Patents Assigned to ElectroCore, Inc.
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Patent number: 10286211Abstract: In a device, system and method for electrical stimulation of the vagus nerve to treat or prevent disorders in a patient, the device comprises a handheld device having one or more electrode interfaces for contacting the outer skin surface of a patient, and a power source and a signal generator coupled to the electrode/interfaces for applying one or more electrical impulses to a deep nerve within the patient, such as the vagus nerve. In certain embodiments, the device further comprises a filter situated in series between the signal generator and the electrode/interfaces for filtering out undesired high frequency components of the electrical impulses to create a cleaner, smoother signal. The filter may comprise an electrically conductive medium and/or a low-pass filter between the signal generator and the electrode/interface.Type: GrantFiled: February 13, 2017Date of Patent: May 14, 2019Assignee: Electrocore, Inc.Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
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Patent number: 10279163Abstract: Transcutaneous electrical nerve stimulation devices and magnetic stimulation devices are disclosed, along with methods of treating medical disorders using energy that is delivered noninvasively by such devices. The disorders comprise migraine and other primary headaches such as cluster headaches, including nasal or paranasal sinus symptoms that resemble an immune-mediated response (“sinus” headaches). The devices and methods may also be used to treat rhinitis, sinusitis, or rhinosinusitis, irrespective of whether those disorders are co-morbid with a headache. They may also be used to treat other disorders that may be co-morbid with migraine or cluster headaches, such as anxiety disorders. In preferred embodiments of the disclosed methods, one or both of the patient's vagus nerves are stimulated non-invasively. In other embodiments, parts of the sympathetic nervous system and/or the adrenal glands are stimulated.Type: GrantFiled: March 18, 2014Date of Patent: May 7, 2019Assignee: Electrocore, Inc.Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
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Patent number: 10265523Abstract: The present disclosure includes methods and devices for a non-invasive treatment of a neurodegenerative disease through a delivery of energy to a target nervous tissue, such as a vagus nerve of a patient. Such energy can be applied to the patient to generate an electrical impulse. The electrical impulse can be modulated to increase an activity of an anti-inflammatory cytokine in the patient to inhibit inflammation and treat the neurodegenerative disease. Such stimulation can bring about a reduction of neuro-inflammation in some patients suffering from one or more conditions, such as Alzheimer's Disease, Parkinson's Disease, Multiple Sclerosis, postoperative cognitive dysfunction, or postoperative delirium.Type: GrantFiled: August 19, 2014Date of Patent: April 23, 2019Assignee: Electrocore, Inc.Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
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Patent number: 10238859Abstract: Devices, systems and methods are disclosed for treating or preventing an autism spectrum disorder, a pervasive developmental disorder, or a disorder of psychological development. The methods comprise transmitting impulses of energy non-invasively to selected nerve fibers, particularly those in a vagus nerve. The nerve stimulation may be used as a behavior conditioning tool, by producing euphoria in an autistic individual. Vagus nerve stimulation is also used to modulate circulating serotonin levels in a pregnant woman so as to reduce the risk of having an autistic child; modulate the levels of growth factors within a child; promote balance of neuronal excitation/inhibition; modulate the activity of abnormal resting state neuronal networks; increase respiratory sinus arrhythmia; and avert episodes of motor stereotypies with the aid of forecasting methods.Type: GrantFiled: March 3, 2013Date of Patent: March 26, 2019Assignee: Electrocore, Inc.Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
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Patent number: 10232178Abstract: Devices, systems and methods are disclosed for treating or preventing dementia, such as Alzheimer's disease. The methods comprise transmitting impulses of energy non-invasively to selected nerve fibers, particularly those in a vagus nerve, that modulate the activity of a patient's locus ceruleus. The transmitted energy impulses, comprising magnetic and/or electrical energy, stimulate the selected nerve fibers to cause the locus ceruleus to release norepinephrine into regions of the brain that contain beta-amyloids. The norepinephrine counteracts neuroinflammation that would damage neurons in those regions and the locus ceruleus, thereby arresting or slowing the progression of the disease in the patient.Type: GrantFiled: November 8, 2012Date of Patent: March 19, 2019Assignee: Electrocore, Inc.Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
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Patent number: 10232174Abstract: Transcutaneous electrical and magnetic nerve stimulation devices and methods of treating lower urinary tract disorders deliver energy noninvasively to nerves within a patient. The disorders comprise overactive bladder, urge incontinence, stress incontinence, urge frequency, non-obstructive urinary retention and interstitial cystitis/painful bladder syndrome. For example, a posterior tibial nerve of a patient is stimulated non-invasively. Protocol parameters are selected for a nerve stimulation session for treating each individual patient, where modules of the bladder of the patient are represented as coupled non-linear oscillators.Type: GrantFiled: October 29, 2015Date of Patent: March 19, 2019Assignee: Electrocore, Inc.Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
