Patents Assigned to ElectroCore LLC
-
Patent number: 9089719Abstract: A novel non-invasive magnetic stimulator is used to modulate electrical activity of a patient's vagus nerve. Parameters of the stimulation are selected in such a way as to induce a state of euphoria in the patient. The methods and devices may be used for anesthesia, or to treat insomnia, depression, or premenstrual syndromes. They may be used as substitution withdrawal tools for individuals who otherwise would depend on substances and behaviors to achieve a euphoric state of mind, particularly individuals who abusively consume drugs, alcohol or food, or who exhibit behavioral disorders such as compulsive gambling. The devices and methods may also be used to prevent, manage, or relieve stress.Type: GrantFiled: February 10, 2011Date of Patent: July 28, 2015Assignee: Electrocore, LLCInventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
-
Patent number: 9067054Abstract: A non-invasive electrical stimulator shapes an elongated electric field of effect that can be oriented parallel to a long nerve, such as a vagus nerve in a patient's neck, producing a desired physiological response in the patient. The stimulator comprises a source of electrical power, at least one electrode and a continuous electrically conducting medium in contact with the electrodes. The conducting medium is also in contact with an interface element that may conform to the contour of a target body surface of the patient when the interface element is applied to that surface. When the interface element is made of insulating (dielectric) material, and disclosed stimulation waveforms are used, the power source need not supply high voltage, in order to capacitively stimulate the target nerve.Type: GrantFiled: February 24, 2014Date of Patent: June 30, 2015Assignee: Electrocore, LLCInventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
-
Patent number: 9043001Abstract: Non-invasive electrical nerve stimulation devices and magnetic stimulation devices are disclosed, along with methods of treating medical disorders using energy that is delivered noninvasively by such devices. The disorders comprise migraine and other primary headaches such as cluster headaches, including sinus symptoms that resemble an immune-mediated response (“sinus” headaches), irrespective of whether those symptoms arise from an allergy that is co-morbid with the headache. The disclosed methods may also be used to treat other disorders that may be co-morbid with migraine headaches, such as anxiety disorders. In preferred embodiments of the disclosed methods, one or both of the patient's vagus nerves are stimulated non-invasively. In other embodiments, parts of the sympathetic nervous system and/or the adrenal glands are stimulated.Type: GrantFiled: September 16, 2013Date of Patent: May 26, 2015Assignee: Electrocore, LLCInventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
-
Publication number: 20150142082Abstract: Devices, systems and methods are disclosed that are used to treat a medical condition, by electrical stimulation of a nerve or nerve ganglion, used in conjunction with biofeedback. The system comprises a stimulator that applies electrical impulses sufficient to modulate a nerve at a target site within the patient. A sensor measures a physiological output from the patient, such as heart rate variability, and a property of the stimulation signal is varied based on the physiological output.Type: ApplicationFiled: November 15, 2013Publication date: May 21, 2015Applicant: ElectroCore, LLCInventors: Bruce J. Simon, Joseph P. Errico
-
Patent number: 9037247Abstract: Devices, systems and methods for treating bronchoconstriction associated with asthma, anaphylaxis or chronic obstructive pulmonary disease. The treatment comprises transmitting impulses of energy non-invasively to selected nerve fibers that are responsible for smooth muscle dilation, such as the vagus nerve.Type: GrantFiled: August 19, 2010Date of Patent: May 19, 2015Assignee: Electrocore, LLCInventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle, Steven Mendez
-
Patent number: 9037246Abstract: Methods and devices for treating bronchial constriction related to asthma and anaphylaxis wherein the treatment includes providing an electrical impulse to a selected region of the vagus nerve and/or the lungs of a patient suffering from bronchial constriction.Type: GrantFiled: May 25, 2010Date of Patent: May 19, 2015Assignee: Electrocore, LLCInventors: Joseph P. Errico, James R. Pastena, Steven Mendez, Hecheng Hu, Arthur Ross
-
Publication number: 20150127068Abstract: Devices, systems and methods for applying electrical impulse(s) to one or more selected nerves are described. An electrical stimulator is introduced through a to a target location within, adjacent to, or in close proximity with, the carotid sheath. The stimulator has an antenna that allows it to be powered solely by far-field or approximately plane wave electromagnetic radiation, having frequencies in the range of 0.3 to 10 GHz. Electrical impulses are applied through the stimulator to a vagus nerve to stimulate, block or otherwise modulate activity of the nerve and treat the patient's condition. The stimulator uses an adjustable number of fixed voltage (or fixed current) pulses with fixed duration to elicit desired changes in nerve response, the timing of which are controlled by an external power transmitter and controller.Type: ApplicationFiled: November 4, 2013Publication date: May 7, 2015Applicant: ElectroCore, LLCInventors: Bruce J. Simon, Joseph P. Errico, Steven Mendez
-
