Patents Assigned to Ehime University
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Patent number: 8936920Abstract: The present invention provides an easy and rapid method for detecting/identifying the presence or absence of specific Plasmodium parasites and four species of malaria parasites in a human specimen, an anti-malaria measure support system, and a malaria infection-prevention/treatment system, which can contribute to practical diagnosis in a malaria endemic area. According to the present invention, using a genus-specific primer set that can detect four Plasmodium parasites that infect humans at a time, and the primer sets each specific to each of four species of Plasmodium parasites (P. falciparum, P. vivax, P. malariae, and P. ovale), the presence or absence of infection with these parasites can be detected/identified easily and rapidly.Type: GrantFiled: June 13, 2012Date of Patent: January 20, 2015Assignees: Ehime University, Otsuka Pharmaceutical Co., Ltd.Inventors: Takafumi Tsuboi, Eun-Taek Han
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Patent number: 8889649Abstract: Provided is a composition that contains an antisense oligonucleotide to a micro RNA and is capable of inhibiting the growth of cancer cells. The present invention, as one aspect, relates to a composition for suppressing the growth of human cancer cells, the composition containing an antisense oligonucleotide to a micro RNA, wherein the micro RNA is selected from the group consisting of hsa-miR-133a, hsa-miR-133b, hsa-miR-346 and hsa-miR-361-3p. The present invention, as another aspect, relates to a composition for suppressing the growth of human head/neck cancer cells, the composition containing an antisense oligonucleotide to a micro RNA, wherein the micro RNA is selected from the group consisting of hsa-miR-92a, hsa-miR-133a, hsa-miR-133b, hsa-miR-139-5p, hsa-miR-197, hsa-miR-328, hsa-miR-346, hsa-miR-361-3p, hsa-miR-605, hsa-miR-766, hsa-miR-1228, hsa-miR-1252, hsa-miR-1260 and hsa-miR-1271.Type: GrantFiled: November 10, 2011Date of Patent: November 18, 2014Assignee: National University Corporation Ehime UniversityInventors: Koichi Nakashiro, Hiroyuki Hamakawa, Hiroshi Tanaka
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Patent number: 8828734Abstract: Provided are a nitric oxide detection element capable of detecting NO gas contained in a mixed gas at a high speed even when the amount thereof is a super trace amount of ten and several parts per billion; and a process for producing the element. In a nitric oxide detection element having a substrate 12 and a sensing film 11 formed on a surface of the substrate, the sensing film is composed of nitric oxide sensing particles and a polymer adhesive. The nitric oxide sensing particles are produced by adsorbing a dye having a porphyrin skeleton and having, as a central metal, divalent cobalt onto surfaces of inorganic particles.Type: GrantFiled: July 12, 2011Date of Patent: September 9, 2014Assignees: Panasonic Healthcare Co., Ltd., National University Corporation Ehime UniversityInventors: Kouichi Hiranaka, Toyofumi Nagamatsu, Yoshihiko Sadaoka, Yoshiteru Itagaki
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Publication number: 20140170173Abstract: The purpose of the present invention is to provide a method for treating autoimmune diseases. Disclosed is a method or the like for the treatment of autoimmune diseases, which utilizes an antigen-specific tolerogenic antigen presenting cell. Specifically disclosed are: a method for producing an antigen-specific tolerogenic antigen presenting cell, which is characterized by using carbonic anhydrase I; an immunogenic antigen presenting cell which is specific to carbonic anhydrase I; and a method or the like for the treatment of autoimmune diseases (especially inflammatory bowel diseases), which is characterized by using a tolerogenic antigen presenting cell which is specific to carbonic anhydrase I.Type: ApplicationFiled: December 5, 2013Publication date: June 19, 2014Applicant: NATIONAL UNIVERSITY CORPORATION EHIME UNIVERSITYInventors: Hidehiro MURAKAMI, Hirofumi YAMANISHI, Morikazu ONJI
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Patent number: 8739002Abstract: An objective of the present invention is to provide a decoder, a perpendicular magnetic recording and reproducing device, a receiving device, and a decoding method that are used for performing decoding resistant to burst errors such as a pole-erase phenomenon, where the burst errors do not have amplitude fluctuation, without the addition of a special code (redundant code) for detecting burst errors. The present invention is a decoder, a perpendicular magnetic recording and reproducing device, a receiving device, and a decoding method that perform a decoding process on an encoded data signal, wherein a parity check is performed on the encoded data signal that is encoded with a low density parity check code to output burst information.Type: GrantFiled: December 26, 2008Date of Patent: May 27, 2014Assignee: Ehime UniversityInventors: Yasuaki Nakamura, Yoshihiro Okamoto, Hisashi Osawa