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Patent number: 10220207Abstract: Systems, devices and methods for averting imminent medical attacks comprise transcutaneous electrical and magnetic nerve stimulation devices using energy that is delivered non-invasively to the patient. One or more sensors detect physiological and/or environmental signals within a patient and the values of these signals are used to forecast an acute medical event, which can be treated via non-invasive nerve stimulation. The acute medical events may comprise, among others, bronchoconstriction, epileptic seizures, primary headache, such as migraine or cluster headaches, transient ischemic attack or stroke, onset of atrial fibrillation, myocardial infarction, and acute depression or anxiety.Type: GrantFiled: October 19, 2012Date of Patent: March 5, 2019Assignee: Electrocore, Inc.Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
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Patent number: 10213601Abstract: Energy is transmitted noninvasively to a patient using electrode-based stimulation devices or magnetic stimulation devices that are designed to non-invasively stimulate nerves selectively. The devices produce impulses that are used to treat atrial fibrillation, by stimulating a vagus nerve of a patient. The devices are also used to forecast the imminent onset of atrial fibrillation and then avert it by stimulating a vagus nerve.Type: GrantFiled: September 4, 2015Date of Patent: February 26, 2019Assignee: Electrocore, Inc.Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
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Patent number: 10173048Abstract: Transcutaneous electrical nerve stimulation devices and magnetic stimulation devices are disclosed, along with methods of treating medical disorders using energy that is delivered noninvasively by such devices. The disorders comprise migraine and other primary headaches such as cluster headaches, including nasal or paranasal sinus symptoms that resemble an immune-mediated response (“sinus” headaches). The devices and methods may also be used to treat rhinitis, sinusitis, or rhinosinusitis, irrespective of whether those disorders are co-morbid with a headache. They may also be used to treat other disorders that may be co-morbid with migraine or cluster headaches, such as anxiety disorders. In preferred embodiments of the disclosed methods, one or both of the patient's vagus nerves are stimulated non-invasively. In other embodiments, parts of the sympathetic nervous system and/or the adrenal glands are stimulated.Type: GrantFiled: March 18, 2014Date of Patent: January 8, 2019Assignee: Electrocore, Inc.Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
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Publication number: 20110046432Abstract: Devices, systems and methods are disclosed for treating bronchial constriction related to asthma, anaphylaxis or chronic obstructive pulmonary disease. The treatment comprises transmitting impulses of energy non-invasively to selected nerve fibers that are responsible for smooth muscle dilation. The transmitted energy impulses, comprising magnetic and/or electrical, mechanical and/or acoustic, and optical and/or thermal energy, stimulate the selected nerve fibers.Type: ApplicationFiled: August 19, 2010Publication date: February 24, 2011Applicant: ElectroCore Inc.Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle, Steven Mendez
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Publication number: 20100241188Abstract: Devices, systems and methods for applying electrical impulse(s) to one or more selected nerves in or around the carotid sheath are described. An electrode assembly is introduced through a percutaneous penetration in a patient to a target location adjacent to, or in close proximity with, the carotid sheath. Once in position, one or more electrical impulses are applied through the electrode assembly to one or more selected nerves to stimulate, block or otherwise modulate the nerve(s) and acutely treat the patient's condition.Type: ApplicationFiled: April 13, 2009Publication date: September 23, 2010Applicant: ElectroCore, Inc.Inventors: Joseph P. Errico, James R. Pastena, Steven Mendez, Hecheng Hu, Arthur Ross, Bruce Simon, Richard P. Dickerson
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Publication number: 20100174340Abstract: The present invention provides systems, apparatus and methods for selectively applying electrical energy to body tissue. More specifically, systems and methods are provided for introducing a flowable electrode to a target site within the patient such that the flowable electrode converts to a hardened electrode after being introduced to the target site. An electrical impulse is applied to the hardened electrode to modulate one or more nerve(s) at the target site. The electrode preferably comprises a conductive polymer material.Type: ApplicationFiled: January 5, 2010Publication date: July 8, 2010Applicant: ElectroCore, Inc.Inventor: Bruce J. Simon
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Publication number: 20100160996Abstract: Methods and apparatus for treating ailments provide for: inserting a balloon-electrode device into an esophagus of a mammal, the balloon-electrode device including: (i) a nasogastral (NG) having an internal passageway and an external surface, (ii) at least one electrode coupled to the external surface of the NG tube, (iii) a conductor extending through the internal passageway of the NG tube and electrically connecting to the electrode, and (iv) a balloon surrounding the electrode and a portion of the NG tube; inflating the balloon with fluid such that the electrode is substantially centrally located within an interior volume of the balloon; and applying at least one electrical signal to the electrode via the conductor such that an electromagnetic field emanates from the electrode to at least one of nerves and muscles of the mammal.Type: ApplicationFiled: December 18, 2008Publication date: June 24, 2010Applicant: ElectroCore, Inc.Inventors: Bruce Simon, Steven Mendez, Hecheng Hu, Richard P. Dickerson, James R. Pastena
