode structures. The multiple channel structure with three-dimensional electrodes can be applied to semiconductors devices such as field effect transistors, diodes, and other similar electronic or quantum-effect devices. This structure is practical for materials where multiple parallel conduction channels can be formed, such as in III-V semiconductors. Ill-Nitride semiconductors with such structures are described which can lead to increased power density, reduced on-resistance and improved device performance, in addition to reducing dynamic on-resistance, and improving the stability of their threshold voltage and reliability.
    Type: Grant
    Filed: November 14, 2017
    Date of Patent: April 20, 2021
    Assignee: ECOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE (EPFL)
    Inventors: Elison de Nazareth Matioli, Jun Ma
  • Publication number: 20210107851
    Abstract: The present invention relates to a method for preparing monomers via depolymerisation from lignocellulose-containing biomass.
    Type: Application
    Filed: December 21, 2020
    Publication date: April 15, 2021
    Applicant: Ecole Polytechnique Federale de Lausanne (EPFL)
    Inventors: Jeremy Scott LUTERBACHER, Li SHUAI
  • Patent number: 10969276
    Abstract: A dual-frequency-comb spectrometer and a method for spectroscopic investigation of a sample are described. The spectrometer includes first and second frequency comb devices for emitting laser pulses along first and second light paths, wherein the repetition frequency of the laser pulses emitted by the second device is offset from that of the first device. First and second multi-core waveguides including at least two separate single core waveguides having field-coupling via a coupling gap therebetween are arranged in the first and second light paths. The sample is irradiated by the second frequency comb in the second light path. A detector device is arranged in a third light path where the first and second light paths are combined, for simultaneously sensing the first frequency comb and the second frequency comb after an interaction with the sample. A computing device receives output of the detector device and calculates spectroscopic properties of the sample.
    Type: Grant
    Filed: June 19, 2019
    Date of Patent: April 6, 2021
    Assignee: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)
    Inventors: Tobias Kippenberg, Hairun Guo, Junqiu Liu, Wenle Weng
  • Publication number: 20210085973
    Abstract: A polymer-based optoelectronic interface comprises an elastomeric substrate (10) and a plurality of discrete photovoltaic pixel elements (20) disposed on top of the substrate. Each pixel element comprises at least one active layer comprising a semiconducting polymer or polymer mixture. The pixel elements are excitable by light to generate an electric signal via a photovoltaic process. For mechanically protecting the pixel elements, an elastomeric encapsulation layer (30) can be disposed on top of the substrate, the encapsulation layer defining access openings (31) for the pixel elements (20). Pillar-like structures (40) can be disposed on the pixel elements. Methods for fabricating such an optoelectronic interface are also disclosed. The optoelectronic interface can be used as a retinal prosthesis.
    Type: Application
    Filed: March 31, 2017
    Publication date: March 25, 2021
    Applicant: Ecole Polytechnique Fédérale de Lausanne (EPFL)
    Inventors: Diego GHEZZI, Marta Jole Ildelfonsa AIRAGHI LECCARDI, Laura FERLAUTO
  • Patent number: 10953101
    Abstract: Several embodiments of the present disclosure relate to therapeutic compositions configured to target the liver of a subject and that are useful in the treatment or prevention of one or more of transplant rejection, autoimmune disease, food allergy, and immune response against a therapeutic agent. In several embodiments, the compositions are configured to target the liver and deliver antigens to which tolerance is desired. In several embodiments, the compositions are configured for clearance of a circulating protein or peptide or antibody associated with one or more of the above-mentioned maladies. Methods and uses of the compositions for induction of immune tolerance are also disclosed herein.
    Type: Grant
    Filed: March 19, 2018
    Date of Patent: March 23, 2021
    Assignee: École Polytechnique Fédérale de Lausanne (EPFL)
    Inventors: Jeffrey A. Hubbell, David Scott Wilson
  • Patent number: 10947637
    Abstract: The invention relates to a method for making nanopores in thin layers or monolayers of transition metal dichalcogenides that enables accurate and controllable formation of pore within those thin layer(s) with sub-nanometer precision.
    Type: Grant
    Filed: June 5, 2019
    Date of Patent: March 16, 2021
    Assignees: Ecole Polytechnique Federale De Lausanne (EPFL), Roche Sequencing Solutions, Inc.
