Patents Assigned to Ed. Geistlich Soehne AG
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Publication number: 20090186062Abstract: A method of repairing a meniscal tear of a subject includes providing a sheet of collagen membrane material having on one side thereof a smooth barrier face which inhibits cell adhesion thereon and inhibits passage of cells therethrough. The sheet has a fibrous face opposite the smooth barrier face, the fibrous face allowing cell growth thereon. The collagen is predominantly collagen I. The sheet of collagen membrane material is fixed over a meniscal tear so that the fibrous face is oriented toward the meniscal tear.Type: ApplicationFiled: September 1, 2006Publication date: July 23, 2009Applicant: ED. GEISTLICH SOEHNE AG FUER CHEMISCHE INDUSTRIEInventors: Myron Spector, Peter Geistlich, Lothar Schloesser, Roland Jakob, Jean-Francois Clemence
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Publication number: 20090156584Abstract: A composition formed by subjecting to ionizing radiation a combination containing a radiation-protective amount of PVP along with a solution, gel or adhesive including taurolidine, taurultam or a mixture thereof; or an aggregate including collagen-free crystals of taurolidine, taurultam or a mixture thereof.Type: ApplicationFiled: January 4, 2007Publication date: June 18, 2009Applicant: ED. GEISTLICH SOEHNE AG FUER CHEMISCHE INDUSTRIEInventors: Paul H. Redmond, Rolf W. Pfirrmann
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Publication number: 20090062781Abstract: A method and combination for performing laser therapy, involving the steps of providing a sheet of clear film of appropriate size and thickness, and placing the sheet of clear film over an area of a skin to be treated prior to laser therapy. The method may further include steps of replacing the sheet with a new sheet of clear film, periodically during the therapy.Type: ApplicationFiled: November 10, 2008Publication date: March 5, 2009Applicant: ED. GEISTLICH SOEHNE AG FUR CHEMISCHE INDUSTRIEInventors: Wolfgang Strasser, Heinrich Wokalek
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Publication number: 20080281432Abstract: An implant for repair of a cartilaginous defect in a subject includes a collagen matrix charged with synovial cells. A method preparing an implant for repair of a cartilaginous defect in a subject includes obtaining a fluid containing synovial cells and charging the synovial cells to the matrix. A device for preparing a cell-charged implant includes a first chamber and a second chamber, the first and second chambers being separated by a membrane and a perforated filter. The membrane is adapted to collect cells from a cell-containing fluid introduced into the first chamber and the perforated filter is adapted to permit passage or diffusion of the fluid through the second chamber. A method for preparing a cell-charged implant utilizes the device.Type: ApplicationFiled: October 23, 2006Publication date: November 13, 2008Applicant: ED. GEISTLICH SOEHNE AG FUER CHEMISCHE INDUSTRIEInventors: Birgit Schaefer, Lothar Schloesser
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Publication number: 20080268053Abstract: A collagen matrix material is charged with a cell growth-promoting derived nucleic acid sequence. The nucleic acid sequence-charged collagen matrix material may be utilized in a method of promoting regeneration of surface cartilage of a joint. In the method, an area of injury is covered with the nucleic acid sequence-charged collagen matrix material, the collagen matrix material is fixed over the area to be treated, and the area is allowed to heal.Type: ApplicationFiled: October 30, 2007Publication date: October 30, 2008Applicant: Ed. Geistlich Soehne AG fuer chemistrie IndustrieInventors: Peter Geistlich, Lothar Schloesser
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Publication number: 20080171738Abstract: A method of treating a patient with breast cancer includes administering to the patient a breast cancer cell proliferation-inhibiting amount of a methylol-containing compound such as taurolidine, taurultam or a mixture thereof.Type: ApplicationFiled: January 2, 2008Publication date: July 17, 2008Applicant: ED. GEISTLICH SOEHNE AG FUER CHEMISCHE INDUSTRIEInventors: H. Paul Redmond, Rolf W. Pfirrmann
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Publication number: 20080114011Abstract: Tumor growth and metastases in cancer patients are inhibited by administration of a combination therapy including effective amounts of 5-Fluorouracil and a methylol transfer agent such as taurolidine, taurultam or mixtures thereof.Type: ApplicationFiled: January 18, 2008Publication date: May 15, 2008Applicant: ED. GEISTLICH SOEHNE AG FUER CHEMISCHE INDUSTRIEInventors: H. Redmond, Rolf Pfirrmann
