Patents Assigned to ElectroCore, Inc.
  • Patent number: 10639490
    Abstract: Devices, systems and methods are disclosed for treating bronchial constriction related to asthma, anaphylaxis or chronic obstructive pulmonary disease. The treatment comprises transmitting impulses of energy non-invasively to selected nerve fibers that are responsible for smooth muscle dilation. The transmitted energy impulses, comprising magnetic and/or electrical, mechanical and/or acoustic, and optical and/or thermal energy, stimulate the selected nerve fibers.
    Type: Grant
    Filed: July 9, 2018
    Date of Patent: May 5, 2020
    Assignee: ElectroCore, Inc.
    Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle, Steven Mendez
  • Patent number: 10512769
    Abstract: Devices, systems and methods are disclosed for treating or preventing an autism spectrum disorder, a pervasive developmental disorder, or a disorder of psychological development. The methods comprise transmitting impulses of energy non-invasively to selected nerve fibers, particularly those in a vagus nerve. The nerve stimulation may be used as a behavior conditioning tool, by producing euphoria in an autistic individual. Vagus nerve stimulation is also used to modulate circulating serotonin levels in a pregnant woman so as to reduce the risk of having an autistic child; modulate the levels of growth factors within a child; promote balance of neuronal excitation/inhibition; modulate the activity of abnormal resting state neuronal networks; increase respiratory sinus arrhythmia; and avert episodes of motor stereotypies with the aid of forecasting methods.
    Type: Grant
    Filed: March 3, 2013
    Date of Patent: December 24, 2019
    Assignee: ElectroCore, Inc.
    Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
  • Patent number: 10507325
    Abstract: A non-invasive electrical stimulation device shapes an elongated electric field of effect that can be oriented parallel to a long nerve, such as a vagus nerve in a patient's neck, producing a desired physiological response in the patient. The stimulator comprises a source of electrical power, at least one electrode and a continuous electrically conducting medium in which the electrode(s) are in contact. The stimulation device is configured to produce a peak pulse voltage that is sufficient to produce a physiologically effective electric field in the vicinity of a target nerve, but not to substantially stimulate other nerves and muscles that lie between the vicinity of the target nerve and patient's skin. Current is passed through the electrodes in bursts of preferably five sinusoidal pulses, wherein each pulse within a burst has a duration of preferably 200 microseconds, and bursts repeat at preferably at 15-50 bursts per second.
    Type: Grant
    Filed: November 2, 2015
    Date of Patent: December 17, 2019
    Assignee: ElectroCore, Inc.
    Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
  • Patent number: 10441780
    Abstract: Devices, systems and methods are disclosed for electrical stimulation of the vagus nerve to treat or prevent disorders in a patient. The methods comprise transmitting impulses of energy to the vagus nerve according to a treatment paradigm that includes single doses of 30 seconds to 5 minutes of continuous stimulation. The treatment paradigm further comprises one or more daily treatment sessions that each include one or more doses for prophylactic or acute treatment of the patient's condition. Vagus nerve stimulation is used to modulate the release of inhibitory neurotransmitters in the brain, such as GABA, norepinephrine, and/or serotonin.
    Type: Grant
    Filed: July 29, 2013
    Date of Patent: October 15, 2019
    Assignee: Electrocore, Inc.
    Inventors: Bruce J. Simon, Joseph P. Errico
  • Patent number: 10384061
    Abstract: Non-invasive electrical nerve stimulation devices and magnetic stimulation devices are disclosed, along with methods of treating medical disorders using energy that is delivered noninvasively by such devices. The disorders comprise migraine and other primary headaches such as cluster headaches, including sinus symptoms that resemble an immune-mediated response (“sinus” headaches), irrespective of whether those symptoms arise from an allergy that is co-morbid with the headache. The disclosed methods may also be used to treat other disorders that may be co-morbid with migraine headaches, such as anxiety disorders. In preferred embodiments of the disclosed methods, one or both of the patient's vagus nerves are stimulated non-invasively. In other embodiments, parts of the sympathetic nervous system and/or the adrenal glands are stimulated.