    Inventors: Jiandong Feng, Ke Liu, Aleksandra Radenovic, Yann Astier
  • Patent number: 10945911
    Abstract: A system for adjusting pressure locally acting on the skin including a set of adjacent modules distributed so as to form a layer each module includes a cushion capable of changing shape and comprising a cavity, a valve, a tank, and a pressure sensor, wherein the cavity and the tank are in communication with each other by means of the valve, and the sensor is placed so as to sense pressure directly or indirectly acting on the cushion and a feedback loop arranged such as to increase or decrease the change in the shape of the cushion on the basis of the pressure detected by the sensor.
    Type: Grant
    Filed: November 6, 2015
    Date of Patent: March 16, 2021
    Assignee: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)
    Inventors: Yves Perriard, Zoltan Pataky, Daniel Grivon, Yoan René Cyrille Civet
  • Patent number: 10940209
    Abstract: Several embodiments of the present disclosure relate to glycotargeting therapeutics that are useful in the treatment of transplant rejection, autoimmune disease, food allergy, and immune response against a therapeutic agent. In several embodiments, the compositions are configured to target the liver and deliver antigens to which tolerance is desired. Methods and uses of the compositions for induction of immune tolerance are also disclosed herein.
    Type: Grant
    Filed: July 5, 2018
    Date of Patent: March 9, 2021
    Assignee: École Polytechnique Fédérale de Lausanne (EPFL)
    Inventors: Jeffrey A. Hubbell, David Scott Wilson
  • Publication number: 20210061653
    Abstract: The present relates to a carbon material having a 3D structure and made of graphene oxide and carbon nanotubes, characterized in that the 3D structure consists in that the carbon nanotubes are located with some agglomeration between the graphene oxide layers so as to extend the spacing between the graphene oxide layers
    Type: Application
    Filed: January 14, 2019
    Publication date: March 4, 2021
    Applicant: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)
    Inventors: Heena Yang, Andreas ZÜTTEL
  • Publication number: 20210052744
    Abstract: The present invention relates to a bicistronic expression vector for silencing a gene specifically in astrocytes and neurons, comprising two expression cassettes comprising a first and a second silencer sequence, respectively, wherein the expression of said first silencer sequence within astrocytes is regulated by an astrocyte-specific promoter and the expression of said second silencer sequence within neurons is regulated by a neuron-specific promoter. In a preferred embodiment, said first and second silencer sequences are SOD1 silencer sequences. Pharmaceutical composition comprising said bicistronic vector and the use of the same in the treatment of motoneuron diseases are further described.
    Type: Application
    Filed: October 26, 2020
    Publication date: February 25, 2021
    Applicant: Ecole Polytechnique Federale De Lausanne (EPFL)
    Inventors: Julianne Aebischer, Bernard Schneider, Cylia Rochat
  • Patent number: 10929174
    Abstract: A distributed memory system including a plurality of chips, a plurality of nodes that are distributed across the plurality of chips such that each node is comprised within a chip, each node includes a dedicated local memory and a processor core, and each local memory is configured to be accessible over network communication, a network interface for each node, the network interface configured such that a corresponding network interface of each node is integrated in a coherence domain of the chip of the corresponding node, wherein each of the network interfaces are configured to support a one-sided operation, the network interface directly reading or writing in the dedicated local memory of the corresponding node without involving a processor core, and the one-sided operation is configured such that the processor core of a corresponding node uses a protocol to directly inject a remote memory access for read or write request to the network interface of the node, the remote memory access request allowing to read
    Type: Grant
    Filed: December 12, 2017
    Date of Patent: February 23, 2021
    Assignee: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)
    Inventors: Alexandros Daglis, Boris Robert Grot, Babak Falsafi
  • Patent number: 10919963
    Abstract: Peptides that specifically bind erythrocytes are described. These are provided as peptidic ligands having sequences that specifically bind, or as antibodies or fragments thereof that provide specific binding, to erythrocytes. The peptides may be prepared as molecular fusions with therapeutic agents, tolerizing antigens, or targeting peptides. Immunotolerance may be created by use of the fusions and choice of an antigen on a substance for which tolerance is desired. Fusions with targeting peptides direct the fusions to the target, for instance a tumor, where the erythrocyte-binding ligands reduce or entirely eliminate blood flow to the tumor by recruiting erythrocytes to the target.