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Patent number: 8715931Abstract: Provided are a method for analyzing metastasis of head and neck cancer to a cervical lymph node, and a tumor marker for head and neck cancer used therein. Specifically, provided is a method for analyzing metastasis of head and neck cancer to a cervical lymph node, involving: measuring an expression level of at least one gene selected from the group consisting of genes represented by SEQ ID NOS: 1 to 36 in the sequence listing in a cervical lymph node sample; and comparing the aforementioned expression level with a reference value. Also provided is a tumor marker for head and neck cancer used in the aforementioned method for analyzing cervical lymph node metastasis, including at least one gene selected from the group consisting of genes represented by SEQ ID NOS: 1 to 36 in the sequence listing, and/or an expression product of the aforementioned gene and/or an expression level thereof.Type: GrantFiled: December 22, 2010Date of Patent: May 6, 2014Assignee: National University Corporation Ehime UniversityInventors: Koichi Nakashiro, Hiroyuki Hamakawa, Hiroyuki Goda
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Patent number: 8685360Abstract: This invention is to provide a method for the production of diamond at a high rate and in a high efficiency using in-liquid plasma. The present invention is a method for the production of diamond using electromagnetic waves irradiated to a liquid containing carbon, hydrogen and oxygen in which the ratio of hydrogen atoms to the sum of carbon atoms and hydrogen atoms is from 0.75 to 0.82 and the ratio of carbon atoms to the sum of carbon atoms and oxygen atoms is from 0.47 to 0.58 so as to generate plasma in the liquid.Type: GrantFiled: February 7, 2008Date of Patent: April 1, 2014Assignees: Kabushiki Kaisya Toyota Jidosyokki, Ehime UniversityInventors: Shinfuku Nomura, Hiromichi Toyota, Shinobu Mukasa
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Patent number: 8653404Abstract: An in-liquid plasma electrode according to the present invention is an in-liquid plasma electrode for generating plasma in a liquid and has an electrically conductive member having an electric discharge end surface in contact with the liquid, and an electrically insulating member covering an outer periphery of the conductive member at least except the electric discharge end surface. Preferably, d and x satisfy ?2d?x?2d, where d is a length of a minor axis of the cross section when a conductive end portion of the electrically conductive member having the electric discharge end surface has an approximately circular cross section, or d is a length of a short side of the cross section when the conductive end portion has an approximately rectangular cross section, and x is a distance from a reference plane to a plane containing the electric discharge end surface when the reference plane is an end surface of the electrically insulating member that is approximately parallel with the electric discharge end surface.Type: GrantFiled: December 2, 2005Date of Patent: February 18, 2014Assignees: Kabushiki Kaisha Toyota Jidoshokki, Ehime UniversityInventors: Hitotoshi Murase, Toshihisa Shimo, Hiroaki Takashima, Hiromichi Toyota, Shinfuku Nomura, Tsunehiro Maehara
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Publication number: 20140045917Abstract: Provided is a composition that contains an antisense oligonucleotide to a micro RNA and is capable of inhibiting the growth of cancer cells. The present invention, as one aspect, relates to a composition for suppressing the growth of human cancer cells, the composition containing an antisense oligonucleotide to a micro RNA, wherein the micro RNA is selected from the group consisting of hsa-miR-133a, hsa-miR-133b, hsa-miR-346 and hsa-miR-361-3p. The present invention, as another aspect, relates to a composition for suppressing the growth of human head/neck cancer cells, the composition containing an antisense oligonucleotide to a micro RNA, wherein the micro RNA is selected from the group consisting of hsa-miR-92a, hsa-miR-133a, hsa-miR-133b, hsa-miR-139-5p, hsa-miR-197, hsa-miR-328, hsa-miR-346, hsa-miR-361-3p, hsa-miR-605, hsa-miR-766, hsa-miR-1228, hsa-miR-1252, hsa-miR-1260 and hsa-miR-1271.Type: ApplicationFiled: November 10, 2011Publication date: February 13, 2014Applicant: NATIONAL UNIVERSITY CORPORATION EHIME UNIVERSITYInventors: Koichi Nakashiro, Hiroyuki Hamakawa, Hiroshi Tanaka
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Publication number: 20140042011Abstract: A nanometer-size-particle production apparatus is provided which can prevent the occurrence of waste fluids, and which makes quick and continuous syntheses feasible while suppressing damages to the electrode.Type: ApplicationFiled: April 24, 2012Publication date: February 13, 2014Applicant: NATIONAL UNIVERSITY CORPORATION EHIME UNIVERSITYInventors: Yoshiaki Hattori, Shinfuku Nomura, Hiromichi Toyota, Shinobu Mukasa
