Abstract: The present invention provides compositions and methods for the selective silencing of neurons in pain pathway by using a combination of inhibitory light-sensitive protein gene transfer and wavelength specific illumination.

Abstract: Disclosed is a method for providing a control command set for an additive manufacturing device. The method includes providing a parameter set consisting of a number of parameters, and a construction rule, which is suitable for describing at least one section of the object by the parameter set geometrically as a number of linear or flat elements in space; generating a computer-based layer model of the section of the object by determining, for each layer, the position and shape of a cross-section of the section of the object within the layer, generating a control command set for an additive manufacturing device by which the production of the section of the object is implemented on the basis of the layer model.

Abstract: The invention relates to a method for generating control data for a device for additively manufacturing a component in a manufacturing process, in which method the energy beam is moved along a number of solidification paths across the construction field, and operation takes place at least temporarily in a toothing mode in which, when the energy beam is being moved across the construction field, a location-dependent desired welding-in depth of the energy beam is switched over at a plurality of switchover points which are randomly distributed over at least one defined region of a cross-section of the component in the layer in question.

Abstract: A device for the making of a three-dimensional object by means of layer by layer consolidation of a powderlike construction material by electromagnetic radiation or particle beam has a control unit that controls an irradiation device such that the powder particles of the construction material are bonded together at the sites where the radiation impinges on the construction material. A selective heating device is designed so that any given partial surface of the construction field can be heated before and/or after to a plateau temperature, which is significantly higher than the temperature of at least a portion of the construction field outside the partial surface. The control unit actuates the selective heating device such that the partial surface has a predefined minimum distance from the edge of the construction field.

Abstract: A calibration method includes positioning the coating unit in a first measuring position and detecting a first position reference value with respect to the reference point and a first measuring point associated with the coating unit at the first measuring position, positioning the coating unit in a second measuring position by moving the coating unit in the direction of movement and detecting a second position reference value with respect to the reference point and a second measuring point associated with the coating unit at the second measuring position, and determining a correction value for the first application element and/or the second application element from the detected first position reference value and the detected second position reference value.

Abstract: A face mask including a base model of a mask body having a front side and a back side and defining an interior. The back side includes a face opening within which a portion of a user face including a nose and mouth can be inserted and encompassed. The face opening is defined by a perimeter and is modified to substantially correspond to contours of the user face based on scan of topographical facial features of the user face. The face mask is manufactured from a thermoplastic elastomer (TPE) using an Additive Manufacturing (AM) system.

Abstract: A method for post-treating a three-dimensional object produced by selectively solidifying, layer by layer, of a building material in powder form and/or post-treating unsolidified building material in which the three-dimensional object is embedded. The three-dimensional object and/or the unsolidified building material may be treated with a liquid. The liquid may comprises a liquid carrier substance and at least one further substance that reduces surface tension of the carrier substance.

Abstract: Disclosed is a filter system for an additive manufacturing device for purifying a process gas of the additive manufacturing device wherein, in order to purify a volume of process gas during operation, the filter system has at least one permanent filter. The permanent filter is configured so as to be thermally stable in a manner such that during operation, the permanent filter is stable at a temperature of more than 110° C. Further disclosed is an additive manufacturing device as well as an additive manufacturing process.

Abstract: A method of manufacturing a permanent magnet, including providing a powder composition, of which a first fraction includes ferromagnetic metal particles and a second fraction includes thermoplastic polymer particles; using the powder composition in a powder-bed based additive manufacturing process to form a part including ferromagnetic metal particles embedded in a fused thermoplastic polymer body; and subsequently conferring magnetism on the built part by arranging the finished part in a magnetic field.

Abstract: A process for producing a three-dimensional object by selectively layer-by-layer solidification of a powdery material layer at the locations corresponding to the cross-section of the object in a respective layer by exposure to electromagnetic radiation. The powdery material comprises at least one polymer which is obtainable from its melt only in substantially amorphous or completely amorphous form, or a polyblend which is obtainable from its melt only in substantially amorphous or completely amorphous form. The powdery material has a specific melting enthalpy of at least 1 J/g.

Abstract: The present invention provide a non-aqueous electrolyte for use in static or non-flowing rechargeable electrochemical cells or batteries, wherein the electrolyte comprises a first deep eutectic solvent comprises a zinc salt, a second deep eutectic solvent comprising one or more quaternary ammonium salts, and a hydrogen bond donor. Another aspect of the present invention also provides a non-flowing rechargeable electrochemical cell that employs the non-aqueous electrolyte of the present invention.

