Patents Assigned to Eli Lilly & Company
  • Naphthofluorene compounds, intermediates, compositions, and methods
    Patent number: 5959103
    Abstract: The invention provides naphthofluorene compounds, intermediates, formulations, processes, and methods of inhibiting bone loss or bone resorption, particularly osteoporosis, cardiovascular-related pathological conditions, including hyperlipidemia, and estrogen-dependent cancer.
    Type: Grant
    Filed: September 30, 1998
    Date of Patent: September 28, 1999
    Assignee: Eli Lilly and Company
    Inventors: Henry Uhlman Bryant, Jeffrey Alan Dodge, Charles Willis Lugar, III
  • Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical agents
    Patent number: 5955608
    Abstract: Novel processes for producing benzothiophenes employing ethylene carbonate or propylene carbonate are provided.
    Type: Grant
    Filed: January 30, 1998
    Date of Patent: September 21, 1999
    Assignee: Eli Lilly and Company
    Inventor: Douglas P. Kjell
  • Naphthyl compounds and compositions, as estrogen receptor binding agents
    Patent number: 5952350
    Abstract: The invention provides a compound of formula I: ##STR1## or a pharmaceutically acceptable salt or solvate thereof; pharmaceutical compositions containing a compound of formula I, and methods of using a compound of formula I for inhibiting bone loss or bone resorption, particularly osteoporosis, and cardiovascular-related pathological conditions including hyperlipidemia, and estrogen dependent cancer.
    Type: Grant
    Filed: October 23, 1997
    Date of Patent: September 14, 1999
    Assignee: Eli Lilly and Company
    Inventors: George Joseph Cullinan, Brian Stephen Muehl
  • Reductive alkylation of glycopeptide antibiotics
    Patent number: 5952466
    Abstract: This invention is concerned with improved processes for reductive alkylation of glycopeptide antibiotics. The improvement residing in providing a source of copper which results in the initial production of a copper complex of the glycopeptide antibiotic. Reductive alkylation of this complex favors regioselective alkylation and increased yields. Copper complexes of the glycopeptide antibiotic starting materials and of the alkylated products are also part of the invention.
    Type: Grant
    Filed: November 12, 1997
    Date of Patent: September 14, 1999
    Assignee: Eli Lilly and Company
    Inventors: Richard Alan Berglund, Nancy Anne Lockwood, Howard Eugene Magadanz, Hua Zheng
  • Glycopeptide hexapeptides
    Patent number: 5952310
    Abstract: The present invention is directed to glycopeptides and more particularly to derivatives of the glycopeptide A82846B. In these derivatives, the leucyl has been removed to create "hexapeptides" of A82846B and its N.sup.DISACC variations. These hexapeptides are useful as antibacterials and also as starting materials from which further antibacterial compounds are prepared.
    Type: Grant
    Filed: April 30, 1998
    Date of Patent: September 14, 1999
    Assignee: Eli Lilly and Company
    Inventors: Richard Craig Thompson, Stephen Charles Wilkie
  • Methods for inhibiting smooth muscle cell proliferation
    Patent number: 5952364
    Abstract: The present invention provides novel methods of lowering serum cholesterol and inhibiting smoother muscle cell proliferation, particularly restenosis, in humans, and inhibiting uterine fibroid disease and endometriosis in women comprising administering to a human/woman in need of treatment an effective amount of a compound of formula I ##STR1## wherein R is C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, halo, or trifluoromethyl;R.sup.1 and R.sup.2 each are the same or different C.sub.1 -C.sub.6 alkyl group;n is an integer from 2 to 6; andR.sup.3 and R.sup.4 each are independently C.sub.1 -C.sub.4 alkyl, or combine to form a substituent selected from the group consisting of pyrrolidino, morpholino, piperidino, piperazino, 4-(C.sub.1 -C.sub.6 alkyl)piperazino, and 4-phenyl-piperazino;or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: June 30, 1998
    Date of Patent: September 14, 1999
    Assignee: Eli Lilly and Company
    Inventors: Henry U. Bryant, Jeffrey A. Dodge
  • Method for treating neuropathic pain
    Patent number: 5952360
    Abstract: The present invention provides a method for treating neuropathic pain comprising administering an analgesic dosage of a compound of formula I to an animal in need of such treatment certain phenyl oxazoles or phenyl thiazoles.
