Patents Assigned to Ed. Geistlich Soehne AG fuer Chemische Industrie
-
Publication number: 20080281432Abstract: An implant for repair of a cartilaginous defect in a subject includes a collagen matrix charged with synovial cells. A method preparing an implant for repair of a cartilaginous defect in a subject includes obtaining a fluid containing synovial cells and charging the synovial cells to the matrix. A device for preparing a cell-charged implant includes a first chamber and a second chamber, the first and second chambers being separated by a membrane and a perforated filter. The membrane is adapted to collect cells from a cell-containing fluid introduced into the first chamber and the perforated filter is adapted to permit passage or diffusion of the fluid through the second chamber. A method for preparing a cell-charged implant utilizes the device.Type: ApplicationFiled: October 23, 2006Publication date: November 13, 2008Applicant: ED. GEISTLICH SOEHNE AG FUER CHEMISCHE INDUSTRIEInventors: Birgit Schaefer, Lothar Schloesser
-
Publication number: 20080171738Abstract: A method of treating a patient with breast cancer includes administering to the patient a breast cancer cell proliferation-inhibiting amount of a methylol-containing compound such as taurolidine, taurultam or a mixture thereof.Type: ApplicationFiled: January 2, 2008Publication date: July 17, 2008Applicant: ED. GEISTLICH SOEHNE AG FUER CHEMISCHE INDUSTRIEInventors: H. Paul Redmond, Rolf W. Pfirrmann
-
Publication number: 20080114011Abstract: Tumor growth and metastases in cancer patients are inhibited by administration of a combination therapy including effective amounts of 5-Fluorouracil and a methylol transfer agent such as taurolidine, taurultam or mixtures thereof.Type: ApplicationFiled: January 18, 2008Publication date: May 15, 2008Applicant: ED. GEISTLICH SOEHNE AG FUER CHEMISCHE INDUSTRIEInventors: H. Redmond, Rolf Pfirrmann
-
Patent number: 7345039Abstract: Tumor growth and metastases in cancer patients are inhibited by administration of a combination therapy including effective amounts of 5-Fluorouracil and a methylol transfer agent such as taurolidine, taurultam or mixtures thereof.Type: GrantFiled: September 12, 2003Date of Patent: March 18, 2008Assignee: Ed. Geistlich Soehne AG fuer chemische IndustrieInventors: H. Paul Redmond, Rolf W. Pfirrmann
-
Patent number: 7208177Abstract: A resorbable extracellular matrix for reconstruction of cartilage tissue includes a purified collagen II derived from natural cartilage tissue from which non-collagen proteins have been removed. The matrix can be utilized as a scaffold implant for meniscal or vertebral cartilage regeneration.Type: GrantFiled: November 20, 2001Date of Patent: April 24, 2007Assignee: Ed. Geistlich Soehne AG fuer Chemische IndustrieInventors: Peter Geistlich, Lothar Schloesser
-
Publication number: 20070031388Abstract: A multi-layer sheet of collagen membrane material includes a barrier layer including an outer smooth barrier face and further including a fibrous face opposite the smooth barrier face, and a matrix layer of collagen material adhered to the fibrous face, the matrix layer including collagen I, collagen III, or a combination thereof, the matrix layer carrying cultivated bone-forming cells including osteocytes, osteoblasts, stromal cells and/or stem cells committed to differentiation into bone-forming osteoblasts.Type: ApplicationFiled: August 25, 2006Publication date: February 8, 2007Applicant: Ed. Geistlich Soehne AG fuer chemische IndustrieInventor: Peter Geistlich
-
Patent number: 7151099Abstract: Taurolidine and/or taurultam is administered during and after surgical removal of a cancerous tumor to treat abdominal cancer.Type: GrantFiled: October 9, 2001Date of Patent: December 19, 2006Assignee: Ed. Geistlich Soehne AG fuer Chemische IndustrieInventors: H. Paul Redmond, Rolf W. Pfirrmann
-
Method for promoting regeneration of surface cartilage in a damaged joint using multi-layer covering