Patent number: 9020598Abstract: Non-invasive electrical nerve stimulation devices and magnetic stimulation devices are disclosed, along with methods of treating medical disorders using energy that is delivered noninvasively by such devices. The disorders comprise migraine and other primary headaches such as cluster headaches, including sinus symptoms that resemble an immune-mediated response (“sinus” headaches), irrespective of whether those symptoms arise from an allergy that is co-morbid with the headache. The disclosed methods may also be used to treat other disorders that may be co-morbid with migraine headaches, such as anxiety disorders. In preferred embodiments of the disclosed methods, one or both of the patient's vagus nerves are stimulated non-invasively. In other embodiments, parts of the sympathetic nervous system and/or the adrenal glands are stimulated.Type: GrantFiled: September 16, 2013Date of Patent: April 28, 2015Assignee: ElectroCore, LLCInventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
-
Patent number: 9014823Abstract: Non-invasive electrical nerve stimulation devices and magnetic stimulation devices are disclosed, along with methods of treating medical disorders using energy that is delivered noninvasively by such devices. The disorders comprise migraine and other primary headaches such as cluster headaches, including sinus symptoms that resemble an immune-mediated response (“sinus” headaches), irrespective of whether those symptoms arise from an allergy that is co-morbid with the headache. The disclosed methods may also be used to treat other disorders that may be co-morbid with migraine headaches, such as anxiety disorders. In preferred embodiments of the disclosed methods, one or both of the patient's vagus nerves are stimulated non-invasively. In other embodiments, parts of the sympathetic nervous system and/or the adrenal glands are stimulated.Type: GrantFiled: September 16, 2013Date of Patent: April 21, 2015Assignee: ElectroCore, LLCInventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
-
Patent number: 8983628Abstract: Devices, systems and methods are disclosed for treating a variety of diseases and disorders that are primarily or at least partially driven by an imbalance in neurotransmitters in the brain, such as asthma, COPD, depression, anxiety, epilepsy, fibromyalgia, and the like. The invention involves the use of an energy source comprising magnetic and/or electrical energy that is transmitted non-invasively to, or in close proximity to, a selected nerve to temporarily stimulate, block and/or modulate the signals in the selected nerve such that neural pathways are activated to release inhibitory neurotransmitters in the patient's brain.Type: GrantFiled: September 5, 2012Date of Patent: March 17, 2015Assignee: Electrocore, LLCInventors: Bruce Simon, Joseph P. Errico, John T. Raffle
-
Patent number: 8983629Abstract: Devices, systems and methods are disclosed for treating bronchial constriction related to asthma, anaphylaxis, chronic obstructive pulmonary disease (COPD), exercise-induced bronchospasm and post-operative bronchospasm. The treatment comprises transmitting impulses of energy non-invasively to selected nerve fibers that activate neural pathways to reduce the release of acetycholine from airway-related vagal preganglionic neurons within the brain of the patient. The transmitted energy impulses, comprising magnetic and/or electrical energy, stimulate the selected nerve fibers to produce the bronchodilation.Type: GrantFiled: September 5, 2012Date of Patent: March 17, 2015Assignee: Electrocore, LLCInventors: Bruce Simon, Joseph P. Errico, John T. Raffle
-
Patent number: 8972004Abstract: Devices and systems are disclosed for the non-invasive treatment of medical conditions through delivery of energy to target tissue, comprising a source of electrical power, a magnetically permeable toroidal core, and a coil that is wound around the core. The coil and core are embedded in a continuous electrically conducting medium, which is adapted to have a shape that conforms to the contour of an arbitrarily oriented target body surface of a patient. The conducting medium is applied to that surface by any of several disclosed methods, and the source of power supplies a pulse of electric charge to the coil, such that the coil induces an electric current and/or an electric field within the patient, thereby stimulating tissue and/or one or more nerve fibers within the patient. The invention shapes an elongated electric field of effect that can be oriented parallel to a long nerve. In one embodiment, the device comprises two toroidal cores that lie adjacent to one another.Type: GrantFiled: July 10, 2013Date of Patent: March 3, 2015Assignee: Electrocore, LLCInventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
-
Patent number: 8948873Abstract: The present invention includes methods and devices for treating hypotension, such as in cases of shock, including septic shock, anaphylactic shock and hypovolemia. The method includes the step of applying at least one electrical impulse to at least one selected region of a parasympathetic nervous system of the patient. The electrical impulse is sufficient to modulate one or more nerves of the parasympathetic nervous system to increase the ratio of blood pressure to heart rate and relieve the condition and/or extend the patient's life.Type: GrantFiled: December 17, 2013Date of Patent: February 3, 2015Assignee: Electrocore, LLCInventors: Bruce J. Simon, Joseph P. Errico, Steven Mendez
-
Patent number: 8934977Abstract: Methods and devices for treating anaphylaxis, anaphylactic shock, bronchial constriction, and/or asthma include providing an electrical impulse to a selected region of the vagus nerve of a patient suffering from anaphylaxis to block and/or modulate nerve signals that would regulate the function of, for example, myocardial tissue, vasodilation/constriction and/or pulmonary tissue.Type: GrantFiled: April 11, 2014Date of Patent: January 13, 2015Assignee: Electrocore, LLCInventors: Joseph P. Errico, Steven Mendez
-