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Publication number: 20100057178Abstract: The present invention provides systems, apparatus and methods for selectively applying electrical energy to body tissue. More specifically, systems and methods are provided for introducing a spinal cord stimulation electrode device into a patient's epidural space through a small portal, such as a percutaneous penetration, and then expanding the electrode device once inside the epidural space to achieve a larger footprint of contact on the dura. This substantially prevents migration of the electrode within the epidural space and provides for more efficient and effective treatment.Type: ApplicationFiled: September 11, 2009Publication date: March 4, 2010Applicant: ElectroCore, Inc.Inventor: Bruce J. Simon
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Publication number: 20100042178Abstract: Methods and devices for treating bronchial constriction related to asthma and anaphylaxis wherein the treatment includes providing an electrical impulse to a selected region of the vagus nerve and/or the lungs of a patient suffering from bronchial constriction.Type: ApplicationFiled: November 1, 2006Publication date: February 18, 2010Applicant: ElectroCore, Inc.Inventors: Joseph Errico, James Pastena, Steven Mendez, Hecheng Hu, Arthur Ross
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Publication number: 20100010564Abstract: The present invention provides systems, apparatus and methods for treating nerve disorders in the brain. An electrode is introduced into a patient's sinus cavity and an electrical impulse is applied to the electrode to modulate one or more target nerves in the brain to treat the disorder. In preferred embodiments, the electrode is positioned within a sinus cavity adjacent to or near the frontal cortex of the brain and the electrical signal is sufficient to modulate, stimulate and/or inhibit nerves within the frontal cortex. The electrode may be movable between a collapsed or compact configuration for introduction into the sinus cavity and an expanded configuration for contacting tissue within the sinus cavity to deliver the electrical impulse through the tissue to the target nerves in the brain.Type: ApplicationFiled: July 22, 2009Publication date: January 14, 2010Applicant: ElectroCore, Inc.Inventor: Bruce Simon
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Publication number: 20090319002Abstract: The present invention provides systems, apparatus and methods for applying electric current to neurons in the brain to treat disorders and to improve motor and/or memory functions in a patient. In a method according to the invention, an electrode is positioned adjacent to and spaced from the skin surface of the patient's head and an electric current is applied through the electrode to a target region in the brain to modulate one or more neurons in the target region. The electrode is housed within an enclosure and spaced from the skin surface so that the electrode does not directly contact the patient's tissue, which reduces the potential for collateral tissue damage or necrosis and shields the electrode from the patient's tissue which substantially inhibits Faradic products (e.g., H+, OH?, H2O2) of the electrode from reaching the target site.Type: ApplicationFiled: August 27, 2009Publication date: December 24, 2009Applicant: ElectroCore, Inc.Inventor: Bruce Simon
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Publication number: 20090292333Abstract: Methods and devices for treating hypotension, such as in cases of shock, including septic shock and anaphylactic shock, wherein the treatment includes providing an electrical impulse to a selected region of the vagus nerve of a patient suffering from hypotension to block and/or modulate nerve signals that regulate blood pressure.Type: ApplicationFiled: July 21, 2009Publication date: November 26, 2009Applicant: ElectroCore, Inc.Inventors: Joseph P. Errico, Steven Mendez, James R. Pastena
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Publication number: 20090281593Abstract: Devices, systems and methods for treating bronchial constriction related to asthma, anaphylaxis or chronic obstructive pulmonary disease wherein the treatment includes stimulating selected nerve fibers responsible for smooth muscle dilation at a selected region within a patient's neck, thereby reducing the magnitude of constriction of bronchial smooth muscle.Type: ApplicationFiled: March 20, 2009Publication date: November 12, 2009Applicant: ElectroCore, Inc.Inventors: Joseph P. Errico, James R. Pastena, Steven Mendez, Hecheng Hu, Arthur Ross, Bruce Simon
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Publication number: 20090259274Abstract: The present invention provides systems, apparatus and methods for selectively applying electrical energy to body tissue. A device is provided having an enclosure within an outer wall formed from an electrically-permeable material to allow for electrical energy to pass from the interior of the enclosure through the outer wall. The device further includes an electrode positioned within the interior of the enclosure and a fluid passage coupled to the enclosure for delivery of an electrically conductive fluid into the interior of the enclosure such that the electrically conductive fluid couples the electrode with the electrically-permeable section of the outer wall. The conductive fluid allows for the passage of electrical energy from the electrode through the fluid and the outer wall of the enclosure for treatment of tissue on or in a patient.Type: ApplicationFiled: February 27, 2009Publication date: October 15, 2009Applicant: ElectroCore, Inc.Inventors: Bruce Simon, Steven Mendez, Hecheng Hu, Richard P. Dickerson, James R. Pastena, Puyun Guo