    Type: Grant
    Filed: August 24, 1998
    Date of Patent: September 14, 1999
    Assignee: Eli Lilly and Company
    Inventors: Jill Ann Panetta, Harlan Edgar Shannon
  • Monomeric insulin analog formulations
    Patent number: 5952297
    Abstract: The present invention discloses various parenteral pharmaceutical formulations having a protracted effect, which comprise: a sterile aqueous suspension of about 20 U/mL to about 500 U/mL insulin analog, about 5 mg/mL to about 10 mg/mL sodium chloride, about 0.2 to about 2.0 mg/mL physiologically acceptable buffer, a zinc ion content of about 0.07 mg/mL to about 0.1 mg/mL, and a physiologically acceptable preservative at a pH of about 6.5 to about 7.8; such that less than 5% of the analog present in the suspension is in the dissolved state.
    Type: Grant
    Filed: September 26, 1997
    Date of Patent: September 14, 1999
    Assignee: Eli Lilly and Company
    Inventors: Michael R. De Felippis, Bruce H. Frank
  • Benzo?b! thiophene compounds
    Patent number: 5952513
    Abstract: The instant invention provides novel benzo?b!thiophene compounds, intermediates, compositions, pharmaceutical formulations, and methods of use.
    Type: Grant
    Filed: June 30, 1998
    Date of Patent: September 14, 1999
    Assignee: Eli Lilly and Company
    Inventor: Alan David Palkowitz
  • Biosynthetic gene muri from Streptococcus pneumoniae
    Patent number: 5948645
    Abstract: The invention provides isolated nucleic acid compounds encoding the stem peptide biosynthetic gene murI of Streptococcus pneumoniae. Also provided are vectors and transformed heterologous host cells for expressing the MurI enzyme product and a method for identifying compounds that inhibit stem peptide biosynthesis.
    Type: Grant
    Filed: December 4, 1996
    Date of Patent: September 7, 1999
    Assignee: Eli Lilly and Company
    Inventors: Jo Ann Hoskins, Franklin Harpold Norris, Pamela Kay Rockey, Paul Robert Rosteck, Jr., Paul Luther Skatrud, Patti Jean Treadway, Michele Louise Young Bellido, Chyun-Yeh Earnest Wu
  • Benzothiopene compounds, and uses and formulations thereof
    Patent number: 5948795
    Abstract: Novel benzothiophenes, ##STR1## wherein R.sub.1, R.sub.2, and R.sub.3 are independently --OH, --OCO(C.sub.1 -C.sub.6 alkyl), --O(CO)O(C.sub.1 -C.sub.6 alkyl), --OCO--Ar, where Ar is phenyl or substituted phenyl, or --O(CO)O--phenyl; and R.sub.4 is N-pyrrolidinyl, N-piperidinyl, or N-hexamethyleneimino, and intermediates thereof, and the uses and formulations thereof, are provided by the present invention.
    Type: Grant
    Filed: June 25, 1997
    Date of Patent: September 7, 1999
    Assignee: Eli Lilly and Company
    Inventors: David Thompson Berg, George Joseph Cullinan, Brian William Grinnell, Mark Alan Richardson
  • Synthesis of bisindolylmaleimides
    Patent number: 5948907
    Abstract: The present invention provides for the reaction of optionally substituted indole-3-acetamides with optionally substituted methyl indole-3-glyoxyl reagent to prepare potent PKC inhibitors.
    Type: Grant
    Filed: May 19, 1998
    Date of Patent: September 7, 1999
    Assignee: Eli Lilly and Company
    Inventors: Margaret Mary Faul, Leonard Larry Winneroski, Jr.