Patent number: 8918178Abstract: Devices, systems and methods are disclosed for treating a variety of diseases and disorders that are primarily or at least partially driven by an imbalance in neurotransmitters in the brain, such as asthma, COPD, depression, anxiety, epilepsy, fibromyalgia, and the like. The invention involves the use of an energy source comprising magnetic and/or electrical energy that is transmitted non-invasively to, or in close proximity to, a selected nerve to temporarily stimulate, block and/or modulate the signals in the selected nerve such that neural pathways are activated to release inhibitory neurotransmitters in the patient's brain.Type: GrantFiled: September 5, 2012Date of Patent: December 23, 2014Assignee: Electrocore, LLCInventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
-
Patent number: 8914122Abstract: A non-invasive electrical stimulation device shapes an elongated electric field of effect that can be oriented parallel to a long nerve, such as a vagus nerve in a patient's neck, producing a desired physiological response in the patient. The stimulator comprises a source of electrical power, at least one electrode and a continuous electrically conducting medium in which the electrode(s) are in contact. The stimulation device is configured to produce a peak pulse voltage that is sufficient to produce a physiologically effective electric field in the vicinity of a target nerve, but not to substantially stimulate other nerves and muscles that lie between the vicinity of the target nerve and patient's skin. Current is passed through the electrodes in bursts of preferably five sinusoidal pulses, wherein each pulse within a burst has a duration of preferably 200 microseconds, and bursts repeat at preferably at 15-50 bursts per second.Type: GrantFiled: August 31, 2011Date of Patent: December 16, 2014Assignee: Electrocore, LLCInventors: Bruce Simon, Joseph Errico, John T Raffle
-
Patent number: 8880175Abstract: Systems and devices for selectively applying electrical energy to a target region beneath a skin surface of a patient involve applying an electrical impulse to one or more electrodes on a skin surface of the patient to modulate one or more nerves at the target region, where the impulse is substantially blocked at nerves located between the target region and the skin surface such that only the nerves at the target region are modulated by the electrical impulse.Type: GrantFiled: July 8, 2013Date of Patent: November 4, 2014Assignee: Electrocore, LLCInventor: Bruce J. Simon
-
Publication number: 20140324118Abstract: Devices, systems and methods for treating medical disorders, such as migraine or other primary headaches, or fibromyalgia, by noninvasive electrical stimulation of a vagus nerve, used in conjunction with the measurement of evoked potentials (EPs). The system comprises a stimulator that is applied to the surface of the patient's neck to apply electrical impulses sufficient to stimulate a cervical vagus nerve, scalp electrodes that are used to measure EPs that are evoked by that stimulation, feedback or biofeedback circuits to vary the stimulation based upon EP characteristics, and other sensory stimulation modalities that produce EPs. The system is preferably used to optimize the placement of the stimulator, to test whether a patient is a suitable candidate for treatment using vagus nerve stimulation, and to select the stimulation parameters that optimized acute or chronic treatment, e.g., by correcting an EP habituation deficit.Type: ApplicationFiled: March 14, 2014Publication date: October 30, 2014Applicant: ElectroCore, LLCInventors: Bruce J. Simon, Joseph P. Errico
-
Device and methods for non-invasive electrical stimulation and their use for vagal nerve stimulation
Patent number: 8874205Abstract: A non-invasive electrical stimulation device shapes an elongated electric field of effect that can be oriented parallel to a long nerve, such as a vagus nerve in a patient's neck, producing a desired physiological response in the patient. The stimulator comprises a source of electrical power, at least one electrode and a continuous electrically conducting medium in which the electrode(s) are in contact. The stimulation device is configured to produce a peak pulse voltage that is sufficient to produce a physiologically effective electric field in the vicinity of a target nerve, but not to substantially stimulate other nerves and muscles that lie between the vicinity of the target nerve and patient's skin. Current is passed through the electrodes in bursts of preferably five sinusoidal pulses, wherein each pulse within a burst has a duration of preferably 200 microseconds, and bursts repeat at preferably at 15-50 bursts per second.Type: GrantFiled: March 30, 2011Date of Patent: October 28, 2014Assignee: Electrocore, LLCInventors: Bruce Simon, Joseph P. Errico, John T. Raffle -
Patent number: 8874227Abstract: A non-invasive electrical stimulator shapes an elongated electric field of effect that can be oriented parallel to a long nerve, such as a vagus nerve in a patient's neck, producing a desired physiological response in the patient. The stimulator comprises a source of electrical power, at least one electrode and a continuous electrically conducting medium in contact with the electrodes. The conducting medium is also in contact with an interface element that may conform to the contour of a target body surface of the patient when the interface element is applied to that surface. When the interface element is made of insulating (dielectric) material, and disclosed stimulation waveforms are used, the power source need not supply high voltage, in order to capacitively stimulate the target nerve.Type: GrantFiled: July 15, 2011Date of Patent: October 28, 2014Assignee: Electrocore, LLCInventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle