Patents Assigned to Eli Lilly & Company
  • Method for knockout mutagenesis in Streptococcus pneumoniae
    Patent number: 5981281
    Abstract: Provided herein is a method to produce knockout mutations at targeted sites in the genome of Streptococcus pneumoniae.
    Type: Grant
    Filed: December 8, 1997
    Date of Patent: November 9, 1999
    Assignee: Eli Lilly and Company
    Inventors: Richard Henry Baltz, Jo Ann Hoskins, Patricia Jean Solenberg, Patti Jean Treadway
  • Effect of compounds that suppress induction of plasminogen activator inhibitor 1 (PAI-1)
    Patent number: 5980938
    Abstract: The present invention provides methods of inhibiting PAI-1 using benzopyrans.
    Type: Grant
    Filed: June 25, 1997
    Date of Patent: November 9, 1999
    Assignee: Eli Lilly and Company
    Inventors: David Thompson Berg, George Joseph Cullinan, Brian William Grinnell, Mark Alan Richardson
  • Benzothiophene compounds, compositions, and methods
    Patent number: 5981570
    Abstract: The invention provides benzothiophene compounds, formulations, and methods of inhibiting bone loss or bone resorption, particularly osteoporosis, cardiovascular-related pathological conditions, including hyperlipidemia.
    Type: Grant
    Filed: September 22, 1997
    Date of Patent: November 9, 1999
    Assignee: Eli Lilly and Company
    Inventors: Henry Uhlman Bryant, George Joseph Cullinan, Jeffrey Alan Dodge
  • Benzo[B]thiophene compounds, intermediates, processes, compositions, and methods
    Patent number: 5977098
    Abstract: The invention provides a compound of formula I: ##STR1## or a pharmaceutically acceptable salt or solvate thereof; pharmaceutical formulations containing a compound of formula I, and methods of using a compound of formula I for the inhibition of bone loss or bone resorption and for treatment of cardiovascular-related pathological conditions.
    Type: Grant
    Filed: June 30, 1998
    Date of Patent: November 2, 1999
    Assignee: Eli Lilly and Company
    Inventor: Alan David Palkowitz
  • Process for preparing pharmaceutical compounds
    Patent number: 5977387
    Abstract: This invention provides processes for preparing cryptophycin compounds and novel intermediates which are useful in such processes.
    Type: Grant
    Filed: February 25, 1998
    Date of Patent: November 2, 1999
    Assignees: Eli Lilly and Company, Wayne State University, University of Hawaii
    Inventor: Vinod F Patel
  • Use of moxonidine for the treatment of atherosclerosis
    Patent number: 5977121
    Abstract: There is disclosed a method of treating atherosclerosis, of preventing atherosclerotic lesions and plaque formation, of inhibiting atherogenesis, and of decreasing intracellular cholesterol accumulation through the administration of an effective amount of moxonodine, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: December 22, 1997
    Date of Patent: November 2, 1999
    Assignee: Eli Lilly and Company
    Inventor: Hans Jurgen Mest
  • Screen for inhibitors of fungal IPC synthase
    Patent number: 5976866
    Abstract: This invention provides novel fungal strains altered in IPC synthase production, and a method for screening for inhibitors of fungal IPC synthase using whole cells.
    Type: Grant
    Filed: April 9, 1997
    Date of Patent: November 2, 1999
    Assignee: Eli Lilly and Company
    Inventors: Steven Alan Heidler, Jeffrey Alan Radding, Debra Ann Young
  • Glucagon-like insulinotropic peptides, compositions and methods
    Patent number: 5977071
    Abstract: The present invention provides novel complexes consisting of certain GLP-1 molecules associated with a divalent metal cation that is capable of co-precipitating with a GLP-1 molecule. Pharmaceutical compositions and methods of using such complexes for enhancing the expression of insulin in B-type islet cells is claimed, as is a method for treating maturity onset diabetes mellitus in mammals, particularly humans.
