Patents Assigned to Ed. Geistlich Soehne AG
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Publication number: 20050119254Abstract: A method of treating mesothelioma in a mammal, whereby a methylol-containing compound is administered to the mammal intrapleurally.Type: ApplicationFiled: September 28, 2004Publication date: June 2, 2005Applicant: Ed. Geistlich Soehne AGInventor: Rolf Pfirrmann
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Publication number: 20050096314Abstract: A method of inhibiting growth of a tumor cell in a mammal may include steps of administering to the mammal a first solution including a tumor-inhibiting methylol-containing compound, the first solution further including a first combination having a plurality of physiologically acceptable electrolytes or a second combination having at least one amino acid in combination with at least one physiologically acceptable electrolyte. Alternatively, another solution may be administered to the mammal containing a tumor-inhibiting methylol-containing compound, while concurrently administering to the mammal a further solution including the first combination with the plurality of physiologically acceptable electrolytes or the second combination with at least one said amino acid in combination with at least one physiologically acceptable electrolyte.Type: ApplicationFiled: September 28, 2004Publication date: May 5, 2005Applicant: Ed. Geistlich Soehne AG fuer chemische IndustrieInventor: Rolf Pfirrmann
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Publication number: 20040234577Abstract: The invention provides a multi-layer membrane comprising a matrix layer predominantly of collagen II and having an open sponge-like texture, and at least one barrier layer having a close, relatively impermeable texture. Such a membrane is particularly suitable for use in guided tissue regeneration, in particular for use in vivo in the reconstruction of bone or cartilage tissue.Type: ApplicationFiled: June 18, 2004Publication date: November 25, 2004Applicant: Ed. Geistlich Soehne AG fuer chemische IndustrieInventors: Peter Geistlich, Zdenek Eckmayer, Lothar Schlosser
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Patent number: 6821968Abstract: A taurolidine composition includes an aqueous solution containing about 1.5-3% by weight taurolidine, the solution containing a stability-enhancing effective amount of at least one physiologically acceptable electrolyte, such that the solution is substantially isotonic.Type: GrantFiled: September 25, 2002Date of Patent: November 23, 2004Assignee: Ed. Geistlich Soehne AG fuer chemische IndustrieInventor: Rolf W. Pfirrmann
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Patent number: 6815441Abstract: Reaction products of taurultam and glucose are useful as antineoplastic agents. They are produced by reacting an aqueous solution of taurultam and glucose at about 100 degrees Celsius for about 30 minutes, yielding a reaction product which has a melting point of 168 to 170 degrees Celsius.Type: GrantFiled: October 28, 2002Date of Patent: November 9, 2004Assignee: Ed. Geistlich Soehne AG fuer chemische IndustrieInventors: Ruediger Stendel, Rolf W. Pfirrmann
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Publication number: 20040220181Abstract: A method of treatment for preventing or inhibiting growth of cancer cells utilizes an antineoplastic composition including an antineoplastic-effective amount of a methylol transfer agent (MTA) in combination with biodegradable adhesive capable of adhering to tissue of a living subject.Type: ApplicationFiled: March 26, 2004Publication date: November 4, 2004Applicant: Ed. Geistlich Soehne AG fuer chemische IndustrieInventors: Ruediger Stendel, Rolf W. Pfirrmann
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Publication number: 20040170664Abstract: Injured nerves are reconnected and regenerated by inserting injured nerve ends into a collagen tube having an outer compact smooth barrier surface preventing ingrowth of connective tissue, avoiding formation of scar tissue and allowing for unimpaired healing of injured nerves. The tube has an inner fibrous surface opposite the outer smooth barrier surface. The soft fibrous inner surface of the tube facilitates nerve growth promotion.Type: ApplicationFiled: March 10, 2004Publication date: September 2, 2004Applicant: Ed. Geistlich Soehne AGInventors: Myron Spector, Lothar Schloesser, Peter Geistlich