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Patent number: 8607732Abstract: In an in-liquid plasma film-forming apparatus having: a vessel 1 being capable of accommodating a substrate “S” and a liquid “L” including raw material therein; an electrode 2 for in-liquid plasma, electrode 2 which is disposed in the vessel 1; an electric power device 3 for supplying electricity to the electrode 2 for in-liquid plasma; the electrode 2 for in-liquid plasma is equipped with: a main electrode 21 having a discharging end 22; an auxiliary electrode 26 not only facing the discharging end 22 but also being disposed between the discharging end 22 and the substrate “S” that face each other; and a plasma generating unit 29 having a space that is demarcated by a surface 22a of the discharging end 22 and a surface 26a of the auxiliary electrode 26 facing the surface 22a, and being for generating plasma by means of electricity being supplied to the main electrode 21.Type: GrantFiled: March 2, 2009Date of Patent: December 17, 2013Assignees: Kabushiki Kaisha Toyota Jidoshokki, National University Corporation Ehime UniversityInventors: Kenji Shibata, Toshihisa Shimo, Kyoko Kumagai, Hidetaka Hayashi, Shinya Okuda, Shinfuku Nomura, Hiromichi Toyota
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Patent number: 8570230Abstract: An antenna includes a simple structure and a small null angle, which achieves communication using a circularly-polarized wave. The antenna includes a conductive wire arranged in loops in such a way as to form a cross shape. A part at which two line portions projecting outward from the center portion define a right angle is included in the loop path of the conductive wire. This part allows the antenna to transmit and receive an electromagnetic wave in all directions and have a circular polarization characteristic.Type: GrantFiled: February 29, 2008Date of Patent: October 29, 2013Assignee: National University Corporation Ehime UniversityInventors: Mayumi Matsunaga, Yasuhiro Yokota
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Publication number: 20130273579Abstract: Provided are a detection method for a myriad of proteins involved in an autoimmune disease with high sensitivity and high efficiency, and an analysis method for data resulting from the detection method. In order to construct the detection method and analysis method, there is provided means for comprehensively analyzing the proteins involved in an autoimmune disease by bringing a mammal-derived protein expressed in a cell-free protein synthesis system into contact with a sample derived from a patient with an autoimmune disease to detect autoantibody production, and subjecting the detected data to statistical analysis processing, and further, gene ontology analysis and/or pathway analysis.Type: ApplicationFiled: November 16, 2011Publication date: October 17, 2013Applicants: Public University Corporation Yokohama City University, National University Corporation Ehime UniversityInventors: Tatsuya Sawasaki, Yaeta Endo, Tomoaki Ishigami, Ichiro Aoki
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Patent number: 8520867Abstract: Provided is a high-accuracy embedded audiphone. A transducer (34) made of a giant magnetostrictive element is provided in an intracorporeal unit (3) that is embedded in a skull (5). An audible sound modulation transmission signal (S1), which is amplitude-modulated by a sound collection signal generated in an extracorporeal unit (2), is transmitted from an extracorporeal transmitter coil (31) to an intracorporeal receiver coil (32) provided in the intracorporeal unit (3) with the help of a transmission magnetic flux (33). Moreover, because of an induced electromotive force of the intracorporeal receiver coil (32), the transducer (34) expands and contracts. Therefore, it is possible to highly accurately conduct an audible sound signal through bone with no power source or demodulation circuit provided in the intracorporeal unit (3).Type: GrantFiled: September 16, 2009Date of Patent: August 27, 2013Assignees: The University of Electro-Communications, Ehime UniversityInventors: Takuji Koike, Naohito Hato, Kensei Yamamoto
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Publication number: 20130137184Abstract: Provided are a nitric oxide detection element capable of detecting NO gas contained in a mixed gas at a high speed even when the amount thereof is a super trace amount of ten and several parts per billion; and a process for producing the element. In a nitric oxide detection element having a substrate 12 and a sensing film 11 formed on a surface of the substrate, the sensing film is composed of nitric oxide sensing particles and a polymer adhesive. The nitric oxide sensing particles are produced by adsorbing a dye having a porphyrin skeleton and having, as a central metal, divalent cobalt onto surfaces of inorganic particles.Type: ApplicationFiled: July 12, 2011Publication date: May 30, 2013Applicants: NATIONAL UNIVERSITY CORPORATION EHIME UNIVERSITY, PANASONIC HEALTHCARE CO., LTD.Inventors: Kouichi Hiranaka, Toyofumi Nagamatsu, Yoshihiko Sadaoka, Yoshiteru Itagaki