    Type: Grant
    Filed: September 10, 1997
    Date of Patent: November 2, 1999
    Assignee: Eli Lilly and Company
    Inventors: John A. Galloway, James A. Hoffmann
  • Benzothiophene compounds, intermediates, compositions, and methods
    Patent number: 5977093
    Abstract: A method for alleviating the symptoms of post-menopausal syndrome comprising administering to a woman in need thereof an effective amount of a compound of formula I whereinR.sup.1a is --H or --OR.sup.7a in which R.sup.7a is --H or a hydroxy protecting group;R.sup.2a is --H, halo, or --OR.sup.8a in which R.sup.8a is --H or a hydroxy protecting group;R.sup.3 is 1-piperidinyl, 1-pyrrolidino, methyl-1-pyrrolidinyl, dimethyl-1-pyrrolidino, 4-morpholino, dimethylamino, diethylamino, diisopropylamino, or 1-hexamethyleneimino;n is 2 or 3; andZ is --O-- or --S--;or a pharmaceutically acceptable salt thereof, and further comprising administering to said woman an effective amount of progestin.
    Type: Grant
    Filed: November 3, 1995
    Date of Patent: November 2, 1999
    Assignee: Eli Lilly and Company
    Inventor: Alan David Palkowitz
  • Glycopeptide antibiotic derivatives
    Patent number: 5977062
    Abstract: The present invention provides glycopeptide antibiotic derivative compounds. These derivative compounds possess antibacterial activity against a wide variety of bacteria, including activity against vancomycin-resistant isolates. Methods of making and using these glycopeptide antibiotic derivative compounds are also provided.
    Type: Grant
    Filed: April 17, 1998
    Date of Patent: November 2, 1999
    Assignee: Eli Lilly and Company
    Inventors: Robin D. G. Cooper, Bret E. Huff, Thalia I. Nicas, John T. Quatroche, Michael J. Rodriguez, Nancy J. Snyder, Michael A. Staszak, Richard C. Thompson, Stephen C. Wilkie, Mark J. Zweifel
  • Methods for inhibiting endometriosis
    Patent number: 5977157
    Abstract: The present invention provides novel methods of lowering serum cholesterol and inhibiting smoother muscle cell proliferation, particularly restenosis, in humans, and inhibiting uterine fibroid disease and endometriosis in women comprising administering to a human/woman in need of treatment an effective amount of a compound of formula I ##STR1## wherein R is C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, halo, or trifluoromethyl;R.sup.1 and R.sup.2 each are the same or different C.sub.1 -C.sub.6 alkyl group;n is an integer from 2 to 6; andR.sup.3 and R.sup.4 each are independently C.sub.1 -C.sub.4 alkyl, or combine to form a substituent selected from the group consisting of pyrrolidino, morpholino, piperidino, piperazino, 4-(C.sub.1 -C.sub.6 alkyl)piperazino, and 4-phenyl-piperazino;or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: June 30, 1998
    Date of Patent: November 2, 1999
    Assignee: Eli Lilly and Company
    Inventors: Henry U. Bryant, Jeffrey A. Dodge
  • Selective .beta.3 adrenergic agonist
    Patent number: 5977154
    Abstract: The present invention is in the field of medicine, particularly in the treatment of Type II diabetes and obesity. More specifically, the present invention relates to selective .beta.3 adrenergic receptor agonists useful in the treatment of Type II diabetes and obesity.
    Type: Grant
    Filed: June 26, 1997
    Date of Patent: November 2, 1999
    Assignee: Eli Lilly and Company
    Inventors: Michael Gregory Bell, Christine Ann Droste, Cynthia Darshini Jesudason, Christopher John Rito, Anthony John Shuker, Mark Alan Winter
  • Benzo[b]thiophene compounds, intermediates, processes, compositions, and methods
    Patent number: 5977382
    Abstract: The instant invention provides novel benzo[b]thiophene compounds, intermediates, compositions, pharmaceutical formulations, and methods of use.