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Publication number: 20080107710Abstract: A collagen matrix material is charged with a cell growth-promoting derived nucleic acid sequence. The nucleic acid sequence-charged collagen matrix material may be utilized in a method of promoting regeneration of surface cartilage of a joint. In the method, an area of injury is covered with the nucleic acid sequence-charged collagen matrix material, the collagen matrix material is fixed over the area to be treated, and the area is allowed to heal.Type: ApplicationFiled: October 30, 2007Publication date: May 8, 2008Applicant: Ed. Geistlich Soehne AG fuer chemistrie IndustrieInventors: Peter Geistlich, Lothar Schloesser
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Patent number: 7345039Abstract: Tumor growth and metastases in cancer patients are inhibited by administration of a combination therapy including effective amounts of 5-Fluorouracil and a methylol transfer agent such as taurolidine, taurultam or mixtures thereof.Type: GrantFiled: September 12, 2003Date of Patent: March 18, 2008Assignee: Ed. Geistlich Soehne AG fuer chemische IndustrieInventors: H. Paul Redmond, Rolf W. Pfirrmann
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Publication number: 20070275955Abstract: A method of treatment for preventing or reducing tumor growth in a patient includes administering to the patient an effective about of taurolidine, taurultam or a mixture thereof, so as to prevent or reduce the tumor growth in the patient.Type: ApplicationFiled: February 2, 2007Publication date: November 29, 2007Applicant: Ed. Geistlich Soehne AGInventor: Rolf PFIRRMANN
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Patent number: 7208177Abstract: A resorbable extracellular matrix for reconstruction of cartilage tissue includes a purified collagen II derived from natural cartilage tissue from which non-collagen proteins have been removed. The matrix can be utilized as a scaffold implant for meniscal or vertebral cartilage regeneration.Type: GrantFiled: November 20, 2001Date of Patent: April 24, 2007Assignee: Ed. Geistlich Soehne AG fuer Chemische IndustrieInventors: Peter Geistlich, Lothar Schloesser
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Publication number: 20070031388Abstract: A multi-layer sheet of collagen membrane material includes a barrier layer including an outer smooth barrier face and further including a fibrous face opposite the smooth barrier face, and a matrix layer of collagen material adhered to the fibrous face, the matrix layer including collagen I, collagen III, or a combination thereof, the matrix layer carrying cultivated bone-forming cells including osteocytes, osteoblasts, stromal cells and/or stem cells committed to differentiation into bone-forming osteoblasts.Type: ApplicationFiled: August 25, 2006Publication date: February 8, 2007Applicant: Ed. Geistlich Soehne AG fuer chemische IndustrieInventor: Peter Geistlich
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Patent number: 7151099Abstract: Taurolidine and/or taurultam is administered during and after surgical removal of a cancerous tumor to treat abdominal cancer.Type: GrantFiled: October 9, 2001Date of Patent: December 19, 2006Assignee: Ed. Geistlich Soehne AG fuer Chemische IndustrieInventors: H. Paul Redmond, Rolf W. Pfirrmann
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Method for promoting regeneration of surface cartilage in a damaged joint using multi-layer covering
Patent number: 7141072Abstract: A method of promoting regeneration of surface cartilage of a joint includes the steps of covering the area to be treated with a patch which includes a sheet of collagen membrane material. The collagen membrane material has at least one barrier layer to prevent passage of cells therethrough. The collagen membrane further includes a matrix layer predominantly of collagen II having an open sponge-like texture. The patch is fixed over the area to be treated, and the area is allowed to regenerate cartilage.Type: GrantFiled: August 10, 2001Date of Patent: November 28, 2006Assignee: Ed. Geistlich Soehne AG fuer Chemische IndustrieInventors: Peter Geistlich, Lothar Schloesser -