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Publication number: 20130125618Abstract: Provided is a nitric oxide detection element which is capable of measuring a trace amount of NO gas contained in a gas in a scale of several ppb and of which the time degradation in performance is suppressed. The nitric oxide detection element includes at a surface thereof: a dye having a porphyrin skeleton and containing divalent cobalt as a central metal; and a radical scavenger. The nitric oxide detection element includes a substrate 12 and a sensing film 11 formed on a surface of the substrate 12. The sensing film 11 may contain the dye and the radical scavenger.Type: ApplicationFiled: July 12, 2011Publication date: May 23, 2013Applicants: NATIONAL UNIVERSITY CORPORATION EHIME UNIVERSITY, PANASONIC HEALTHCARE CO., LTD.Inventors: Kouichi Hiranaka, Yoshihiko Sadaoka, Yoshiteru Itagaki
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Publication number: 20130017221Abstract: The present invention provides an easy and rapid method for detecting/identifying the presence or absence of specific Plasmodium parasites and four species of malaria parasites in a human specimen, an anti-malaria measure support system, and a malaria infection-prevention/treatment system, which can contribute to practical diagnosis in a malaria endemic area. According to the present invention, using a genus-specific primer set that can detect four Plasmodium parasites that infect humans at a time, and the primer sets each specific to each of four species of Plasmodium parasites (P. falciparum, P. vivax, P. malariae, and P. ovale), the presence or absence of infection with these parasites can be detected/identified easily and rapidly.Type: ApplicationFiled: June 13, 2012Publication date: January 17, 2013Applicants: OTSUKA PHARMACEUTICAL CO., LTD., EHIME UNIVERSITYInventors: Takafumi TSUBOI, Eun-Taek HAN
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Patent number: 8329473Abstract: Column which includes a first column with an upper layer of H2SO4 silica gel and a lower layer AgNO3 silica gel and a second column packed with alumina, connected detachably to a lower end of the first column. An oily liquid containing polychlorinated biphenyls, is added to the upper layer and heated. An aliphatic hydrocarbon solvent is supplied to the upper layer, whereby polychlorinated biphenyls captured by the first column are dissolved in the aliphatic hydrocarbon and then flow to the second column. The polychlorinated biphenyls are captured by the alumina which is located near the inlet of the second column, which is then detached from the first column. A hydrophobic solvent is passed through the second column in a direction opposite to the direction in which the aliphatic hydrocarbon was passed, providing an extract containing the polychlorinated biphenyls dissolved in a small amount of the hydrophobic solvent.Type: GrantFiled: March 21, 2008Date of Patent: December 11, 2012Assignees: Ehime University, Miura Co., Ltd.Inventors: Katsuhisa Honda, Tomofumi Takahashi
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Patent number: 8309702Abstract: The present invention provides an easy and rapid method for detecting/identifying the presence or absence of specific Plasmodium parasites and four species of malaria parasites in a human specimen, an anti-malaria measure support system, and a malaria infection-prevention/treatment system, which can contribute to practical diagnosis in a malaria endemic area. According to the present invention, using a genus-specific primer set that can detect four Plasmodium parasites that infect humans at a time, and the primer sets each specific to each of four species of Plasmodium parasites (P. falciparum, P. vivax, P. malariae, and P. ovale), the presence or absence of infection with these parasites can be detected/identified easily and rapidly.Type: GrantFiled: May 27, 2008Date of Patent: November 13, 2012Assignees: Ehime University, Otsuka Pharmaceutical Co., Ltd.Inventors: Takafumi Tsuboi, Eun-Taek Han
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Publication number: 20120213808Abstract: The purpose of the present invention is to provide a method for treating autoimmune diseases. Disclosed is a method or the like for the treatment of autoimmune diseases, which utilizes an antigen-specific tolerogenic antigen presenting cell. Specifically disclosed are: a method for producing an antigen-specific tolerogenic antigen presenting cell, which is characterized by using carbonic anhydrase I; an immunogenic antigen presenting cell which is specific to carbonic anhydrase I; and a method or the like for the treatment of autoimmune diseases (especially inflammatory bowel diseases), which is characterized by using a tolerogenic antigen presenting cell which is specific to carbonic anhydrase I.Type: ApplicationFiled: October 7, 2010Publication date: August 23, 2012Applicant: National University Corporation Ehime UniversityInventors: Hidehiro Murakami, Hirofumi Yamanishi, Morikazu Onji