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Patent number: 6752834Abstract: The invention provides a multi-layer membrane comprising a matrix layer predominantly of collagen II and having an open sponge-like texture, and at least one barrier layer having a close, relatively impermeable texture. Such a membrane is particularly suitable for use in guided tissue regeneration, in particular for use in vivo in the reconstruction of bone or cartilage tissue.Type: GrantFiled: April 7, 2000Date of Patent: June 22, 2004Assignee: Ed Geistlich Soehne AG Fuer Chemische IndustrieInventors: Peter Geistlich, Zdenek Eckmayer, Lothar Schlösser
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Patent number: 6713085Abstract: Healing of mucosa injury is promoted by applying thereto a membrane of purified collagen material derived from natural collagen-containing tissue.Type: GrantFiled: April 24, 2002Date of Patent: March 30, 2004Assignee: Ed. Geistlich Soehne AG fuer Chemische IndustrieInventors: Peter Geistlich, Lothar Schloesser, Phillip J. Boyne
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Patent number: 6676969Abstract: A resorbable extracelluar matrix for reconstruction of cartilage tissue includes a purified collagen II derived from natural cartilage tissue from which non-collagen proteins have been removed.Type: GrantFiled: November 9, 2001Date of Patent: January 13, 2004Assignee: Ed. Geistlich Soehne AG fuer Chemische IndustrieInventors: Peter Geistlich, Myron Spector, Zdenek Eckmayer
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Patent number: 6641571Abstract: Patients undergoing cardiopulmonary bypass surgery are treated perioperatively with methylol transfer agents, such as Taurolidine. Patients undergoing crystalloid cardioplegia who are treated with taurolidine show reduced levels of IL-6 and increased levels of IL-10 when compared to crystalloid cardioplegia patients administered a placebo. Crystalloid cardioplegia patients administered Taurolidine also show reduced levels of IL-6 and increased levels of IL-10 when compared to blood cardioplegia patients who were administered Taurolidine.Type: GrantFiled: January 4, 2001Date of Patent: November 4, 2003Assignee: Ed. Geistlich Soehne AG fuer Chemische IndustrieInventors: H. Paul Redmond, Rolf W. Pfirrmann
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Patent number: 6576015Abstract: A bone mineral product for use in repair of combined cartilage defects and bone defects in articulating bone joints includes porous bone mineral particles derived from natural bone having a crystal structure substantially that of natural bone and being substantially free from all endogenous organic material, the particles having at least at a surface thereof resorbable, physiologically compatible collagen II fibers wherein the weight ratio of the collagen II fibers to the porous bone mineral particles is at least about 1:40.Type: GrantFiled: July 18, 2001Date of Patent: June 10, 2003Assignee: Ed. Geistlich Soehne AG fuer Chemische IndustrieInventors: Peter Geistlich, Lothar Schloesser
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Publication number: 20030039695Abstract: A collagen matrix material is charged with a cell growth-promoting derived nucleic acid sequence. The nucleic acid sequence-charged collagen matrix material may be utilized in a method of promoting regeneration of surface cartilage of a joint. In the method, an area of injury is covered with the nucleic acid sequence-charged collagen matrix material, the collagen matrix material is fixed over the area to be treated, and the area is allowed to heal.Type: ApplicationFiled: August 7, 2002Publication date: February 27, 2003Applicant: ED. GEISTLICH SOEHNE AG FUER CHEMISCHE INDUSTRIEInventors: Peter Geistlich, Lothar Schloesser
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Patent number: 6488912Abstract: A method of therapeutic treatment of an area of severe infection of soft tissue within or surrounding a tooth of a patient involves administering Taurolidine, Taurultam or mixtures thereof to the area of severe infection.Type: GrantFiled: July 1, 1999Date of Patent: December 3, 2002Assignee: Ed. Geistlich Soehne AG fuer Chemische IndustrieInventors: Rolf Wilhelm Pfirrmann, Peter Geistlich
