Patents Assigned to ElectroCore LLC
  • Patent number: 8666496
    Abstract: The present invention provides systems, apparatus and methods for selectively applying electrical energy to body tissue. A device is provided with an electrode positioned within the interior of an enclosure and a fluid passage coupled to the enclosure for delivery of an electrically conductive fluid such that the electrically conductive fluid. The conductive fluid allows for the passage of electrical energy from the electrode through the fluid and the outer wall of the enclosure for treatment of tissue on or in a patient. The electrode does not directly contact the tissue of the patient, which reduces the potential for collateral tissue damage or necrosis and/or excessive electric fields in the tissue.
    Type: Grant
    Filed: February 17, 2013
    Date of Patent: March 4, 2014
    Assignee: Electrocore, LLC
    Inventors: Bruce Simon, Steven Mendez, Hecheng Hu, Richard P. Dickerson, James R. Pastena, Puyun Guo
  • Patent number: 8626298
    Abstract: The present invention provides systems, apparatus and methods for treating nerve disorders in the brain. An electrode is introduced into a patient's sinus cavity and an electrical impulse is applied to the electrode to modulate one or more target nerves in the brain to treat the disorder. In preferred embodiments, the electrode is positioned within a sinus cavity adjacent to or near the frontal cortex of the brain and the electrical signal is sufficient to modulate, stimulate and/or inhibit nerves within the frontal cortex. The electrode may be movable between a collapsed or compact configuration for introduction into the sinus cavity and an expanded configuration for contacting tissue within the sinus cavity to deliver the electrical impulse through the tissue to the target nerves in the brain.
    Type: Grant
    Filed: May 13, 2013
    Date of Patent: January 7, 2014
    Assignee: Electrocore, LLC
    Inventor: Bruce J. Simon
  • Patent number: 8612004
    Abstract: The present invention includes methods and devices for treating hypotension, such as in cases of shock, including septic shock, anaphylactic shock and hypovolemia. The method includes the step of applying at least one electrical impulse to at least one selected region of a parasympathetic nervous system of the patient. The electrical impulse is sufficient to modulate one or more nerves of the parasympathetic nervous system to increase the ratio of blood pressure to heart rate and relieve the condition and/or extend the patient's life.
    Type: Grant
    Filed: June 29, 2012
    Date of Patent: December 17, 2013
    Assignee: Electrocore, LLC
    Inventors: Joseph P. Errico, Bruce J. Simon, Steven Mendez
  • Publication number: 20130317580
    Abstract: Devices, systems and methods are disclosed for treating or preventing a stroke and/or a transient ischemic attack in a patient. The methods comprise transmitting impulses of energy non-invasively to selected nerve fibers, particularly those in a vagus nerve. Vagus nerve stimulation is used to modulate the release of GABA, norepinephrine, and/or serotonin, thereby providing neuroprotection to the patient; to modulate the activity of resting state neuronal networks, particularly the sensory-motor network or resting state networks containing the insula; and to avert a stroke or transient ischemic attack that has been forecasted.
    Type: Application
    Filed: July 29, 2013
    Publication date: November 28, 2013
    Applicant: ElectroCore, LLC
    Inventors: Bruce J. Simon, Joseph P. Errico
  • Publication number: 20130310909
    Abstract: Devices, systems and methods are disclosed for electrical stimulation of the vagus nerve to treat or prevent disorders in a patient. The methods comprise transmitting impulses of energy to the vagus nerve according to a treatment paradigm that includes single doses of 30 seconds to 5 minutes of continuous stimulation. The treatment paradigm further comprises one or more daily treatment sessions that each include one or more doses for prophylactic or acute treatment of the patient's condition. Vagus nerve stimulation is used to modulate the release of inhibitory neurotransmitters in the brain, such as GABA, norepinephrine, and/or serotonin.
    Type: Application
    Filed: July 29, 2013
    Publication date: November 21, 2013
    Applicant: ElectroCore, LLC
    Inventors: Bruce J. Simon, Joseph P. Errico
  • Publication number: 20130253625
    Abstract: The present invention provides systems, apparatus and methods for treating nerve disorders in the brain. An electrode is introduced into a patient's sinus cavity and an electrical impulse is applied to the electrode to modulate one or more target nerves in the brain to treat the disorder. In preferred embodiments, the electrode is positioned within a sinus cavity adjacent to or near the frontal cortex of the brain and the electrical signal is sufficient to modulate, stimulate and/or inhibit nerves within the frontal cortex. The electrode may be movable between a collapsed or compact configuration for introduction into the sinus cavity and an expanded configuration for contacting tissue within the sinus cavity to deliver the electrical impulse through the tissue to the target nerves in the brain.
