Abstract: Vagal nerve stimulation devices and methods are provided herein. A device comprises one or more electrodes having a contact surface for contacting an outer skin surface of a patient and an energy source coupled to the electrodes. The energy source generates one or more electrical impulses and transmits the electrical impulses to the electrodes and transcutaneously through the outer skin surface of the patient at or near a vagus nerve. The one or more electrical pulses comprise bursts of 2 to 20 pulses within each burst with each burst having a frequency of about 5 Hz to about 100 Hz.

Abstract: Devices and methods for the non-invasive stimulation of nerves, such as the vagus nerve, include a housing and an electrode coupled to the housing. The electrode is configured to be positioned adjacent to, or in contact with, an outer skin surface of a patient. A source of energy is coupled to the housing and operably coupled to the electrode. The source of energy emits an electrical signal to the electrode such that the electrical signal passes through the outer skin surface of the user to a nerve at a target region in the patient sufficient to modulate the nerve. The electrical impulse comprises burst periods and constant periods and each burst period includes a plurality of pulses. The pulses have a frequency of about 1 kHz to about 20 kHz and alternate between a positive voltage and a negative voltage within each burst period.

Abstract: Systems, devices and methods are provided for stimulating one or more nerves within a user. A system comprises a stimulator comprising an electrode configured for contacting the outer skin surface and an energy source coupled to the stimulator and configured to generate a plurality of positive voltage waves. The stimulator further comprises a bridge circuit configured to convert the positive voltage waves into alternating positive and negative voltage waves. The stimulator transmits the alternating positive and negative voltage waves transcutaneously from the electrode through the outer skin surface of the user to a selected nerve in the user adjacent to, or near, the target location. This allows the energy source to drive a full AC sine wave to the electrode using a single positive voltage rail, which reduces the complexity of the overall circuit, thereby reducing its overall size or footprint within the stimulation and its manufacturing cost.

Abstract: Systems and methods are provided for treating blood clots associated with a replicating pathogen, such as a virus in the coronaviridae family. The systems and methods include applying an electrical impulse transcutaneously through the outer skin surface of the patient to a cervical branch of the vagus nerve of the patient. The electrical impulse is sufficient to reduce a number of antibodies associated with blood clotting to reduce a level of blood clotting in the patient. The systems and methods are particularly useful for treating post-COVID conditions or post-acute sequelae of COVID-19 that develop in “long-haul” or COVID patients.

Abstract: Systems, devices and methods are provided for stimulating one or more nerves within a user. A system comprises a stimulator comprising an electrode configured for contacting the outer skin surface at, or near, the target location and an energy source coupled to the stimulator and configured to generate at least one electrical impulse and to transmit the at least one electrical impulse transcutaneously from the electrode through the outer skin surface of the user to a selected nerve in the user adjacent to, or near, the target location. The energy source comprises a primary circuit board that includes a processor and a computer-readable data storage device storing program instructions that, when executed by the processor, the program instructions generate the electrical impulse, and a secondary circuit board removably coupled to the main circuit board.

Abstract: Systems, devices and methods are provided for stimulating one or more cranial nerve(s) of a user. The systems and methods combine an electrical stimulation signal with an audio signal, such as music, white noise, ambient sound, filtered music, and the like. The combination of the nerve stimulation and the audio signal may be specifically designed to treat various diseases or disorders and/or for non-medical purposes, such as improving the general well-being of the user, reducing stress and the like. In certain embodiments, the electrical impulses comprise a burst stimulation and a tonic stimulation. The burst stimulation may comprise a burst of pulses. The bursts and/or the pulses may have frequencies that vary throughout the duration of the treatment.

Abstract: Devices, systems and methods are disclosed that allow a patient to self-treat a medical condition, such as migraine headache, by electrical non-invasive stimulation of a nerve, such as the trigeminal nerve. A system comprises one or more electrodes configured for contacting an outer skin surface of a patient and a stimulator coupled to the one or more electrodes. The stimulator is configured to transmit an electrical impulse from the electrodes through the outer skin surface to a target site within a patient. A software application coupled to the stimulator. The software application may, for example, be downloadable onto a mobile device and may allow the user to transmit data to and from the stimulator and/or control operation of the stimulator.

Abstract: Systems and methods are provided for treating blood clots associated with a replicating pathogen, such as a virus in the coronaviridae family. The methods include emitting an electrical impulse near a vagus nerve within the patient sufficient to inhibit or reduce an inflammatory or allergic response in the patient, provide relief for bronchoconstriction that results in the tightening of airways and the inability to breath without ventilator support and/or lessen the abnormal blot clotting that develops in some patients. The systems and methods are particularly useful for treating post-COVID conditions or post-acute sequelae of COVID-19 that develop in “long-haul” or COVID patients.

