Abstract: The present invention concerns a magnet-assisted ball drive. The drive comprises a ball and a drive element in contact with the ball. The drive element is arranged to be rotated around its axis of rotation to drive the ball. The ball and the drive element each comprise magnetic material such that at least one of the ball and the drive element comprises a magnet to generate a magnetic pulling force to pull the ball and the drive element against each other.

Abstract: 2-homopiperazine-1-yl-4H-1,3-bensothiazine-4-one derivatives of formula (I) are provided. They are useful in the treatment of bacterial infections, in particular tuberculosis, buruli ulcer and leprosy. A process for the preparation of 2-(homo)piperazine 1,3-benzothiazine-4-one hydrochlorides is also provided.

Abstract: A compound having the following formula: which can also be embedded into a conjugated oligomeric of polymeric backbone, is proposed for optical and electro optical applications.

Abstract: The present invention relates to the use of benzimidazole sulfide derivatives and prodrugs thereof in the treatment and/or prevention of tuberculosis.

Abstract: An implantable device for the electrical and/or pharmaceutical stimulation of the central nervous system, especially the spinal cord, is suggested. The device comprises a conformable substrate which is primarily composed of a flexible and stretchable polymer, and a plurality of flexible electrodes and conductive leads embedded in the conformable substrate. Not only the substrate, but also the leads are stretchable. The substrate may consist of PDMS, and the leads may consist of a conductive PDMS, in particular, PDMS with an electrically conductive filler material, and may optionally be metal-coated. The device defines a multi-electrode array which may be employed for neurostimulation in the epidural or subdural space of an animal or human.

Abstract: The present invention describes methods and apparatuses for creating superposition shape images by superposed base and revealing layers of lenslet gratings. The superposition shape images form a message recognizable by a human observer or by an image acquisition and computing device such as a smartphone. The superposition shape images may be created by different superposition techniques ranging from 1D moiré, 2D moiré and level-line moiré superposition techniques to lenticular image and phase shift superposition techniques. Moiré superposition techniques enable creating superposition shape images at different apparent depth levels. Applications comprise the protection of documents and valuable articles against counterfeits, the creation of eye-catching advertisements as well as the decoration of buildings and exhibitions.

Abstract: A method for the preparation of a sample comprising highly polarized nuclear spins is proposed, comprising at least the following steps: a) provision of molecules with 1,2-dione structural units and/or molecules with 2,5-diene-1,4-dione structural units in the solid state; b) generation of radicals from these molecules by photo induced electron transfer by a first electromagnetic irradiation in the visible or ultraviolet frequency range in the solid state; c) dynamic nuclear polarization in the presence of a magnetic field in the solid state by applying a second electromagnetic irradiation with a frequency adapted to transfer spin polarization from the electrons to the nuclear spins leading to a highly polarized state thereof. Furthermore uses of correspondingly prepared samples for NMR, MRS and MRI experiments are proposed.

Abstract: The disclosed invention describes a new apparatus performing a new data acquisition for quantitative refractive index tomography. It is based on a linear scanning of the specimen, opposed to the classical approaches based on rotations of either the sample or the illumination beam, which are based on the illumination with plane waves, which orientation is successively modified in order to acquire angular information. On the contrary, the inventive apparatus and method rely on a specially shaped illumination, which provides straightforwardly an angular distribution in the illumination of the specimen. The specimen can thus be linearly scanned in the object plane in order to acquire the data set enabling tomographic reconstruction, where the different positions directly possess the information on various angles for the incoming wave vectors.

Abstract: A variable stiffness device, including a core including a low melting point alloy, an encapsulation surrounding the core, the encapsulation made of an elastic material and sealing the core, and a heating device arranged around the encapsulation, configured to heat the core, wherein the elastic material of the encapsulation is subject to a tensile stress in a direction along a longitudinal extension of the thread-like variable stiffness device.

Abstract: The invention refers to a method for analyzing reflected light of an object. First a light angle distribution for a point of the object is determined. Then a plenoptic projector is controlled to illuminate the point of the object with the determined light angle distribution. Then the reflected light intensity of the point of the object is measured and the measured reflected light is analyzed in dependence of the determined light angle distribution.