    Type: Grant
    Filed: January 11, 2016
    Date of Patent: August 20, 2019
    Assignee: Electrocore, Inc.
    Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
  • Patent number: 10384059
    Abstract: Devices, systems and methods are disclosed for treating a variety of diseases and disorders that are primarily or at least partially driven by an imbalance in neurotransmitters in the brain, such as asthma, COPD, depression, anxiety, epilepsy, fibromyalgia, and the like. The invention involves the use of an energy source comprising magnetic and/or electrical energy that is transmitted non-invasively to, or in close proximity to, a selected nerve to temporarily stimulate, block and/or modulate the signals in the selected nerve such that neural pathways are activated to release inhibitory neurotransmitters in the patient's brain.
    Type: Grant
    Filed: June 2, 2016
    Date of Patent: August 20, 2019
    Assignee: Electrocore, Inc.
    Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
  • Patent number: 10376696
    Abstract: Devices, systems and methods are disclosed that allow a patient to self-treat a medical condition, such as migraine headache, by electrical noninvasive stimulation of a vagus nerve. The system comprises a stimulator that is applied to the surface of the patient's neck. The device housing transmits data to a patient interface device such as a mobile phone or computer relating to the status of a stimulation session. The interface device in turn may communicate with a database contained within other computers, via a network or the internet. The system is designed to address problems that arise particularly during self-treatment, when a medical professional is not present.
    Type: Grant
    Filed: February 1, 2016
    Date of Patent: August 13, 2019
    Assignee: Electrocore, Inc.
    Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
  • Patent number: 10376695
    Abstract: Devices and methods are disclosed that allow a patient to self-treat a medical condition, such as migraine headache and trigeminal neuralgia and the like, by noninvasive electrical stimulation of nerves of the head, particularly supraorbital, supratrochlear, infraorbital, and mental nerves in the vicinity of their foramen or notch. The system comprises a handheld mobile device, such as a smartphone, that is applied to the surface of the patient's head. One or more electrodes on the mobile device apply electrical impulses transcutaneously through the patient's skin to the targeted nerve to treat the medical condition. The system is designed to address problems that arise particularly during self-treatment, when a medical professional is not present.
    Type: Grant
    Filed: July 21, 2014
    Date of Patent: August 13, 2019
    Assignee: Electrocore, Inc.
    Inventors: Joseph P. Errico, Steven Mendez, Bruce J. Simon
  • Patent number: 10363415
    Abstract: A non-invasive electrical stimulation device shapes an elongated electric field of effect that can be oriented parallel to a long nerve, such as a vagus nerve in a patient's neck, producing a desired physiological response in the patient. The stimulator comprises a source of electrical power, at least one electrode and a continuous electrically conducting medium in which the electrode(s) are in contact. The stimulation device is configured to produce a peak pulse voltage that is sufficient to produce a physiologically effective electric field in the vicinity of a target nerve, but not to substantially stimulate other nerves and muscles that lie between the vicinity of the target nerve and patient's skin. Current is passed through the electrodes in bursts of preferably five sinusoidal pulses, wherein each pulse within a burst has a duration of preferably 200 microseconds, and bursts repeat at preferably at 15-50 bursts per second.
    Type: Grant
    Filed: May 9, 2016
    Date of Patent: July 30, 2019
    Assignee: Electrocore, Inc.
    Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
  • Patent number: 10363419
    Abstract: Devices, systems and methods for treating at least one of a condition or a symptom of a patient by positioning a stimulation device at a target site adjacent to or near a nerve within a patient. The stimulation device comprising an antenna and one or more electrodes. Transmitting electrical energy to the antenna and generating electrical impulses within the stimulation device with the electrical energy and applying the series of electrical impulses to the nerve via the electrode. The electrical impulses sufficient to modulate the nerve and treat the condition or symptom of the patient; and which have on periods where the electrical impulses are generated and applied to the nerve and off periods between the electrical impulses, where the electrical energy is transmitted to the antenna.
    Type: Grant
    Filed: May 19, 2017
    Date of Patent: July 30, 2019
    Assignee: Electrocore, Inc.
