Abstract: The present invention relates to a method for the generation of single chain immunoglobulins in a mammal. In particular, the present invention relates to a method for the generation of single chain camelid VHH antibodies in a mammal which undergo the process of class-switching and affinity maturation found within antibody producing B cells. Single chain antibodies generated using the method of the present invention and the uses thereof are also described.

Abstract: The invention relates to the field of immunology. Specifically, the invention relates to the field of immune-mediated disorders such as allergies, auto-immune disease, transplantation-related disease or inflammatory disease. The invention provides for an immunoregulator (IR), use of an IR in preparing a pharmaceutical composition for treating an immune-mediated disorder and a method for treating an immune-mediated disorder.

Abstract: The present invention relates to a method for the generation of single chain immunoglobulins in a mammal. In particular, the present invention relates to a method for the generation of single chain camelid VHH antibodies in a mammal which undergo the process of class-switching and affinity maturation found within antibody producing B cells. Single chain antibodies generated using the method of the present invention and the uses thereof are also described.

Abstract: The invention relates to the field of cytogenetics and the application of genetic diagnostic techniques in pathology and hematology. Specifically, the invention relates to nucleic acid probes that can be used in hybridization techniques for the detection of chromosomal aberrations and other gene rearrangements such as immunoglobulin and T cell receptor gene rearrangements. The probes provided by the invention are a distinct and balanced set of probes of comparable size each preferably being from 1 to 100 kb, or smaller, and flanking a potential breakpoint in a chromosome.

Abstract: The invention relates to methods and means for preventing, treating or reducing inflammation by inhibiting proteolytic activity. Specifically, the invention relates to preventing or reducing inflammations in the skin or intestine. The invention provides a method for reducing or preventing an inflammation by subjecting a mammal to treatment with at least one inhibitor which is capable of inhibiting proteolytic activity. In a preferred embodiment of the invention, the inhibitor is a plant product such as potato juice or a derivative thereof.

Abstract: The invention relates to the field of cancer diagnosis and the application of diagnostic techniques in pathology and hematology. Specifically, the invention relates to flow cytometric techniques for the detection of chromosomal aberrations and the detection of tumor specific gene products exclusively expressed by tumor cells containing said chromosomal aberrations. The invention provides a method to detect chromosomal aberrations in a biological sample via the exclusive detection of tumor-specific gene-product using at least two different probes directed against the gene-product.

Abstract: The invention relates to the field of cancer diagnosis and the application of diagnostic techniques in pathology and haematology. Specifically, the invention relates to techniques for the detection of chromosomal aberrations and the detection of tumor specific gene products exclusively expressed by tumor cells containing said chromosomal aberrations. The invention provides a method to detect chromosomal aberrations in a biological sample via the exclusive detection of tumor-specific gene-product using at least two different probes directed against the gene-product.

Abstract: Isolated nucleic acid molecules that include a tau gene sequence are described. The tau gene sequences have a mutation linked to a Tau pathology. Transgenic non-human mammals containing a Tau pathology also are also described.

Abstract: The present invention relates to a method for treatment of an ocular disorder, and especially retinal edema, comprising the administration to a patient of a compound that binds to at least one somatostatin receptor.

Abstract: Electronic angle-measuring device with two legs which are pivotably attached to one another. An angle-measuring sensor having two measurement plates which can be displaced with respect to one another is situated in the pivot point of these legs. At the end which is remote form the pivot point, the legs are provided with a sensor part which is pivotably attached thereto and is connected, via a cord connection, to the measurement plates of the sensor.

Abstract: The presence of cytotoxic T-cells to the Rev and/or Tat protein in samples from a subject infected with immunodeficiency virus, particularly HIV in humans, is an indication of a stable disease condition and a favorable prognosis of lack of progression to disease. Immunogenic compositions containing at least one cytotoxic T-cell epitope of the Rev and/or Tat protein of an immunodeficiency virus, particularly HIV, or a vector encoding the T-cell epitope, may be used to prevent infection by disease caused by the immunodeficiency virus, by stimulating, in the host, a specific cytotoxic T-cell response specific for the respective Rev and/or Tat proteins.

Abstract: A method and apparatus are described for estimating the cardiac output of the heart of a patient. An indicator is injected as an impulse in the blood stream of the patient, whereafter a first signal corresponding with the concentration variation of the indicator is measured at a position at a distance downstream of the injection position. Said first signal is supplied to a processor unit for determining the cardiac output from said first signal and the injected amount of indicator. Further, a second signal at least substantially proportional to the cardiac output is measured in the same blood stream adjacent the measurement position for the first signal. Both said signals are stored in a memory. Thereafter, said second signal is normalized by a predetermined value of said second signal and the first signal is corrected by means of the normalized second signal. The processor unit now determines the cardiac output from the corrected first signal.

Abstract: A medicine having transplant rejection and/or immunological inflammation inhibiting activities is provided, said medicine comprising a combination of a prostaglandin derivative and an immunosuppressive drug, such as a corticosteroid or a mercaptopurine, whereas further a method for treating patients is provided.

Abstract: Patients suffering from anxiety neurosis and anxietylike neurosis often accompanied by alcoholism are treated by administration of medicine containing a .beta.-(p-halogen phenyl)-.GAMMA.-aminobutyric acid as active compound. As a result these patients were totally freed from the above mentioned complaints.