Abstract: A medical device, such as a neurostimulator, is provided that includes a housing, a power supply, a signal generator and one or more electrodes coupled to the housing. The signal generator is configured to apply one or more electrical impulses to the one or more electrodes for a period of time, the period of time being defined as a single dose. The device is configured to switch from an activated mode and a deactivated mode after specific number of single doses have been emitted by the signal generator.

Abstract: Devices, systems and methods are disclosed for electrical stimulation of nerves to treat one or more symptoms in a user. The methods comprise transcutaneously transmitting electrical impulses to the nerve according to a treatment paradigm. The treatment paradigm may include generating and transmitting the electrical impulse as a single dose from about 30 seconds to about 5 minutes. The treatment paradigm may comprise a treatment session that includes applying each single dose for about 2 to 5 times during the day.

Abstract: Devices and methods for the non-invasive stimulation of nerves, such as the vagus nerve, include a housing and an electrode coupled to the housing. The electrode is configured to be positioned adjacent to, or in contact with, an outer skin surface of a patient. A source of energy is coupled to the housing and operably coupled to the electrode. The source of energy emits an electrical impulse to the electrode such that the electrical impulse passes through the outer skin surface of the patient to a nerve at a target region in the patient sufficient to modulate the nerve. The electrical impulse comprises burst periods and constant periods, wherein each burst period includes 2 to 20 pulses and has a duration of less than 20,000 microseconds.

Abstract: A medical device, such as a neurostimulator, is provided that includes a housing, a power supply, a signal generator and one or more electrodes coupled to the housing. The signal generator is configured to apply one or more electrical impulses to the one or more electrodes for a period of time, the period of time being defined as a single dose. The device is configured to switch from an activated mode and a deactivated mode after specific number of single doses have been emitted by the signal generator.

Abstract: Methods are disclosed for electrical stimulation of nerves to treat one or more symptoms in a user. The methods comprise transcutaneously transmitting electrical impulses to the nerve according to a treatment paradigm. The treatment paradigm may include generating and transmitting the electrical impulse as a single dose from about 30 seconds to about 5 minutes. The treatment paradigm may comprise a treatment session of 2 to 4 times within an hour time period and/or as a single dose from 2 to 5 times during a day.

Abstract: Systems and methods for non-invasive nerve stimulation are provided. A method for treating a patient with a medical condition comprises contacting an outer skin surface of a patient with a contact surface of a stimulator, generating an electrical impulse, and transmitting the electrical impulse from the stimulator transcutaneously through the outer skin surface to a nerve within the patient. The method further includes detecting a physiological parameter of the patient during the transmitting and modifying one or more parameters of the electrical impulse applied to the nerve based on the physiological parameter.

Abstract: Devices and methods are described to produce therapeutic effects in a patient by utilizing an energy source that transmits energy non-invasively to nervous tissue. A device for modulating a nerve within a body of a patient comprises a housing comprising a power supply and a signal generator for generating an electrical impulse. The electrical impulse comprises bursts of 2 to 20 pulses, wherein each of the bursts has a frequency of 15 to 50 Hz. The device further comprises first and second electrodes coupled to the housing and having a contact surface configured for contacting an outer skin surface of a neck of a user. The energy source is configured to transmit the electrical impulse from the first and second electrodes through the outer skin surface of the user to a vagus nerve.

Abstract: Systems, devices and methods are provided for delivering electrical impulses to bodily tissues for therapeutic purposes. A system for stimulating a nerve within a patient comprises a stimulator having an electrode configured for contacting the outer skin surface at, or near the target location and an energy source coupled to the stimulator, The energy source is configured to generate at least one electrical impulse and to transmit the electrical impulse transcutaneously from the electrode through the outer skin surface of the patient to a selected nerve in the patient adjacent to, or near, the target location. The system may include a wearable treatment device designed to optimize placement of the electrode at the target site.

Abstract: Devices and methods for the non-invasive stimulation of nerves, such as the vagus nerve, include a housing and an electrode coupled to the housing. The electrode is configured to be positioned adjacent to, or in contact with, an outer skin surface of a patient. A source of energy is coupled to the housing and operably coupled to the electrode. The source of energy emits an electrical impulse to the electrode such that the electrical impulse passes through the outer skin surface of the patient to a nerve at a target region in the patient sufficient to modulate the nerve.

Abstract: A system is provided that includes a medical device comprising a power supply, a signal generator and an electrode. The signal generator is configured to apply one or more electrical impulses to the electrode for a period of time defined as a single dose. The system further comprises a downloadable software application coupled to the medical device. The software application is configured to switch the medical device from an activated mode to a deactivated mode after a specific number of single doses have been applied by the signal generator.