Abstract: An article made of an alloy of the general formula Pt1-a-bMa(B1-xMdx)b in which i) M stands for one or a mixture of metallic element(s) of the group Zr, Ti, Fe, Ni, Co, Cu, Pd, Ag, Al; ii) Md stands for one or a mixture of several metalloids of the group Si, P, C, S, As, Ge; iii) a is smaller than 0.2; iv) b is comprised between 0.2 and 0.5; v) x is comprised between 0 and 0.8; vi) the overall P content, if present, is less than 10 atomic percent the proportions of the elements forming the alloy having been selected to confer a hardness of at least 400 HV, a melting point below 1000° C. and improved processibility to the alloy.

Abstract: A method for manufacturing an electrical conductor includes: depositing a solid metal conductive layer or film on a substrate 30; depositing a liquid metal on the solid layer; and allowing the liquid metal and the solid layer 40 to alloy by diffusion of the liquid metal into the solid layer or film so as to form a solid conductive layer or film of the alloy; as well as allowing the liquid metal to further infiltrate the alloy so as to form percolating paths and/or droplets of the liquid metal in the the solid conductive layer or film, thus forming a biphasic conductive layer.

Abstract: The present invention concerns an electromagnetic actuator for a haptic display.

Abstract: The present invention concerns a method of sampling a test signal. The method comprises: acquiring training signals sampled at a plurality of sampling locations; running an optimization procedure for determining an index set of n indices, representing a subset of the sampling locations, that maximize a function, over the training signals, of a quality parameter representing how well a given training signal is represented by the n indices; and sampling the test signal at the sampling locations represented by the n indices.

Abstract: A power flow control system for an interconnected power system, the interconnected power system comprising a plurality of electrical subsystems; an abstract framework configured to work as a utility maximizer under constraints (that applies to the electrical subsystems by specifying their capabilities, expected behavior and a simplified view of their internal state); and a plurality of agents. Each agent is responsible of one or a plurality of the electrical subsystems, comprises means configured to express an internal state of the electrical subsystem within a common system of coordinates, and has communication means configured to communicate among agents according to a protocol. The abstract framework means enables a composition of a set of the interconnected electrical subsystems into a further subsystem for which a further internal state is expressed within the same common system of coordinates used before, the further internal state being communicated with other agents according to the protocol.

Abstract: The invention relates to a vehicle which includes at least four wheels and a base. Said wheels are attached in pairs at the base via connections and form a bogie consisting of a pair of wheels. Said bogies are rotatably hinged onto the base such that the pivot point of the path of the wheels is not physically present and said pivot point is located under the rotational axis of the wheels when the bogie is horizontal. The rotation of a bogie is transmitted by a transmission means to the other bogie such that the slant of each bogie in relation to the base forms an angle of identical but opposite value.

Abstract: The present invention relates to use of inhibitors of Notch signalling pathway selected from the group consisting of 6-(4-Tert-Butylphenoxy)Pyridin-3-Amine (I3), its derivatives, in treating and/or preventing cancers.

Abstract: The present invention relates to a bicistronic expression vector for silencing a gene specifically in astrocytes and neurons, comprising two expression cassettes comprising a first and a second silencer sequence, respectively, wherein the expression of said first silencer sequence within astrocytes is regulated by an astrocyte-specific promoter and the expression of said second silencer sequence within neurons is regulated by a neuron-specific promoter. In a preferred embodiment, said first and second silencer sequences are SOD1 silencer sequences. Pharmaceutical composition comprising said bicistronic vector and the use of the same in the treatment of motoneuron diseases are further described.

Abstract: Several embodiments of the present disclosure relate to glycotargeting therapeutics that are useful in the treatment of transplant rejection, autoimmune disease, food allergy, and immune response against a therapeutic agent. In several embodiments, the compositions are configured to target the liver and deliver antigens to which tolerance is desired. Methods and uses of the compositions for induction of immune tolerance are also disclosed herein.

Abstract: Neuroprosthetic device for restoring daily-life action movements of upper limbs in patients suffering from motor impairments. The neuroprosthetic device comprises several non-invasive electrodes adapted to be fixed on a patient body, in a way as to stimulate at least two separate muscles which participate to the movement execution of the upper limb, an electrical stimulation device for injecting electrical current into said electrodes and a controller unit for regulating said currents through said electrodes. The neuroprosthetic device is characterized by the fact that the controller unit comprises transducing means which are adapted to convert an input current. The input current is regulated according to the intention to execute a movement, into a plurality of electrical currents defined in a way as to generate and modulate the movement execution, in order to generate complex goal-oriented movements for performing daily-living activities.