    Type: Application
    Filed: May 13, 2013
    Publication date: September 26, 2013
    Applicant: ElectroCore, LLC
    Inventor: Bruce J. Simon
  • Patent number: 8543211
    Abstract: The present invention provides systems, apparatus and methods for treating nerve disorders in the brain. An electrode is introduced into a patient's sinus cavity and an electrical impulse is applied to the electrode to modulate one or more target nerves in the brain to treat the disorder. In preferred embodiments, the electrode is positioned within a sinus cavity adjacent to or near the frontal cortex of the brain and the electrical signal is sufficient to modulate, stimulate and/or inhibit nerves within the frontal cortex. The electrode may be movable between a collapsed or compact configuration for introduction into the sinus cavity and an expanded configuration for contacting tissue within the sinus cavity to deliver the electrical impulse through the tissue to the target nerves in the brain.
    Type: Grant
    Filed: July 22, 2009
    Date of Patent: September 24, 2013
    Assignee: Electrocore, LLC
    Inventor: Bruce J. Simon
  • Publication number: 20130245712
    Abstract: Devices, systems and methods are disclosed for treating bronchial constriction related to asthma, anaphylaxis, chronic obstructive pulmonary disease (COPD), exercise-induced bronchospasm and post-operative bronchospasm. The treatment comprises transmitting impulses of energy non-invasively to selected nerve fibers that activate neural pathways to reduce the release of acetycholine from airway-related vagal preganglionic neurons within the brain of the patient. The transmitted energy impulses, comprising magnetic and/or electrical energy, stimulate the selected nerve fibers to produce the bronchodilation.
    Type: Application
    Filed: September 5, 2012
    Publication date: September 19, 2013
    Applicant: ElectroCore, LLC.
    Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
  • Publication number: 20130245711
    Abstract: Devices, systems and methods are disclosed for treating a variety of diseases and disorders that are primarily or at least partially driven by an imbalance in neurotransmitters in the brain, such as asthma, COPD, depression, anxiety, epilepsy, fibromyalgia, and the like. The invention involves the use of an energy source comprising magnetic and/or electrical energy that is transmitted non-invasively to, or in close proximity to, a selected nerve to temporarily stimulate, block and/or modulate the signals in the selected nerve such that neural pathways are activated to release inhibitory neurotransmitters in the patient's brain.
    Type: Application
    Filed: September 5, 2012
    Publication date: September 19, 2013
    Applicant: ElectroCore, LLC
    Inventors: Bruce Simon, Joseph P. Errico, John T. Raffle
  • Publication number: 20130245486
    Abstract: Devices and methods are disclosed that treat a medical condition, such as migraine headache, by electrically stimulating a nerve noninvasively, which may be a vagus nerve situated within a patient's neck. Preferred embodiments allow a patient to self-treat his or her condition. Disclosed methods assure that the device is being positioned correctly on the neck and that the amplitude and other parameters of the stimulation actually stimulate the vagus nerve with a therapeutic waveform. Those methods comprise measuring properties of the patient's larynx, pupil diameters, blood flow within an eye, electrodermal activity and/or heart rate variability.
    Type: Application
    Filed: April 28, 2013
    Publication date: September 19, 2013
    Applicant: ElectroCore, LLC.
    Inventors: Bruce J. Simon, Joseph P. Errico
  • Publication number: 20130238049
    Abstract: Devices, systems and methods are disclosed for treating a variety of diseases and disorders that are primarily or at least partially driven by an imbalance in neurotransmitters in the brain, such as asthma, COPD, depression, anxiety, epilepsy, fibromyalgia, and the like. The invention involves the use of an energy source comprising magnetic and/or electrical energy that is transmitted non-invasively to, or in close proximity to, a selected nerve to temporarily stimulate, block and/or modulate the signals in the selected nerve such that neural pathways are activated to release inhibitory neurotransmitters in the patient's brain.
    Type: Application
    Filed: September 5, 2012
    Publication date: September 12, 2013
    Applicant: ElectroCore, LLC
    Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
  • Publication number: 20130238050
    Abstract: Devices, systems and methods are disclosed for treating a variety of diseases and disorders that are primarily or at least partially driven by an imbalance in neurotransmitters in the brain, such as asthma, COPD, depression, anxiety, epilepsy, fibromyalgia, and the like. The invention involves the use of an energy source comprising magnetic and/or electrical energy that is transmitted non-invasively to, or in close proximity to, a selected nerve to temporarily stimulate, block and/or modulate the signals in the selected nerve such that neural pathways are activated to release inhibitory neurotransmitters in the patient's brain.
    Type: Application
    Filed: September 5, 2012
    Publication date: September 12, 2013
    Applicant: ElectroCore, LLC.
    Inventors: Bruce Simon, Joseph P. Errico, John T. Raffle
  • Publication number: 20130204334
    Abstract: The present invention provides systems, apparatus and methods for selectively applying electrical energy to body tissue. A device is provided with an electrode positioned within the interior of an enclosure and a fluid passage coupled to the enclosure for delivery of an electrically conductive fluid such that the electrically conductive fluid. The conductive fluid allows for the passage of electrical energy from the electrode through the fluid and the outer wall of the enclosure for treatment of tissue on or in a patient. The electrode does not directly contact the tissue of the patient, which reduces the potential for collateral tissue damage or necrosis and/or excessive electric fields in the tissue.