Abstract: A device for an adjustment of a heater control includes a nominal parameter provision unit designed such that it provides at least one nominal parameter value, an actual parameter detection unit designed such that it is able to detect for at least one of the nominal parameter values the corresponding actual parameter value in a heater control or in an additive manufacturing device, wherein an actual parameter value is the actual value of a controlled variable and/or the actual value of its change with time and/or the actual value of a heater parameter and/or the actual value of its change with time, and a control change unit that automatically changes at least one control parameter value, if a predefined difference between the nominal parameter value and its corresponding actual parameter value is exceeded.

Abstract: An additive manufacturing method including repeatedly applying a layer of building material on a previously selectively solidified building material layer and scanning the layer at positions corresponding to the cross-section of the object in this layer, where the laser radiation is generated by a laser light source and is directed onto the building material layer via optical components. An optics compartment is encased by an optics compartment housing and accommodates the optical components. A defined gas atmosphere is maintained inside of the optics compartment, wherein the relative humidity of the defined gas atmosphere is kept below 3%.

Abstract: A standard powder bed fusion additive manufacture apparatus is provided with a device to modify the building space, including the powder feed for the building space, yielding a reduction in the active build area, with a concomitant reduction in the adjacent powder supply. A retrofit kit or assembly which is quickly emplaced on the existing equipment with little modification of the regular building space is provided, and is therefore readily removable when the building space is to be returned to its original condition. One advantage is the relatively quick manner in which the building space can be modified. A reduced area build piston is slideably received in a shaft depending from a cover that is emplaceable on the unmodified build area. The build piston moves with the pre-existing build platform. A like arrangement is provided for the feed container.

Abstract: A spinal correction rod implant manufacturing process includes: estimating a targeted spinal correction rod implant shape based on a patient specific spine shape correction and including spine 3D modeling, one or more simulation loops each including: first simulating an intermediate spinal correction rod implant shape from modeling mechanical interaction between the patient specific spine and: either, for the first simulation, the implant shape, or, for subsequent simulation, if any, an overbent implant shape resulting from the previous simulation loop, a second simulation of an implant shape overbending applied to the targeted spinal correction rod implant shape producing an overbent spinal correction rod implant shape representing a difference between: either, for the first loop, the targeted spinal correction rod implant shape, or, for subsequent loop, if any, the overbent spinal correction rod implant shape resulting from the previous simulation loop, and the intermediate spinal correction rod implant sha

Abstract: A mixing device serves for producing a powder mixture of a first powder component and at least one second powder component for an additive manufacturing device. The mixing device includes a first container for receiving the first and/or the second powder component, where a discharge opening for discharging the first and/or the second powder component is provided at a lower boundary of the first container, and a second container for receiving the first and/or the second powder component. The second container is designed to be at least partially open towards an upper side. The first and second container each include at least one fluidization zone for introducing a gas into the first and second container. The mixing device further includes a powder conduit that connects to the discharge opening of the first container and is guided into the second container.

Abstract: A method for making an article for application to the human body. Data from measurement of pressures across an area of a person's body is obtained, which is then corresponded to a two-dimensional pressure map of a model of an article for application to that body area and identifying pressure-point locations and a pressure value for identified pressure-point location within the pressure map. Each different pressure value has a compression unit structure corresponding to that pressure value. The article is formed by generating the assigned respective structures in an integrated one-piece construct through layerwise build up in an additive manufacture system, where the build up includes a process that forms a joinder in an interface between adjacent contiguous structures which differ in geometry from one another so as to bond those contiguous structures together across the interface.

Abstract: The present invention relates to a composition comprising at least one polymer system and at least one anti-agglomeration agent, the polymer system being selected from at least one thermoplastic polymer, the bulk density of the composition being more than 300 g/l. Furthermore, the present invention relates to a method for producing the composition according to the invention and its use.

Abstract: A static battery with a non-conductive elastomeric or thermoplastic housing. The, battery housing is adapted to receive at least one anode assembly, at least one cathode assembly, and at least one bipolar electrode assembly. At least the bipolar electrode assembly is formed from a conductive plastic resin that is formed as a CPE sheet. A carbon material is affixed to the CPE sheet to form the bipolar electrode. The at least one cathode assembly, the at least one anode assembly and the at least one bipolar electrode assembly are received into the battery box such that a liquid, and/or gas seal is formed, between electrode assemblies. The battery housing has slots into which the electrode assemblies are received. When the electrode assemblies are received into the housing, cells are formed by the cooperation of the electrode assemblies and the battery housing. The cells are then filled with electrolyte such as zinc bromide and a lid is placed on the battery box.