    Inventors: Bruce J. Simon, Joseph P. Errico, Steven Mendez
  • Patent number: 10350411
    Abstract: Devices, systems and methods for treating medical disorders, such as migraine or other primary headaches, or fibromyalgia, by noninvasive electrical stimulation of a vagus nerve, used in conjunction with the measurement of evoked potentials (EPs). The system comprises a stimulator that is applied to the surface of the patient's neck to apply electrical impulses sufficient to stimulate a cervical vagus nerve, scalp electrodes that are used to measure EPs that are evoked by that stimulation, feedback or biofeedback circuits to vary the stimulation based upon EP characteristics, and other sensory stimulation modalities that produce EPs. The system is preferably used to optimize the placement of the stimulator, to test whether a patient is a suitable candidate for treatment using vagus nerve stimulation, and to select the stimulation parameters that optimized acute or chronic treatment, e.g., by correcting an EP habituation deficit.
    Type: Grant
    Filed: August 9, 2016
    Date of Patent: July 16, 2019
    Assignee: Electrocore, Inc.
    Inventors: Bruce J. Simon, Joseph P. Errico
  • Patent number: 10335593
    Abstract: Devices and methods are disclosed that treat a medical condition, such as migraine headache, by electrically stimulating a nerve noninvasively, which may be a vagus nerve situated within a patient's neck. Preferred embodiments allow a patient to self-treat his or her condition. Disclosed methods assure that the device is being positioned correctly on the neck and that the amplitude and other parameters of the stimulation actually stimulate the vagus nerve with a therapeutic waveform. Those methods comprise measuring properties of the patient's larynx, pupil diameters, blood flow within an eye, electrodermal activity and/or heart rate variability.
    Type: Grant
    Filed: February 8, 2016
    Date of Patent: July 2, 2019
    Assignee: Electrocore, Inc.
    Inventors: Bruce J. Simon, Joseph P. Errico
  • Patent number: 10293160
    Abstract: Devices, systems and methods are disclosed that allow a patient to self-treat neurodegenerative diseases, such as dementia, Alzheimer's disease, ischemic stroke, post-concussion syndrome, chronic traumatic encephalopathy and the like by electrical noninvasive stimulation of a vagus nerve. The system comprises a handheld stimulator that is applied to the surface of the patient's neck, wherein the stimulator comprises or is joined to a smartphone. A camera of the smartphone may be used to position and reposition the stimulator to a particular location on the patient's neck. The system may also comprise a base station that is used to meter the charging of a rechargeable battery within the stimulator. The base station and stimulator transmit data to one another regarding the status of a stimulation session.
    Type: Grant
    Filed: July 18, 2014
    Date of Patent: May 21, 2019
    Assignee: Electrocore, Inc.
    Inventors: Joseph P. Errico, Steven Mendez, Bruce J. Simon
  • Patent number: 10286211
    Abstract: In a device, system and method for electrical stimulation of the vagus nerve to treat or prevent disorders in a patient, the device comprises a handheld device having one or more electrode interfaces for contacting the outer skin surface of a patient, and a power source and a signal generator coupled to the electrode/interfaces for applying one or more electrical impulses to a deep nerve within the patient, such as the vagus nerve. In certain embodiments, the device further comprises a filter situated in series between the signal generator and the electrode/interfaces for filtering out undesired high frequency components of the electrical impulses to create a cleaner, smoother signal. The filter may comprise an electrically conductive medium and/or a low-pass filter between the signal generator and the electrode/interface.
    Type: Grant
    Filed: February 13, 2017
    Date of Patent: May 14, 2019
    Assignee: Electrocore, Inc.
    Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
  • Patent number: 10286212
    Abstract: Transcutaneous electrical and magnetic nerve stimulation devices are disclosed, along with methods of averting imminent medical attacks using energy that is delivered noninvasively by the devices. In particular, the devices and methods involve handheld devices designed to stimulate the vagus nerve of a patient with a signal sufficient to minimize or avert epileptic seizures.
    Type: Grant
    Filed: January 24, 2012
    Date of Patent: May 14, 2019
    Assignee: Electrocore, Inc.
    Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
  • Patent number: 10279163
    Abstract: Transcutaneous electrical nerve stimulation devices and magnetic stimulation devices are disclosed, along with methods of treating medical disorders using energy that is delivered noninvasively by such devices. The disorders comprise migraine and other primary headaches such as cluster headaches, including nasal or paranasal sinus symptoms that resemble an immune-mediated response (“sinus” headaches). The devices and methods may also be used to treat rhinitis, sinusitis, or rhinosinusitis, irrespective of whether those disorders are co-morbid with a headache. They may also be used to treat other disorders that may be co-morbid with migraine or cluster headaches, such as anxiety disorders. In preferred embodiments of the disclosed methods, one or both of the patient's vagus nerves are stimulated non-invasively. In other embodiments, parts of the sympathetic nervous system and/or the adrenal glands are stimulated.
    Type: Grant
    Filed: March 18, 2014
    Date of Patent: May 7, 2019
    Assignee: Electrocore, Inc.
    Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
  • Patent number: 10265523
    Abstract: The present disclosure includes methods and devices for a non-invasive treatment of a neurodegenerative disease through a delivery of energy to a target nervous tissue, such as a vagus nerve of a patient. Such energy can be applied to the patient to generate an electrical impulse. The electrical impulse can be modulated to increase an activity of an anti-inflammatory cytokine in the patient to inhibit inflammation and treat the neurodegenerative disease. Such stimulation can bring about a reduction of neuro-inflammation in some patients suffering from one or more conditions, such as Alzheimer's Disease, Parkinson's Disease, Multiple Sclerosis, postoperative cognitive dysfunction, or postoperative delirium.
    Type: Grant
    Filed: August 19, 2014
    Date of Patent: April 23, 2019
    Assignee: Electrocore, Inc.
    Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
  • Patent number: 10238859
    Abstract: Devices, systems and methods are disclosed for treating or preventing an autism spectrum disorder, a pervasive developmental disorder, or a disorder of psychological development. The methods comprise transmitting impulses of energy non-invasively to selected nerve fibers, particularly those in a vagus nerve. The nerve stimulation may be used as a behavior conditioning tool, by producing euphoria in an autistic individual. Vagus nerve stimulation is also used to modulate circulating serotonin levels in a pregnant woman so as to reduce the risk of having an autistic child; modulate the levels of growth factors within a child; promote balance of neuronal excitation/inhibition; modulate the activity of abnormal resting state neuronal networks; increase respiratory sinus arrhythmia; and avert episodes of motor stereotypies with the aid of forecasting methods.
    Type: Grant
    Filed: March 3, 2013
    Date of Patent: March 26, 2019
    Assignee: Electrocore, Inc.
    Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
  • Patent number: 10232174
    Abstract: Transcutaneous electrical and magnetic nerve stimulation devices and methods of treating lower urinary tract disorders deliver energy noninvasively to nerves within a patient. The disorders comprise overactive bladder, urge incontinence, stress incontinence, urge frequency, non-obstructive urinary retention and interstitial cystitis/painful bladder syndrome. For example, a posterior tibial nerve of a patient is stimulated non-invasively. Protocol parameters are selected for a nerve stimulation session for treating each individual patient, where modules of the bladder of the patient are represented as coupled non-linear oscillators.
    Type: Grant
    Filed: October 29, 2015
    Date of Patent: March 19, 2019
    Assignee: Electrocore, Inc.
    Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
  • Patent number: 10232178
    Abstract: Devices, systems and methods are disclosed for treating or preventing dementia, such as Alzheimer's disease. The methods comprise transmitting impulses of energy non-invasively to selected nerve fibers, particularly those in a vagus nerve, that modulate the activity of a patient's locus ceruleus. The transmitted energy impulses, comprising magnetic and/or electrical energy, stimulate the selected nerve fibers to cause the locus ceruleus to release norepinephrine into regions of the brain that contain beta-amyloids. The norepinephrine counteracts neuroinflammation that would damage neurons in those regions and the locus ceruleus, thereby arresting or slowing the progression of the disease in the patient.
    Type: Grant
    Filed: November 8, 2012
    Date of Patent: March 19, 2019
    Assignee: Electrocore, Inc.
    Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle