Abstract: The invention concerns a method for determining, by flow cytometry, the hemoglobin F (HbF) content of each erythroid cell of a set of erythroid cells. This method applies in particular to determining the HbF content of each red blood cell of a set of red blood cells. The invention also concerns a method for determining the amount of red blood cells transfused into a patient and for monitoring the therapeutic efficacy of a treatment for sickle cell disease or ?-thalassemia.

Abstract: The present invention relates to a method for genotyping single nucleotide polymorphisms (SNPs) using a lateral flow test device. The invention also relates to a kit comprising said lateral flow test device and also to the use thereof for genotyping single nucleotide polymorphisms (SNPs).

Abstract: The present invention relates to a thiol compound suitable for forming a chain of oligomers that can be grafted to an oligonucleotide. The invention also relates to an oligonucleotide grafted by such a compound, thus having one or more thiol functions, suitable for being immobilized on a gold surface or on a grafted surface.

Abstract: A sealed and cryoresistant device for injecting a solution, the device being designed to be associated with a needle for subsequent injection of the solution and including an injection body, a plug and a plunger head. The injection body includes a first, proximal end closed in a sealed manner by the plunger head and a second, distal end closed in a sealed manner by the plug. The plug is held on the injection body by a fastening and includes a breakable portion allowing a needle to be mounted, the plug being a divisible plug, the separation of a divisible portion releasing an element for fastening an injector including a needle. The materials forming the device are cryoresistant.

Abstract: A composition including a supernatant obtained from co-culture of phagocytes with apoptotic cells. The composition is obtained by a) providing phagocytes, b) providing apoptotic cells, c) optionally washing the cells from step a) and b), d) co-culturing the cells of step a) and b), and e) separating the supernatant from the cells. The composition may be used in preventing or treating a pathological immune response.

Abstract: The present invention relates to a method for preserving, preferably human, cells, tissues or organs in severe hypothermia, comprising a step during which the cells, tissues or organs are kept in moderate hypothermia and preferably in a hypoxic and/or hypercapnic atmosphere, before placing them in severe hypothermia.

Abstract: Provided herein is a method for treating or preventing a pathological immune response comprising administering a supernatant obtainable from co-culture of phagocytes with apoptotic cells.

Abstract: The present disclosure is related to a live-attenuated strain of Pseudomonas for its use as a vaccine, and for use in a method for preventive immunizing and for treating Pseudomonas infection, in particular in patients suffering from cystic fibrosis. Preferably, the live-attenuated strain of Pseudomonas is furthermore treated to become ‘killed but metabolically active’.

Abstract: Compositions containing micropeptides capable of modulating the accumulation of miRs involved in certain pathologies, and the use of these micropeptides for treating the certain pathologies. Also, methods of identifying these micropeptides modulating the accumulation of miRs involved in pathologies. Further, nuclei acids encoding those micropeptides that modulate the accumulation of miRs involved in pathologies.

Abstract: A device for the storage of a corneal specimen has means for the reception and entrapment of a corneal specimen, connected to the means for the creation of a pressure gradient with overpressure on the endothelial side and to the preservation medium circulation means in the layouts that present the means for the reception and entrapment of the cornea specimen. The means for the reception and entrapment of the corneal specimen entrap the sclera ciliary zone surrounding the cornea in an airtight manner to delimit a separate endothelial chamber and epithelial chamber in which the preservation medium can circulate with an overpressure in the endothelial chamber; The intermediate component and the endothelial lid comprise inlet and outlet orifices for the preservation medium which are connected to the means for the circulation of the preservation medium and the creation of a pressure gradient between the endothelial chamber and the epithelial chamber with overpressure in the endothelial chamber.

Abstract: The present invention relates to a thiol compound suitable for forming a chain of oligomers that can be grafted to an oligonucleotide. The invention also relates to an oligonucleotide grafted by such a compound, thus having one or more thiol functions, suitable for being immobilized on a gold surface or on a grafted surface.

Abstract: The present invention relates to a method for inducing and amplifying specific effectors, which comprises obtaining pulsed plasmacytoid dendritic cells (pDC) by incubation of a pDC line with at least one antigen, the pulsed pDC being subsequently irradiated and brought into contact with peripheral blood mononuclear cells (PBMC), and cultured or injected into an organism. The pulsed and irradiated pDC and the PBMC share at least one major histocompatibility complex (MHC) allele.

Abstract: The invention relates to a secure system for the perfusion of a body liquid, enabling a final control of compatibility of a treatment with the patient and/or the medical situation previously diagnosed by a doctor, in a simple, efficient and energy-saving manner. To this end, the system includes a fluidic circuit of a perfusion having a perfusion catheter, a perfusion tubing and a container for the determined perfusion product to be perfused to a patient. The system is also configured to take a body liquid sample from a patient and to analyze and compare the body liquid sample to the determined perfusion product so as to control the flow of the perfusion product.

Abstract: The invention relates to a device (200) for taking a sample of a body fluid, such as blood, to be incorporated into a fluid circuit of a perfusion (100) of a patient who has a perfusion catheter (104), said device having a tubular structure (202) for connecting to the fluid circuit of the perfusion, provided with a zone for intubation, during use, of a sampling channel (300) comprising a distal end (301); and a means (203) for holding, during use, in the tubular structure, the part of the sampling channel (300) comprising a distal end (301) in such a way that the distal end (301) is oriented towards the perfusion catheter (104), in the direction of flow (F1) of the perfusion product (102), from a perfusion product reservoir (101) towards the perfusion catheter (104).

Abstract: The present invention relates to improved methods and kits for typing HLA class I and class II loci using DNA amplification and sequencing.

Abstract: Diagnostic kit comprising an oligonucleotide probe for the mRNA encoding a polypeptide having an amino acid sequence substantially identical to that of SEQ ID NO: 2.

Abstract: Novel use of HLA-G isoforms in the treatment or prevention of diseases in which bone resorption is observed.

Abstract: A method for preserving whole placental blood comprising introducing whole placental blood into an air barrier storage bag, storing said bag containing whole placental blood at a temperature of more than 0° C. and less than 40° C., so as to preserve the whole placental blood.

Abstract: The present invention relates to an in vitro method for detecting a pathogenic conformational isomer of the prion protein in a sample, said method comprising a preliminary step for capturing the pathogenic conformational isomer by putting the sample into contact with nanobeads covered with a ligand of the pathogenic conformational isomer, and then applying a cyclic amplification of the misfolded prion protein directly on the solid support having captured the pathogenic conformational isomer, and detecting the presence of the pathogenic conformational isomer. The invention also relates to a kit for applying this method and to a method for decontaminating a biological sample.

Abstract: The present invention relates to a new method for the preservation of blood platelets. In particular, the present invention provides a method which includes submitting the platelets to zeodration carried out at temperatures between 18° C. and 24° C. The dried platelets thus obtained can be preserved at room temperature for long period of time. The invention also provides kits and compositions for using the preserved platelets.