  • Benzo?B!thiophene compounds, intermediates, formulations, and methods
    Patent number: 5948796
    Abstract: This invention relates to the field of pharmaceutical and organic chemistry and provides benzothiophene compounds, intermediates, formulations, and methods.
    Type: Grant
    Filed: September 3, 1997
    Date of Patent: September 7, 1999
    Assignee: Eli Lilly and Company
    Inventors: Henry Uhlman Bryant, Michael John Martin, Ken Matsumoto
  • Platenolide synthase gene
    Patent number: 5945320
    Abstract: A DNA molecule isolated from Streptomyces ambofaciens encodes the multi-functional proteins which direct the synthesis of the polyketide platenolide.
    Type: Grant
    Filed: February 21, 1997
    Date of Patent: August 31, 1999
    Assignee: Eli Lilly and Company
    Inventors: Stanley G. Burgett, Stuart A. Kuhstoss, Ramachandra N. Rao, Mark A. Richardson, Paul R. Rosteck, Jr.
  • Multiple drug resistance gene ATRC of aspergillus nidulans
    Patent number: 5945324
    Abstract: The invention provides isolated nucleic acid compounds encoding a multiple drug resistance protein of Aspergillus nidulans. Vectors and transformed host cells comprising the multiple drug resistance-encoding DNA of Aspergillus nidulans atrC are also provided. The invention further provides assays which utilize these transformed host cells.
    Type: Grant
    Filed: December 23, 1997
    Date of Patent: August 31, 1999
    Assignee: Eli Lilly and Company
    Inventors: Paul Luther Skatrud, Maarten A. de Waard, Alan C. Andrade, Robert Brown Peery
  • Method for treating pain
    Patent number: 5945416
    Abstract: The present invention provides a method for treating pain using a composition comprising olanzapine and Drug Useful in the Treatment of Pain.
    Type: Grant
    Filed: March 24, 1997
    Date of Patent: August 31, 1999
    Assignee: Eli Lilly and Company
    Inventors: Harlan E. Shannon, Daniel E. Womer
  • Imtermediate in process to make 2', 2'-difluoronucleosides
    Patent number: 5945547
    Abstract: The compound 2-deoxy-2,2-difluoro-D-erythro-pentofuranos-1-ulose-3,5-dibenzoate is described and claimed.
    Type: Grant
    Filed: March 19, 1997
    Date of Patent: August 31, 1999
    Assignee: Eli Lilly and Company
    Inventors: Ta-Sen Chou, Perry C. Heath
  • Method for treating pain
    Patent number: 5942530
    Abstract: The present invention provides a method for treating pain using a composition comprising certain phenyl oxazoles or phenyl thiazoles in combination with a Drug Useful in the Treatment of Pain.
    Type: Grant
    Filed: August 24, 1998
    Date of Patent: August 24, 1999
    Assignee: Eli Lilly and Company
    Inventors: Jill Ann Panetta, Harlan Edgar Shannon
  • N-?2-substituted-3-(2-aminoethyl)-1H-indol-5-YL!-Amides: new 5-HT.sub.1F agonists
    Patent number: 5942536
    Abstract: The invention provides novel 5-HT.sub.1f agonists of formula (I) where X, R.sup.1, R.sup.2, and R.sup.3 are defined in the specification, which are useful for the treatment of migraine and associate disorders.
    Type: Grant
    Filed: March 13, 1998
    Date of Patent: August 24, 1999
    Assignee: Eli Lilly and Company
    Inventors: James E Fritz, Patric J Hahn, Stephen W Kaldor, Miles G Siegel, Yao-Chang Xu
  • Reaction vessel for combining chemicals
    Patent number: D414271
    Type: Grant
    Filed: February 3, 1997
    Date of Patent: September 21, 1999
    Assignee: Eli Lilly and Company
    Inventor: Jose S. Mendoza