    Type: Grant
    Filed: June 30, 1998
    Date of Patent: November 2, 1999
    Assignee: Eli Lilly and Company
    Inventor: Alan David Palkowitz
  • Process for the synthesis of benzothiophenes
    Patent number: 5977383
    Abstract: The instant invention provides improved processes for preparing benzothiophenes utilizing cation exchange resins.
    Type: Grant
    Filed: September 22, 1997
    Date of Patent: November 2, 1999
    Assignee: Eli Lilly and Company
    Inventors: Jeffrey Thomas Vicenzi, Tony Yantao Zhang
  • Alkylated hexapeptides
    Patent number: 5977063
    Abstract: The present invention is directed to N.sup.1 -alkylated derivatives of desleucyl A82846B. These derivatives are useful as antibacterials and also as starting materials from which further antibacterial compounds are prepared.
    Type: Grant
    Filed: April 30, 1998
    Date of Patent: November 2, 1999
    Assignee: Eli Lilly and Company
    Inventors: Richard Craig Thompson, Stephen Charles Wilkie
  • Solid orally administerable raloxifene hydrochloride pharmaceutical formulation
    Patent number: 5972383
    Abstract: This invention provides orally administerable pharmaceutical formulations comprising raloxifene, its ethers or esters, or a pharmaceutically-acceptable salt thereof, in combination with a hydrophilic carrier composition.
    Type: Grant
    Filed: June 1, 1998
    Date of Patent: October 26, 1999
    Assignee: Eli Lilly and Company
    Inventors: Lowell L. Gibson, Kerry J. Hartauer, Julian L. Stowers, Stephanie A. Sweetana, Arvind L. Thakkar
  • Pyrazoles as human non-pancreatic secretory phospholipase A.sub.2 inhibitors
    Patent number: 5972972
    Abstract: A class of novel pyrazoles is disclosed together with the use of such compounds for inhibiting sPLA.sub.2 mediated release of fatty acids for treatment of conditions such as septic shock.
    Type: Grant
    Filed: December 3, 1997
    Date of Patent: October 26, 1999
    Assignee: Eli Lilly and Company
    Inventors: Edward D. Mihelich, Tulio Suarez, Gary A. Hite, Peter J. Doman, Stuart E. Willetts
  • Method for treatment of chronic bronchitis using indole compounds
    Patent number: 5972988
    Abstract: A method is disclosed for the treatment of chronic bronchitis by administering to a mammal in need thereof a therapeutically effective amount of a 1H-indole-3-glyoxylamide compound.
    Type: Grant
    Filed: March 12, 1998
    Date of Patent: October 26, 1999
    Assignee: Eli Lilly and Company
    Inventor: William Louis Macias
  • Methods of treating nueropeptide Y-associated conditions
    Patent number: 5972888
    Abstract: This invention describes methods of treating conditions associated with an excess of neuropeptide Y which comprises administering an obesity protein. This invention also describes methods of treating conditions associated with an excess of neuropeptide Y which comprises administering an obesity protein in combination with a neuropeptide Y antagonist. This invention demonstrates that the obesity protein acts by reducing the production of neuropeptide Y by the hypothalamus.
    Type: Grant
    Filed: October 23, 1997
    Date of Patent: October 26, 1999
    Assignee: Eli Lilly and Company
    Inventors: Juliana Maude Bue-Valleskey, Mark Louis Heiman, Thomas Wesley Stephens, Frank C. Tinsley
  • Protein kinase which specifically phosphorylates BRCA-1
    Patent number: 5972675
    Abstract: The present invention describes a protein kinase which catalyzes the in phosphorylation of BRCA-1 protein. The present invention also describes the use of the BRCA-1 protein kinase as a molecular target for therapeutic intervention and/or as a therapeutic tool for diagnosing and treating breast and/or ovarian cancer.
    Type: Grant
    Filed: January 17, 1997
    Date of Patent: October 26, 1999
    Assignee: Eli Lilly and Company
    Inventors: Richard P. Beckmann, Teresa F. Burke, Kimberly S. Cocke, Stephanie J. Lemke