Patent number: 6720306
Abstract: A compound of Formula I, providing tetrapartate prodrugs is provided
wherein:
L1 is a bifunctional linking moiety;
D is a moiety that is a leaving group, or a residue of a compound to be delivered into a cell;
Z is covalently linked to [D]y, wherein Z is selected from the group consisting of: a moiety that is actively transported into a target cell, a hydrophobic moiety, and combinations thereof,
Y1, Y2, Y3 and Y4 are each independently O, S, or NR12;
R11 is a mono- or divalent polymer residue;
R1, R4, R9, R10 and R12 are independently selected from the group consisting of hydrogen, C1-6 alkyls, C3-12 branched alkyls, C3-8 cycloalkyls, C1-6 substituted alkyls, C3-8 substituted cycloalkyls, aryls, substituted aryls, aralkyls, C1-6 heteroalkyls and substituted C1-6 heteroalkyls;
R2, R3, R5 and R6 are independently selected from the group consisting of hydrogen, C1-6 alkyls, C1-6 alkoxy, phenoxy, C1-8 heteroalkyls, C1-8 heteroalkoxy, substituted C1-6 alkyls, C3-8 cycloalkyls, C
Type:
Grant
Filed:
January 12, 2001
Date of Patent:
April 13, 2004
Assignee:
Enzon Pharmaceuticals, Inc.
Inventors:
Richard B. Greenwald, Hong Zhao