Patent number: 7132413Abstract: Compositions and methods are provided for preventing formation of thrombosis on a liquid-contacting surface of a liquid delivery system, such as a port, catheter or port-catheter system. The liquid delivery system is connected to a patient for delivery of a liquid to the patient. The method involves contacting the surface with a thrombosis-preventing liquid containing taurolidine, taurultam or a mixture thereof, the thrombosis-preventing liquid further containing an anticoagulant agent. In an alternative embodiment, the liquid-contacting surface of the delivery system is contacted with a solution containing an anticoagulant agent, and thereafter contacted with a solution containing taurolidine, taurultam or a mixture thereof.Type: GrantFiled: March 16, 2000Date of Patent: November 7, 2006Assignee: ED. Geistlich Soehne AG Fuer Chemische IndustrieInventor: Rolf W. Pfirrmann
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Publication number: 20060160792Abstract: A method of inhibiting growth of a tumor cell in a mammal may include steps of administering to the mammal a first solution including a tumor-inhibiting methylol-containing compound, the first solution further including a first combination having a plurality of physiologically acceptable electrolytes or a second combination having at least one amino acid in combination with at least one physiologically acceptable electrolyte. Alternatively, another solution may be administered to the mammal containing a tumor-inhibiting methylol-containing compound, while concurrently administering to the mammal a further solution including the first combination with the plurality of physiologically acceptable electrolytes or the second combination with at least one said amino acid in combination with at least one physiologically acceptable electrolyte.Type: ApplicationFiled: December 22, 2005Publication date: July 20, 2006Applicant: Ed. Geistlich Soehne AG fuer chemische IndustrieInventor: Rolf Pfirrmann
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Publication number: 20060159668Abstract: A bone healing combination material includes a matrix carrying cultivated bone-forming cells which may be osteocytes, osteoblasts, stromal stem cells or stem cells committed to differentiation into bone-forming osteoblasts. The matrix is a purified collagen matrix material derived from natural collagen-containing animal tissue, a collagen-free porous bone mineral matrix material derived from natural bone having a crystal structure substantially that of natural bone and being substantially free from endogenous organic material, or a combination of purified collagen matrix material and porous bone mineral matrix material.Type: ApplicationFiled: December 27, 2005Publication date: July 20, 2006Applicant: Ed. Geistlich Soehne AG fuer chemistrie IndustrieInventor: Peter Geistlich
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Publication number: 20050186673Abstract: A collagen matrix material is charged with a cell growth-promoting derived nucleic acid sequence. The nucleic acid sequence-charged collagen matrix material may be utilized in a method of promoting regeneration of surface cartilage of a joint. In the method, an area of injury is covered with the nucleic acid sequence-charged collagen matrix material, the collagen matrix material is fixed over the area to be treated, and the area is allowed to heal.Type: ApplicationFiled: February 1, 2005Publication date: August 25, 2005Applicant: Ed. Geistlich Soehne AG fuer chemistrie IndustrieInventors: Peter Geistlich, Lothar Schloesser
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Publication number: 20050186283Abstract: A collagen matrix material is charged with a cell growth-promoting derived nucleic acid sequence. The nucleic acid sequence-charged collagen matrix material may be utilized in a method of promoting regeneration of surface cartilage of a joint. In the method, an area of injury is covered with the nucleic acid sequence-charged collagen matrix material, the collagen matrix material is fixed over the area to be treated, and the area is allowed to heal.Type: ApplicationFiled: February 1, 2005Publication date: August 25, 2005Applicant: Ed. Geistlich Soehne AG fuer chemistrie IndustrieInventors: Peter Geistlich, Lothar Schloesser
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Publication number: 20050124609Abstract: Patients suffering from inflammatory bowel disease such as Crohn's disease or ulcerative colitis are treated either orally or intravenously with methylol transfer agents, such as taurolidine and/or taurultam. These agents can be used in combination with other drugs thereby allowing the use of smaller amounts of the other drugs and limiting unwanted side effects.Type: ApplicationFiled: January 24, 2005Publication date: June 9, 2005Applicant: Ed. Geistlich Soehne AGInventors: H. Redmond, Rolf Pfirrmann