    Type: Application
    Filed: February 17, 2013
    Publication date: August 8, 2013
    Applicant: ElectroCore LLC
    Inventors: Bruce Simon, Steven Mendez, Hecheng Hu, Richard P., James R. Pastena, Puyun Guo
  • Publication number: 20130184792
    Abstract: Devices, systems and methods are disclosed for treating or preventing an autism spectrum disorder, a pervasive developmental disorder, or a disorder of psychological development. The methods comprise transmitting impulses of energy non-invasively to selected nerve fibers, particularly those in a vagus nerve. The nerve stimulation may be used as a behavior conditioning tool, by producing euphoria in an autistic individual. Vagus nerve stimulation is also used to modulate circulating serotonin levels in a pregnant woman so as to reduce the risk of having an autistic child; modulate the levels of growth factors within a child; promote balance of neuronal excitation/inhibition; modulate the activity of abnormal resting state neuronal networks; increase respiratory sinus arrhythmia; and avert episodes of motor stereotypies with the aid of forecasting methods.
    Type: Application
    Filed: March 3, 2013
    Publication date: July 18, 2013
    Applicant: ElectroCore, LLC.
    Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
  • Patent number: 8483835
    Abstract: Methods and devices for treating anaphylaxis, anaphylactic shock, bronchial constriction, and/or asthma include providing an electrical impulse to a selected region of the vagus nerve of a patient suffering from anaphylaxis to block and/or modulate nerve signals that would regulate the function of, for example, myocardial tissue, vasodilation/constriction and/or pulmonary tissue.
    Type: Grant
    Filed: May 21, 2012
    Date of Patent: July 9, 2013
    Assignee: Electrocore, LLC
    Inventors: Joseph P. Errico, Steven Mendez
  • Patent number: 8483832
    Abstract: Systems and devices for selectively applying electrical energy to a target region beneath a skin surface of a patient involve applying an electrical impulse to one or more electrodes on a skin surface of the patient to modulate one or more nerves at the target region, where the impulse is substantially blocked at nerves located between the target region and the skin surface such that only the nerves at the target region are modulated by the electrical impulse.
    Type: Grant
    Filed: May 20, 2009
    Date of Patent: July 9, 2013
    Assignee: Electrocore, LLC
    Inventor: Bruce Simon
  • Publication number: 20130172957
    Abstract: The present disclosure describes a circuit that may be used in a non-invasive nerve stimulator. The circuit contains a signal source, a power source, an amplification source and a user interface portion. The circuit may be used in a handheld device that is applied directly to the surface of a patient or it may be used in other configurations.
    Type: Application
    Filed: December 14, 2012
    Publication date: July 4, 2013
    Applicant: ElectroCore, LLC.
    Inventors: Steven Mendez, Hechung Hu, Arthur Ross, Puyon Guo
  • Publication number: 20130131753
    Abstract: Devices, systems and methods are disclosed for treating or preventing gastroparesis, functional dyspepsia, and other functional gastrointestinal disorders. The methods comprise transmitting impulses of energy non-invasively to selected nerve fibers, particularly those in a vagus nerve. The methods provide damaged interstitial cells of Cajal (ICC) with trophic factors via vagal afferent nerve fibers, thereby reversing ICC damage, and as a consequence improving gastric motility. The methods also increase levels of inhibitory neurotransmitters in the brain so as to decrease neural activity within the area postrema, or they deactivate a resting state neural network containing parts of the anterior insula and anterior cingulate cortex, which will thereby reduce abnormal interoception and visceral hypersensitivity.
    Type: Application
    Filed: December 30, 2012
    Publication date: May 23, 2013
    Applicant: ElectroCore, LLC.
    Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
  • Publication number: 20130131746
    Abstract: Energy is transmitted noninvasively to a patient using electrode-based stimulation devices or magnetic stimulation devices that are designed to non-invasively stimulate nerves selectively. The devices produce impulses that are used to treat atrial fibrillation, by stimulating a vagus nerve of a patient. The devices are also used to forecast the imminent onset of atrial fibrillation and then avert it by stimulating a vagus nerve.
    Type: Application
    Filed: January 8, 2013
    Publication date: May 23, 2013
    Applicant: ElectroCore, LLC.
    Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
  • Patent number: 8401650
    Abstract: The present invention provides systems, apparatus and methods for selectively applying electrical energy to body tissue. A device is provided having an enclosure within an outer wall formed from an electrically-permeable material to allow for electrical energy to pass from the interior of the enclosure through the outer wall. The device further includes an electrode positioned within the interior of the enclosure and a fluid passage coupled to the enclosure for delivery of an electrically conductive fluid into the interior of the enclosure such that the electrically conductive fluid couples the electrode with the electrically-permeable section of the outer wall. The conductive fluid allows for the passage of electrical energy from the electrode through the fluid and the outer wall of the enclosure for treatment of tissue on or in a patient.
    Type: Grant
    Filed: February 27, 2009
    Date of Patent: March 19, 2013
    Assignee: ElectroCore LLC
    Inventors: Bruce Simon, Steven Mendez, Hecheng Hu, Richard P. Dickerson, James R. Pastena, Puyun Guo