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Patent number: 6482240Abstract: Collagen membranes are formed from porcine rinds (i.e., pig skins) for us in a variety of applications and, most preferably, for wrapping food products, such as hams and the like. First, after removing skins from the porcine, the skins are promptly frozen. In later processing, the rinds are thawed and then enzymatically defatted. Then, a quick alkalinic hydrolyzation is performed on the rinds. Then, an acidic hydrolyzation is performed on the rinds. The rinds are then ground into a gel-like fluid mass. Finally, the fluid mass is extruded, sheeted and dried into a collagen membrane. The collagen membrane produced can be, in preferred embodiments, used for wrapping food products, such as hams.Type: GrantFiled: December 7, 1999Date of Patent: November 19, 2002Assignee: Ed. Geistlich Soehne AG fur Chemische IndustrieInventors: Zdenek Eckmayer, Rainer Dorstewitz, Lothar Schlösser, Josef Anton Böhni, Peter Geistlich
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Patent number: 6479481Abstract: Methods and compositions for the treatment and/or prophylaxis and/or suppression of primary and/or secondary tumors of the central nervous system (brain and spinal cord, eyes) in mammalian subjects are disclosed, wherein an effective dose of a methylol transfer agent such as Taurolidine and/or Taurultam and/or a bioequivalent is administered to a mammalian subject suffering from, or at risk of growth of, tumors of the central nervous system. Furthermore, methods for local application of Taurolidine and/or Taurultam and/or a bioequivalent in solution are disclosed using microdialysis methods, irrigation methods, implantation methods and angiographic methods.Type: GrantFiled: June 1, 2000Date of Patent: November 12, 2002Assignee: Ed. Geistlich Soehne AG fur Chemische IndustrieInventors: Ruediger Stendel, Rolf W. Pfirrmann
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Patent number: 6352558Abstract: A method of promoting regeneration of surface cartilage of a joint includes the steps of forming punctures in a subchondral plate of an area of the joint to be treated, covering the puncture and the area to be treated with a chondrocyte-free patch made of a sheet of collagen membrane material without adding chondrocytes to the area to be treated, fixing the patch over the area to be treated, and allowing the area to be treated to regenerate cartilage without adding chondrocytes to the area to be treated.Type: GrantFiled: December 29, 1999Date of Patent: March 5, 2002Assignee: Ed. Geistlich Soehne AG fuer Chemische IndustrieInventor: Myron Spector
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Method for promoting regeneration of surface cartilage in a damaged joint using multi-layer covering
Publication number: 20020013627Abstract: A method of promoting regeneration of surface cartilage of a joint includes the steps of covering the area to be treated with a patch which includes a sheet of collagen membrane material. The collagen membrane material has at least one barrier layer to prevent passage of cells therethrough. The collagen membrane further includes a matrix layer predominantly of collagen II having an open sponge-like texture. The patch is fixed over the area to be treated, and the area is allowed to regenerate cartilage.Type: ApplicationFiled: August 10, 2001Publication date: January 31, 2002Applicant: Ed. Geistlich Soehne AG fur Chemische Industrie SwitzerlandInventors: Peter Geistlich, Lothar Schloesser -
Patent number: 6326029Abstract: A resorbable extracellular matrix for reconstruction of cartilage tissue, the matrix being substantially free from non-native collagen, and including a purified collagen II material formed form natural cartilage and having fibers of native collagen II which are physiologically acceptable for implant into a mammalian body.Type: GrantFiled: November 10, 1997Date of Patent: December 4, 2001Assignee: Ed Geistlich Soehne AG fuer Chemische IndustrieInventors: Peter Geistlich, Myron Spector, Zdenek Eckmayer
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Patent number: 6258797Abstract: The use of taurolidine or taurultam in a method of combatting infection or sepsis in delivery systems is disclosed. In the method, taurolidine or taurultam solutions are used as a temporary seal or flush to prevent or reduce sepsis in delivery systems, such as port systems and/or catheters by which liquids are delivered into a patient.Type: GrantFiled: June 21, 1999Date of Patent: July 10, 2001Assignee: Ed. Geistlich Soehne AG fuer Chemische IndustrieInventor: Joachim Hermann Lehner