Patent number: 7141072Abstract: A method of promoting regeneration of surface cartilage of a joint includes the steps of covering the area to be treated with a patch which includes a sheet of collagen membrane material. The collagen membrane material has at least one barrier layer to prevent passage of cells therethrough. The collagen membrane further includes a matrix layer predominantly of collagen II having an open sponge-like texture. The patch is fixed over the area to be treated, and the area is allowed to regenerate cartilage.Type: GrantFiled: August 10, 2001Date of Patent: November 28, 2006Assignee: Ed. Geistlich Soehne AG fuer Chemische IndustrieInventors: Peter Geistlich, Lothar Schloesser -
Patent number: 7132413Abstract: Compositions and methods are provided for preventing formation of thrombosis on a liquid-contacting surface of a liquid delivery system, such as a port, catheter or port-catheter system. The liquid delivery system is connected to a patient for delivery of a liquid to the patient. The method involves contacting the surface with a thrombosis-preventing liquid containing taurolidine, taurultam or a mixture thereof, the thrombosis-preventing liquid further containing an anticoagulant agent. In an alternative embodiment, the liquid-contacting surface of the delivery system is contacted with a solution containing an anticoagulant agent, and thereafter contacted with a solution containing taurolidine, taurultam or a mixture thereof.Type: GrantFiled: March 16, 2000Date of Patent: November 7, 2006Assignee: ED. Geistlich Soehne AG Fuer Chemische IndustrieInventor: Rolf W. Pfirrmann
-
Publication number: 20060160792Abstract: A method of inhibiting growth of a tumor cell in a mammal may include steps of administering to the mammal a first solution including a tumor-inhibiting methylol-containing compound, the first solution further including a first combination having a plurality of physiologically acceptable electrolytes or a second combination having at least one amino acid in combination with at least one physiologically acceptable electrolyte. Alternatively, another solution may be administered to the mammal containing a tumor-inhibiting methylol-containing compound, while concurrently administering to the mammal a further solution including the first combination with the plurality of physiologically acceptable electrolytes or the second combination with at least one said amino acid in combination with at least one physiologically acceptable electrolyte.Type: ApplicationFiled: December 22, 2005Publication date: July 20, 2006Applicant: Ed. Geistlich Soehne AG fuer chemische IndustrieInventor: Rolf Pfirrmann
-
Publication number: 20050096314Abstract: A method of inhibiting growth of a tumor cell in a mammal may include steps of administering to the mammal a first solution including a tumor-inhibiting methylol-containing compound, the first solution further including a first combination having a plurality of physiologically acceptable electrolytes or a second combination having at least one amino acid in combination with at least one physiologically acceptable electrolyte. Alternatively, another solution may be administered to the mammal containing a tumor-inhibiting methylol-containing compound, while concurrently administering to the mammal a further solution including the first combination with the plurality of physiologically acceptable electrolytes or the second combination with at least one said amino acid in combination with at least one physiologically acceptable electrolyte.Type: ApplicationFiled: September 28, 2004Publication date: May 5, 2005Applicant: Ed. Geistlich Soehne AG fuer chemische IndustrieInventor: Rolf Pfirrmann
-
Publication number: 20040234577Abstract: The invention provides a multi-layer membrane comprising a matrix layer predominantly of collagen II and having an open sponge-like texture, and at least one barrier layer having a close, relatively impermeable texture. Such a membrane is particularly suitable for use in guided tissue regeneration, in particular for use in vivo in the reconstruction of bone or cartilage tissue.Type: ApplicationFiled: June 18, 2004Publication date: November 25, 2004Applicant: Ed. Geistlich Soehne AG fuer chemische IndustrieInventors: Peter Geistlich, Zdenek Eckmayer, Lothar Schlosser
-
Patent number: 6821968Abstract: A taurolidine composition includes an aqueous solution containing about 1.5-3% by weight taurolidine, the solution containing a stability-enhancing effective amount of at least one physiologically acceptable electrolyte, such that the solution is substantially isotonic.Type: GrantFiled: September 25, 2002Date of Patent: November 23, 2004Assignee: Ed. Geistlich Soehne AG fuer chemische IndustrieInventor: Rolf W. Pfirrmann
-
Patent number: 6815441Abstract: Reaction products of taurultam and glucose are useful as antineoplastic agents. They are produced by reacting an aqueous solution of taurultam and glucose at about 100 degrees Celsius for about 30 minutes, yielding a reaction product which has a melting point of 168 to 170 degrees Celsius.Type: GrantFiled: October 28, 2002Date of Patent: November 9, 2004Assignee: Ed. Geistlich Soehne AG fuer chemische IndustrieInventors: Ruediger Stendel, Rolf W. Pfirrmann
-
Publication number: 20040220181Abstract: A method of treatment for preventing or inhibiting growth of cancer cells utilizes an antineoplastic composition including an antineoplastic-effective amount of a methylol transfer agent (MTA) in combination with biodegradable adhesive capable of adhering to tissue of a living subject.Type: ApplicationFiled: March 26, 2004Publication date: November 4, 2004Applicant: Ed. Geistlich Soehne AG fuer chemische IndustrieInventors: Ruediger Stendel, Rolf W. Pfirrmann
-
Patent number: 6752834Abstract: The invention provides a multi-layer membrane comprising a matrix layer predominantly of collagen II and having an open sponge-like texture, and at least one barrier layer having a close, relatively impermeable texture. Such a membrane is particularly suitable for use in guided tissue regeneration, in particular for use in vivo in the reconstruction of bone or cartilage tissue.Type: GrantFiled: April 7, 2000Date of Patent: June 22, 2004Assignee: Ed Geistlich Soehne AG Fuer Chemische IndustrieInventors: Peter Geistlich, Zdenek Eckmayer, Lothar Schlösser
-
Patent number: 6713085Abstract: Healing of mucosa injury is promoted by applying thereto a membrane of purified collagen material derived from natural collagen-containing tissue.Type: GrantFiled: April 24, 2002Date of Patent: March 30, 2004Assignee: Ed. Geistlich Soehne AG fuer Chemische IndustrieInventors: Peter Geistlich, Lothar Schloesser, Phillip J. Boyne
-
Patent number: 6676969Abstract: A resorbable extracelluar matrix for reconstruction of cartilage tissue includes a purified collagen II derived from natural cartilage tissue from which non-collagen proteins have been removed.Type: GrantFiled: November 9, 2001Date of Patent: January 13, 2004Assignee: Ed. Geistlich Soehne AG fuer Chemische IndustrieInventors: Peter Geistlich, Myron Spector, Zdenek Eckmayer
-
Patent number: 6641571Abstract: Patients undergoing cardiopulmonary bypass surgery are treated perioperatively with methylol transfer agents, such as Taurolidine. Patients undergoing crystalloid cardioplegia who are treated with taurolidine show reduced levels of IL-6 and increased levels of IL-10 when compared to crystalloid cardioplegia patients administered a placebo. Crystalloid cardioplegia patients administered Taurolidine also show reduced levels of IL-6 and increased levels of IL-10 when compared to blood cardioplegia patients who were administered Taurolidine.Type: GrantFiled: January 4, 2001Date of Patent: November 4, 2003Assignee: Ed. Geistlich Soehne AG fuer Chemische IndustrieInventors: H. Paul Redmond, Rolf W. Pfirrmann
-
Patent number: 6576015Abstract: A bone mineral product for use in repair of combined cartilage defects and bone defects in articulating bone joints includes porous bone mineral particles derived from natural bone having a crystal structure substantially that of natural bone and being substantially free from all endogenous organic material, the particles having at least at a surface thereof resorbable, physiologically compatible collagen II fibers wherein the weight ratio of the collagen II fibers to the porous bone mineral particles is at least about 1:40.Type: GrantFiled: July 18, 2001Date of Patent: June 10, 2003Assignee: Ed. Geistlich Soehne AG fuer Chemische IndustrieInventors: Peter Geistlich, Lothar Schloesser