    Type: Grant
    Filed: July 26, 2019
    Date of Patent: February 16, 2021
    Assignee: École Polytechnique Fédérale de Lausanne (EPFL)
    Inventors: Jeffrey A. Hubbell, Stephan Kontos, Karen Y. Dane
  • Patent number: 10923874
    Abstract: The present invention concerns a multiple soliton comb generation method comprising the steps of: providing a single optical resonator configured to support a plurality of distinct spatial modes in which light can propagate; providing an optical pump laser source; simultaneously optically pumping a plurality of distinct spatial modes of the single optical resonator to simultaneously generate independent soliton states in the distinct spatial modes and generate a plurality of frequency combs.
    Type: Grant
    Filed: April 9, 2019
    Date of Patent: February 16, 2021
    Assignee: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)
    Inventors: Erwan Guillaume Albert Lucas, Grigory Lihachev, Nikolay Pavlov, Michael Gorodetsky, Tobias Kippenberg
  • Patent number: 10908441
    Abstract: A retinal projector system, comprising a coupling means, a spacial light modulator, and a tapered optical waveguide having an input side surface and an output side surface, whereby the input side surface is larger than the output side surface, the coupling means being configured to couple coherent light into the spatial light modulator, the spacial light modulator being configured to receive the coherent light and output modulated light modulated in 2 dimensions towards the input side surface, the tapered optical waveguide being configured to guide the modulated light received at the input side surface and reduce a size of the tapered optical waveguide towards the output side surface, without losing any information from the modulated light at the output side surface such to allow an image formation.
    Type: Grant
    Filed: October 17, 2019
    Date of Patent: February 2, 2021
    Assignee: ECOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE (EPFL)
    Inventors: Christophe Moser, Demetri Psaltis
  • Patent number: 10906856
    Abstract: The present invention relates to a method for preparing monomers via depolymerisation from lignocellulose-containing biomass.
    Type: Grant
    Filed: April 12, 2017
    Date of Patent: February 2, 2021
    Assignee: Ecole Polytechnique Federale de Lausanne (EPFL)
    Inventors: Jeremy Scott Luterbacher, Li Shuai
  • Patent number: 10910749
    Abstract: A connector for providing both a fluidic and electrical connection is disclosed, said connector having a proximal end, a distal end and an elongated body in between, characterized in that the elongated body has an inner cavity spanning throughout its length, and the distal end comprises: a) an inner body portion comprising a first inner electrical contact and b) an outer body portion comprising a second outer electrical contact having a spring element. The connector is easily adaptable to many kind of fluidic actuators and particularly to pipette instruments usually found in laboratory practice and developed to adapt fluidic actuators and pipette instalments to work according to the Coulter principle in every working condition, in particular to adapt the electrical and fluidic connection between a sensing tip and an instrumented pipette.
    Type: Grant
    Filed: April 5, 2018
    Date of Patent: February 2, 2021
    Assignee: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)
    Inventors: David Vincent Bonzon, Jean-Pierre Bonzon, Georges Henri Muller, Jean-Baptiste Bureau, Yann Barrandon, Philippe Renaud, David Forchelet, Nicolas Uffer
  • Patent number: 10905704
    Abstract: The present invention relates to agents that induce mitochondrial unfolded protein response (UPR mt) in muscle stem cells and prevents or reverse process of muscle stem cell senescence. Further, the invention relates to methods and compositions useful in the prevention and/or treatment of muscle stem senescence.
    Type: Grant
    Filed: September 7, 2016
    Date of Patent: February 2, 2021
    Assignee: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)
    Inventors: Hongbo Zhang, Keir Menzies, Johan Auwerx, Dongryeol Ryu
  • Patent number: 10907263
    Abstract: Disclosed are methods of synthesis of an oxidized nickel foam electrode incorporating iron including the step of subjecting a nickel foam electrode to repetitive cyclic voltammetric scans in a basic solution containing iron. Also disclosed is an oxidized nickel foam electrode the oxidized nickel foam incorporating iron, and use of such an electrode as a catalyst for oxygen evolution reaction. Also disclosed is a water splitting device such as an electrolyzer including such an electrode.
    Type: Grant
    Filed: September 14, 2017
    Date of Patent: February 2, 2021
    Assignee: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)
    Inventors: Xile Hu, Fang Song, Elitsa Petkucheva